8-Bromo-cAMP and 8-CPT-cAMP increase the density of β-adrenoceptors in hepatocytes by a mechanism not mimicking the effect of cAMP

Pharmacology and Toxicology

Volumn 79, Issue 1, 1996, Pages 15-22

  Sandnes, Dagny ^a   Jacobsen, Frede W ^a   Refsnes, Magne ^a   Christoffersen, Thoralf ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

8 (4 CHLOROPHENYLTHIO) CYCLIC AMP; 8 BROMO CYCLIC AMP; ADENOSINE DERIVATIVE; BETA ADRENERGIC RECEPTOR; FORSKOLIN; GLUCAGON; ISOBUTYLMETHYLXANTHINE; VASOPRESSIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; LIVER CELL CULTURE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY;

ANIMALIA;

EID: 0029992393     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0773.1996.tb00235.x     Document Type: Article

References (55)

1. Benovic, J. L., M. Bouvier, M. G. Caron & R. J. Lefkowitz: Regulation of adenylyl cyclase-coupled β-adrenergic receptors. Ann. Rev. Cell Biol. 1988, 4, 405-428.
2. Bennett, L. L., C.-H. Chang, P. W. Allan, D. J. Adamson, L. M. Rose, R. W. Brockman, J. A. Secrist, A. Shortnacy & J. A. Montgomery: Metabolism and metabolic effects of halopurine nucleosides in tumor cells in culture. Nucleosides & Nucleotides 1985, 4, 107-116.
3. Bouvier, M., S. Collins, B. F. O'Dowd, P.T. Campbell, A. de Blasio, B. K. Kobilka, C. MacGregor, G. P. Irons, M. G. Caron & R. J. Lefkowitz: Two distinct pathways for cAMP-mediated down-regulation of the β-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level. J. Biol. Chem. 1989, 264, 16786-16792.
4. Braumann, T., B. Jastorff & C. Richter-Landsberg: Fate of cyclic nucleotides in PC12 cell cultures: Uptake, metabolism and effects of metabolites on nerve growth factor-induced neurite outgrowth. J. Neurochem. 1986, 47, 912-919.
5. Chiang, P. K., H. H. Richards & G. L. Cantoni: S-Adenosyl-L-homocysteine hydrolase: Analogues of S-adenosyl-L-homocysteine as potential inhibitors. Mol. Pharmacol. 1977, 13, 939-947.
6. Christoffersen, T., M. Refsnes, G. O. Brønstad, E. Østby, J. Huse, F. Haffner, T.-E. Sand, N. H. Hunt & O. Sonne: Changes in hormone responsiveness and cyclic AMP metabolism in rat hepatocytes during primary culture and effects of supplementing the medium with insulin and dexamethasone. Eur. J. Biochem. 1984, 138, 217-226.
7. Clark, R.B.: Desensitization of hormonal stimuli coupled to regulation of cyclic AMP levels. Adv. Cycl. Nucleotides Protein Phosphoryl. Res. 1986, 20, 151-209.
8. 2-adrenergic receptor gene in response to short-term agonist exposure. Proc. Natl. Acad. Sci. 1989, 86, 4853-4857.
9. Collins, S., M. G. Caron & R. J. Lefkowitz: Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression. Ann. Rev. Physiol. 1991, 53, 497-508.
10. Daly, J. W.: Adenosine receptors: Targets for future drugs. J. Med. Chem. 1982, 25, 197-207.
11. Duffy, D. M., P. L. Ballard, A. Goldfien & J. M. Roberts: Cyclic adenosine 3′,5′-monophosphate increases β-adrenergic receptor concentration in cultured human fetal lung explants and type II Clara cells. Endocrinol. 1992, 131, 841-846.
12. Fox, I. H. & W. N. Kelley: The role of adenosine and 2′-deoxyadenosine in mammalian cells. Ann. Rev Biochem. 1978, 47, 655-686.
13. Guranowski, A., J. A. Montgomery, G. L. Cantoni & P. K Chiang: Adenosine analogues as substrates and inhibitors of S-adenosylhomocysteine hydrolase. Biochemistry 1981, 20, 110-115.
14. Hadcock, J. R., H. Wang & C. C. Malbon: Agonist-induced destabilization of β-adrenergic receptor mRNA. J. Biol. Chem. 1989, 264, 19928-19933.
15. Han, Z., D. Chatterjee & J. H. Wyche: Proliferation of nontransformed cells is inhibited by adenosine metabolite of but not by parental 8-Cl-cyclic AMP. J. Pharmacol. Exp. Therap. 1993, 265, 790-794.
16. Hargrove, J. L. & D. K. Granner: Inhibition of hepatoma cell growth by analogs of adenosine and cyclic AMP and the influence of enzymes in mammalian sera. J. Cell. Physiol. 1982, 111, 232-238.
17. Hertel, C., S. J. Coulter & J. P. Perkins: The involvement of cellular ATP in receptor-mediated internalization of epidermal growth factor and hormone-induced internalization of the β-adrenergic receptor. J. Biol. Chem. 1986, 261, 5974-5980.
18. Hoover, R. K. & M. L. Toews: Evidence for an agonist-induced, ATP-dependent change in muscarinic receptors of intact 1321N1 cells. J. Pharmacol. Exp. Therap. 1989, 251, 63-70.
19. Iyengar, R., J. Abramowitz, M. Bordelon-Riser, A. J. Blume & L. Birnbaumer: Regulation of hormone-receptor coupling to adenylyl cyclase. Effects of GTP and GDP. J. Biol. Chem. 1980, 255, 10312-10321.
20. Jelinek, L. J., S. Lok, G. B. Rosenberg, R. A. Smith, F. J. Grant, S. Biggs, P. A Bensch, J. L. Kuijper, P. O. Sheppard, C. A. Sprecher, P. J. O'Hara, D. Foster, K. M. Walker, L. H. J. Chen, P. A. McKernan & W. Kindsvogel: Expression cloning and signaling properties of the rat glucagon receptor. Science 1993, 259, 1614-1616.
21. Knecht, M., T. Ranta & K. C. Catt: Granulosa cell differentiation in vitro: Induction and maintenance of follicle-stimulating hormone receptors by adenosine 3′,5′-monophosphate. Endocrinol. 1983, 113, 949-956.
22. Koontz, J. W. & W. D. Wicks: Cytotoxic effects of two novel 8-substituted cyclic nucleotide derivatives in cultured rat hepatoma cells. Mol. Pharmacol. 1980, 18, 65-71.
23. Kuncl, R. W., D. B. Drachman & R. Adams: Inhibition of methyltransferase reduces the turnover of actylcholine receptors. Proc. Natl. Acad. Sci. 1988, 85, 4032-4036.
24. Kuncl, R. W., D. B. Drachman, R. Adams & M. Lehar: 3-Deazaadenosine: A therapeutic strategy for myasthenia gravis by decreasing the endocytosis of acetylcholine receptors. J. Pharmacol. Exp. Therap. 1993, 267, 582-589.
25. Lange-Carter, C. A., J. J. Vuillequez & A. M. Malkinson: 8-Chloroadenosine mediates 8-chloro-cyclic AMP-induced down-regulation of cyclic AMP-dependent protein kinase in normal and neoplastic mouse lung epithelial cells by a cyclic AMP-independent mechanism. Cancer Res. 1993, 53, 393-400.
26. Langeveld, C. H., C. A. M. Jongenelen, J. J. Heimans & J. C. Stoof: Growth inhibition of human glioma cells induced by 8-chloroadenosine, an active metabolite of 8-chloro cyclic adenosine 3′,5′-monophosphate. Cancer Res. 1992, 52, 3994-3999.
27. Lefkowitz, R.J., W.P. Hausdorff & M.G. Caron: Role of phosphorylation in desensitization of the β-adrenoceptor. Trends Pharmacol. Sci. 1990, 11, 190-194.
28. Londos, C., D. M. F. Cooper & J. Wolff: Subclasses of external adenosine receptors. Proc. Natl. Acad. Sci. 1980, 77, 2551-2554.
29. Lowry, O. H., N. J. Rosebrough, A. L. Farr & R. J. Randall: Protein measurement with the folin phenol reagent. J. Biol. Chem. 1951, 193, 265-275.
30. Martin, T. F. J. & J. A. Kowalchyk: Growth inhibition by adenosine 3′,5′-monophosphate derivatives does not require 3′,5′ phosphodiester linkage. Science 1981, 213, 1120-1122.
31. 1 pituitary cells: Isolation of an adenylate cyclase-deficient variant. J. Cell. Physiol. 1981, 190, 289-297.
32. Miller, R. L., D. L. Adamczyk, W. H. Miller, G. W. Koszalka, J. L. Rideout, L. M. Beacham, E. Y. Chao, J. J. Haggery, T. A. Krenitsky & G. B. Elion: Adenosine kinase from rabbit liver. II Substrate and inhibitor specificity. J. Biol. Chem. 1979, 254, 2346-2352.
33. 1 receptors mediate chronic ethanol-induced increases in receptor-stimulated cyclic AMP in cultured hepatocytes. Biochem. J. 1994, 304, 205-210.
34. Nakamura, T., A. Tomomura, C. Noda, M. Shimoji & A. Ichihara: Acquisition of a β-adrenergic response by adult rat hepatocytes during primary culture. J. Biol. Chem. 1983, 258, 9283-9289.
35. Olsson, R. A.: Ligand binding to the adenine analogue binding protein of the rabbit erythrocyte. Biochemistry 1978, 17, 367-375.
36. 3 in unstimulated and vasopressin-stimulated rat hepatocytes. Cell. Signal. 1989, 1, 147-156.
37. Refsnes, M., D. Sandnes, Ø. Melien, T. E. Sand, S. Jacobsen & T. Christoffersen: Mechanisms for the emergence of catecholamine-sensitive adenylate cyclase and β-adrenergic receptors in cultured hepatocytes. FEBS Lett. 1983, 164, 291-297.
38. Refsnes, M., D. Sandnes & T. Christoffersen: The relationship between β-adrenoceptor regulation and β-adrenergic responsiveness in hepatocytes. Studies on acquisition, desensitization and resensitization of isoproterenol-sensitive adenylate cyclase in primary cultures. Eur. J. Biochem. 1987, 163, 457-466.
39. Reuter, H. & H. Porzig: Regulation by 8-Br-cAMP of β-adrenoceptors in cultured myocardial cells. J. Mol. Cell. Cardiol. 1985, 17, 307-316.
40. Salomon, Y., C. Londos & M. Rodbell: A highly sensitive adenylate cyclase assay. Anal. Biochem. 1974, 58, 541-548.
41. 125I-iodocyanopindolol in rat liver. Acta pharmacol. et toxicol. 1984, 55, 287-296.
42. Sandnes, D., F. W. Jacobsen, M. Refsnes & T. Christoffersen: Long-term inhibitory effect of cAMP on β-adrenoceptor acquisition and nonselective attenuation of adenylyl cyclase in hepatocytes. Eur. J. Pharmacol. 1993, 246, 163-169.
43. Schaap, P., M. van Ments-Cohen, R. D. M. Soede, R. Brandt, R. A. Firtel, W. Dostmann, H.-G. Genieser, B. Jastorff & P. J. van Haaster: Cell-permeable non-hydrolyzable cAMP derivatives as tools for analysis of signaling pathways controlling gene regulation in Dictyostelium. J. Biol. Chem. 1993, 268, 6323-6331.
44. Scatchard, G.: The attractions of proteins for small molecules and ions. Ann. N. Y. Acad. Sci. 1949, 51, 660-672.
45. Schaeffer, H. J. & C. F. Schwender: Enzyme inhibitors. Bridging hydrophobic and hydrophilic regions of adenosine deaminase with some 9-(2-hydroxy-3-alkyl)adenines. J. Med. Chem. 1974, 17, 6-8.
46. Seglen, P. O.: Preparation of isolated rat liver cells. Methods in Cell Biol. 1976, 13, 29-83.
47. 3H-cAMP) ligand, or of unlabeled ligand only. Acta pharmacol. et toxicol. 1980, 46, 200-204.
48. Strehler, B. L.: Bioluminescence assay: Principles and practice. Methods Biochem. Anal. 1968, 16, 99-181.
49. Taylor, C. W. & L. C. Yeoman: Inhibition of colon tumor cell growth by 8-chloro-cAMP is dependent on its conversion to 8-chloro-adenosine. Anti-Cancer Drugs 1992, 3, 485-491.
50. Ueland, P. M.: Pharmacological and biochemical aspects of S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase. Pharmacol. Rev. 1982, 34, 223-253.
51. Van Lookeren Campagne, M. M., F. V. Diaz, B. Jastorff & R. H. Kessin: 8-Chloroadenosine 3′,5′-monophosphate inhibits the growth of Chinese hamster ovary and Molt-4 cells through its adenosine metabolite. Cancer Res. 1991, 51, 1600-1605.
52. Wakelam, M. J. O., G. J. Murphy, V. J. Hruby & M. D. Houslay: Activation of two signal-transduction systems in hepatocytes by glucagon. Nature 1986, 323, 68-71.
53. Yokazaki, H., G. Tortora, S. Pepe, E. Maronde, H.-G. Genieser, B. Jastorff & Y. S. Cho-Chung: Unhydrolyzable analogues of adenosine 3′:5′-monophosphate demonstrating growth inhibition and differentiation in human cancer cells. Cancer Res. 1992, 52, 2504-2508.
54. Zhu, S-J. & M. L. Toews: Effects of antimycin A on the binding properties of beta and alpha-1 adrenergic receptors measured on intact cells. J. Pharmacol. Exp. Therap. 1993, 267, 123-127.
55. 6-substituted cAMP analogues on C6 glioma cells. Eur. J. Cell Biol. 1993, 60, 351-357.