The absolute configuration of (R)-(+)-nadifloxacin

Chemical and Pharmaceutical Bulletin

Volumn 44, Issue 2, 1996, Pages 421-423

  Kido, Masaru ^a   Nomi, Daisuke ^a   Hashimoto, Koji ^a  

^a OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

absolute configuration; dibenzoyl D tartaric acid, 5,6 difluoro 2 methyl 1,2,3,4 tetrahydroquinoline; nadifloxacin; OPC 7251; X ray analysis

Indexed keywords

NADIFLOXACIN;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG STRUCTURE; RACEMIC MIXTURE; SKIN DISEASE; X RAY ANALYSIS;

EID: 0029993406     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.44.421     Document Type: Article

References (8)

1. Ishikawa H., Tabusa F., Miyamoto H., Kano M., Ueda H., Tamaoka H., Nakagawa K., Chem. Pharm. Bull., 37, 2103 (1989).
2. Kido M., Hashimoto K., Chem. Pharm. Bull., 42, 872 (1994).
3. a) Morita S., Otsubo K., Matsubara J., Ohtani T., Uchida M., Tetrahedron: Asymmetry, 6, 255 (1995);
4. b) Sato K., Mitsuhashi S., Kagakuryohou No Ryoiki, 7, 59 (1991).
5. Hashimoto K., Fujimura T., Tominaga M., Manabe Y., Japan. Patent Tokkyo Koho Showa 63-192753 (1988) [Chem. Abstr., 111, 231449j (1989)].
6. Molecular Structure Corporation (1985). TEXSAN. TEXRAY Structure Analysis Package. MSC, 3200A Research Forest Drive The Woodlands, TX 77381, U.S.A.
7. Cromer D. T., Waber J. T , "International Tables for X-Ray Crystallography," Vol. IV, Kynoch Press, Birmingham, 1974, pp. 72-149.
8. The authors have deposited atomic coordinates for these structures with the Cambridge Crystallographic Data Centre. The coordinates can be obtained on request from The Director, Cambridge Crystallographic Data Centre, University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK.