Concurrent MCMV infection augments donor antihost-specific activity and alters clinical outcome following experimental allogeneic bone marrow transplantation

Transplantation

Volumn 61, Issue 6, 1996, Pages 856-861

  Jones, Monica ^a   Cray, Carolyn ^a   Levy, Robert B ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOGENIC BONE MARROW TRANSPLANTATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CYTOMEGALOVIRUS INFECTION; GRAFT VERSUS HOST REACTION; IMMUNE RESPONSE; INFECTION RISK; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; BONE MARROW TRANSPLANTATION; CD4-POSITIVE T-LYMPHOCYTES; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; GRAFT VS HOST DISEASE; HERPESVIRIDAE INFECTIONS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MUROMEGALOVIRUS; SENSITIVITY AND SPECIFICITY; TREATMENT OUTCOME;

EID: 0029993586     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199603270-00002     Document Type: Article

References (28)

1. Lonnqvist B, Ringden O, Wahren B, Gahrton G, Lundgren G. Cytomegalovirus infection associated with and preceding chronic graft-versus-host disease. Transplantation 1984; 38: 465.
2. Meyers JD, Shepp DH, Bowden RA, Reed EC. Viral infections in marrow transplant recipients. In: Gale RP, Champlin RE, eds. Progress in bone marrow transplantation. New York: Liss, 1989: 545.
3. Anonymous. Workshop on CMV-infections during organ transplantation. J Immunol 1979; 126: 1255.
4. Ho M. Cytomegalovirus: biology and infection. New York Plenum, 1982.
5. Sissons JGP, Borysiewicz LK, Rodgers B, Scott D. Cytomegalovirus - Its cellular immunology and biology. Immunol Today 1986; 7: 57.
6. Bruning JH, Bruggeman CA, van boven CPA, van Breda Vriesman PJC. Reactivation of latent rat cytomegalovirus by a combination of immunosuppression and administration of allogeneic immunocompetent cells. Transplantation 1989; 47: 917.
7. Storb R, Prentice RL, Buckner CD, et al. Graft-versus-host disease and survival in patients with aplastic anemia treated by marrow grafts from HLA-identical siblings. N Eng J Med 1983; 308: 302.
8. Ringden O, Bostrom L, Paulin T. On herpesvirus immunity, graft-versus-host disease, pneumonitis, and relapse. In: Gale RP, Champlin RE, eds. Bone marrow transplantation: current controversies. New York: Liss, 1989: 573.
9. Cray C, Levy RB. The ability of murine cytomegalovirus and class I major histocompatability complex-disparate parental cells to induce alterations characteristic of severe graft-versus-host reactions. Transplantation 1989; 48: 1057.
10. Levy RB, Jones M, Cray C. HSV-1 enhances graft-versus-host reaction associated parent anti-F1 alloreactivity in vivo and in vitro. Cell Immunol 1990; 129: 1.
11. Gratama JW, Sinnige LGF, Weijers TF, et al. Marrow donor immunity to herpes simplex virus: association with acute graft-versus-host disease. Exp Hematol 1987; 15: 735.
12. Grundy JE, Shanley JD, Shearer GM. Augmentation of graft-versus-host reaction by cytomegalovirus infection resulting in interstitial pneumonitis. Transplantation 1985; 39: 548.
13. Grundy JE, Shearer GM. The effect of cytomegalovirus infection on the host response to foreign and hapten-modified self histocompatibility antigens. Transplantation 1984; 37: 484.
14. Singals DP, Rawls WE. Effect of herpes simplex virus antigens on human mixed lymphocyte culture. Transplantation 1980; 29: 500.
15. Yang H, Welsh RM. Induction of alloreactive cytotoxic T cells by acute virus infection of mice. J Immunol 1986; 136: 1186.
16. Yang H, Dundon PL, Nahill SR, Welsh RM. Virus-induced polyclonal cytotoxic T lymphocyte stimulation. J Immunol 1989; 142: 1710.
17. Hamilton BL, Harris D. Prevention of graft-versus-host disease using antibody to Thy-1: a role for complement in vivo. Transplantation 1985; 40: 90.
18. Cray C, Levy RB. Virus-associated immune responses in mice undergoing GvHR exacerbated by concurrent MCMV infection. Transplantation 1990; 50: 1027.
19. Hamilton BL. Absence of correlation between cytolytic T lymphocytes and lethal murine graft-versus-host disease in response to minor histocompatibility antigens. Transplantation 1984; 38: 357.
20. Cray C, Levy RB. CD8+ and CD4+ T cells contribute to the exacerbation of class I MHC disparate GvHR by concurrent MCMV infection. Clin Immunol Immunopathol 1993; 670: 84.
21. Lucas CJ, Levy RB, Shearer GM. Cytotoxic T lymphocyte responses against alloantigens exhibit preferential effector cell activity for H-2K or H-2D region products similar to that for H-2 restricted responses. J Immunol 1981; 126: 1255.
22. Treiber W, Lapp WS. Graft-versus-host-induced immunosuppression: the effect of antigeneic stimulation on cell-mediated and humoral immune responses. Transplantation 1973; 16: 211.
23. Ferrara JLM, Daley JP, Burakoff SJ, Miller RA. Functional T cell deficits after bone marrow transplantation across minor histocompatibility barriers: effects of graft-vs-host disease on precursor frequency of reactive cells. J Immunol 1987; 138: 3598.
24. Wall DA, Hamberg SD, Reynolds DS, Burakoff SJ, Abbas AK, Ferrara JLM. Immunodeficiency in graft-versus-host disease. I. mechanism of immune suppression. J Immunol 1988; 140: 2970.
25. Hamilton BL, Ochs HD. Immune dysfunction associated with graft-versus-host reaction in mice transplanted across minor histocompatibility barriers. Transplantation 1989; 47: 1061.
26. Shanley JD, Korngold R, Forman SJ. The effect of graft-versus-host disease in response to minor histocompatibility antigens on acute murine cytomegalovirus infection. Transplantation 1993; 56: 487.
27. Levy RB, Baker M, Podack ER. Perform deficiency delays the onset of GVHD following bone marrow transplantation across major and minor histocompatibility barriers. Ann New York Acad Sci 1995; 770: 366.
28. Alexander-Miller MA, Burke K, Koszinowski UH, Hansen TH, Connolly JM. Alloreactive cytotoxic T lymphocytes generated in the presence of viral-deprived peptides show exquisite peptide and MHC specificity. J Immunol 1993; 151: 1.