Differential phosphorylation of Alpha-A crystallin in human lens of different age

Experimental Eye Research

Volumn 62, Issue 5, 1996, Pages 499-504

  Takemoto, Larry J ^a  

^a KANSAS STATE UNIVERSITY   (United States)

Author keywords

alpha A crystallin; Lens aging; Phosphorylation

Indexed keywords

ALPHA CRYSTALLIN;

ADOLESCENT; ADULT; AGED; AGING; ARTICLE; HUMAN; HUMAN TISSUE; INFANT; LENS; PHOSPHORYLATION; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; AGING; CHILD; CRYSTALLINS; HUMANS; INFANT; LENS, CRYSTALLINE; PHOSPHORYLATION;

EID: 0029992808     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1006/exer.1996.0060     Document Type: Article

References (24)

1. Benedek, G. (1971). Theory of transparency of the eye. Appl. Optics. 10, 459-72.
2. Boyle, D. and Takemoto, L. (1994). Characterization of the α-β and α-β complex : evidence for an in vivo functional role of α-crystallin as a molecular chaperone. Exp. Eye Res. 58, 9-16.
3. Bradford, M. (1976). A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-54.
4. Caspars, G.-J., Pennings, J. and de Jong, W. (1994). A partial cDNA sequence corrects the human αA-crystallin primary structure. Exp. Eye Res. 59, 125-6.
5. 1 chain. Curr. Eye Res. 6, 539-42.
6. Chiesa, R., McDermott, M. and Spector, A. (1989). Differential synthesis and phosphorylation of the α-crystallin A and B chains during bovine lens fiber cell differentiation. Curr. Eye Res. 8, 151-8.
7. Chiesa, R. and Spector, A. (1989). The dephosphorylation of lens α-crystallin A chain. Biochem. Biophys. Res. Commun. 162, 1494-501.
8. de Jong, W. (1982). In Macromolecular Sequences in Systemic Evolutionary Biology. (Ed. Goodman, M.). Pp. 75-114. Plenum: New York, U.S.A.
9. Delcour, J. and Papaconstantinou, J. (1970). A change in α-crystallin subunit composition in relation to cellular differentiation in adult bovine lens. Biochem. Biophys. Res. Commun. 41, 401-6.
10. Garland, D., Duglas-Tabor, Y., Datiles, M., Zigler, S. and Magno, B. (1995). Analysis of human lens proteins during fiber cell maturation. Invest. Ophthalmol. Vis. Sci. 36, S822.
11. Groenen, P., Merck, K., de Jong, W. and Bloemendal, H. (1994). Structure and modifications of the junior chaperone α-crystallin : From lens transparency to molecular pathology. Eur. J. Biochem. 225, 1-19.
12. Horwitz, J. (1993). The function of alpha crystallin. Invest. Ophthalmol Vis. Sci. 34, 10-22.
13. Inagaki, N., Ito, M., Nakano, T. and Inagaki, M. (1994). Spatiotemporal distribution of protein kinase and phosphatase activities. Trends Biochem. Sci. 227, 448-59.
14. Jedziniak, J., Kinoshita, J., Yates, E., Hocker, L. and Benedek, G. (1973). On the presence and mechanism of formation of heavy molecular weight aggregates in human normal and cataractous lenses. Exp. Eye Res. 15, 185-92.
15. Kantorow, M. and Piatigorsky, J. (1994). α-Crystallin/small heat shock protein has autokinase activity. Proc. Natl. Acad. Sci., USA 91, 3112-16.
16. Kramps, J., de Jong, W., Wollensak, J. and Hoenders, H. (1978). The polypeptide chains of α-crystallin from old human eye lenses. Biochim. Biophys. Acta 533, 487-95.
17. Kodama, T., Wong, F. and Takemoto, L. (1988). High molecular weight aggregate from cataractous and normal human lenses : Characterization by antisera to lens crystallins. Jpn. J. Ophthalmol. 32, 159-65.
18. Miesbauer, L., Zhou, S., Yang, Z., Yang, Z., Sun, Y., Smith, D. and Smith, J. (1994). Post-translational modifications of water-soluble human lens crystallin from young adults. J. Biol. Chem. 269, 12494-502.
19. Spector, A., Chiesa, R., Sredy, J. and Garner, W. (1985). cAMP-dependent phosphorylation of bovine lens α-crystallin. Proc. Natl. Acad. Sci., USA 82, 4712-16.
20. Takemoto, L. and Azari, P. (1976). Amino acid composition of normal and cataractous human lens proteins. Exp. Eye Res. 23, 1-7.
21. Takemoto, L. and Gopalakrishnan, S. (1994). Alpha-A crystallin: Quantitation of C-terminal modification during lens aging. Curr. Eye Res. 13, 879-83.
22. Takemoto, L. (1995). Quantitation of C-terminal modification of alpha-A crystallin during aging of the human lens. Exp. Eye Res. 60, 721-4.
23. Till, J., Annan, R., Carr, S. and Miller, T. (1994). Use of synthetic peptide libraries and phosphopeptide-selective mass spectrometry to probe protein kinase substrate specificity. J. Biol. Chem. 269, 7423-8.
24. Voorter, D., Mulders, J., Bloemendal, H. and de Jong, W. (1986). Some aspects of the phosphorylation of α-crystallin A. Eur. J. Biochem. 160, 203-10.