Effect of fenfluramine on episodic ACTH and cortisol secretion

Clinical Endocrinology

Volumn 45, Issue 1, 1996, Pages 39-45

  Schürmeyer, Thomas H ^a   Brademann, Götz ^b   Von Zur Mühlen, Alexander ^b  

^a FPP ^*  (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; DEXFENFLURAMINE; FENFLURAMINE; HYDROCORTISONE; NORFENFLURAMINE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PULSATILE HORMONE RELEASE;

ADRENOCORTICOTROPIC HORMONE; ADULT; CORTICOTROPIN-RELEASING HORMONE; DATA INTERPRETATION, STATISTICAL; FENFLURAMINE; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; PITUITARY-ADRENAL SYSTEM; SEROTONIN UPTAKE INHIBITORS;

EID: 0029993898     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2265.1996.tb02058.x     Document Type: Article

References (55)

1. Asnis, G.M., Eisenberg, J., van Praag, H.M., Lemus, C.Z., Harkavy Friedman, J.M. & Miller, A.H. (1988) The neuroendocrine response to funfluramine in depressives and normal controls. Biological Psychiatry, 24, 117-120.
2. Beckett, A.H. & Salmon, J.A. (1972) Pharmacokinetics of absorption, distribution and elimination of fenfluramine and its main metabolite in man. Journal of Pharmacy and Pharmacology, 24, 108-114.
3. Bernini, G.P.F., Argenio, G.F., Vivaldi, M.S., Birindelli, R. & Franchi, F. (1992) Serotoninergic receptor activation by dextrofenfluramine enhances the blunted pituitary-adrenal responsiveness to corticotropin-releasing hormone in obese subjects. Metabolism, 41, 17-21.
4. Bruce, R.B. & Maynard, W.R. (1968) Fenfluramine metabolism. Journal of Pharmaceutical Sciences, 57, 1173-1176.
5. Buckingham, J.C. & Hodges, J.R. (1979) Hypothalamic receptors involved in the secretion of corticotrophin releasing factor. Journal of Physiology (London), 290, 421-431.
6. Caccia, S., Conforti, I., Duchier, J. & Garattini, S. (1985) Pharmacokinetics of fenfluramine and norfenfluramine in volunteers given d- and d,l-fenfluramine for 15 days. European Journal of Clinical Pharmacology, 29, 221-224.
7. Chase, T.N. & Shoulson, I. (1975) Behavioral and biochemical effects of fenfluramine in patients with neurologic disease. Postgraduate Medical Journal, 51 (Suppl. 1), 105-109.
8. Davies, E. & Rossiter, S. (1992) Serotoninergic stimulation of aldosterone secretion in viro: role of the hypothalamopituitary adrenal axis. Journal of Steroid Biochemistry and Molecular Biology, 42, 29-36.
9. Fornal, C. & Radulovacki, M. (1983) Sleep suppressant action of fenfluramine in rats. Evidence against the involvement of a presynaptic serotonergic mechanism. Journal of Pharmacology and Experimental Therapeutics, 225, 675-681.
10. Fuller, R.W. (1992) The involvement of serotonin in regulation of pituitary-adrenocortical function. Frontiers in Neuroendocrinology, 13, 250-270.
11. Garatti, S., Mennini, T. & Samanín, R. (1987) From fenfluramine racemate to d-fenfluramine. Specificity and potency of the effects on the serotoninergic system and food intake. Annals of the New York Academy of Sciences, 499, 156-166.
12. Gardner, C.R. (1985) Pharmacological studies of the role of serotonin in animal models of anxiety. In Neuropharmacology of Serotonin (ed. A.R. Green), pp. 281-325, Oxford, University Press.
13. Gartside, S.E., Ellis, P.M., Sharp, T. & Cowen, P.J. (1992) Selective 5-HT1 A and 5-HT2 receptor-mediated adrenocorticotropin release in the rat: effect of repeated antidepressant treatments. European Journal of Pharmacology, 221, 27-33.
14. Gold, P.W., Goodwin, F.K. & Chrousos, G.P. (1988) Clinical and biochemical manifestation of depression Relation to the neurobiology of stress. New England Journal of Medicine, 319, 348-354 and 413-420.
15. Grossman, A. & Costa, A. (1993) The regulation of hypothalamic CRH: impact of in vitro studies on the central control of the stress response. Functional Neurology, 8, 325-334.
16. Guillaume, V., Grino, M., Jevoza, D., Bondouresque, F., Oliver, C., Guardiola-Lemaitre, B. & Nathan, C. (1989) Effect of acute or chronic administration of d-fenfluramine on the hypothalamohypophysoadrenal axis in the rat. International Journal of Obesity, 13, 87-89.
17. Hauser, H., Schürmeyer, T.H., Brabant, G., Rathke, B. & von zur Mühlen, A. (1989) Effect of sleep and sleep deprivation on ACTH- and cortisol secretion patterns. Acta Endocrinologica, 120 (Suppl. 1), 100-101.
18. Heybach, J.P. & Vernikos-Danellis, J. (1978) Effect of fenfluramine administration on activity of the pituitary-adrenal system in the rat. Proceedings of the Western Pharmacological Society, 21, 19-25.
19. Holmes, M.C., Di Renzo, G., Beckford, U., Gillham, B. & Jones, M.T. (1982) Role of serotonin in the control of secretion of corticotropin releasing factor. Journal of Endocrinology, 93, 151-160.
20. Imura, H., Nakay, Y. & Yoshimi, T. (1973) Effect of 5-hydroxytryptophan on growth hormone and ACTH release in man. Journal of Clinical Endocrinology and Metabolism, 36, 204-209.
21. Innes, J.A., Watson, M.L., Ford, M.J., Monro, J.F., Stoddart, M.E. & Campbell, D.B. (1977) Plasma fenfluramine levels, weight loss, and side effects. British Medical Journal, 2, 1311-1325.
22. Iranmanesh, A., Lizarralde, G., Johnson, ML. & Veldhuis, J.D. (1989) Circadian, ultradian, and episodic release of beta-endorphin in men, and its temporal coupling with cortisol. Journal of Clinical Endocrinology & Metabolism, 68, 1019-1026.
23. Ixart, G., Szafarczyk, A., Belugou, L. & Assenmacher, I. (1977) Temporal relationships between the diurnal rhythm of hypothalamic corticotrophin releasing factor, pituitary corticotrophin, and plasma corticosterone in the rat. Journal of Endocrinology, 72, 113-120.
24. Krieger, D.T. (1975) Rhythm of ACTH and corticosteroid secretion in health and disease, and their experimental modification. Journal of Steroid Biochemistry, 6, 785-791.
25. Krieger, D.T. & Rizzo, F. (1969) Serotonin mediation of circadian periodicity of plasma 17-hydroxycorticosteroids. Journal of Physiology (London), 1703-1707.
26. Lee, M.A. & Meltzer, H.Y. (1991) Neuroendocrine responses to serotonergic agents in alcoholics. Biological Psychiatry, 30, 1017-1030.
27. Lee, M.A., Nash, J.F., Barnes, M. & Meltzer, H.Y. (1991) Inhibitory effect of ritanserin on the 5-hydroxytryptophan-mediated cortisol, ACTH and prolactin secretion in humans. Psychopharmacology, 103, 258-264.
28. Lesch, K.P.O., Wiesmann, M., Hoh, A., Müller, T., Disselkamp-Tietze, J., Osterheider, M. & Schulte HM. (1992) 5-HT1 A receptor-effector system responsivity in panic disorder. Psychopharmacology (Berlin), 106, 111-117.
29. Levy, A.D., Li, Q., Rittenhouse, P.A. & Van de Kar, L.D. (1993) Investigation of the role of 5-HT3 receptors in the secretion of prolactin, ACTH and renin. Neuroendocrinology, 58, 65-70.
30. Lewis, S.A., Oswald, I. & Dunleavy, D.L.F. (1971) Chronic fenfluramine administration: some cerebral effects. British Medical Journal, 3, 67-70.
31. McElroy, J.F., Miller, J.M. & Meyer, J.S. (1984) Fenfluramine, p-chloroamphetamine and p-flouroamphetamine stimulation of pituitary- adrenocortical activity in rat: evidence of differences in site and mechanism of action. Journal of Pharmacology and Experimental Therapeutics, 228, 593-599.
32. Merriam, G.R. & Wachter, K.W. (1982) Algorithms for the study of episodic hormone secretion. American Journal of Physiology, 243, E310-E318.
33. Murphy, D.L., Campbell, I.C. & Costa, J.L. (1978) The brain serotonergic system in the affective disorders. Progress in Neuropsychopharmacology, 2, 5-31.
34. Murphy, D.L., Mueller, E.A., Garrick, N.A. & Aulakh, C.S. (1986) Use of serotonergic agents in the clinical assessment of central serotonin function. Journal of Clinical Psychiatry, 47, 9-13.
35. Naumenko, E.V. (1969) Effect of local injection of 5-hydroxytryptamine into rhinencephalic and mesencephalic structures on pituitary-adrenal function in guinea pigs. Neuroendocrinology, 5, 81-88.
36. Nicholson, W.E., Davis, D.R., Sherrell, B.J. & Orth, D.N. (1984) Rapid radioimmunoassay for corticotropin in unextracted human plasma. Clinical Chemistry, 30, 259-265.
37. Oerter, K.E., Guardabasso, V. & Rodbard, D. (1986) Detection and characterization of peaks and estimation of instantaneous secretory rates for episodic pulsatile hormone secretion. Computers and Biomededical Research, 19, 170-191.
38. Owens, M.J., Knight, D.L., Ritchie, J.C. & Nemeroff, C.B. (1991) The 5-hydroxytryptamine2 agonist, 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane stimulates the hypothalamic-pituitary-adrenal (HPA) axis. II. Biochemical and physiological evidence for the development of tolerance after chronic administration. Journal of Pharmacology and Experimental Therapeutics, 256, 795-800.
39. Pijl, H., Koppeschaar, H.P., Willekens, F.L., Frolich, M., Meinders, A.E. (1993) The influence of serotonergic neurotransmission on pituitary hormone release in obese and non-obese females. Acta Endocrinologica, 128, 319-324.
40. Raleigh, M.J., Brammer, G.L., Ritvo, E.R., Geller, E., McGuire, M.T. & Yuwiler, A. (1986) Effects of chronic fenfluramine on blood serotonin, cerebrospinal fluid metabolites, and behavior in monkeys. Psychopharmacology, 90, 503-508.
41. Ranft, U., Prank, K. & Brabant, G. (1988) Detection of episodic secretion activity by discrete deconvolution (DESADE) a new method for the analysis of episodic hormone secretion. Acta Endocrinologica, 177 (Suppl. 287), 79-80.
42. Richards, R.P., Gordon, B.H., Ings, R.M.J., Campbell, D.B., King, L.J. (1989) The measurement of d-fenfluramine and its metabolite, d-norfenfluramine in plasma and urine with an application of the method to pharmacokinetic studies. Xenobiotica, 19, 547-553.
43. Roberts, M.H.T. (1984) Hydroxytryptamine and antinociception. Neuropharmacologv, 23, 1529-1536.
44. Rowland, N.E. & Carlton, J. (1986) Neurobiology of an anorectic drug: fenfluramine. Progress in Neurobiology, 27, 13-62.
45. Scapagnini, U., Moberg, G.P., Van Loon, G.R., deGroot, J. & Ganong, W.F. (1971) Relation of brain 5-hydroxytryptamine content to the diurnal variation in plasma corticosterone in the rat. Neuroendocrinology, 7, 90-96.
46. Schürmeyer, T.H., Brabant, G. & von zur Mühlen, A. (1990) Evidence, that the hypothesis on a hypothalamic origin of Cushing's disease is not an outdated concept. In: ACTH, Cushing's Syndrome and other Hypercortisolemic States (eds D.K. Lüdecke, G.P. Chrousos & G. Tolis, pp. 105-113, New York, Raven Press.
47. Schürmeyer, T.H., Brademann, G. & von zur Mühlen, A. (1996) Effect of cyproheptadine on episodic ACTH and cortisol secretion. European Journal of Clinical Investigation, 26, 397-403.
48. Serri, O. & Rasio, E. (1987) The effect of d-fenfluramine on anterior pituitary hormone release in the rat: in vivo and in vitro studies. Canadian Journal of Physiology and Pharmacology, 65, 2449-2453.
49. Steiner, J.A. & Grahame-Smith, D.G. (1980) Central pharmacological control of corticosterone secretion in the intact rat. Demonstration of cholinergic and serotoninergic facilitory and α-adrenergic inhibitory mechanisms. Psvchopharmacology, 71, 213-217.
50. Sulaiman, W.R., Johnson, R.H. & Rennie, M.J. (1975) Hormonal and metabolic studies of the action of fenfluramine in normal man, obesity, acromegaly and diabetes mellitus. Postgraduate Medical Journal, 51, 125-131.
51. Szafarczyk, A., Alonso, G., Ixart, G., Malaval, F., Nouguier-Soule, J. & Assenmacher, I. (1980) Serotonergic system and circadian rhythms of ACTH and corticosterone in rats. American Journal of Physiology, 239, 482-489.
52. Tagliamonte, A., Biggio, G., Targiu, L. & Gessa, G.L. (1973) Free tryptophan in serum controls brain tryptophan level and serotonin synthesis. Life Sciences, 12, 277-287.
53. Thompson, C.J., Jones, I.R., Walker, M., Baylis, P.H. & Kendall-Taylor, P. (1992) The effects of the specific serotonin antagonist ICI, 169, 369 on the pituitary hormone response to insulin-induced hypoglycaemia in humans. Clinical Endocrinology, 36, 235-240.
54. Veldhuis, J.D., Iranmanesh, A., Johnson, M.L. & Lizarralde, G. (1990) Amplitude, but not frequency, modulation of adrenocorticotropin secretory bursts gives rise to the nyctohemeral rhythm of the corticotropic axis in man. Journal of Clinical Endocrinology and Metabolism, 71, 452-463.
55. Veldhuis, J.D. & Johnson, M.L. (1986) Cluster analysis: a simple, versatile and robust algorithm for endocrine pulse detection. American Journal of Physiology, 13, E486-E493.