Immunologic reconstitution following stem cell transplantation

Current Opinion in Hematology

Volumn 3, Issue 6, 1996, Pages 461-465

  Small, Trudy N ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN;

ADOPTIVE IMMUNOTHERAPY; BONE MARROW TRANSPLANTATION; CELLULAR IMMUNITY; CYTOMEGALOVIRUS; EPSTEIN BARR VIRUS; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL; HLA MATCHING; HUMAN; OPPORTUNISTIC INFECTION; PRIORITY JOURNAL; REVIEW; SIBLING; STEM CELL TRANSPLANTATION;

EID: 0029994194     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/00062752-199603060-00010     Document Type: Review

References (26)

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3. Speiser DE, Tiercy J-M, Rufer N, Grundschober C, Gratwohl A, Chapuis B, Helg C, Logler C-C, Kaisa M-K, Rossnek E, Jeannet M: High resolution HLA matching associated with decreased mortality after unrelated bone marrow transplantation. Blood 1996, 87:4455-4462. Compares the outcomes of unrelated transplants in serologically, DRβ1-matched versus DRβ1-mismatched donor/recipient pairs, demonstrating the superior outcome when matching is found by high-resolution typing.
4. Walter EA, Greenberg PD, Gilbert MJ, Finch RJ, Watanabe KS, Thomas ED, Riddell SR: Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N Engl J Med 1995, 333:1038-1044. Demonstrates the durable transfer of donor-derived cytomegalovirus cytotoxic donor clones after allogeneic BMT without inducing GVHD.
5. Lucas KG, Small T, Heller B, Dupont B, O'Reilly RJ: The development of cellular immunity to Epstein-Barr virus after allogeneic bone marrow transplantation. Blood 1996, 87:2594. Compares the time to acquire cellular immunity against Epstein-Barr virus following unmodified related, T-cell-depleted related and unrelated BMT, as well as the rapid restoration of normal cytotoxic T-lymphocytic precursors against Epstein-Barr virus in a recipient of donor leukocyte infusions for the treatment of posttransplantation Epstein-Barr virus LPD.
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7. Storek J, Witherspoon RP, Storb R: T cell reconstitution after bone marrow transplantation into adult patients does not resemble T cell development in early life. Bone Marrow Transplant 1995, 16:13-425. Compares T-cell phenotype following autologous and unmodified related and unrelated BMT with that of normal neonates, young children, and adults.
8. Small TN: Advances and controversies in BMT. Is there a difference in immunoreconstitution following autologous or allogenenic BMT? Bone Marrow Transplant 1995, suppl 1:153S. Demonstrates that children, regardless of transplant type, reconstitute their T-cell function more rapidly than adults and shows the profound effect of stem source on T-cell recovery in adults.
9. Kurtzberg J, Laughlin M, Graham ML, Smith C, Olson JF, Halperin EC, Giocci G, Carrier C, Stevens CE, Rubinstein P: Placental blood as a source of hematopoietic stem cells for transplantation in unrelated recipients. N Engl J Med 1996, 335:157-166. Demonstrates the curative potential of matched and mismatched unrelated cord blood transplants for the treatment of hematologic malignancis and bone marrow failure states as well as preliminary data on immune reconstitution after unrelated cord blood transplantation.
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11. Masuko K, Kato S, Hagihara M, Tsuchida F, Takemoto Y, Izawa K, Kato T, Yamamori S, Mizushima Y, Nishioka K, Tsuji K, Yamamoto K: Stable clonal expansion of T cells induced by bone marrow transplantation. Blood 1996, 87:789-799. Analyzes the development of the T-cell repertoire following allogeneic and autologous BMT and demonstrates that oligoclonality is a common characteristic of T-cell reconstitution after BMT.
12. Gaschet J, Dennis C, Milpied N, Hallet MM, Romagne F, Necker A, Vivien R, David-Ameline J, Davodeau F, Bonneville M, Vie H: Alterations of T cell repertoire after bone marrow transplantation: characterization of over-represented subsets. Bone Marrow Transplant 1995, 16:427-435. Analyzes the development of the T-cell repertoire following allogeneic and autologous BMT and demonstrates that oligoclonality is a common characteristic of T-cell reconstitution after BMT.
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15. Jin NR, Lum LG, Buren EV, Lerman SP, Walker AL, June CH: Signal transduction by B and T cells early after bone marrow transplantation: B cell calcium flux responses are intact whereas lack of CD4 cells accounts for impaired T cell responses. Bone Marrow Transplant 1995, 16:103-109.
16. Storek J, Witherspoon RP, Luthy D, Storb R: Low IgQ production by mononuclear cells from marrow transplant survivors and from normal neonates is due to a defect of B cells. Bone Marrow Transplant 1995, 15:679-684.
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18. Minegishi Y, Ishii N, Tsuchida M, Okawa H, Sugamura K, Yata J: T cell reconstitution by haploidentical BMT does not restore the diversification of the Ig heavy chain gene in patients with X-linked SCID. Bone Marrow Transplant 1995, 16:801-806. This study and that by Suzuki et al. (Blood 1996, 87:1873-1880) demonstrate the decreased somatic mutation of Ig heavy chain genes after transplantation in donor-derived as well as persistent host B cells following HLA-matched conventional and T-cell-depleted mismatched BMT for severe combined immunodefi-ciency, respectively.
19. Suzuki I, Milner ECB, Glas AM, Hufnagle WO, Rao SP, Pfister L, Nottenburg C: Immunoglobulin heavy chain variable region gene usage in bone marrow transplant recipients: lack of somatic mutation indicates a maturational arrest. Blood 1996, 87:5:1873-1880. This study and that by Minegishi et al. (Bone Marrow Transplant 1995, 16:801-806) demonstrate the decreased somatic mutation of Ig heavy chain genes after transplantation in donor-derived as well as persistent host B cells following HLA-matched conventional and T-cell-depleted mismatched BMT for severe combined immunodeficiency, respectively.
20. Suzuki I, Milner ECB, Glas AM, Hufnagle WO, Rao SP, Pfister L, Nottenburg C: Immunoglobulin heavy chain variable region gene usage in bone marrow transplant recipients: lack of somatic mutation indicates a maturational arrest. Blood 1996, 87:5:1873-1880. This study and that by Minegishi et al. (Bone Marrow Transplant 1995, 16:801-806) demonstrate the decreased somatic mutation of Ig heavy chain genes after transplantation in donor-derived as well as persistent host B cells following HLA-matched conventional and T-cell-depleted mismatched BMT for severe combined immunodeficiency, respectively.
21. Van tol MJD, Gerritsen EJA, Delange GG, Vanleeuwen AM, Jolvanderzijde CM, Oudemangruber NJ, Devries E, Radl J, Vossen JM: The origin of IgG production and homogeneous IgQ components after allogeneic bone marrow transplantation. Blood 1996, 87:818-826. This paper demonstrates the persistence of host IgG secretion for years after BMT, indicating resistance of host B cells to multiple, including total-body irradiation-containing, regimens.
22. King SM, Saunders EF, Petric M, Gold R: Response to measles, mumps, and rubella vaccination in paediatric bone marrow transplant recipients. Bone Marrow Transplant 1996, 17:633-636. Demonstrates the safety and efficacy of measles, mumps, and rubella vaccination in 22 patients following allogeneic and autologous BMT.
23. Pauksen K, Linde A, Ljungman P, Bolme P, Lonnerholm G, Oberg G, Sjolin J: Specific T and B cell immunity to measles after allogeneic and autologous bone marrow transplantation. Bone Marrow Transplant 1995, 16:807-813. Demonstrates the safety and efficacy of measles, mumps, and rubella vaccination in 22 patients following allogeneic and autologous BMT.
24. Nagler A, Ilan Y, Adler R, Or R, Naparstek E, Shouval D, Slavin B: Successful immunization of autologous bone marrow transplantation recipients against hepatitis B virus by active vaccination. Bone Marrow Transplant 1995, 15:3:475-478.
25. Molrine DC, Guinan EC, Antin J, Parsons SK, Weinstein HJ, Wheeler C, McGarigle C, Blanding P, Phillips NR, Kinsella K, Deans K, Ciamarra A, Goorin A, George S, Ambrosino DM: Donor immunization with Haemophilus influenzae type b (HIB)-conjugate vaccine in allogeneic bone marrow transplantation. Blood 1996, 87:3012-3018. Demonstrates the improved efficacy of vaccinating donors and patients before and after BMT with H. influenzae conjugate vaccine rather than patients alone; this method offers a promising strategy to prevent these infections after BMT, even potentially in patients with chronic GVHD.
26. Ljungman P, Cordonnier C, Debock R, Einsele H, Engelhard D, Grundy J, Link H, Locasciulli A, Prentice G, Reusser P, Ribaud P: Immunisations after bone marrow transplantation: results of a European survey and recommendations from the infectious diseases working party of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplant 1995, 15:455-460. Recommendations of the European Group for Blood and Marrow Transplantation working party on revaccination schedules following autologous and allogeneic BMT with regard to tetanus, diphtheria, polio, influenza, measles, mumps, rubella, and hepatitis based on results from 107 European transplant centers.