Reversible modification of tissue-type plasminogen activator by methylphosphonate esters

Bioorganic and Medicinal Chemistry

Volumn 4, Issue 4, 1996, Pages 523-529

  Zhao, Qinjian ^a   Kovach, Ildiko M ^a  

^a CATHOLIC UNIVERSITY OF AMERICA   (United States)

Author keywords

Fibrinolytic enzymes; Serine hydrolase inhibition; Serine protease; Serine protease inhibition; t PA inhibition

Indexed keywords

PHOSPHONIC ACID DERIVATIVE; TISSUE PLASMINOGEN ACTIVATOR;

ARTICLE; BLOOD; CONTROLLED STUDY; ENANTIOMER; ENZYME INHIBITION; ENZYME REACTIVATION; HUMAN; HUMAN TISSUE; NORMAL HUMAN; PH; PROTEIN MODIFICATION;

EID: 0029992178     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/0968-0896(96)84792-4     Document Type: Article

References (50)

1. Abbreviations: BSA, bovine serum albumin; Chiralcel-OJ, cellulose tri-4-methyl-benzoate coated on silica; EDTA, ethylene diamine tetraacetate; PMNs, 4-nitrophenyl phenacyl methylphosphonates; OP, organophosphorus; MPMN, 4-nitrophenyl, 4-methylphenacyl methylphoshponate; MOPMN, 4-nitrophenyl 4-methoxyphenacyl methylphosphonate; CPMN, 4-nitrophenyl 4-chlorophenacyl methyl phosphonate; NPMN, 4-nitrophenyl 4-nitrophenacyl methylphosphonate; pNA, p-nitroanilide; HPLC, high pressure liquid chromatography; Tris, tris hydroxymethyl aminoethane; t-PA, tissue-type plasminogen activator enzyme; S-2288, H-D-Ile-Pro-Arg-pNA.
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