Interactions between CD44 and hyaluronic acid: Their role in tumor growth and metastasis

Current Topics in Microbiology and Immunology

Volumn 213 III, Issue , 1996, Pages 129-153

  Sy, M S ^a   Liu, D ^a   Schiavone, R ^a   Ma, J ^a   Mori, H ^a   Guo, Y ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HERMES ANTIGEN; HYALURONIC ACID; TUMOR MARKER;

GENE EXPRESSION REGULATION; HUMAN; IN VITRO STUDY; METASTASIS; PRIORITY JOURNAL; REVIEW; TUMOR GROWTH;

EID: 0029991535     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-80071-9_9     Document Type: Review

References (146)

1. Alho AM, Underhill CB (1989) The hyaluronate receptor is preferentially expressed on proliferating epithelial cells. J Cell Biol 108: 1557-1565
2. Altomonte M, Colizzi F, Esposito G, Maio M (1993) Circulating intercellular adhesion molecule 1 as a marker of disease progression in cutaneous melanoma. N Engl J Med 327: 959
3. Andres JL, Stanley K, Cheifetz K, Massague J (1989) Membrane anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor B. J Cell Biol 109. 3137-3145
4. Aruffo A, Stamenkovic I, Melnick M, Underhill CB, Seed B (1990) CD44 is the principal cell surface receptor for hyaluraonate. Cell 61. 1303-1311
5. Asplund T, Heldin P (1994) Hyaluronan receptors are expressed on human malignant mesothelioma cells but not on normal mesothelial cells Cancer 54: 4516-4523
6. Bartolazzi A, Peach R, Aruffo A, Stamenkovic I (1994) Interaction between CD44 and hyaluronate is directly implicated in the regulation of tumor development. J Exp Med 180: 53-66
7. Bazil V, Horejsi V (1992) Shedding of the CD44 adhesion molecules from leukocytes induced by anti-CD44 monoclonal antibody stimulating the effect of a natural receptor ligand. J Immunol 149 747-753
8. Bennet KL, Jackson DG, Simon JC et al (1995) CD44 isoforms containing exon V3 are responsible for the presentation of heparin binding growth factor J Cell Biol 128: 687-698
9. Birch M, Mitchell S, Hart IR (1991) Isolation and characterization of human melanoma variants expressing high and low levels of CD44 Cancer Res 51: 6660-6667
10. Bourguignon LYW, Kalomiris EL, Lokeshwar VB (1991) Acylation of the lymphoma transmembrane glycoprotein GP85, may be required for GP-85 ankyrin interaction. J Biol Chem 266: 1761-1765
11. Brown TA, Bouchard T, St John T, Wayner E, Carter WG (1991) Human keratinocytes express a new CD44 core protein (CD44E) as a heparin sulfate intransic membrane proteoglycan with additional exons. J Cell Biol 113 207-216
12. Budd RC, Cerottini C, Horvath C et al. (1987) Distinction of virgin and memory T lymphocytes: stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation J Immunol 138 3120-3129
13. Butcher EC (1986) The regulation of lymphocytes traffic. Curr Top Microbiol Immunol 128: 85-124
14. Camp RL, Kraus TS, Birkeland L, Pure E (1991) High levels of CD44 expression distinguish virgin from antigen primed B cells. J Exp Med 173: 763-766
15. Camp RL, Kraus TA, Pure E (1992) Variations in the cytoskeletal interaction and post translational modifications of the CD44 homing receptor in macrophages. J Cell Biol 115: 1283-1292
16. Cannistra SP, Kanasa GS, Niloff J, DeFranzo B, Kim Y, Ottensmeier C (1993) Binding of ovarian cancer cells to peritoneal mesothelium in vitro is partly mediated by CD44 H. Cancer Res 53: 3830-3838
17. Carter WG, Wayner EA (1988) Characterization of the class III collagen receptor, a phosphorylated, transmembrane glycoprotein expressed in nucleared human cells J Biol Chem 263: 4193-4201
18. Chandrasekhar S, Kleinman HK, Rassell JR (1983) Interaction of link protein with collagen J Biol Chem 258: 6226-6231
19. Classen SD, Eierman W, Wolf H, Kopp R, Wilmans W (1995) CD44 variant in serum of breast cancer patients: a prognostic factor for clinical progresison? Proc Am Assoc Cancer Res 36 209
20. Cross AS, Wright DG (1991) Mobilization of sialidase from intracellular stores to the surface of human neutrophils and its role in stimulated adhesion responses of these cells. J Clin Invest 88: 2067-2076
21. Culty M, Miyake K, Underhill CB (1992) Binding and degradation of hyaluronan by human breast cancer cell lines expresssion different forms of CD44; correlation with invasive potential. J Cell Physiol 160: 275-286
22. Deak F, Kiss I, Sparks KJ, Argraves WS, Hampikian G, Foetinck PF (1986) Complete amino acid sequence of chicken cartilage link protein deduced from cDNA clones Proc Natl Acad Sci USA 83: 3766-3770
23. DeGasperi R, Thomas LJ, Sugiyama E et al (1990) Correction of a defect in mammalian GPI anchor biosynthesis by a transfected yeast gene. Science 250: 988-991
24. Denning SM, Lee PT, Singer KH, Haynes BF (1990) Antibodies against the CD44 p80, lymphocyte homing receptor molecule augment human peripheral blood T cell activation. J Immunol 144: 7-15
25. Dennis J, Waller C, Timpl R, Schirmacher V (1982) Surface sialic acid reduces attachment of metastatic tumor cells to collagen type IV and fibronectin. Nature 300: 274-276
26. Doege K, Sasaki M, Horigan E, Hassel J, Yamada Y (1987) Complete primary structure of the rat cartilage proteoglycan core protein deduced from cDNA sequences. J Biol Chem 262: 17757-17763
27. Faassem AE, Schrager JA, Klein DJ, Oegema TR, Couchman JR, McCarthy JB (1992) A cell surface chondroitin sulfate proteoglycan, immunologically related to CD44 is involved in type collagen mediated melanoma cell motility and invasion. J Cell Biol 116: 521-531
28. Fidler IJ (1978) Tumor heterogeneity and the biology of cancer invasion and metastasis. Cancer Res 38: 2651-2660
29. Fidler IJ (1991) Orthotopic implantation of human colon carcinomas into nude mice provides a valuable model for the biology and therapy of metastasis. Cancer Metastasis Rev 10: 229-243
30. Fidler IJ, Radinsky R (1990) Genetic control of cancer metastasis J Natl Cancer Inst 82. 166-168
31. Fidler IJ, Naito S, Pathak S (1990) Orthotopic implantation is essential for the selection, growth and metastasis of human renal cell cancer in nude mice Cancer Metastasis Rev 9: 149-165
32. Fogel M, Altevogt P, Schiramacher V (1983) metastatic potential severely altered by changes in tumor cell adhesiveness and cell surface sialylation. J Exp Med 157. 371-376
33. Folkman J, Klagsbum M (1987) Angiogenesis factors. Science 235: 442-447
34. Folkman J (1991) Tumor angiogenesis In. Holland JF (ed) Cancer medicine Lee and Febiger, Philadelphia
35. Fox SB, Gatter KC, Jackson DG et al (1993) CD44 and cancer screening. Lancet 342. 548-549
36. Fox SB, Fawcett J, Jackson DG et al (1994) Normal human tissues, in addition to some tumors, express multiple different CD44 isoforms. Cancer Res 54: 4539-4546
37. Fujita N, Yaegashi N, Ide Y et al (1994) Expression of CD44 in normal versus tumor endometnal tissues: possible implication of reduced expression of CD44 in lymph-vascular space involvement of cancer cells. Cancer Res 54: 3922-3928
38. Gross N, Beretta C, Eruisseau GM, Jackson D, Simmons D, Beck D (1994) CD44H expression by human neuroblastoma cells: relation to MYCN amplication and lineage differentiation. Cancer Res 54: 4238-4242
39. Gunthert U, Hofman M, Rudy S et al (1991) A new variant of glycoprotein CD44 congers metastatic potential to rat carcinoma cells. Cell 65: 13-24
40. Guo YJ, Ma J, Wong H et al. (1993) Monoclonal anti-CD44 antibody acts in synergy with anti-CD2 but inhibtis anti-CD3 or T cell receptor mediated signaling in murine T cell hybridomas. Cell Immunol 153 186-191
41. Guo YJ, Ling SC, Wong, Sy MS (1994) Acylation of CD44 may interfere with CD3 mediated signaling in human lymphocytes. Int Immunol 6(2): 213-221
42. Guo YJ, Ma J, WAng JH et al (1994) Inhibition of human melanoma growth and metastasis in vivo by anti-CD44 monoclonal antibody. Cancer Res 54 1561-1565
43. Guo YJ, Liu GG, Wang XN et al (1994) Soluble CD44 in the serum as an indicator of tumor growth and metastasis in patients with gastric or colon cancer. Cancer Res 54: 422-426
44. Hanning R, Mainolfi E, Bystryn JC, Henn M, Merluzzi VJ, Rothlein R (1991) Serum levels of circulating intercellular adhesion molecule 1 expression in human malignant melanoma. Cancer Res 51: 5003-5005
45. Hardingham TE, Hosang AJ (1992) proteoglycans: many forms and many functions. FASEB J 6: 861-870
46. Hardwick C, Hoare K, Owens R et al (1992) Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility. J Cell Biol 117: 1343-1350
47. Hart I, Birch M, Marshall JF (1991) Cell adhesion receptor expression during melanoma progression and metastasis. Cancer Metastasis Rev 10: 115-135
48. Haynes BF, Telen MJ, Hale LP, Denning SM (1989) CD44a molecule involved in leukocyte adherence and T cell activation. Immunol Today 10: 423-427
49. Haynes BF, Hale LP, Patton KL, Martin ME, McCallum RM (1991) Measurement of an adhesion molecule as an indicator of inflammatory disease activity. UP-regulation of the receptor for hyaluronate (CD44) in rheumatoid arthritis Arthritis Rheum 34. 1434-1441
50. Heider K-H, Hofmann M, Hors E et al. (1993) A human homologue of the rat metastasis associated variant of CD44 is expressed in colorectal carcinomas and adenomatous polyps. J Cell Biol 120: 227-233
51. Herlyn M, Rodeck U, Koprowski H (1987) Shedding of human tumor associated antigens in vitro and in vivo. Adv Cancer Res 49: 189-221
52. Herrlich P, Rudy W, Hofmann M et al. (1993) CD44 and splice variants of CD44 in normal differentiation and tumor progression In: Hemler M, Mihich E (eds) Cell adhesion molecules. Plenum, New York, pp 265-288
53. Hoessli DC (1980) T lymphocyte differentiation is accompanied by increase in sialic acid content of Thy-1 antigen. Nature 283. 576-577
54. Hofmann U, Rudy W, Zooler M et al (1991) CD44 splice variants confer metastatic behavior in rats: homologous sequences are expressed in human tumor cell lines. Cancer Res 51: 5292-5297
55. Horai T, Nakamura N, Tateishi R, Hattori S (1981) Glycosaminoglycans in human lung cancer. Cancer 48: 2016-2021.
56. Horst E, Meijer CJ, Radaszkiewicz T, Oseloppele GJ, Van Krieken JH, Pals ST (1990) Adhesion molecules in the prognosis of diffuse lage-cell lymphoma: expression of a lymphocyte homing receptor (CD44), LFA-1, (CD11a/18) and ICAM-1 (CD54). Leukemia 4. 595-599
57. Huet SH, Groux H, Caillou B, Valentin H, Prieur AM, Bernard A (1989) CD44 contributes to T cell activation J Immunol 143: 798-801
58. Hughes EN, Mengod G, August JT (1981) Murine cell surface glycoproteins Characterization of a major components of 80,000 daltons as a polymorphic differentiation antigen of mesenchyma cells. J Biol Chem 256: 7023-7027
59. Jalkanen S, Bargatze RF, del los Toyos J, Butcher EC (1987) Lymphocyte recognition of high endothelium: antibodies to distinct epitopes of an 85-95-kD glycoprotein antigen differentially inhibit lymphocyte binding to lymph node, mucosal, or synovial endothelial cells. J Cell Biol 105: 983-990
60. Jalkanen S, Jalknen M (1992) Lymphocyte CD44 binds the COOH-terminal heparin binding domain of fibronectin J Cell Biol 116 817-825
61. Kageshita T, Yoshii A, Kimura T et al (1993) Clinical relevance of ICAM-1 expression in primary lesions and serum of patients with malignant melanoma. Cancer Res 53: 4927-4932
62. Kahn P (1992) Adhesion protein studies provide new clue to metastasis. Science 257. 614-615
63. Kalomiris EL, Bourguignon LYW (1988a) Mouse T lymphoma cells contain a transmembrane glycoprotein (GP85) that binds ankyrin. J Cell Biol 106: 319-327
64. Kalomiris EL, Bourguignon LYW (1988b) Lymphoma protein kinase C is associated with the transmembrane glycoprotein gp85, and may function in gp85 ankyrin binding. J Biol Chem 264: 8113-8120
65. Katoh S, McCarthy JB, Kincade PW (1994) Characterization of soluble CD44 in the circulation of mice: levels are affected by immune activity and tumor growth. J Immunol 152. 3441-3449
66. Kennel SJ, Lankford TK, Foote LJ, Shinpock SG, Stringer C (1993) CD44 expression of murine tissues. J Cell Sci 104 373-382
67. Kiefer MC, Stephans JC, Crawford K, Okino K, Barr PJ (1990) Ligand affinity cloning and structure of a cell surface heparan sulfate proteoglycan that binds basic fibroblast growth factor. Proc Natt Acad Sci USA 87: 6985-6989
68. Knudson W, Biswas C, Li X-Q, Nemec RE, Toole BP (1989) The role and regulation of tumor associated hyaluronan. The biology of hyaluronan. Ciba Found Symp 143: 150-160
69. Knutson JR, Fields GB, Lida J, Miles AJ, McCarthy JB (1995) A type IV collagen derived synthetic peptide, IN-H1, interacts with human meianoma CD44 chondroitin sulfate proteoglycan and inhibitis invasion of basement membranes. Proc Am Assoc Cancer Res 36 68
70. Koopman G, Heider K-H, Horst E et al. (1993) Activated human lymphocytes and aggressive non-Hodgkin's lymphomas express a homologue of the rat metastasis associated variant of CD44. J Exp Med 177 897-904
71. Krusius T, Gehlsen KR, Ruoslahti E (1987) A fibroblast chondroitin sulfate proteoglycan core protein contains lectin like and growth factor like sequence. J Cell Biol 262. 13120-13125
72. Lacy BE, Underhill CB (1987) The hyaluronate receptor is associated with actin filaments. J Cell Biol 105 1395-1404
73. Laurent TC, Fraser JRE (1992) Hyaluronan. FASEB J 6. 2397-2404
74. Lee TH, Wisniewski H-G, Vilcek J (1992) A novel secretory tumor necrosis factor inducible protein is a member of the family of hyaluronate binding proteins closely related to the adhesion receptor CD44. J Cell Biol 116. 545-557
75. Legras S, Günthert U, Li Y et al. (1995) CD44 alternative splicing in normal human myelopoiesis and its deregulation in acute myeloblastic leukemia (AML) Proc Am Assoc Cancer Res 36: 465-465
76. Lesley J, Schulte R, Hyman R (1990) Binding of hyaluronic acid to lymphoid cell lines is inhibited by monoclonal antibodies against Pgp-1. J Exp Cell Res 187: 224-229
77. Lesley J, Q H, Miyake K, Hamann A, Hyman R, Kincade PW (1992) Requirements for hyaluronic acid binding by CD44. a role for the cytoplasmic domain and activation by antibody J Exp Med 172: 257-266
78. Lesley J, Hyman R, Kincade PL (1993) CD44 and its interaction with extracellular matrix. Adv Immunol 34: 271-335
79. Liao HX, Levesque MC, Patton K et al (1993) Regulation of human CD44H and CD44E isoform binding to hyaluronan by phorbol myristate acetate and anti-CD44 monoclonal and polyclonal antibodies J Immnol 151: 6490-6499
80. Lloyd CW (1975) Sialic acid and the social behavior of cells. Biol Rev 50: 325-350
81. Lokeshwar VB, Bourguignon LYW (1992) The lymphoma transmembrane glycoprotein GP85 (CD44) is a novel guanine nucleotide binding protein which regulates GP85 (CD44)-ankyrin interaction. J Biol Chem 267: 22073-22078
82. Lucas MG, Green AM, Telen MJ (1989) Characterization of the serum In (Lu)-retated antigen: identification of a serum protein related to erythrocyte p80. Blood 73: 596-600
83. Lynch F, Ceredig R (1988) Lyt24 (Pgp-1) expression by thymocytes and peripheral T cells Immunol Today 9: 7-10
84. MacLeod CL, Weinroth SE, Sterifinger C, Glaser SM, Hays EF (1985) SL12 murine T lymphoma: a new model for tumor cell heterogeneity. J Natl Cancer Inst 74: 875-879
85. Matsumura Y, Tarin D (1993) Significance of CD44 gene products for cancer diagnosis and disease evaluation Lancet 340: 1053-1058
86. Matsumura Y, Smith S, Tarin JC (1995) Cancer diagnosis by detection of new abnormalities in splicing of CD44 gene products in bladder tumors and urine cell sediments Proc Am Assoc Cancer Res 36: 283
87. Merzak A, Koocheckpour S, Pilkington GJ (1994) CD44 mediates human glioma cell adhesion and invasion in vitro. Cancer Res 54 3988-3992
88. Miyake K, Underhill CB, Lesley J, Kincade PW (1989) Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition. J Exp Med 172: 69-75
89. Murakami S, Miyake K, June CH, Kincade PW, Hodes RJ (1990) IL-5 induces a Pgp-1 bright B cell subpopulation that is highly enriched in proliferative and Ig secretory activity and binds hyaluronate. J Immunol 145: 3618-3627
90. Murakami S, Miyake K, Bel R, Kincade PW, Hodes RJ (1991) Characterization of autoantibody secreting B cells in mice stimulatory chronic graft versus host reactions: identification of a CD44 high population that binds specifically to hyaluronate. J Immunol 146. 1422-1427
91. Murakami S, Shimabukuro Y, Miki Y et al (1994) Inducible binding of human lymphocytes to hyaluronate via CD44 does not require cytoskeleton association but does require new protein synthesis. J Immunol 152. 467-477
92. Nagabhushan M, Pretlow TG, Guo YJ, Amini SB, Pretlow TP, Sy MS (1995) Altered expression of CD44 in prostate cancer metastases (submitted)
93. Nemec RE, Toole BP, Knudson (1987) The cell surface hyaluronate binding sites of invasive human bladder carcinoma cells. Biochem Biophy Res Commun 149. 249-257
94. Nicolson GL (1988) Organ specificity of tumor metastasis: role of preferential adhesion, invasion and growth of malignant cells at specific secondary sites Cancer Metastasis Rev 7. 143-188
95. Nottenburg C, Rees G, St. John T (1989) Isolation of mouse CD44 cDNA. structure features are distinct from the primate cDNA Proc Natl Acad Sci USA 86: 8521-8525
96. Oyama F, Hiroshashi S, Shimosato Y, Titani K, Sekiguchi K (1989) Deregulation of alternative splicing of fibronectin pre-mRNA in malignant human liver tumors. J Biol Chem 264: 10331-10334
97. Payne LN, Pani PK, Weiss RA (1971) A domain epistatic gene which inhibits cellular susceptibility to RSV. J Gen Virol 13: 455-462
98. Peach RJ, Hollenbaugh D, Stamemkovic I, Aruffo A (1993) Identification of hyaluronic acid binding sites in the extracellular domain of CD44. J Cell Biol 122 257-264
99. Peacock EEJ (1984) Wound repair, 3rd edn. Saunders, Philadelphia
100. Penno MB, August JT, Baylin SB et al (1994) Expression of CD44 in human lung tumors. Cancer Res 54: 1381-1387
101. Perschl A, Lesley J, English N, Trowbridge I, Hyman R (1995) Role of CD44 cytoplasic domain in hyaluronan binding Eur J Immunol 25: 495-501
102. Philipson LH, Schwartz NB (1984) Subcellular localization of hyaluronate synthetase in oligoden-drocytoma cells J Biol Chem 259: 5017-5023
103. Picker LJ, Nakache M, Butcher EC (1989) Monoclonal antibodies to human lymphocytes homing receptors define a novel class of adhesion molecules on diverse cell types. J Cell Biol 109: 927-935
104. Poole AR (1986) Proteoglycans in health and disease: structure and functions. Biochem J 236: 1-14
105. Reid T, Flint MH (1974) Changes in glycosaminoglycan content of healing rabbit tendon. J Embryol Exp Morphol 31: 489-495
106. Rothbard JB, Brackenbury R, Cunnigham AB, Edelman GM (1982) Differences in the carbohydrate structures of neural adhesion molecules from adult and embryonic chicken brains. J Biol Chem 257. 11064-11069
107. Rothman BL, Blue M, Kelley KA, Wunderlich D, Mierz DV, Aune TM (1991) Human T cell activation of OKT3 is inhibited by a monoclonal antibody to CD44. J Immunol 147: 2493-2497
108. Rouslahti E (1988) Structure and biology of proteoglycans. Ann Rev Cell Biol 4: 229-255
109. Ruoslahti E, Yamagushi Y (1991) Proteoglycans as modulators of growth factor activities. Cell 64: 867-869
110. Saksela O, Rifkin DB (1990) Release of basic fibroblast growth factor-heparan sulfate complexes from endothelial cells by plasminogen activated mediated proteolytic activity. J Cell Biol 110: 767-775
111. Salmi M, Gron-Virta K, Sointu P, Grenman R, Kalimo H, Jalkannen S (1993) Regulated expression of exon V6 containing isoforms of CD44 in man: downregulation during malignant transformation of tumors of squamocellular origin J Cell Biol 122. 431-442
112. Schauer R (1985) Sialic acids and their role as biological masks Trends Biochem Sci 10: 357-360
113. Schwarzbauer JE, Patel RS, Fonda D, Hynes RO (1987) Multiple sites of alternative splicing of the rat fibronectin gene transcripts. EMBO J 6: 2573-2580
114. Screaton GR, Bell MV, Jackson DG, Cornelis FB, Gerth U, Bell JE (1992) Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons. Proc Natl Acad Sci USA 89: 12160-12164
115. Screaton GR, Bell MV, Bell Jl, Jackson D (1993) The identification of a new alternative exon with highly restricted tissue expression in transcripts encoding the mouse Pgp-1 (CD44) homing receptor. J Biol Chem 268: 12235-12238
116. Shimizu Y, Seventer GA, Siraganian R, Wahl L, Shaw S (1989) Dual role of the CD44 molecule in T cell adhesion and activation. J Immunol 143 2457-2463
117. Shtivelman E, Bishop MJ (1991) Expression of CD44 is repressed in neuroblastoma cells. Mol Cell Biol 11: 5446-5453
118. Sieweke MH, Thompson NL, Sporn MB, Bissell MJ (1990) Mediation of wound related Rous sarcoma virus tumorigenesis by TGFB. Science 248. 1656-1660
119. Springer TA (1990) Adhesion receptors of the immune system. Nature 346: 426-434
120. Stamenkovic I, Aminot M, Pesando JM, Seed B (1989) A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family. Cell 56: 1057-1062
121. Stamenkovic I, Aruffo A, Aminot M, Seed B (1991) The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate bearing cells. EMBO 10. 343-348
122. Stetler-Stevenson WG, Aznavoonan S, Liotta LA (1993) Tumor cell interactions with the extracellular matrix during invasion and metastasis Annu Rev Cell Biol 9: 541-573
123. Stoolman LM (1989) Adhesion molecules controlling lymphocytes migration. Cell 56: 907-910
124. Sy MS, Guo YJ, Stamenkovic I (1991) Distinct effects of two CD44 isoforms on tumor growth in vivo J Exp Med 174: 859-866
125. Sy MS, Guo YJ, Stamenkovic I (1992) Inhibition of tumor growth in vivo with a chimeric CD44-immunoglobulin molecule. J Exp Med 176: 623-627
126. Takeuchi J, Sobue M, Sato E, Yoshida M, Uchibori N, Miura K (1981) A high level of glycosaminoglycan synthesis of squamous cell carcinoma of the parotid cland Cancer 47: 2030-2035
127. Tan PHS, Santos EB, Rossbach HC, Sandmaier BM (1993) Enhancement of natural killer activity by an antibody to CD44. J Immunol 150. 812-820
128. Tanabe KK, Ellis LM, Saya H (1993) Expression of CD44R1 adhesion molecule in colon carcinomas and metastasis. Lancet 341. 725-726
129. Tanaka Y, Adams DH, Hubscher S, Hirano H, Siebenlist U, Shaw S (1993) T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-1B. Nature 361: 79-82
130. Thomas LJ, DeGasperi R, Sugiyama E et al (1991) Functional analysis of T cell mutants defective in the biosynthesis of glycosyl phosphatidylinositol anchor J Biol Chem 266. 23175-23184
131. Thomas L, Byers HR, Vink J, Stamenkovic I (1992) CD44H regulates tumor cell migration of hyaluronate coated substrate. J Cell Biol: 971-991
132. Tolg C, Hofmann M, Herrlich P, Ponta H (1993) Splicing choice from ten variant exons establishes CD44 variability Nucleic Acids Res 21: 1225-1229
133. Toole BP (1990) Hyaluronan and its binding proteins, the hyaladherins. Curr Opin Cell Biol 2: 839-844
134. Toole BP, Biswas C, Gross J (1979) Hyaluronate and invasiveness of the rabbit V2 carcinoma. Proc Natl Acad Sci USA 76 6299-6303
135. Trowbridge IS, Lesley J, Schutte R, Trotter J (1982) Biochemical characterization and cellular distribution of a polymorphic, murine cell surface glycoprotein expressed on lymphoid tissues Immunogenetics 15. 299-312
136. Tsujisaki M, Imai K, Hirata H et al (1991) Detection of circulating intercellular adhesion molecule 1 antigen in malignant diseases. Clin Exp Immunol 85: 3-8
137. Turley EA (1984) Proteoglycans and cell adhesion: their putative role during tumorigenesis. Cancer Metastasis Rev 3: 325-339
138. Underhill CH, Dorfman A (1978) The role of hyaluronic acid in intercellular adhesion of cultured mouse cells. Exp Cell Res 117: 155-164
139. Underhill CB, Toole BP (1982) Transformation-dependent loss of the hyaluronate containing coats of cultured cells. J Cell Physiol 110: 123-128
140. Underhill CB (1982) Interaction of hyaluronate with the surface of simian virus 40-transformed 3T3 cells: aggregation and binding studies. J Cell Sci 56L. 177-189
141. Webb DSS, Shimizu Y, Van Seventer GA, Shaw S, Gerrard TL (1990) LFA-3, CD44 and CD45: Physiologic triggers of human monocyte TNF and IL-1 release. Science 249: 1295-1297
142. West DC, Sattar A, Kumar S (1985) Angiogenesis induced by the degradation products of hyaluronic acid. Science 228: 1324-1326
143. Wielenga VJM, Heider K-H, Offerhaus GJA et al. (1993) Expression of CD44 variant proteins in humal colorectal cancer is related to tumor progression Cancer Res 53: 4754-4756
144. Wolffe EJ, Cause WC, Pelfrey CM, Holland SM, Steinberg AD, August JT (1990) The cDNA sequence of mouse Pgp-1 and to human CD44 cell surface antigen and proteoglycan core/link proteins J Biol Chem 265: 341-352
145. Woodland H, Jones L (1988) Growth factors in amphibian cell differentiation Nature 332: 113-115
146. Zhou DF, Ding JF, Picker LJ, Bargatze RF, Butcher EC, Goeddel DV (1989) Molecular cloning and expression of Pgp-1. The mouse homolog of the human H-CAM (Hermes) lymphocyte homing receptor. J Immunol 143. 3390-3395