Neurobiology of treatment-resistant schizophrenia: New insights and new models

European Neuropsychopharmacology

Volumn 6, Issue SUPPL.2, 1996, Pages

  Beerpoot, Lucas J ^a   Lipska, Barbara K ^a   Weinberger, Daniel R ^a  

^a St Elizabeths Hospital   (United States)

Author keywords

Antipsychotic drugs; Development; Dopaminergic systems; Gene expression; Neurobiology; Schizophrenia

Indexed keywords

DOPAMINE RECEPTOR; NEUROLEPTIC AGENT; DOPAMINE;

CONFERENCE PAPER; DNA TRANSCRIPTION; DOPAMINERGIC SYSTEM; GENE EXPRESSION; HUMAN; NEUROBIOLOGY; PRIORITY JOURNAL; SCHIZOPHRENIA; ANIMAL; BIOLOGICAL MODEL; BRAIN CORTEX; METABOLISM; PATHOPHYSIOLOGY; REVIEW;

ANIMALS; CEREBRAL CORTEX; DOPAMINE; HUMANS; MODELS, BIOLOGICAL; SCHIZOPHRENIA;

EID: 0029992677     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (107)

1. Adams, W., Kendell, R.E., Hare, E.H. and Munk-Jorgensen, P. (1993) Epidemiological evidence that maternul influenza contributes to the aetiology of schizophrenia: an analysis of Scottish, English and Danish data. Br. J. Psychiatr. 163, 522-534.
2. Akbarian, S., Kim, J.J., Potkin, S.G., Hagman, J.O. Taffazzoli, A., Bunney, W.E. Jr. and Jones, E.G. (1995) Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics. Arch. Gen. Psychiatr. 52, 258-266; Discussion 267-278.
3. Akbarian, S., Vinuela, A., Kim, J.J., Potkin, S.G., Bunney, W.E. Jr. and Jones, E.G. (1993) Distorted distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase neurons in temporal lobe of schizophrenia implies anomalous cortical development. Arch. Gen. Psychiatr. 50, 178-187.
4. Andreasen, N.C., Flashman, L., Flaum, M., Arndt, S., Swayze, V.N., Ehrhardt, J.C. and Yuh, W.T. (1994) Regional brain abnormalities in schizophrenia measured with magnetic resonance imaging. J.A.M.A. 272, 1763-1769.
5. Angrist, B., Sathananthan, G., Wilk, S. and Gershon, S. (1974) Amphetamine psychosis: behavioural and biochemical aspects. J. Psychiatr. Res. 11, 13-23.
6. Arnold, S.E., Franz, B.R., Gur, R.C., Gur, R.E., Shapiro, R.M., Moberg, P.J. and Trojanowski, J.Q. (1995) Smaller neuron size in schizophrenia in hippcampal subfields that mediate cortical-hippocampal interactions. Am. J. Psychiatr. 152, 738-748.
7. Arnold, S.E., Hyam, B.T., Van Hoesen, G.W. and Damasio, A.R. (1991) Some cytoarchitectural abnormalities of the entorbinal cortex in schizophrenia. Arch. Gen. Psychiatr. 48, 625-632.
8. Benes, F.M. (1989) Myelination of cortical-hippocampal relays during late adolescence. Schizophr. Bull. 15, 585-593.
9. Benes, F.M., Davidson, J. and Bird, E.D. (1986) Quantitative cytoarchitectural studies of the cerebral cortex of schizophrenics. Arch. Gen. Psychiatr. 43, 31-35.
10. Benes, F.M., McSparren, J., Bird, E.D., SanGiovanni, J.P. and Vincent, S.L. (1991) Doticits in small interneurons in prefrontal and eingulate cortices of schizophrenia and schizoaffective patients. Arch. Gen. Psychiatr. 48, 996-1001.
11. Benes, F.M., Turtle, M., Kan, Y. and Farol, P. (1994) Myelination of a key relay zone in the hippocampal formation occurs in the human brain during childhood, adolescence, and adulthood. Arch. Gen. Psychiatr. 51, 477-484.
12. Berendse, H.W., Galis-de Graaf, Y. and Groenewgen, H.J. (1992) Topographical organization and relationship with ventral striatal compartments of prefrontal corticostriatal projections in the rat. J. Comp. Neurol. 316, 314-347.
13. Berman, K.F., Illowsky, B.P. and Weinberger, D.R. (1988) Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. IV. Further evidence for regional and behavioural specificity. Arch. Gen. Psychiatr. 45, 616-622.
14. Berman, K.F. and Weinberger, D.R. (1991) Functional localization in the brain in schizophrenia. In Tasman, A. (Ed), American Psychiatric Press Review of Psychiatry. APPA Press, Washington D.C., pp. 24-59.
15. Bogerts, B. (1993) Recent advances in the neuropathology of schizophrenia. Schizophr. Bull. 19, 431-445.
16. Bogerts, B., Ashtari, M., Degreef, G., Alvir, J.M., Bilder, R.M. and Lieberman, J.A. (1990) Reduced temporal limbic structure volumes on magnetic resonance images in first episode schizophrenia. Psychiatr. Res. 35, 1-13.
17. Bogerts, B., Lieberman, J.A., Ashtari, M., Bilder, R.M., Degreef, G., Lerner, G., Johns, C. and Masiar, S. (1993) Hippocampal-amygdala volumes and psychopathology in chronic schizophrenia. Biol. Psychiatr. 33, 236-246.
18. Bracha, H.S., Torrey, E.F., Bigelow, L.B., Lohr, J.B. and Linington, B.B. (1991) Subtle signs of prenatal maldevelopment of the hand ectoderm in schizophrenia: a preliminary monozygotic twin study. Biol. Psychiatr. 30, 719-725.
19. Braff, D.L., Grillon, C. and Geyer, M.A. (1992) Gating and habituation of the startle reflex in schizophrenic patients. Arch Gen. Psychiatr. 49, 206-215.
20. Braff, D.L., Heaton, R., Kuck, J., Cullum, M., Moranville. J., Grant, I. and Zisook, S. (1991) The generalized pattern of neuropsychologieal deficits in outpatients with chronic schizophrenia with heterogeneous Wisconsin Card Sortins Test results. Arch. Gen. Psychiatr. 48, 891-898.
21. Buchsbaum, M.S., Haier, R.J., Potkin, S.G., Nuechterlein, K., Bracha, H.S., Katz, M., Lohr, J., Wu, J., Lottenberg, S., Jerabek, P.A. et al (1992) Frontostriatal disorder of cerebral metabolism in never-medicated schizophrenics. Arch. Gen. Psychiatr. 49, 935-942.
22. Chua, S.E. and McKenna, P.J. (1995) Sehizophrenia: a brain disease? A critical review of structural and functional cerebral abnormality in the disorder. Br. J. Psychiatr. 166, 563-582.
23. Colpaert, F.C., Niemegeers, C.J. and Janssen, P.A. (1978) Neuroleptic interference with cocaine: internal stimulus control of behaviour and psychosis. Psychopharmacology 58, 257-255.
24. Deutch, A.Y. (1994) Identification of the neural systems subserving the actions of clozapine: clues from immediate-early gene expression. J. Clin. Psychiatr. 55 (Suppl. B), 37-42.
25. Devor, M. and Schneider, G.E. (1975) Neuroanatomical plasticity: the principle of conservation of total axonul arborization. In Vital-Durand. F. and Jeannerod, M. (Eds), Aspects of neural plasticity. INSERM. Paris, pp. 191-201.
26. Farde, L., Nyberg, S., Oxenstierna, G., Nakashima, V., Halldin, C. and Ericsson, B. (1995) Positron emission tomography studies on D. and 5-HT . receptor binding in risperidone-treated schizophrenic patients. J. Clin. Psychopharmacol. 15, 19S-23S.
27. 11C]raclopride. Arch. Gen. Psychiatr. 47, 213-219.
28. Gold, J.M. Hermann, B.P. Randolph. C., Wyler, A.R., Goldberg, T.E. and Weinberger. D.R. (1994) Schizophrenic and temporal lobe epilepsy: a neuropsychological analysis. Arch. Gen. Psychiatr. 51, 265-272.
29. Goldberg, T.E., Torrey, E.F., Berman, K.F. and Weinberger, D.R. (1994) Relations between neuropsychological performance and brain monphological and physiological measures in monozygotic twins discordant for schizophrenia. Psychiatr. Res. 55, 51-61.
30. Goldberg, T.E. and Weinberger, D.R. (1994). The effects of clozapine on neurocognition: an overview. J. Clin. Psychiatr. 55 (Suppl. B), 88-90.
31. Goldman-Rakic, P.S. (1994) Working memory dysfunction in schizophrenia. J. Neuropsychiatry Clin. Neurosci. 6, 348-357.
32. Goldsmith, S.K. and Joyce, J.N. (1995). Alternations in hippocampal mossy fiber pathways in schizophrenia and Alzheimer's disease. Biol. Psychiatr. 37, 122-126.
33. Green, M.F., Satz, P. and Christenson, C. (1994) Minor physical anomalies in schizophrenia patients, bipolar patients, and their siblings. Schizophr. Bull. 20, 433-440.
34. Gur, R.E., Mozley, P.D., Resnick, S.M., Shtasel, D., Kohn, M., Zimmerman, R., Herman, G., Atlas, R., Grossman, R., Erwin, R. et al (1991) Magnetic resonance imaging in schizophrenia. I. Volumetric analysts of brain and cerebrospinal fluid. Arch. Gen. Psychiatr. 48, 407-412.
35. Hare, A.O., Walsh, D. and Torrey, F. (1980) Seasonality of schizophrenic births in Ireland. Br. J. Psychiatr. 137, 74-77.
36. Harrison, P.J. (1995) On the neuropathology of schizophrenia and its dementia: neurodevelopmental. neurodegenerative, or both? Neurodegeneration 4, 1-12.
37. Heaton, R., Paulsen, J.S., McAdams, L.A., Kuck, J., Zisook, S., Braff, D., Harris, J. and Jeste, D.V. (1994) Neuropsychological deficits in schizophrenics: relationship to age, chronicity, and dementia. Arch. Gen. Psychiatr. 51, 469-476.
38. Heckers, S., Heinsen, H., Geiger, B. and Beckmann, H. (1991a) Hippocampal neuron numbers in schizophrenia: a stereological study. Arch. Gen. Psychiatr. 48, 1002-1008.
39. Heckers, S., Heinsen, H., Heinsen, Y. and Beckmann, H. (1991b). Cortex, white matter and basal ganglia in schizophrenia: a volumetric postmortem study. Biol. Psychiatr. 29, 556-566.
40. Iacono, W.G., Smith, G.N., Moreau, M., Beiser, M., Fleming, J.A., Lin, T.Y. and Flak, B. (1988) Ventricular and sulcal size at the onset of psychosis. Am. J. Psychiatr. 145, 820-824.
41. Jakob, H. and Beckmann, H. (1986) Prenatal developmental disturbances in the limbic allocortex in schizophrenics. J. Neural. Transm. 65, 303-326.
42. 2 antagonistic properties. J. Pharmacol. Exp. Ther. 244, 685-693.
43. Juskiw, G.E., Juliano, D.M., Goldberg, T.E., Hertzman, M., UrowHamell, E. and Weinberger, D.R. (1994) Cerebral ventricular enlargement in schizophreniform disorder does not progress: a seven year follow-up study. Schizophr. Res. 14, 23-28.
44. Jernigan, T.L., Zisook, S., Heaton, R.K., Moranville, J.T., Hesselink, J.R. and Braff, D.L. (1991) Magnetic resonance imaging abnormalities in lenticular nuclei and cerebral cortex in schizophrenia. Arch. Gen. Psychiatr. 48, 881-890.
45. Jones, P., Rodgers, B., Murray, R. and Marmot, M. (1994) Child development risk factor for adult schizophrenia in the British 1946 birth cohort. Lancet 344, 1398-1402.
46. Jones, P.B., Bebbington, P., Foerster, A., Lewis, S.W., Murray, R.M., Russell, A., Sham, P.C., Toone, B.K. and Wilkins. S. (1993) Premorbid social underachievement in schizophrenia: results from the Camberwell Collaborative Psychosis Study. Br. J. Psychiatr. 162, 65-71.
47. Kalsbeek, A., Voorn, P., Buijs, R.M., Pool, C.W. and Uylings, H.B. (1988) Development of the dopaminergic innervation in the prefrontal cortex of the rat. J. Comp. Neurol. 269, 58-72.
48. Keshavan, M.S., Anderson, S. and Pettegrew, J.W. (1994) Is schizophrenia due to excessive synaptic pruning in the prefrontal cortex? The Feinberg hypothesis revisited. J. Psychiatr. Res. 28, 239-265.
49. 2 receptors, and dopamine uptake sites in postmortem striatal specimens from schizophrenic patients. Biol. Psychiatr. 36, 827-835.
50. Knable, M.B. and Weinberger, D.R. (1994) Limbie-prefrontal connectivity and clozapine. J. Clin. Psychiatr. 55 (Suppl. B), 70-73.
51. Kotrla, K.J. and Weinberger, D.R. (1995) Brain imaging in schizophrenia. Annu. Rev. Med. 46, 113-122.
52. Lee, M.A., Thompson, P.A. and Meltzer, M.Y. (1994) Effects of clozapine on cognitive function in schizophrenia. J. Clin. Psychiatr. 55 (Suppl. B), 82-87.
53. Levitt, J.J., Shenton, M.E., McCarley, R.W., Faux, S.F and Ludwig, A.S. (1994) Premorbid adjustment in schizophrenia: implications for psychosocial and ventricular pathology, Schizophr. Res. 12, 159-168.
54. Leysen, J.E., Gommeren, W., Eens, A., de Chaffoy de Courcelles, D., Stoof, J.C. and Janssen, P.A. (1988) Biochemical profile of risperidone, a new antipsychotic. J. Pharmacol. Exp. Ther. 247, 661-670.
55. Leysen, J.E., Janssen, P.M., Megens, A.A. and Schotte, A. (1994) Risperidone: a novel antispychotic with balanced scrotonin-dopamine antagonism, receptor occupancy profile and pharmacologic activity. J. Clin. Psychiatr. 55 (Suppl. B), 5-12.
56. Liberman, R.P., Van Putten, T., Marshall, B.D. Jr., Mintz, J., Bowen, L., Kuchnel, T.G., Aravagiri, M. and Marder, S.R. (1994) Optimal drug and behavior therapy for treatment-refractory schizophrenic patients. Am. J. Psychiatr. 151, 756-759.
57. Liddle, P.F. (1995) Brain imaging. In Hirsch, S.R. and Weinberger, D.R. (Eds.), Schizophrenia. Blackwood, London, pp. 425-439.
58. Lipska, B.K., Jaskiw, G.E. and Weinberger, D.R. (1993) Postpubertal emergence of hyperresponsiveness to stress and to amphetamine after neonatal excitotoxic hippocampal damage: a potential animal model of schizophrenia. Neurophsychopharmacology 9, 67-75.
59. Lipska, B.K., Swerdlow, N.R., Geyer, M.A., Jaskiw, G.E., Braff, D.L. and Weinberger, D.R. (1995) Neontal excitotoxic hippocampal damage in rats causes post-pubertal changes in prepulse inhibition of startle and its disruption by apomorphine. Psychopharmacology (In press).
60. Lipska, B.K. and Weinberger, D.R. (1994) Subchronic treatment with haloperidol and clozapine in rats with neonatal excitotoxic hippocampal damage. Neuropsychopharmacology 10, 199-205.
61. MacGibbon, G.A., Lawlor, P.A., Bravo, R. and Dragunow, M. (1994) Clozapine and haloperidol produce a differential pattern of immediate early gene expression in rat caudate-putamen, nucleus accumbens, lateral septum and islands of Calleja. Brain Res. Mol. Brain Res. 23, 21-32.
62. Mauri, M.C., Vita, A., Giobbo, G.M., Ferrara, A., Dieci, M., Bitetto, A. and Altamura, A.C. (1994) Prediction of response of haloperidol in schizophrenia: neuroendocrine, neuromorphological and clinical variables. Int. Clin. Psychopharmacol. 9, 3-7.
63. Meltzer, H.Y. (1995) The role of serotonin in schizophrenia and the place of serotonin-dopamine antagonist antipsychotics. J. Clin. Psychopharmacol. 15, 2S-3S.
64. 2 affinities differentiate atypical and typical antipsychotic drugs. Psychophannacol. Bull. 23, 390-392.
65. Merchant, K.M. and Dorsa, D.M. (1993) Differential induction of neurotensin and c-fos gene expression by typical versus atypical antipsychotics. Proc. Natl. Acad. Sci. USA 90, 3447-3451.
66. Nopoulos, P., Flushman, L., Flaum, M., Arndt, S. and Andreasen, N. (1994) Stability of cognitive functioning early in the course of schizophrenia. Schizophr Res. 14, 29-37.
67. 2 receptor occupancy in clozapine treated patients demonstrated by PET. Psychopharmacology 110, 365-367.
68. Pakkenberg, B. (1992) Stereological quantitation of human brains from normal and schizophrenic individuals. Acta Neurol. Scand. Suppl. 137, 20-33.
69. Pearlson, G.D., Kim, W.S., Kubos, D.L., Moberg, P.J., Jayaram, G., Bascom, M.J., Chase, G.A., Goldtinger, A.D. and Tune, L.E. (1989) Ventricle-brain ratio, computed tomographic density, and brain area in 50 schizophrenics. Arch. Gen. Psychiatr. 46, 690-697.
70. 2 dopamine receptor density in psychotic and nonpsychotic patients with bipolar disorder. Arch. Gen. Psychiatr. 52, 471-477.
71. Pennartz, C.M., Groenewegen, H.J. and Lopes da Silva, F.H. (1994). The nucleus accumbens as a complex of functionally distinct neuronal ensembles: an integration of behavioural, electrophysiological and anatomical data. Prog. Neurobiol. 42, 719-761.
72. Pfefferbaum, A., Zipursky, R.B., Lim, K.O., Zatz, L.M., Stahl, S.M. and Jernigan, T.L. (1988) Computed tomographic evidence for generalized sulcal and ventricular enlargement in schizophrenia. Arch. Gen. Psychiatr. 45, 633-640.
73. Pickar, D., Owen, R.R. Jr., Litman, R.E., Hsiao, J.K. and Su, T.P. (1994) Predictors of clozapine response in schizophrenia. J. Clin. Psychiatr. 55 (Suppl. B), 129-132.
74. 2 dopamine receptor binding in the basal ganglia of antipsychotic-free schizophrenic patients: an 1231-IBZM single photon emission computerised tomography study. Br. J. Psychiatr. 164, 16-26.
75. Raine, A., Lenez, T., Reynolds, G.P., Harrison, G., Sheard, C., Medley, I., Reynolds, L.M. and Cooper, J.E. (1992) An evaluation of structural and functional prefrontal deficits in schizophrenia: MRI and neuropsychological measures. Psychiatr. Res. 45, 123-137.
76. Rakic, P. (1988) Specification of cerebral cortical areas. Science 241, 170-176.
77. Randolph, C., Gold, J.M., Carpenter, C.J., Goldberg, T.E. and Weinberger, D.R. (1992) Release from proactive interference: determinants of performance and neuropsychological correlates. J Clin. Exp. Neuropsychol. 14, 785-800.
78. 4) gene does not predict response to clozapine. Arch. Gen. Psychiatr. 51, 912-917.
79. Robertson, G.S. and Fibiger, H.C. (1992) Neuroleptics increase c-fos expression in the forebrain: contrasting ettects of haloperidol and clozapine. Neuroscience 46, 315-328.
80. Robertson, G.S., Matsumura, H. and Fibiger, H.C. (1994) Induction patterns of Fos-like immunoreactivity in the forebrain as predictors of atypical antipsychotic activity. J. Pharmacol. Exp. Ther. 271, 1058-1066.
81. Royston, M.C. and Roberts, G.W (1995). Schizophrenia: when neurons go astray. Curr. Biol. 5, 342-344.
82. Sacchetti, H., Calzeroni, A., Vita, A., Terzi, A., Pollastro, F. and Cazzullo, C.L. (1992) The brain damage hypothesis of the seasonality of births in schizophrenia and major affective disorders: evidence from computerised tomography Br. J. Psychiatr. 160, 390-397.
83. Sautter, F.J., McDermott, B.E., Cornwell, J., Black, F.W., Borges, A., Johnson, J. and ONP?. (1994) Patterns of neuropsychological deficit in cases of schizophrenia spectrum disorder with and without a family history of psychosis. Psychiatr. Res. 54, 37-49.
84. Scheibel, A.B. and Conrad, A.S. (1993) Hippocampal dysgenesis in mutant mouse and schizophrenic man: is there a relationship? Schizophr. Bull. 19, 21-33.
85. Schroder, J., Buchsbaum, M.S., Siegel, B.V., Geider, F.J. and Niethammer, R. (1995) Structural and functional correlates of subsyndromes in chronic schizophrenia. Psychopathology 28, 38-45.
86. Shelton, R.C., Karson, C.N., Doran, A.R., Pickar, D., Bigelow, L.B. and Weinberger, D.K. (1988) Cerebral structural pathology in schizophrenia: evidence for a selective pretrontal cortical defect. Am. J. Psychiatr. 145, 154 163.
87. Stanley, J.A., Williamson, P.C., Drost, D.J., Carr, T.J., Rylett, R.J., Morrison-Stewart, S. and Thompson, R.T. (1994) Membrane phospholipid metabolism and schizophrenia: an in vivo 31P-MR spectroscopy study. Schizophr. Res. 13, 209 215.
88. Suddath, R.L., Christison, G.W., Torrey, E.F., Casanova, M.R. and Weinberger, D.R. (1990) Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. N. Engl. J. Med. 322, 789-794.
89. Sunahara, R.K., Seeman, P., Van Tol, H.H. and Niznik, B.H. (1993) Dopamine receptors and antipsychotic drug response. Br. J. Psychiatr. Suppl. 31-38.
90. Susser, E.S. and Lin, S.P. (1992) Schizophrenia after prenatal exposure to the Dutch Hunger Winter of 1994-1945. Arch. Gen. Psychiatr. 49, 983-988.
91. Torrey, E.F., Bowler, A.E., Rawlings, R. and Terrazas, A (1993) Seasonality of schizophrenia and stillbirths. Schizophr. Bull. 19, 557-562.
92. Volkow, N.D., Brodic, J.D., Wolf, A.P., Gomez-Mont, F., Cancro, R., Van Gelder, P., Russell, J.A. and Overall, J. (1986) Brain organization in schizophrenia. J. Cereb. Blood Flow Metab. 6, 441-446.
93. Walker, E.F., Savoie, T. and Davis, D. (1994) Neuromotor precursors of schizophrenia. Schizophr. Bull. 20, 441-451.
94. Weinberger, D.R. (1987) Implications of normal brain development for the pathogenesis of schizophrenia. Arch. Gen. Psychiatr. 44, 660-669.
95. Weinberger, D.R. (1993) A connectionist approach to the prefrontal cortex. J. Neuropsychiatry Clin. Neurosci. 5, 241-253.
96. Weinberger, D.R. (1995a) From neuropathology to neurodevelopment. Lancet 346, 552-557.
97. Weinberger, D.R. (1995b) Schizophrenia as a neurodevelopmental disorder. In Hirsch, S.R. and Weinberger, D.R. (Eds.), Schizophrenia. Blackwood, London, pp. 293-323
98. Weinberger, D.R. and Berman, K.F. (1988) Speculation on the meaning of cerebral metabolic hypofrontality in schizophrenia. Schizophr. Bull. 14, 157-168.
99. Weinberger, D.R., Cannon-Spoor, E., Potkin, S.G. and Wyatt, R.J. (1980) Poor premorbid adjustment and CT scan abnormalities in chronic schizophrenia. Am. J. Psychiatr. 137, 1410-1413.
100. Weinberger, D.R. and Lipska, B.K (1995) Cortical maldevelopment, antipsychotic drugs and schizophrenia: a search for common ground. Schizophr. Res. 16, 87-110.
101. Weinberger, D.R., Torrey, E.F., Neophytides, A.N. and Wyatt, R.J (1979) Structural abnormalities in the cerebral cortex of chronic schizophrenic patients. Arch. Gen. Psychiatr. 36, 935-939.
102. Wiesel, F.A., Wik, G., Sjogren, I., Blomqvist, G., Greitz, T. and Stone-Elander, S. (1987) Regional brain glucose metabolism in drug free schizophrenic patients and clinical correlates. Acta Psychiatr. Scand. 76, 628 641.
103. Wolkin, A., Barouche, F., Woll, A.P. Rotrosen, J., Fowler, J.S., Shiue, C.Y. Cooper, T.B. and Brodie, J.D. (1989) Dopamine blockade and clinical response: evidence for two biological subgroups of schizophrenia. Am. J. Psychiatr. 146, 905 908.
104. Wolkin, A., Duncan, E., Sanfilipo, M , Wieland, S., Cooper, T.B. and Rotrosen, J. (1994) Persistent psychosis after reduction in pre- and post synaptic dopaminergic function. J. Neural. Transm. Gen. Sect. 95, 49-61.
105. 2 dopamine receptors in drug-naive schizophrenics. Science 234, 1558-1563.
106. Wright, P., Gill, M., Murray, R.M. et al (1993) Schizophrenia: genetics and the maternal immune response to viral infection. Am. J. Med. Genet. 48, 40-46.
107. Zipursky, R.B., Lim, K.O., Sullivan, E.V., Brown, B.W. and Pfefferbaum. A. (1992) Widespread cerebral gray matter volume deficits in schizophrenia. Arch. Gen. Psychiatr. 49, 195-205.