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Volumn 47, Issue 1, 1996, Pages 7-14

Metabolism and toxicity of the new anesthetic agents

Author keywords

anesthetics, volatile: methoxyflurane, sevoflurane, enflurane, isoflurane, desflurane; ion: fluoride; kidney: function, toxicity, metabolism; liver: function, toxicity, metabolism, hepatitis; metabolism: cytochrome P450, hepatic, renal; toxicity: fluoride, sevoflurane, desflurane, immune

Indexed keywords

DESFLURANE; DRUG METABOLITE; FLUORIDE; HEXAFLUORO 2 PROPANOL; METHOXYFLURANE; SEVOFLURANE; TRIFLUOROACYL CHLORIDE; UNCLASSIFIED DRUG;

EID: 0029993714     PISSN: 00015164     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (34)

References (46)
  • 3
    • 0023848847 scopus 로고
    • Potential metabolic basis for enflurane hepatitis and the apparent cross-sensitization between enflurane and halothane
    • Christ D. D., Satoh H., Kenna J. G., Pohl L. R., Potential metabolic basis for enflurane hepatitis and the apparent cross-sensitization between enflurane and halothane, DRUG METAB. DISP., 16, 135-140, 1988.
    • (1988) Drug Metab. Disp. , vol.16 , pp. 135-140
    • Christ, D.D.1    Satoh, H.2    Kenna, J.G.3    Pohl, L.R.4
  • 4
    • 0021136414 scopus 로고
    • Fluorinated anaesthetic nephrotoxicity : An update
    • Mazze R. I., Fluorinated anaesthetic nephrotoxicity : An update, CAN. ANAESTH. Soc. J., 31, S16-S22, 1984.
    • (1984) Can. Anaesth. Soc. J. , vol.31
    • Mazze, R.I.1
  • 5
    • 0028925110 scopus 로고
    • Human kidney methoxyflurane and sevoflurane metabolism : Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity
    • Kharasch E. D., Hankins D. C., Thummel K. E., Human kidney methoxyflurane and sevoflurane metabolism : Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity, ANESTHESIOLOGY, 82, 689-699, 1995.
    • (1995) Anesthesiology , vol.82 , pp. 689-699
    • Kharasch, E.D.1    Hankins, D.C.2    Thummel, K.E.3
  • 6
    • 0028843993 scopus 로고
    • Biotransformation of sevoflurane
    • Kharasch E. D., Biotransformation of sevoflurane, ANESTH. ANALG., 81 : S27-S38, 1995.
    • (1995) Anesth. Analg. , vol.81
    • Kharasch, E.D.1
  • 7
    • 0015897556 scopus 로고
    • Methoxyflurane nephrotoxicity : A study of dose response in man
    • Cousins M. J., Mazze R. I., Methoxyflurane nephrotoxicity : A study of dose response in man, JAMA, 225, 1611-1616, 1973.
    • (1973) JAMA , vol.225 , pp. 1611-1616
    • Cousins, M.J.1    Mazze, R.I.2
  • 8
    • 0026731027 scopus 로고
    • Characteristics and implications of desflurane metabolism and toxicity
    • Koblin D. D., Characteristics and implications of desflurane metabolism and toxicity, ANESTH. ANALG., 75, S10-S16, 1992.
    • (1992) Anesth. Analg. , vol.75
    • Koblin, D.D.1
  • 9
    • 0027515708 scopus 로고
    • Identification of cytochrome P450 2EI as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane and methoxyflurane
    • Kharasch E. D., Thummel K. E., Identification of cytochrome P450 2EI as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane and methoxyflurane, ANESTHESIOLOGY, 79, 795-807. 1993.
    • (1993) Anesthesiology , vol.79 , pp. 795-807
    • Kharasch, E.D.1    Thummel, K.E.2
  • 12
    • 0025214922 scopus 로고
    • Biotransformation and hepato-renal function in volunteers after exposure to desflurane (I-653)
    • Jones R. M., Koblin D. D., Cashman J. N., Eger E. I. II, Johnson B. H., Damask M. C., Biotransformation and hepato-renal function in volunteers after exposure to desflurane (I-653), BR. J. ANAESTH., 64, 482-487, 1990.
    • (1990) Br. J. Anaesth. , vol.64 , pp. 482-487
    • Jones, R.M.1    Koblin, D.D.2    Cashman, J.N.3    Eger II, E.I.4    Johnson, B.H.5    Damask, M.C.6
  • 13
    • 0026326301 scopus 로고
    • Metabolism of desflurane and isoflurane to fluoride ion in surgical patients
    • Smiley R. M., Ornstein E., Pantuck E. J., Matteo R. S., Metabolism of desflurane and isoflurane to fluoride ion in surgical patients, CAN. J. ANAESTH., 38, 965-968, 1991.
    • (1991) Can. J. Anaesth. , vol.38 , pp. 965-968
    • Smiley, R.M.1    Ornstein, E.2    Pantuck, E.J.3    Matteo, R.S.4
  • 14
    • 0028789701 scopus 로고
    • The hepatic effects of sevoflurane
    • Frink E. J. Jr., The hepatic effects of sevoflurane, ANESTH. ANALG., 81, S46-S50, 1995.
    • (1995) Anesth. Analg. , vol.81
    • Frink Jr., E.J.1
  • 16
    • 0019364126 scopus 로고
    • Clinical characteristics and biotransformation of sevoflurane in healthy human volunteers
    • Holaday D. A., Smith F. R., Clinical characteristics and biotransformation of sevoflurane in healthy human volunteers, ANESTHESIOLOGY, 54, 100-106, 1981.
    • (1981) Anesthesiology , vol.54 , pp. 100-106
    • Holaday, D.A.1    Smith, F.R.2
  • 20
    • 0029077543 scopus 로고
    • Clinical sevoflurane metabolism and disposition : I. Sevoflurane and metabolite pharmacokinetics
    • Kharasch E. D., Karol M. D., Lanni C., Sawchuk R., Clinical sevoflurane metabolism and disposition : I. Sevoflurane and metabolite pharmacokinetics, ANESTHESIOLOGY, 82 : 1369-1378, 1995.
    • (1995) Anesthesiology , vol.82 , pp. 1369-1378
    • Kharasch, E.D.1    Karol, M.D.2    Lanni, C.3    Sawchuk, R.4
  • 21
    • 0028318197 scopus 로고
    • Renal concentrating function with prolonged sevoflurane or enflurane anesthesia in volunteers
    • Frink E. J. Jr., Malan T. P. Jr., Isner J., Brown E. A., Morgan S., Brown B. R. Jr., Renal concentrating function with prolonged sevoflurane or enflurane anesthesia in volunteers, ANESTHESIOLOGY, 80, 1019-1025, 1994.
    • (1994) Anesthesiology , vol.80 , pp. 1019-1025
    • Frink Jr., E.J.1    Malan Jr., T.P.2    Isner, J.3    Brown, E.A.4    Morgan, S.5    Brown Jr., B.R.6
  • 23
    • 0026572498 scopus 로고
    • Serum and urinary inorganic fluoride concentrations after prolonged inhalation of sevoflurane in humans
    • Kobayashi Y., Ochiai R., Takeda J., Sekiguchi H., Fukushima K., Serum and urinary inorganic fluoride concentrations after prolonged inhalation of sevoflurane in humans. ANESTH. ANALG., 74, 753-757, 1992.
    • (1992) Anesth. Analg. , vol.74 , pp. 753-757
    • Kobayashi, Y.1    Ochiai, R.2    Takeda, J.3    Sekiguchi, H.4    Fukushima, K.5
  • 25
    • 0029070863 scopus 로고
    • Clinical sevoflurane metabolism and disposition : II. The role of cytochrome P450 2EI in fluoride and hexafluoroisopropanol formation
    • Kharasch E. D., Armstrong A. S., Gunn K., Artru A., Cox K., Clinical sevoflurane metabolism and disposition : II. The role of cytochrome P450 2EI in fluoride and hexafluoroisopropanol formation. ANESTHESIOLOGY, 82, 1379-1388, 1995.
    • (1995) Anesthesiology , vol.82 , pp. 1379-1388
    • Kharasch, E.D.1    Armstrong, A.S.2    Gunn, K.3    Artru, A.4    Cox, K.5
  • 26
    • 0028278896 scopus 로고
    • The pharmacology of sevoflurane in infants and children
    • Lerman J., Sikich N., Kleinman S., Yentis S., The pharmacology of sevoflurane in infants and children, ANESTHESIOLOGY, 80, 814-824, 1994.
    • (1994) Anesthesiology , vol.80 , pp. 814-824
    • Lerman, J.1    Sikich, N.2    Kleinman, S.3    Yentis, S.4
  • 27
    • 0025602736 scopus 로고
    • Uptake and biotransformation of sevoflurane in humans : A comparative study of sevoflurane with halothane, enflurane, and isoflurane
    • Shiraishi Y., Ikeda K, Uptake and biotransformation of sevoflurane in humans : A comparative study of sevoflurane with halothane, enflurane, and isoflurane, J. CLIN. ANESTH., 2 : 381-386, 1990.
    • (1990) J. Clin. Anesth. , vol.2 , pp. 381-386
    • Shiraishi, Y.1    Ikeda, K.2
  • 29
    • 0027364633 scopus 로고
    • Serum inorganic fluoride levels in mildly obese patients during and after sevoflurane anesthesia
    • Higuchi H., Satoh T., Arimura S., Kanno M., Endoh R., Serum inorganic fluoride levels in mildly obese patients during and after sevoflurane anesthesia, ANESTH. ANALG., 77, 1018-1021, 1993.
    • (1993) Anesth. Analg. , vol.77 , pp. 1018-1021
    • Higuchi, H.1    Satoh, T.2    Arimura, S.3    Kanno, M.4    Endoh, R.5
  • 31
    • 0028021444 scopus 로고
    • Serum and urine inorganic fluoride levels following prolonged low-dose sevoflurane anesthesia combined with epidural block
    • Matsumura C., Kemmotsu O., Kawano Y., Takita K., Sugimoto H., Mayumi T., Serum and urine inorganic fluoride levels following prolonged low-dose sevoflurane anesthesia combined with epidural block, J. CLIN. ANESTH., 6, 419-424, 1994.
    • (1994) J. Clin. Anesth. , vol.6 , pp. 419-424
    • Matsumura, C.1    Kemmotsu, O.2    Kawano, Y.3    Takita, K.4    Sugimoto, H.5    Mayumi, T.6
  • 32
    • 0029154460 scopus 로고
    • Serum fluoride concentration and urine osmolality after enflurane and sevoflurane anesthesia in male volunteers
    • Munday I. T., Stoddart P. A., Jones R. M., Lytle J., Cross M. R., Serum fluoride concentration and urine osmolality after enflurane and sevoflurane anesthesia in male volunteers, ANESTH. ANALG., 81, 353-359, 1995.
    • (1995) Anesth. Analg. , vol.81 , pp. 353-359
    • Munday, I.T.1    Stoddart, P.A.2    Jones, R.M.3    Lytle, J.4    Cross, M.R.5
  • 33
    • 0029157284 scopus 로고
    • Renal function and serum fluoride concentrations in patients with stable renal insufficiency after anesthesia with sevoflurane or enflurane
    • Conzen P. F., Nuscheler M., Melotte A., Verhaegen M., Leupolt T., Van Aken H., Peter K., Renal function and serum fluoride concentrations in patients with stable renal insufficiency after anesthesia with sevoflurane or enflurane, ANESTH. ANALG., 81, 569-575, 1995.
    • (1995) Anesth. Analg. , vol.81 , pp. 569-575
    • Conzen, P.F.1    Nuscheler, M.2    Melotte, A.3    Verhaegen, M.4    Leupolt, T.5    Van Aken, H.6    Peter, K.7
  • 34
    • 0029033232 scopus 로고
    • Renal function in patients with high serum fluoride concentrations after prolonged sevoflurane anesthesia
    • Higuchi H., Sumikura H., Sumita S., Arimura S., Takamatsu F., Kanno M., Satoh T., Renal function in patients with high serum fluoride concentrations after prolonged sevoflurane anesthesia, ANESTMESIOLOGY, 83, 449-458, 1995.
    • (1995) Anestmesiology , vol.83 , pp. 449-458
    • Higuchi, H.1    Sumikura, H.2    Sumita, S.3    Arimura, S.4    Takamatsu, F.5    Kanno, M.6    Satoh, T.7
  • 40
    • 0028008768 scopus 로고
    • Closed-circuit anesthesia with sevoflurane in humans : Effects on renal and hepatic function and concentrations of breakdown products with soda lime in the circuit
    • Bito H., Ikeda K., Closed-circuit anesthesia with sevoflurane in humans : Effects on renal and hepatic function and concentrations of breakdown products with soda lime in the circuit, ANESTHESIOLOGY, 80, 71-76, 1994.
    • (1994) Anesthesiology , vol.80 , pp. 71-76
    • Bito, H.1    Ikeda, K.2
  • 41
    • 0027942388 scopus 로고
    • Plasma inorganic fluoride and intracircuit degradation product concentrations in long-duration, low-flow sevoflurane anesthesia
    • Bito H., Ikeda K., Plasma inorganic fluoride and intracircuit degradation product concentrations in long-duration, low-flow sevoflurane anesthesia, ANESTH. ANALG., 79, 946-951, 1994.
    • (1994) Anesth. Analg. , vol.79 , pp. 946-951
    • Bito, H.1    Ikeda, K.2
  • 42
    • 0028830078 scopus 로고
    • Degradation products of sevoflurane during low-flow anaesthesia
    • Bito H., Ikeda K., Degradation products of sevoflurane during low-flow anaesthesia, BR. J. ANAESTH., 74, 56-59, 1995.
    • (1995) Br. J. Anaesth. , vol.74 , pp. 56-59
    • Bito, H.1    Ikeda, K.2
  • 43
    • 0028988860 scopus 로고
    • Nephrotoxicity of sevoflurane compound a [fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether] in rats : Evidence for glutathione and cysteine conjugate formation and the role of renal cysteine conjugate β-lyase
    • Jin L., Baillie T. A., Davis M. R., Kharasch E. D., Nephrotoxicity of sevoflurane compound A [fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether] in rats : Evidence for glutathione and cysteine conjugate formation and the role of renal cysteine conjugate β-lyase, BIOCHEM. BIOPHYS. RES COMMUN., 210, 498-506, 1995.
    • (1995) Biochem. Biophys. Res Commun. , vol.210 , pp. 498-506
    • Jin, L.1    Baillie, T.A.2    Davis, M.R.3    Kharasch, E.D.4
  • 44
    • 0029061488 scopus 로고
    • Carbon monoxide production from degradation of desflurane, enflurane, isoflurane, halothane and sevoflurane by soda lime and Baralyme
    • Fang Z., Eger E. I. II, Laster M. J., Chortkoff B. S., Kandel L., Ionescu P., Carbon monoxide production from degradation of desflurane, enflurane, isoflurane, halothane and sevoflurane by soda lime and Baralyme, ANESTH. ANALG., 80, 1187-1193, 1995.
    • (1995) Anesth. Analg. , vol.80 , pp. 1187-1193
    • Fang, Z.1    Eger II, E.I.2    Laster, M.J.3    Chortkoff, B.S.4    Kandel, L.5    Ionescu, P.6
  • 45
    • 9444243572 scopus 로고
    • Inhalation anesthetic toxicity : Current controversies, ASA Refresher Course Lectures
    • Kharasch E. D., Inhalation anesthetic toxicity : Current controversies, ASA Refresher Course Lectures, LECTURE 264, 1995.
    • (1995) Lecture , pp. 264
    • Kharasch, E.D.1
  • 46
    • 0005394232 scopus 로고
    • Desflurane anesthesia using dry Baralyme produces high carboxyhemoglobin levels in pigs
    • Frink E. J. Jr., Desflurane anesthesia using dry Baralyme produces high carboxyhemoglobin levels in pigs, ANESTHESIOLOGY, 83, A294, 1995.
    • (1995) Anesthesiology , vol.83
    • Frink Jr., E.J.1


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