The Saccharomyces cerevisiae IMP2 gene encodes a transcriptional activator that mediates protection against DNA damage caused by bleomycin and other oxidants

Molecular and Cellular Biology

Volumn 16, Issue 5, 1996, Pages 2091-2100

  Masson, Jean Yves ^a   Ramotar, Dindial ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; DNA POLYMERASE; FREE RADICAL;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; DNA BINDING; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; GENE ACTIVATION; GENE EXPRESSION REGULATION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION INITIATION;

EUKARYOTA; SACCHAROMYCES CEREVISIAE;

EID: 0029990930     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.5.2091     Document Type: Article

References (65)

1. Absalon, M. J., J. W. Kozarich, and J. Stubbe. 1995. Sequence-specific double-strand cleavage of DNA by Fe-bleomycin. 1 The detection of sequence-specific double strand breaks using hairpin oligonucleotides. Biochemistry 34:2065-2075.
2. Aguilera, A., and H. L. Klein. 1988. Genetic control of intrachromosomal recombination in Saccharomyces cerevisiae. I Isolation and genetic characterization of hyperrecombination mutations. Genetics 119:779-790.
3. Averbeck, D., and S. Averbeck. 1994. Induction of the genes RAD54 and RNR2 by various DNA damaging agents in Saccharomyces cerevisiae. Mutat. Res 315:123-138.
4. Bennett, R. A. O., P. S. Swerdlow, and L. F. Povirk. 1993. Spontaneous cleavage of bleomycin-induced abasic sites in chromatin and their mutagenicity in mammalian shuttle vectors. Biochemistry 23:3188-3195.
5. Budd, M. E., and J. L. Campbell. 1995. DNA polymerases required for repair of UV-induced damage in Saccharomyces cerevisiae. Mol. Cell. Biol. 15:2173-2179.
6. Burger, R. M., K. Drlica, and B. Birdsall. 1994. The DNA cleavage pathway of iron bleomycin: strand scission precedes deoxyribose 3-phosphate bond cleavage. J. Biol. Chem 269:25978-25985.
7. Cunningham, R. P., S. M. Saporito, S. G. Spitzer, and B. Weiss. 1986. Endonuclease IV (nfo) mutant of Escherichia coli. J. Bacteriol. 168:1120-1127.
8. Demple, B., and L. Harrison. 1994. Repair of oxidative damage to DNA: enzymology and biology. Annu. Rev Biochem. 63:915-948.
9. 2-damaged Escherichia coli. Proc. Natl. Acad. Sci. USA 83:7731-7735.
10. Donnini, C., T. Lodi, I. Ferrero, and P. P. Puglisi. 1992. IMP2, a nuclear gene controlling the mitochondrial dependence of galactose, maltose and raffinose utilization in Saccharomyces cerevisiae. Yeast 8:83-93.
11. Draper, M. P., H.-Y. Liu, A. H. Nelsbach, S. P. Mosley, and C. L. Denis. 1994. CCR4 is a glucose-regulated transcription factor whose leucine-rich repeat binds several proteins important for placing CCR4 in its proper promoter context. Mol. Cell Biol 14:4522-4531
12. Enenkel, C., and D. H. Wolf. 1993. BLH1 codes for a yeast thiol aminopeptidase, the equivalent of mammalian bleomycin hydrolase. J. Biol. Chem. 268:7036-7043.
13. Game, J. C. 1993. DNA double-strand breaks and the RAD50-57 genes in Saccharomyces. Semin. Cancer Biol. 4:73-83
14. Gershoni, J. M., and G. E. Palade. 1983. Protein blotting: principles and application. Anal. Biochem. 131:1-15.
15. Gietz, R. D., and R. H. Schiestl. 1992. Applications of high efficiency lithium acetate transformation of intact yeast cells using single-stranded nucleic acids as carrier. Yeast 7:253-263.
16. Giloni, L., M. Takeshita, F. Johnson, C. Iden, and A. P. Grollman. 1981. Bleomycin-induced strand scission of DNA: mechanism of deoxyribose cleavage. J. Biol. Chem. 256:8608-8615.
17. Gstaiger, M., L. Knoepfel, O. Geogiev, W. Schaffner, and C. M. Hovens. 1995. A B-cell coactivator of octamer-binding transcription factors. Nature (London) 373:360-362.
18. Guthrie, C., and G. R. Fink (ed.). 1991. Methods in enzymology, vol. 194. Guide to yeast genetics and molecular biology. Academic Press. Inc., San Diego, Calif.
19. He, C.-H., J.-Y. Masson, and D. Ramotar. Unpublished data.
20. Henner, W. D., S. M. Grunberg, and W. A. Haseltine. 1983. Enzyme action at the 3′-termim of ionizing radiation-induced DNA strand breaks. J. Biol. Chem. 258:15198-15205.
21. Hope, I., S. Mahadevan, and K. Struhl. 1988. Structural and functional characterization of the short acidic transcriptional activation region of yeast GCN4 protein. Nature (London) 333:635-640.
22. Huang, K. N., and L. S. Symington. 1994. Mutation of the gene encoding protein kinase C 1 stimulates mitotic recombination in Saccharomyces cerevisiae. Mol. Cell Biol 14:6039-6045.
23. Keszenman, D. J., V. A. Salvo, and E. Nunes. 1992. Effects of bleomycin on growth kinetics and survival of Saccharomvces cerevisiae: a model of repair pathways J. Bacteriol. 174:3125-3132
24. Khavari, P. A., C. L. Peterson, J. W. Tamkun, D. B. Mendel, and G. R. Crabtree. 1993 BRG1 contains, a conserved domain of the SW12/SNF2 family necessary for normal mitotic growth and transcription. Nature (London) 366:170-174.
25. Kobe, B., and J. Deisenhofer. 1994. The leucine-rich repeat: a versatile binding motif Trends Biochem. Sci. 19:415-421.
26. Kobe, B., and J. Deisenhofer. 1995. A structural basis of the interactions between leucine-rich repeats and protein ligands. Nature (London) 374: 183-186
27. Kolodner, R. D. 1995 Mismatch repair, mechanisms and relationship to cancer susceptibility. Trends Biochem. Sci. 20:397-401.
28. Kuge, S., and N. Jones. 1994. YAP1 dependent activation of TRX2 is essential for the response of Saccharomyces cerevisiae to oxidative stress by hydroperoxides. EMBO. J. 13:655-664
29. Kunz, B. A., E. S. Henson, H. Roche, D. Ramotar, T. Nunoshiba, and B. Demple. 1994. Specificity of the mutator caused by deletion of the yeast structural gene (APN1) for the major apurinic endonuclease. Proc. Natl. Acad Sci. USA 91:8165-8169.
30. Laurent, B. C., M. A. Treitel, and M. Carlson. 1990 The SNF5 protein of Saccharomyces cerevisiae is a glutamine- and proline-rich transcriptional activator that affects expression of a broad spectrum of genes. Mol. Cell. Biol 10:5616-5625
31. Levin, J. D., A. W. Johnson, and B. Demple. 1988. Homogeneous Escherichia coli endonuclease. IV Characterization of an enzyme that recognizes oxidative damage in DNA. J. Biol. Chem. 263:8066-8071.
32. Liang, P., W. Zhu, X. Zhang, Z. Guo, R. P. O'Connell, L. Averboukh, F. Wang, and A. B. Pardee. 1994. Differential display using one-base anchored oligo-dT primers. Nucleic Acids Res. 22:5763-5764
33. Lin, S.-J., and V. C. Culotta. 1995. The ATX1 gene of Saccharomyces cerevisiae encodes a small metal homeostasis factor that protects cells against reactive oxygen toxicity. Proc. Natl. Acad. Sci. USA 92:3784-3788.
34. Loeb, L. A., and B. D. Preston. 1986. Mutagenesis by apurinic/apyrimidinic sites. Annu. Rev Genet. 20:201-230
35. Ma, J., and M. Ptashne. 1987. A new class of yeast transcriptional activators Cell 51:113-119.
36. Magdolen, U., G. Muller, V. Magdolen, and W. Bandlow. 1993. A yeast gene (BLH) encodes a polypeptide with high homology to vertebrate bleomycin hydrolase, a family member of thiol proteinases. Biochim. Biophys Acta 1171:299-303.
37. Masson, J.-Y., and D. Ramotar. Unpublished data.
38. Miller, J. H. 1992. A short course in bacterial genetics: a laboratory manual and handbook for Escherichia coli and related bacteria, p. 72-74. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
39. Moore, C. W. 1991. Further characterizations of bleomycin-sensitive (blm) mutants of Saccharomyces cerevisiae with implications for a radiomimetic model. J. Bacteriol. 173:3605-3608.
40. Popoff, S. C., A. S. Spira, A. W. Johnson, and B. Demple. 1990. The yeast structural gene (APN1) for the major apurinic endonuclease: homology to E. coli endonuclease IV. Proc. Natl. Acad. Sci. USA 87:4193-4197.
41. Povirk, L. F. 1983. Bieomycin, p. 157-181, In S. Neidle and H. Waring (ed), Molecular aspects of anti-cancer drug action. Macmillan Publishers, Ltd., London.
42. Prakash, S., P. Sung, and L. Prakash. 1993 DNA repair genes and proteins of Saccharomyces cerevisiae. Annu. Rev. Genet 27:33-70.
43. Rabindran, S. K., R. I. Haroun, J. Clos, J. Wisniewski, and C. Wu. 1993. Regulation of heat shock factor trimer formation: role of a conserved leucine zipper. Science 259:230-234.
44. Rabow, L., J. Stubbe, and J. W. Kozarich. 1990. Identification and quantitation of the lesion accompanying base release in bleomycin-mediated DNA degradation. J. Am. Chem. Soc. 122:3196-3203.
45. Ramotar, D. 1995. Rapid isolation of any known genes from whole cells of yeast by PCR. Mol. Cell. Biochem. 145:185-187
46. Ramotar, D., and J.-Y. Masson. Unpublished data.
47. Ramotar, D., S. C. Popoff, and B. Demple. 1991. Complementation of DNA repair-deficient Escherichia coli by the yeast Apn1 apurinic/apyrimidinic endonuclease gene. Mol. Microbiol. 5:149-155.
48. Ramotar, D., S. C. Popoff, E. B. Gralla, and B. Demple. 1991. Cellular role of yeast Apn1 apurinic endonuclease/3′-diesterase: repair of oxidative and alkylation DNA damage and control of spontaneous mutation. Mol. Cell. Biol. 11:4537-4544.
49. Reynolds, R. J. 1978. Removal of pyrimidine dimers from Saccharomyces cerevisiae nuclear DNA under nongrowth conditions as detected by a sensitive, enzymatic assay. Mutat. Res. 50:43-56
50. Rose, D. M. 1987. Isolation of genes by complementation in yeast. Methods Enzymol. 152:481-504.
51. Rothstein, R. 1991. Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. Methods Enzymol. 194:281-301.
52. Ruden, D. M., J. Ma, Y. Li, K. Wod, and M. Ptashne. 1991. Generating yeast transcriptional activators containing no yeast protein sequences Nature (London) 350:250-252.
53. Sadowski, I., J. Ma, S. Triezenberg, and M. Ptashne. 1988. GAL4-VP16 is an unusually potent transcriptional activator. Nature (London) 335:563-564.
54. Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463-5467.
55. Schmitt, M. E., T. A. Brown, and B. L. Trumpower. 1990. Rapid and simple method for preparation of RNA from Saccharomyces cerevisiae. Nucleic Acids Res. 18:3091-3092.
56. Seki, S., K. Akiyama, S. Watanabe, M. Hatsushika, S. Ideda, and K. Tsutsui. 1991. cDNA and deduced amino acid sequence of a mouse DNA repair enzyme (APEX nuclease) with significant homology to Escherichia coli exonuclease III. J Biol. Chem 266:20797-20802.
57. Sherman, F., G. Fink, and J. Hicks. 1983. Methods in yeast genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
58. Steighner, R. J., add L. F. Povirk. 1990. Bleomycin-induced DNA lesions at mutational hot spots: implications for the mechanism of double-strand cleavage. Proc. Natl. Acad. Sci. USA 87:8350-8354.
59. Szostak, J. W., T. L. Orr-Weaver, and R. J. Rothstein. 1983. The double-strand-break repair model for recombination. Cell 33:25-35.
60. Tanaka, K., and R. D. Wood. 1994. Xeroderma pigmentosum and nucleotide excision repair of DNA. Trends Biochem. Sci. 19:83-86.
61. Umezawa, H. 1980. Anticancer agents based on natural product models, p. 147-166. Academic Press, London.
62. Umezawa, H., K. Maeda, T. Takeuchi, and Y. Akami. 1966. New antibiotics bleomycin A and B. J. Antibiot. Ser. A 19:200-209.
63. von Sonntag, C. 1987. The chemical basis of radiation biology. Taylor and Francis, London.
64. Worth, L., Jr., B. L. Frank, D. F. Christner, M. J. Absalon, J. Stubbe, and J. W. Kozarich. 1993. Isotope effects on the cleavage of DNA by bleomycin: mechanism and modulation. Biochemistry 32:2601-2609.
65. Wu, A., J. A. Wemmie, N. P. Edgington, M. Goebl, J. L. Guevaras, and W. S. Moye-Rowley. 1993. Yeast bZip proteins mediate pleiotropic drug and metal resistance. J. Biol. Chem. 268:18850-18858.