Dexamethasone for the prevention of postextubation airway obstruction: A prospective, randomized, double-blind, placebo-controlled trial

Critical Care Medicine

Volumn 24, Issue 10, 1996, Pages 1666-1669

  Anene, Okechukwu ^a   Meert, Kathleen L ^a,b   Uy, Herbert ^a   Simpson, Pippa ^a   Sarnaik, Ashok P ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHILDREN'S HOSPITAL OF MICHIGAN   (United States)

Author keywords

airway obstruction; critical illness; croup; dexamethasone; epinephrine; extubation; helium; pediatrics; pulsus paradoxus; stridor

Indexed keywords

DEXAMETHASONE; PLACEBO; RACEPINEFRINE; SODIUM CHLORIDE;

AEROSOL; AIRWAY OBSTRUCTION; ARTICLE; ARTIFICIAL VENTILATION; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRITICAL ILLNESS; CROUP; DOUBLE BLIND PROCEDURE; ENDOTRACHEAL INTUBATION; EXTUBATION; FEMALE; GASTROINTESTINAL HEMORRHAGE; HUMAN; HYPERTENSION; INFANT; INHALATIONAL DRUG ADMINISTRATION; INTENSIVE CARE UNIT; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; NEWBORN; PARADOXICAL PULSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STRIDOR; TREATMENT OUTCOME;

AIRWAY OBSTRUCTION; ANTI-INFLAMMATORY AGENTS; CHILD, PRESCHOOL; CROUP; DEXAMETHASONE; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INTUBATION, INTRATRACHEAL; MALE; PROSPECTIVE STUDIES; RESPIRATION, ARTIFICIAL; RESPIRATORY SOUNDS;

EID: 0029993897     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199610000-00011     Document Type: Article

References (16)

1. Tellez DW, Galvis AG, Storgion SA, et al: Dexamethasone in the prevention of postextubation stridor in children. J Pediatr 1991; 118:289-294
2. Kemper KJ, Benson MS, Bishop MJ: Predictors of postextubation stridor in pediatric trauma patients. Crit Care Med 1991; 19:352-355
3. Koka BV, Jeon IS, Andre JM, et al: Postintubation croup in children. Anesth Analg 1977; 56:501-505
4. Biller HF, Bone RC, Harvey JE, et al: Laryngeal edema: An experimental study. Ann Otol Rhinol Laryngol 1970; 79:1084-1087
5. Goddard JE, Phillips OC, Marcy JH: Betamethasone for prophylaxis of postintubation inflammation: A double blind study. Anesth Analg 1967; 46:348-353
6. Ferrara TB, Georgieff MK, Ebert J, et al: Routine use of dexamethasone for the prevention of postextubation respiratory distress. J Perinatol 1990; 9:287-290
7. Couser RJ, Ferrara TB, Falde B, et al: Effectiveness of dexamethasone in preventing extubation failure in preterm infants at increased risk for airway edema. J Pediatr 1992; 121:591-596
8. Darmon JY, Rauss A, Dreyfuss D, et al: Evaluation of risk factors for laryngeal edema after tracheal extubation in adults and its prevention by dexamethasone. Anesthesiology 1992; 77:245-251
9. American Heart Association and American Academy of Pediatrics: Textbook of Pediatric Advanced Life Support. Chaimeides L, Hazinski MF (Eds). Dallas, American Heart Association, 1994, pp 1-22
10. Gedeit RG, Weigle CGM, Havens PL, et al: Control and variability of gastric pH in critically ill children. Crit Care Med 1993; 21:1850-1855
11. Horan MJ: Report of the Second Task Force on Blood Pressure in Children - 1987. Pediatrics 1987; 79:1-25
12. Taussig LM, Castro O, Beaudry PH, et al: Treatment of laryngotracheobronchitis (croup). Use of intermittent positive-pressure breathing and racemic epinephrine. Am J Dis Child 1975; 129: 790-793
13. Backofen JE, Rogers MC: Upper airway disease. In: Textbook of Pediatric Intensive Care. Rogers MC (Ed). Baltimore, Williams & Wilkins, 1992, pp 231-257
14. Way WL, Sooy FA: Histologic changes produced by endotracheal intubation. Ann Otorhinolaryngol 1965; 74:69-85
15. Haynes RC: Adrenocorticotropic hormone; adrenocortical steroids and their synthetic analogues; inhibitors of the synthesis and actions of adrenocortical hormones. In: The Pharmacological Basis of Therapeutics. Gilman AG, Rall TW, Nies AS, et al (Eds). New York, Pergamon Press, 1990, pp 1431-1462
16. Harel Y, Vardi A, Quigley R, et al: Dexamethasone does not prevent post extubation stridor in pediatric patients who previously failed extubation due to stridor. Abstr. Crit Care Med 1995; 23(Suppl):A186