Release of ischemia in paced rat Langendorff hearts by supply of L-carnitine: Role of endogenous long-chain acylcarnitine

Molecular and Cellular Biochemistry

Volumn 156, Issue 1, 1996, Pages 87-91

  Hulsmann, W C ^a   Peschechera, A ^b   Serafini, F ^b   Ferrari, L E ^b  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^b Department of Biochemistry ^*  (Italy)

Author keywords

Carnitine; Endothelium; Heart; Ischemia; Iysolecithin; Lactate; Long chain acylcarnitine (LCAC); Urate

Indexed keywords

ACYLCARNITINE; CARNITINE; LACTIC ACID; LONG CHAIN FATTY ACID; LYSOPHOSPHATIDYLCHOLINE; URATE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART MUSCLE ISCHEMIA; HEART PACING; HEART PROTECTION; ISOLATED HEART; LIPOLYSIS; MALE; NONHUMAN; RAT; VASCULAR ENDOTHELIUM;

ANIMALIA;

EID: 0029991891     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00239323     Document Type: Article

References (27)

1. Stam H, Hulsmann WC: Release of lipolytic products from rat heart. Hormonal Stimulation, intracardiac origin and pharmacological modification. Biochem Int 2: 477-481, 1981
2. Blaustein MP: Phospholipids as ion exchangers; implications for a possible role in biological membrane excitation and anesthesia. Biochim Biophys Acta 135: 653-658, 1967
3. Post JA, Langer GA, Op den Kamp JAP, Verkley AJ: Phosholipid asymmetry in cardiac sarcolemma. Biochim Biophys Acta 943: 256-266, 1988
4. Hulsmann WC, Schneydenberg CTWM, Verkley AJ: Accumulation and excretion of long-chain acylcarnitine by rat hearts; studies with aminocarnitine. Biochim Biophys Acta 1097: 263-269, 1991
5. Post JA, Leunissen-Bijvelt J, Ruigrok TJC, Verkley AJ: Ultrastructural changes of sarcolemma and mitochondria in the isolated rabbit heart during ischemia and reperfusion. Biochim Biophys Acta 845: 119-123, 1985
6. Hulsmann WC, De Wit LEA, Schneydenberg C, Verkley A: Loss of cardiac contractility and severe morphological changes by acutely lowering the pH of the perfusion medium: protection by fatty acids. Biochim Biophys Acta 1033: 214-218, 1990
7. Hulsmann WC, Dubelaar ML, Lamers JMJ, Maccari F: Protection by acylcarnitine and PMSF of rat heart subjected to ischemia and reperfusion. Biochim Biophys Acta 847: 62-66, 1985
8. Hulsmann WC, De Wit LEA, Stam H, Schoonderwoerd K: Hormonal control of cardiac lipolysis by glyco(geno)lysis. Biochim Biophys Acta 1055: 189-192, 1990
9. Idell-Wenger JA, Grotyohann LW, Neely JR: Coenzyme A and carnitine distribution in normal and ischemic hearts. J Biol Chem 253: 4310-8, 1978
10. Hulsmann WC, Peschechera A, Arrigoni-Martelli E: Carnitine and cardiac interstitium. Cardioscience 5: 67-72, 1994
11. Hulsmann WC, Dubelaar ML: Aspects of fatty acid metabolism in vascular endothelial cells. Biochimie 70: 681-686, 1988
12. Stam H, Geelhoed-Mieras MM, Hulsmann WC. Erucic acid-induced alteration of cardiac triglyceride hydrolysis. Lipids 15: 242, 1990
13. Peschechera A, Ferrari LE, Arrigoni-Martelli E, Hulsmann WC: Up-take and release of carnitine by vascular endothelium in culture;effocts of protons and oxygen free radicals. Mol Cell Biochem 142: 99-106, 1995
14. Hohorst HJ. L(+)lactate: Determination with lactate dehydrogcnase and DPN. hi: H.U. Bergmeyer (ed.). Methods of Enzymatic Analysis. Academic Press Inc., New York, 1985, pp 266-270
15. Pace JA: Improved radiochemical assay for carnitine and its deriva-lives in plasma and tissue extracts. Clin Chem 24: 32-35, 1987
16. Smolenski RT, Lachno DR, Ledingham SJM, Yacoub MH: Determination of sixteen nucleotides, nueleosides and bases using high-performance liquid chromatography and its application to the study of purine metabolism in hearts for transplantation. J Chromatogr 527: 414-420, 1990
17. Hulsmann WC, Stam H, Maccari F: Biochim Biophys Acta: The effect of excess (acyl)carnitine on lipid metabolism in rat heart. Biochim Biophys Acta 713: 9-45, 1982
18. Hoppel CL: The physiological role of carnitine. In: R, Ferrari, S. di Mauro, G. Sherwood (eds). L-camitine and its role in medicine: from function to therapy. Academic Press New York, 1992, pp 287-305
19. Pande SV, Murthy MSR: Carnitine-acylcarnitine translocase deficiency: implications in human pathology. Biochim Biophys Acta 226: 269-276, 1995
20. Hulsmann WC, Peschechera A: Long-cahin Acylcarnitine as membrane stabilizer. In: A.M. Gotto, C. Lenfant, A.L. Catapano and R, Paoletti (eds). Multiple risk factors in cardiovascular disease. Kluwer Publ.Co., Dordrecht, 1995, pp 409-412
21. Van Hinsbergh VWM, Scheffer MA: Effect of propionyl-L-camitine in human endothelial cells. Cardiovasc Drugs and Ther 5 (suppl 1): 97-105, 1991
22. Inoue N, Hirata K, Akita H, Yokoyama M: Paknitoyl-L-carnitine modifies the function of vascular endothelium. Cardiovasc Res 28: 129-134, 1994
23. Ferrari R, Cucchini F, Visioli O. The metabolic effects of L-camitine in angina pectoris. Int J Cardiol 5: 213-216, 1984
24. Brevetti G, Attisano T, Perna S, Rossini A, Policicchio A, Corsi M. Effect of L-carnitine on the reactive hyperemia in patients affected by peripheral vascular disease: A double blind crossover study. Angiology 40: 857-863, 1989
25. Dubelaar ML, Lucas CMHB, Hulsmann WC. Acute effect of L-carnitine upon skeletal muscle force tests in the dog. Am J Physiol 260: E189-E193, 1991
26. Dubelaar ML, Lucas CMBH, Hulsmann WC. The effect of L-camitine on force development of the latissimus dorsi muscle in dogs. J Card Surg 6 suppl 1: 270-275, 1991
27. Nagao B, Kobayashi A, Yamazaki N. Effects of L-carnitine on phospholipids in ischemic myocardium. Jpn Heart J 28: 243-251, 1987