Low magnesium enhances the pro-arrhythmic effect of low potassium in the hypertrophied rat heart but not in the normal rat heart

Journal of Hypertension

Volumn 14, Issue 5, 1996, Pages 635-644

  Evans, Stephen J ^a,b   Levi, Allan J ^a   Jones, John V ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b BRISTOL ROYAL INFIRMARY   (United Kingdom)

Author keywords

Arrhythmia; Hypertension; Hypertrophy; Magnesium; Spontaneously hypertensive rat; Sudden death; Working heart

Indexed keywords

MAGNESIUM; POTASSIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROCARDIOGRAM; HEART AFTERLOAD; HEART ARRHYTHMIA; HEART LEFT VENTRICLE HYPERTROPHY; HEART PERFUSION; HEART VENTRICLE EXTRASYSTOLE; HEART VENTRICLE TACHYCARDIA; HEART VENTRICLE WALL; HYPERTENSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SYSTOLIC BLOOD PRESSURE;

EID: 0029994403     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199605000-00014     Document Type: Article

References (60)

1. Kannel WB: Left ventricular hypertrophy as a risk factor in arterial hypertension. Eur Heart J 1992, 13:82-88.
2. Kannel WB, Doyle JT, McNamara PM, Qickenton P, Gordon T: Precursors of sudden coronary death: factors related to the incidence of sudden death. Circulation 1975, 51:606-613.
3. Kannel WB: Left ventricular hypertrophy as a risk factor: the Framingham experience. J Hypertens 1991, 9:S3-S9.
4. McLenachan JM, Henderson E, Morris KI, Dargie HJ: Ventricular arrhythmias in patients with hypertensive left ventricular hypertrophy. N Engl J Med 1987, 317:787-792.
5. Messerli FH, Ventura HO, Elizardi DJ, Dunn FG, Frohlich ED: Hypertension and sudden death increased ventricular ectopic activity in left ventricular hypertrophy. Am J Med 1984, 77:18-22.
6. Levy D, Anderson KM, Savage DD, Balkus SA, Kannel WB, Castelli WP: Risk of ventricular arrhythmias in left ventricular hypertrophy: the Framingham heart study. Am J Cardiol 1987, 60:560-565.
7. James MA, Jones JV: The paradoxical role of left ventricular hypertrophy in wall stress-related arrhythmia. J Hypertens 1992, 10:167-172.
8. James MA, Jones JV: Ventricular arrhythmia in untreated newly presenting hypertensive patients compared with a matched normal population. J Hypertens 1989, 7:409-415.
9. Ghali JK, Kadakia S, Cooper RS, Liao Y: Impact of left ventricular hypertrophy on ventricular arrhythmias in the absence of coronary artery disease. J Am Coll Cardiol 1991, 17:1277-1282.
10. Caralis FV, Materson BJ, PerezStable E: Potassium and diuretic-induced ventricular arrhythmias in ambulatory hypertensive patients. Mineral Electrolyte Metab 1984, 10:148-154.
11. Hollifield JW: Potassium and magnesium abnormalities: diuretics and arrhythmias in hypertension. Am J Med 1984, 77:28-32.
12. Kannel WB, Cupples LA, D'Agostino RB, Stokes J III: Hypertension, antihypertensive treatment, and sudden coronary death. The Framingham Study. Hypertension 1988, 11 (suppl II):II45-II50.
13. Cohen JD, Neaton JD, Prineas RJ, Daniels KA: Diuretics, serum potassium and ventricular arrhythmias in the multiple risk factor intervention trial. Am J Cardiol 1987, 60:548-554.
14. Siscovick DS, Raghunathan TE, Psaty BM, Koepsell TD, Wicklund KG, Lin XH, et al.: Diuretic therapy for hypertension and the risk of primary cardiac arrest. N Engl J Med 1994, 330:1852-1857.
15. Millane TA, Ward DE, Camm AJ: Is hypomagnesaemia arrhythmogenic? Clin Cardiol 1992, 15:103-108.
16. Evans SJ, Levi AJ, Jones JV: Potassium depletion enhances wall-stress induced arrhythmias in the spontaneously hypertensive rat heart [abstract]. J Physiol 1994, 476:54P.
17. James MA, Jones JV: Systolic wall stress and ventricular arrhythmia: the role of acute change in blood pressure in the isolated working rat heart. Clin Sci Colch 1990, 79:499-504.
18. Lab MJ: Contraction - excitation feedback in myocardium. Physiological basis and clinical relevance. Circ Res 1982, 50:757-766.
19. Taggart P, Sutton P, Lab M, Runnalls M, O'Brien W, Treasure T: Effect of abrupt changes in ventricular loading on repolarization induced by transient aortic occlusion in humans. Am J Physiol 1992, 263:H816-H823.
20. Somers VK, Dyken ME, Mark AL, Abboud FM: Sympathetic-nerve activity during sleep in normal subjects. N Engl J Med 1993, 328:303-307.
21. Rials SJ, Wu Y, Ford N, Pauletto FJ, Abramson SV, Rubin AM, et al.: Effect of left ventricular hypertrophy and its regression on ventricular electrophysiology and vulnerability to inducible arrhythmia in the feline heart. Circulation 1994, 91:426-430.
22. Furukawa T, Bassett AL, Furukawa N, Kimura S, Myerburg RJ: The ionic mechanism of reperfusion-induced early afterdepolarizations in feline left ventricular hypertrophy. J Clin Invest 1993, 91:1521-1531.
23. Sasaki O, Frohlich ED: The spontaneously hypertensive rat as a model for human essential hypertension. In Calcium in Essential Hypertension. Edited by Aoki K, Frohlich ED. Tokyo: Academic Press; 1989:456-469.
24. Taegtmeyer H, Hems R, Krebs H: Utilisation of energy-providing substrates in the isolated working rat heart. Biochem J 1980, 186:701-711.
25. Engelmann GL, Virtullo JC, Gerrity RG: Morphometric analysis of cardiac hypertrophy during development, maturation, and senescence in spontaneously hypertensive rats. Circ Res 1987, 60:487-494.
26. Bing OHL, Brooks WW, Conrad CH, Sen S, Perreault CL, Morgan JP: Intracellular calcium transients in myocardium from spontaneously hypertensive rats during the transition to heart failure. Circ Res 1991, 68:1390-1400.
27. Okamoto K, Aoki K: Development of a strain of spontaneously hypertensive rats. Jpn Circ J 1963, 27:282-293.
28. Noresson E, Ricksten S-E, Hallback-Nordlander M, Thoren P: Performance of the hypertrophied left ventricle in spontaneously hypertensive rats. Effects of changes in preload and afterload. Acta Physiol Scand 1979, 107:1-8.
29. Ringler DH, Dabich L: Haematology and clinical biochemistry. In The Laboratory Rat. Edited by Baker HJ, Lindsay JR, Weisbroth SH. New York: Academic Press; 1979:105-118.
30. Walker MJA, Curtis MJ, Hearse DJ, Campbell RWF, Janse MJ, Yellon DM, et al.: The Lambeth Conventions: guidelines for the study of arrhythmias in ischaemia, infarction, and reperfusion. Cardiovasc Res 1988, 22:447-455.
31. Evans SJ, Levi AJ, Jones JV: Wall stress induced arrhythmia is enhanced by low potassium and early left ventricular hypertrophy in the working rat heart. Cardiovasc Res 1995, 29:555-562.
32. Agus ZS, Morad M: Modulation of cardiac ion channels by magnesium. Annu Rev Physiol 1991, 53:299-307.
33. Boyett MR, Hart G, Levi AJ: Dissociation between force and intracellular sodium activity with strophanthidin in isolated sheep Purkinje fibers. J Physiol 1986, 381:311-331.
34. Reiter MJ, Synhorst DP, Mann DE: Electrophysiological effects of acute ventricular dilatation in the isolated rabbit heart. Circ Res 1988, 62:554-562.
35. Dean JW, Lab MJ: Effect of changes in load on monophasic action potential and segment length of pig heart in situ. Cardiovasc Res 1989, 23:887-896.
36. Brooksby P, Levi AJ, Jones JV: Investigation of the mechanisms underlying the increased contraction of hypertrophied ventricular myocytes isolated from the spontaneously hypertensive rat. Cardiovasc Res 1993, 27:1268-1277.
37. Kincard TA, Liu XY, Liu S, Stimers JR: Effect of Na(pip) on K(o) activation of the Na-K pump in adult rat cardiac myocytes. Am J Physiol 1994, 266:C37-C41.
38. Akera T, Brody TM: Myocardial membranes: regulation and function of the sodium pump. Annu Rev Physiol 1982, 44:375-388.
39. +-ATPase activity and (3H)ouabain binding sites in sarcollema prepared from hearts of spontaneously hypertensive rats. Hypertension 1983, 5:682-688.
40. Ameen M, Davies JE, Ng LL: A comparison of free intracellular calcium and magnesium levels in the vascular smooth muscle and striated muscle cells of the spontaneously hypertensive and Wistar Kyoto normotensive rat. Ann N Y Acad Sci 1991, 639:550-553.
41. 31P-NMR study. Biochim Biophys Acta 1993, 1182:329-332.
42. Waring JJ, Howarth FC, Singh J: Studies on magnesium mobilisation and contractile force in the isolated rat heart [abstract]. J Physiol 1992, C46 (suppl):73P.
43. Limas CJ, Cohn JN: Defective calcium transport by cardiac sarcoplasmic reticulum in spontaneously hypertensive rats. Circ Res 1977, 40 (suppl 1):62-69.
44. Hopp HH: Possible relationship between mechanical response, action potential repolarization and Na/Ca exchange in myocardium of normotensive (NWR) and spontaneously hypertensive rats (SHR). Biomed Biochim Acta 1987, 46 (suppl):S407-S410.
45. Brooksby P, Levi AJ, Jones JV: Calcium handling in ventricular myocytes from the spontaneously hypertensive rat (SHR) [abstract]. J Mol Cell Cardiol 1992, 24 (suppl IV):S46-P33.
46. Hartzell HC, White RE: Effects of magnesium on inactivation of the voltage-gated calcium current in cardiac myocytes. J General Physiol 1989, 94:745-767.
47. Tzivoni D, Banai S, Schuger C, Benhorin J, Keren A, Gottlieb S, et al.: Treatment of torsade de points with magnesium sulfate. Circulation 1988, 77:392-397.
48. Agus ZS, Kelepouris E, Dukes I, Morad M: Cytosolic magnesium modulates calcium channel activity in mammalian ventricular cells. Am J Physiol 1989, 256:C452-C455.
49. Allen BJ, Brodsky MA, Capparelli EV, Luckett CR, Iseri LT: Magnesium sulfate therapy for sustained monomorphic ventricular tachycardia. Am J Cardiol 1989, 64:1202-1204.
50. Whant R: Magnesium and potassium interrelationships in cardiac arrhythmias. In Magnesium in Health and Disease. Edited by Itokawa Y, Durlach J. Paris: John Libbey and Co. Ltd; 1989:209-217.
51. Dubey A, Solomon R: Magnesium, myocardial ischaemia and arrhythmias. The role of magnesium in myocardial infarction. Drugs 1989, 37:1-7.
52. Bustamante JO, Ruknudin A, Sachs F: Stretch-activated channels in heart cells: relevance to cardiac hypertrophy. J Cardiovasc Pharmacol 1991, 17 (suppl 2):S110-S113.
53. Lakatta EG, Guarnieri T: Spontaneous myocardial calcium oscillations: are they linked to ventricular fibrillation? J Cardiovasc Electrophysiol 1993, 4:473-489.
54. Le Guennec JY, White E, Gannier F, Argibay JA, Garnier D: Stretch-induced increase of resting intracellular calcium concentration in single guinea-pig ventricular myocytes. Exp Physiol 1991, 76:975-978.
55. Ryan MP: The effects of diuretics on magnesium and potassium homeostasis. In Magnesium in Health and Disease. Edited by Itokawa Y, Durlach J. Paris: John Libbey and Co. Ltd; 1989:397-408.
56. Millane TA, Jennison SH, Mann JM, Holt DW, McKenna WJ, Camm AJ: Myocardial magnesium depletion associated with prolonged hypomagnesemia: a longitudinal study in heart transplant recipients. J Am Coll Cardiol 1992, 20:806-812.
57. Johnson CJ, Peterson DR, Smith EK: Myocardial tissue concentrations of magnesium and potassium in men dying suddenly from ischaemic heart disease. Am J Clin Nutr 1979, 32:967-970.
58. Reinhart RA, Marx JJ Jr, Broste SK, Haas RG: Myocardial magnesium: relation to laboratory and clinical variables in patients undergoing cardiac surgery. J Am Coll Cardiol 1991, 17:651-656.
59. Mirsky I: Physiological clinical and mathematical considerations. In Cardiac Mechanics. Edited by Mirsky I, Gista DN, Sandler H. New York: Wiley; 1974:381.
60. Kjelsberg E: Baseline rest electrocardiographic abnormalities, antihypertensive treatment, and mortality in the multiple risk factor intervention trial. Multiple risk factor intervention trial research group. Am J Cardiol 1985, 55:1-15.