-
1
-
-
0028198052
-
Regulation of gene expression at early stages of B-cell differentiation
-
Hagman J, Grosschedl R: Regulation of gene expression at early stages of B-cell differentiation. Curr Opin Immunol 1994, 6:222-230.
-
(1994)
Curr Opin Immunol
, vol.6
, pp. 222-230
-
-
Hagman, J.1
Grosschedl, R.2
-
2
-
-
0028230155
-
Transcriptional regulation of T-cell genes during T-cell development
-
Leiden JM, Thompson CB: Transcriptional regulation of T-cell genes during T-cell development. Curr Opin Immunol 1994, 6:231-237.
-
(1994)
Curr Opin Immunol
, vol.6
, pp. 231-237
-
-
Leiden, J.M.1
Thompson, C.B.2
-
3
-
-
0029099805
-
The role of BSAP (Pax-5) in B-cell development
-
Busslinger M, Urbánek P: The role of BSAP (Pax-5) in B-cell development. Curr Opin Genet Dev 1995, 5:595-601.
-
(1995)
Curr Opin Genet Dev
, vol.5
, pp. 595-601
-
-
Busslinger, M.1
Urbánek, P.2
-
4
-
-
0028791705
-
BSAP: A key regulator of B-cell development and differentiation
-
Neurath MF, Stüber ER, Strober W: BSAP: a key regulator of B-cell development and differentiation. Immunol Today 1995, 16:564-569.
-
(1995)
Immunol Today
, vol.16
, pp. 564-569
-
-
Neurath, M.F.1
Stüber, E.R.2
Strober, W.3
-
5
-
-
0028866897
-
A dominant mutation in the Ikeros gene leads to rapid development of leukemia and lymphoma
-
Winandy S, Wu P, Georgopoulos K: A dominant mutation in the Ikeros gene leads to rapid development of leukemia and lymphoma. Cell 1995, 83:289-299.
-
(1995)
Cell
, vol.83
, pp. 289-299
-
-
Winandy, S.1
Wu, P.2
Georgopoulos, K.3
-
6
-
-
0029060412
-
Higher-order nucleoprotein complexes in transcription: Analogies with site-specific recombination
-
Grosschedl R: Higher-order nucleoprotein complexes in transcription: analogies with site-specific recombination. Curr Opin Cell Biol 1995, 7:362-370. A comprehensive review of the role of multicomponent nucleoprotein complexes for transcription and recombination in prokaryotes and eukaryotes.
-
(1995)
Curr Opin Cell Biol
, vol.7
, pp. 362-370
-
-
Grosschedl, R.1
-
7
-
-
0027158441
-
The role of viral enhancer 'core' motif-related sequences in regulating T cell receptor-γ and -δ gene expression
-
Hsiang Y-HH, Spencer D, Wang S, Speck NA, Raulet DH: The role of viral enhancer 'core' motif-related sequences in regulating T cell receptor-γ and -δ gene expression. J Immunol 1993, 150:3905-3916.
-
(1993)
J Immunol
, vol.150
, pp. 3905-3916
-
-
Hsiang, Y.-H.H.1
Spencer, D.2
Wang, S.3
Speck, N.A.4
Raulet, D.H.5
-
8
-
-
0028157961
-
Cooperative binding of Ets-1 and core binding factor to DNA
-
Wotton D, Ghysdael J, Wang S, Speck NA, Owen MJ: Cooperative binding of Ets-1 and core binding factor to DNA. Mol Cell Biol 1994, 14:840-850. This study describes the assembly of ternary complexes comprising CBF (PEBP2) and c-Ets-1 polypeptides on TCRβ enhancer sequences. CBF and c-Ets-1 each bind the enhancer separately, but DNA binding by these proteins is stabilized in the ternary complex.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 840-850
-
-
Wotton, D.1
Ghysdael, J.2
Wang, S.3
Speck, N.A.4
Owen, M.J.5
-
9
-
-
0027256023
-
Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor
-
Wang S, Wang Q, Crute B, Melnikova I, Keller S, Speck N: Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol Cell Biol 1993, 13:3324-3339.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 3324-3339
-
-
Wang, S.1
Wang, Q.2
Crute, B.3
Melnikova, I.4
Keller, S.5
Speck, N.6
-
10
-
-
0027220003
-
PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene
-
Ogawa E, Maruyama M, Kagoshima H, Inuzuka M, Lu J, Satake M, Shigesada K, Ito Y: PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene. Proc Natl Acad Sci USA 1993, 90:6859-6863.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 6859-6863
-
-
Ogawa, E.1
Maruyama, M.2
Kagoshima, H.3
Inuzuka, M.4
Lu, J.5
Satake, M.6
Shigesada, K.7
Ito, Y.8
-
11
-
-
0028804629
-
Expression of the Runt domain-encoding PEBP2α genes in T cells during thymic development
-
Satake M, Nomura S, Yamaguchi-Iwai Y, Takahama Y, Hashimoto Y, Niki M, Kitamura Y, Ito Y: Expression of the Runt domain-encoding PEBP2α genes in T cells during thymic development. Mol Cell Biol 1995, 15:1662-1670. Expression of the two closely related PEBP2α genes (PEBP2αA and AML1/PEBP2αB) was examined in cells from spleen, thymus, and lymph nodes, and during fetal development. Both transcripts were detected at all stages of T-cell differentiation. AML1/PEBP2αB, which is expressed in other cell types, is a proto-oncogene that contributes to myeloid leukemogenesis.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 1662-1670
-
-
Satake, M.1
Nomura, S.2
Yamaguchi-Iwai, Y.3
Takahama, Y.4
Hashimoto, Y.5
Niki, M.6
Kitamura, Y.7
Ito, Y.8
-
12
-
-
0027184229
-
Molecular cloning and characterization of PEBP2β, the heterodimeric partner of a novel Drosophila runt-related DNa binding protein PEBP2α
-
Ogawa E, Inuzuka M, Maruyama M, Satake M, Naito-Fujimoto M, Ito Y, Shigesada K: Molecular cloning and characterization of PEBP2β, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2α. Virology 1993, 194:314-331.
-
(1993)
Virology
, vol.194
, pp. 314-331
-
-
Ogawa, E.1
Inuzuka, M.2
Maruyama, M.3
Satake, M.4
Naito-Fujimoto, M.5
Ito, Y.6
Shigesada, K.7
-
13
-
-
0028986250
-
Assembly and function of a TCRα enhancer complex is dependent on LEF-1-induced DNa bending and multiple protein-protein interactions
-
Giese K, Kingsley C, Kirshner JR, Grosschedl R: Assembly and function of a TCRα enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions. Genes Dev 1995, 9:995-1008. Formation of higher order nucleoprotein complexes on the TCRα enhancer core is facilitated by specific bending induced by the HMG domain protein LEF-1. Bending allows for protein-protein interactions between c-Ets-1 and ATF/CREB factors bound at opposite ends of the enhancer. c-Ets-1 binds the enhancer in a cooperative complex with PEBP2α. These experiments show how multiple protein-protein and protein-DNA interactions function in concert for the regulation of cell type-specific gene expression in T cells.
-
(1995)
Genes Dev
, vol.9
, pp. 995-1008
-
-
Giese, K.1
Kingsley, C.2
Kirshner, J.R.3
Grosschedl, R.4
-
14
-
-
0029003504
-
c-Myb and core-binding factor/PEBP2 display functional synergy but bind independently to adjacent sites in the T-cell receptor δ enhancer
-
Hernandez-Munain C, Krangel MS: c-Myb and core-binding factor/PEBP2 display functional synergy but bind independently to adjacent sites in the T-cell receptor δ enhancer. Mol Cell Biol 1995, 15:3090-3099.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 3090-3099
-
-
Hernandez-Munain, C.1
Krangel, M.S.2
-
15
-
-
0028989583
-
The role of c-Myb or a related factor in regulating the T cell receptor γ gene enhancer
-
Hsiang Y-HH, Goldman JP, Raulet DH: The role of c-Myb or a related factor in regulating the T cell receptor γ gene enhancer. J Immunol 1995, 154:5195-5204.
-
(1995)
J Immunol
, vol.154
, pp. 5195-5204
-
-
Hsiang, Y.-H.H.1
Goldman, J.P.2
Raulet, D.H.3
-
16
-
-
0026643104
-
The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures
-
Giese K, Cox J, Grosschedl R: The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures. Cell 1992, 69:185-195.
-
(1992)
Cell
, vol.69
, pp. 185-195
-
-
Giese, K.1
Cox, J.2
Grosschedl, R.3
-
17
-
-
0025053008
-
The Tα2 nuclear protein binding site from the human T cell receptor α enhancer functions as both a T cell-specific transcriptional activator and repressor
-
Ho I-C, Leiden JM: The Tα2 nuclear protein binding site from the human T cell receptor α enhancer functions as both a T cell-specific transcriptional activator and repressor. J Exp Med 1990, 172:1443-1449.
-
(1990)
J Exp Med
, vol.172
, pp. 1443-1449
-
-
Ho, I.-C.1
Leiden, J.M.2
-
18
-
-
0025794148
-
LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor α enhancer function
-
Travis A, Amsterdam A, Belanger C, Grosschedl R: LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor α enhancer function. Genes Dev 1991, 5:880-894.
-
(1991)
Genes Dev
, vol.5
, pp. 880-894
-
-
Travis, A.1
Amsterdam, A.2
Belanger, C.3
Grosschedl, R.4
-
19
-
-
0025865915
-
A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer
-
Waterman ML, Fischer WH, Jones KA: A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer. Genes Dev 1991, 5:656-669.
-
(1991)
Genes Dev
, vol.5
, pp. 656-669
-
-
Waterman, M.L.1
Fischer, W.H.2
Jones, K.A.3
-
22
-
-
0027317478
-
Selective DNA bending by a variety of bZIP proteins
-
Kerppola TK, Curran T: Selective DNA bending by a variety of bZIP proteins. Mol Cell Biol 1993, 13:5479-5489.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 5479-5489
-
-
Kerppola, T.K.1
Curran, T.2
-
23
-
-
0027945654
-
Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice
-
Van Genderen C, Okamura RM, Fariñas I, Quo R-G, Parslow TG, Bruhn L, Grosschedl R: Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. Genes Dev 1994, 8:2691-2703.
-
(1994)
Genes Dev
, vol.8
, pp. 2691-2703
-
-
Van Genderen, C.1
Okamura, R.M.2
Fariñas, I.3
Quo, R.-G.4
Parslow, T.G.5
Bruhn, L.6
Grosschedl, R.7
-
24
-
-
0028985161
-
An HMG-box-containing T-cell factor required for thymocyte differentiation
-
Verbeek S, Izon D, Hofhuis F, Robanus-Maandag E, Te Riele H, Van de Wetering M, Oosterwegel M, Wilson A, MacDonald HR, Clevers H: An HMG-box-containing T-cell factor required for thymocyte differentiation. Nature 1995, 374:70-74.
-
(1995)
Nature
, vol.374
, pp. 70-74
-
-
Verbeek, S.1
Izon, D.2
Hofhuis, F.3
Robanus-Maandag, E.4
Te Riele, H.5
Van De Wetering, M.6
Oosterwegel, M.7
Wilson, A.8
MacDonald, H.R.9
Clevers, H.10
-
25
-
-
0027222102
-
Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes
-
Van de Wetering M, Oosterwegel M, Van Norren K, Clevers H: Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes. EMBO J 1993, 12:3847-3854.
-
(1993)
EMBO J
, vol.12
, pp. 3847-3854
-
-
Van De Wetering, M.1
Oosterwegel, M.2
Van Norren, K.3
Clevers, H.4
-
26
-
-
0027440761
-
LEF-1 contains an activation domain that stimulates transcription only in a specific context of factor-binding sites
-
Giese K, Grosschedl R: LEF-1 contains an activation domain that stimulates transcription only in a specific context of factor-binding sites. EMBO J 1993, 12:4667-4676.
-
(1993)
EMBO J
, vol.12
, pp. 4667-4676
-
-
Giese, K.1
Grosschedl, R.2
-
27
-
-
0027330923
-
The hLEF/TCF-1α HMG protein contains a context-dependent transcriptlonal activation domain that induces the TCRα enhancer in T cells
-
Carlsson P, Waterman ML, Jones KA: The hLEF/TCF-1α HMG protein contains a context-dependent transcriptlonal activation domain that induces the TCRα enhancer in T cells. Genes Dev 1993, 7:2418-2430.
-
(1993)
Genes Dev
, vol.7
, pp. 2418-2430
-
-
Carlsson, P.1
Waterman, M.L.2
Jones, K.A.3
-
28
-
-
0029113026
-
Pit-1 binding to specific DNa sites as a monomer or dimer determines gene-specific use of a tyrosine-dependent synergy domain
-
Holloway JM, Szeto DP, Scully KM, Glass CK, Rosenfeld MG: Pit-1 binding to specific DNA sites as a monomer or dimer determines gene-specific use of a tyrosine-dependent synergy domain. Genes Dev 1995, 9:1992-2006.
-
(1995)
Genes Dev
, vol.9
, pp. 1992-2006
-
-
Holloway, J.M.1
Szeto, D.P.2
Scully, K.M.3
Glass, C.K.4
Rosenfeld, M.G.5
-
29
-
-
0028136726
-
Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
-
Scott EW, Simon MC, Anastasi J, Singh H: Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 1994, 265:1573-1577.
-
(1994)
Science
, vol.265
, pp. 1573-1577
-
-
Scott, E.W.1
Simon, M.C.2
Anastasi, J.3
Singh, H.4
-
30
-
-
0029655481
-
Activation of transcription by PU.1 requires both acidic and glutamine domains
-
Klemsz MJ, Maki RA: Activation of transcription by PU.1 requires both acidic and glutamine domains. Mol Cell Biol 1996, 16:390-397.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 390-397
-
-
Klemsz, M.J.1
Maki, R.A.2
-
31
-
-
0026584945
-
PU.1 recruits a second nuclear factor to a site important for Igκ3′ enhancer activity
-
Pongubala JMR, Nagulapalli S, Klemsz MH, McKercher SR, Maki R, Atchison ML: PU.1 recruits a second nuclear factor to a site important for Igκ3′ enhancer activity. Mol Cell Biol 1992, 12:368-378.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 368-378
-
-
Pongubala, J.M.R.1
Nagulapalli, S.2
Klemsz, M.H.3
McKercher, S.R.4
Maki, R.5
Atchison, M.L.6
-
32
-
-
0027474319
-
Effect of PU.1 phosphorylation on interaction with NF-EM5 and transcriptional activation
-
Pongubala JMR, Van Beveren C, Nagulapalli S, Klemsz MH, McKercher SR, Maki RA, Atchison ML: Effect of PU.1 phosphorylation on interaction with NF-EM5 and transcriptional activation. Science 1993, 259:1622-1625.
-
(1993)
Science
, vol.259
, pp. 1622-1625
-
-
Pongubala, J.M.R.1
Van Beveren, C.2
Nagulapalli, S.3
Klemsz, M.H.4
McKercher, S.R.5
Maki, R.A.6
Atchison, M.L.7
-
33
-
-
0027494858
-
PU.1 is a component of a multiprotein complex which binds an essential site in the murine Ig λ2-4 enhancer
-
Eisenbeis CF, Singh H, Storb U: PU.1 is a component of a multiprotein complex which binds an essential site in the murine Ig λ2-4 enhancer. Mol Cell Biol 1993, 13:6452-6461.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 6452-6461
-
-
Eisenbeis, C.F.1
Singh, H.2
Storb, U.3
-
34
-
-
0029073345
-
Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator
-
Eisenbeis CF, Singh H, Storb U: Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator. Genes Dev 1995, 9:1377-1387. Cloning of cDNAs and functional analysis of the PU.1 interaction partner (Pip) protein. Pip exhibits properties expected of NF-EM5, which was implicated in the regulation of the Igκ3′ and Igλ enhancers. Association of Pip with PU.1 requires phosphorylation of a specific serine residue in PU.1. The relationship of Pip with other IRF family members is described.
-
(1995)
Genes Dev
, vol.9
, pp. 1377-1387
-
-
Eisenbeis, C.F.1
Singh, H.2
Storb, U.3
-
35
-
-
0027464265
-
Interferon consensus sequence-binding protein, a member of the interferon regulatory factor family, suppresses interferon-induced gene transcription
-
Nelson N, Marks MS, Driggers PH, Ozato K: Interferon consensus sequence-binding protein, a member of the interferon regulatory factor family, suppresses interferon-induced gene transcription. Mol Cell Biol 1993, 13:588-599.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 588-599
-
-
Nelson, N.1
Marks, M.S.2
Driggers, P.H.3
Ozato, K.4
-
36
-
-
0029069958
-
Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE)
-
Matsuyama T, Grossman A, Mittrucker HW, Siderovski DP, Kiefer F, Kawakami T, Richardson CD, Taniguchi T, Yoshinaga SK, Mak TW: Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE). Nucleic Acids Res 1995, 23:2127-2136. LSIRF is identical with Pip. Here, the authors show that LSIRF/Pip binds ISRE sequences in the absence of partner proteins. The authors also show that the regulation of LSIRF/Pip in T cells is consistent with a role for mediating the T-cell response to antigen.
-
(1995)
Nucleic Acids Res
, vol.23
, pp. 2127-2136
-
-
Matsuyama, T.1
Grossman, A.2
Mittrucker, H.W.3
Siderovski, D.P.4
Kiefer, F.5
Kawakami, T.6
Richardson, C.D.7
Taniguchi, T.8
Yoshinaga, S.K.9
Mak, T.W.10
-
37
-
-
0025871394
-
Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A
-
Flanagan WM, Corthésy B, Bram RJ, Crabtree GR: Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. Nature 1991, 352:803-807.
-
(1991)
Nature
, vol.352
, pp. 803-807
-
-
Flanagan, W.M.1
Corthésy, B.2
Bram, R.J.3
Crabtree, G.R.4
-
38
-
-
0025817426
-
Immunoglobulin gene transcription
-
Staudt L, Lenardo MJ: Immunoglobulin gene transcription. Annu Rev Immunol 1991, 9:373-398.
-
(1991)
Annu Rev Immunol
, vol.9
, pp. 373-398
-
-
Staudt, L.1
Lenardo, M.J.2
-
39
-
-
0026693624
-
A novel B cell-derived coactivator potentiates the activation of immunoglobuin promoters by octamer-binding transcription factors
-
Luo Y, Fujii H, Gerster T, Roeder RG: A novel B cell-derived coactivator potentiates the activation of immunoglobuin promoters by octamer-binding transcription factors. Cell 1992, 71:231-241.
-
(1992)
Cell
, vol.71
, pp. 231-241
-
-
Luo, Y.1
Fujii, H.2
Gerster, T.3
Roeder, R.G.4
-
40
-
-
0029041509
-
Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B
-
Luo Y, Roeder RG: Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B. Mol Cell Biol 1995, 15:4115-4124. The B-cell specific coactivator OCA-B was purified and partially sequenced to design probes for the cloning of specific cDNAs. OCA-B consists of proline- and serine/threonine-rich polypeptides with a high degree of similarity to the E1A transactivator of adenovirus and activation domains of other transcription factors. OCA-B allows for Oct-1- or Oct-2-dependent transcription from Ig promoter templates in vitro, but not from histone H2B promoter templates. Activation by the Oct-1/2-OCA-B complex also requires USA, a nuclear fraction that includes general coactivators.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 4115-4124
-
-
Luo, Y.1
Roeder, R.G.2
-
41
-
-
0028842156
-
OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins
-
Strubin M, Newell JW, Matthias P: OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins. Cell 1995, 80:497-506. Oct-1, which does not activate transcription in yeast, was used as bait in a two-hybrid system to screen for interacting proteins. cDNA clones encoding a B-cell specific coactivator (OBF-1; identical with OCA-B and Bob1) were isolated. The encoded protein supports transcriptional activation by Oct-1 or Oct-2 in yeast. OBF-1 interacts with Oct-1/2 POU domains. Increased octamer-dependent transcription from an Ig Vκ promoter was observed in Hela cells in the presence of OBF-1.
-
(1995)
Cell
, vol.80
, pp. 497-506
-
-
Strubin, M.1
Newell, J.W.2
Matthias, P.3
-
42
-
-
0028854837
-
A B-cell coactivator of octamer-binding transcription factors
-
II250). Bob1 associates with the POU domains of Oct-1/2, but not with Oct-3. Bob1 functions as a potent transactivator in transfected Hela cells when tethered to the DNA-binding domain of GAL4.
-
(1995)
Nature
, vol.373
, pp. 360-362
-
-
Gstaiger, M.1
Knoepfel, L.2
Georgiev, O.3
Schaffner, W.4
Hovens, C.M.5
-
43
-
-
0027171744
-
Targeted disruption of the Oct-2 locus in a B cell provides genetic evidence for two distinct cell type-specific pathways of octamer element-mediated gene activation
-
Feldhaus AL, Klug CA, Arvin KL, Singh H: Targeted disruption of the Oct-2 locus in a B cell provides genetic evidence for two distinct cell type-specific pathways of octamer element-mediated gene activation. EMBO J 1993, 12:2753-2772.
-
(1993)
EMBO J
, vol.12
, pp. 2753-2772
-
-
Feldhaus, A.L.1
Klug, C.A.2
Arvin, K.L.3
Singh, H.4
-
44
-
-
0027262608
-
Oct-2, although not required for early B-cell development is critical for later B-cell maturation and for postnatal survival
-
Corcoran LM, Karvelas M, Nossal GJV, Ye Z-S, Jacks T, Baltimore D: Oct-2, although not required for early B-cell development is critical for later B-cell maturation and for postnatal survival. Genes Dev 1993, 7:570-582.
-
(1993)
Genes Dev
, vol.7
, pp. 570-582
-
-
Corcoran, L.M.1
Karvelas, M.2
Nossal, G.J.V.3
Ye, Z.-S.4
Jacks, T.5
Baltimore, D.6
-
45
-
-
0028535406
-
Oct-2 is required early in T cell independent B cell activation for G1 progression and for proliferation
-
-/- B cells respond poorly to T-cell independent mitogens (e.g. LPS) and exhibit defective entry into the cell cycle following stimulation. This effect is overcome by signals from helper T cells.
-
(1994)
Immunity
, vol.1
, pp. 635-645
-
-
Corcoran, L.M.1
Karvelas, M.2
-
46
-
-
0029118199
-
Identification of CD36 as the first gene dependent on the B-cell differentiation factor Oct-2
-
-/- B cell mRNA to identify genes that require Oct-2 for expression. The screen identified the CD36 gene, which is likely involved in cell-cell interactions involving B cells, as a putative regulatory target of Oct-2.
-
(1995)
Genes Dev
, vol.9
, pp. 1598-1607
-
-
König, H.1
Pfisterer, P.2
Corcoran, L.M.3
Wirth, T.4
-
47
-
-
0026006396
-
A novel lineage-specific nuclear factor regulates mb-1 gene transcription at the early stages of B cell differentiation
-
Hagman J, Travis A, Grosschedl R: A novel lineage-specific nuclear factor regulates mb-1 gene transcription at the early stages of B cell differentiation. EMBO J 1991, 10:3409-3417.
-
(1991)
EMBO J
, vol.10
, pp. 3409-3417
-
-
Hagman, J.1
Travis, A.2
Grosschedl, R.3
-
48
-
-
0026562759
-
BlyF, a novel cell-type- And stage-specific regulator of the B-lymphocyte gene mb-1
-
Feldhaus A, Mbangkollo D, Arvin K, Klug CHS: BlyF, a novel cell-type- and stage-specific regulator of the B-lymphocyte gene mb-1. Mol Cell Biol 1992, 12:1126-1133.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 1126-1133
-
-
Feldhaus, A.1
Mbangkollo, D.2
Arvin, K.3
Klug, C.H.S.4
-
49
-
-
0029045161
-
Failure of B-cell differentiation in mice lacking the transcription factor EBF
-
Lin H, Grosschedl R: Failure of B-cell differentiation in mice lacking the transcription factor EBF. Nature 1995, 376:263-267.
-
(1995)
Nature
, vol.376
, pp. 263-267
-
-
Lin, H.1
Grosschedl, R.2
-
50
-
-
0027229972
-
Cloning and functional characterization of early B cell factor, a regulator of lymphocyte-specific gene expression
-
Hagman J, Belanger C, Travis A, Turck C, Grosschedi R: Cloning and functional characterization of early B cell factor, a regulator of lymphocyte-specific gene expression. Genes Dev 1993, 7:760-773.
-
(1993)
Genes Dev
, vol.7
, pp. 760-773
-
-
Hagman, J.1
Belanger, C.2
Travis, A.3
Turck, C.4
Grosschedi, R.5
-
51
-
-
0029076534
-
EBF contains a novel zinc coordinate motif and multiple dimerization and transcriptional activation domains
-
Hagman J, Gutch MJ, Lin H, Grosschedl R: EBF contains a novel zinc coordinate motif and multiple dimerization and transcriptional activation domains. EMBO J 1995, 14:2907-2916. The novel DNA-binding domain of EBF includes sequences that are likely to form a novel loop structure for the coordination of zinc. A carboxy-terminal dimerization domain is esssential for binding to the mb-1 promoter, but the DNA-binding domain alone can mediate homodimerization on binding sites consisting of perfect inverted repeats. EBF includes two domains for transcriptional activation.
-
(1995)
EMBO J
, vol.14
, pp. 2907-2916
-
-
Hagman, J.1
Gutch, M.J.2
Lin, H.3
Grosschedl, R.4
-
52
-
-
0029020682
-
Combinatorial regulation of transcription II: The immunoglobulin μ heavy chain gene
-
Ernst P, Smale ST: Combinatorial regulation of transcription II: the immunoglobulin μ heavy chain gene. Immunity 1995, 2:427-438. A very thorough and informative review on the regulation of Ig μ heavy chain genes.
-
(1995)
Immunity
, vol.2
, pp. 427-438
-
-
Ernst, P.1
Smale, S.T.2
-
53
-
-
0028230988
-
Pan/E2A expression precedes immunoglobulin heavy-chain expression during B lymphopoiesis in nontransformed cells, and Pan/E2A proteins are not detected in myeloid cells
-
Jacobs Y, Xin X-Q, Dorshkind K, Nelson C: Pan/E2A expression precedes immunoglobulin heavy-chain expression during B lymphopoiesis in nontransformed cells, and Pan/E2A proteins are not detected in myeloid cells. Mol Cell Biol 1994, 14:4087-4096. The authors used a long-term rat bone marrow culture system to examine E2A (Pan) protein expression during B cell differentiation in normal cells in vitro. Expression of BCF1 (E47) precedes Ig μ gene expression in differentiating cultures in vitro. Myeloid cells do not express E2A proteins, but detection of these proteins in promyeloid cells suggests that extinction of E2A expression may precede myelopoiesis.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 4087-4096
-
-
Jacobs, Y.1
Xin, X.-Q.2
Dorshkind, K.3
Nelson, C.4
-
54
-
-
0027992622
-
E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements
-
Bain G, Maandag EC, Izon DJ, Amsen D, Kruisbeek AM, Weintraub BC, Krop I, Schlissel MS, Feeney AJ, Van Roon M et al.: E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell 1994, 79:885-892.
-
(1994)
Cell
, vol.79
, pp. 885-892
-
-
Bain, G.1
Maandag, E.C.2
Izon, D.J.3
Amsen, D.4
Kruisbeek, A.M.5
Weintraub, B.C.6
Krop, I.7
Schlissel, M.S.8
Feeney, A.J.9
Van Roon, M.10
-
55
-
-
0028148938
-
The helix-loop-helix gene E2A is required for B cell formation
-
Zhuang Y, Soriano P, Weintraub H: The helix-loop-helix gene E2A is required for B cell formation. Cell 1994, 79:875-884.
-
(1994)
Cell
, vol.79
, pp. 875-884
-
-
Zhuang, Y.1
Soriano, P.2
Weintraub, H.3
-
56
-
-
0028088556
-
Constitutive expression of the Id1 gene impairs mouse B cell development
-
-/- knockout mice. The construction used for B cell-specific expression of Id1 (modified μ enhancer/mb-1 promoter/) will be of general use for directed expression of cDNA sequences in B cells.
-
(1994)
Cell
, vol.79
, pp. 893-900
-
-
Sun, X.-H.1
-
57
-
-
0025931233
-
Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: Implications for B-lymphoid-cell development
-
Wilson RB, Kiledjian M, Shen C-P, Benezra R, Zwollo P, Dymecki SM, Desiderio SV, Kadesch T: Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: implications for B-lymphoid-cell development. Mol Cell Biol 1991, 11:6185-6191.
-
(1991)
Mol Cell Biol
, vol.11
, pp. 6185-6191
-
-
Wilson, R.B.1
Kiledjian, M.2
Shen, C.-P.3
Benezra, R.4
Zwollo, P.5
Dymecki, S.M.6
Desiderio, S.V.7
Kadesch, T.8
-
58
-
-
0025939047
-
Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins
-
Sun X-H, Copeland NA, Jenkins NA, Baltimore D: Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol Cell Biol 1991, 11:5603-5611.
-
(1991)
Mol Cell Biol
, vol.11
, pp. 5603-5611
-
-
Sun, X.-H.1
Copeland, N.A.2
Jenkins, N.A.3
Baltimore, D.4
-
59
-
-
0028815466
-
A novel enhancer, the pro-B enhancer, regulates Id1 gene expression in progenitor B cells
-
Saisanit S, Sun X-H: A novel enhancer, the pro-B enhancer, regulates Id1 gene expression in progenitor B cells. Mol Cell Biol 1995, 15:1513-1521. Transcriptional regulation of Id1 expression in pro-B cells is mediated by a differentiation stage specific enhancer element.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 1513-1521
-
-
Saisanit, S.1
Sun, X.-H.2
-
60
-
-
0026008577
-
B-cell and myocyte-specific E2-box-binding factors contain E12/E47-like subunits
-
Murre C, Voronova A, Baltimore D: B-cell and myocyte-specific E2-box-binding factors contain E12/E47-like subunits. Mol Cell Biol 1991, 11:1156-1160.
-
(1991)
Mol Cell Biol
, vol.11
, pp. 1156-1160
-
-
Murre, C.1
Voronova, A.2
Baltimore, D.3
-
61
-
-
0029058035
-
B-cell-specific DNA binding by an E47 homodimer
-
Shen C-P, Kadesch T: B-cell-specific DNA binding by an E47 homodimer. Mol Cell Biol 1995, 15:4518-4524.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 4518-4524
-
-
Shen, C.-P.1
Kadesch, T.2
-
62
-
-
0028575413
-
An intermoleular disulfide bond stabilizes E2A homodimers and is required for DNA binding at physiological temperatures
-
Benezra, R: An intermoleular disulfide bond stabilizes E2A homodimers and is required for DNA binding at physiological temperatures. Cell 1994, 79:1057-1067. E47 polypeptides can be stabilized as functional DNA-binding homodimers by intermolecular disulfide linkages. E47 disulfide bonds are reduced by an activity in muscle cells, which express E2A polypeptides as heterodimers with muscle-specific bHLH proteins.
-
(1994)
Cell
, vol.79
, pp. 1057-1067
-
-
Benezra, R.1
-
63
-
-
0028074197
-
Displacement of an E-box-binding repressor by basic helix-loop-helix proteins: Implications for B-cell specificity of the immunoglobulin heavy-chain enhancer
-
Genetta T, Ruezinsky D, Kadesch T: Displacement of an E-box-binding repressor by basic helix-loop-helix proteins: implications for B-cell specificity of the immunoglobulin heavy-chain enhancer. Mol Cell Biol 1994, 14:6153-6163. Multiple E boxes in the Ig μ and κ intronic enhancers that are bound by bHLH proteins are also bound in vitro by ZEB, a 'two-handed' zinc finger protein. The authors use mutations that selectively interfere with binding by bHLH proteins, but not ZEB, to show that ZEB binding represses enhancer function in vivo.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 6153-6163
-
-
Genetta, T.1
Ruezinsky, D.2
Kadesch, T.3
-
64
-
-
0026320871
-
Identification of a zinc finger protein that inhibits IL-2 gene expression
-
Williams TW, Moolten D, Burlien J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ III, Kant JA: Identification of a zinc finger protein that inhibits IL-2 gene expression. Science 1991, 254:1791-1794.
-
(1991)
Science
, vol.254
, pp. 1791-1794
-
-
Williams, T.W.1
Moolten, D.2
Burlien, J.3
Romano, J.4
Bhaerman, R.5
Godillot, A.6
Mellon, M.7
Rauscher F.J. III8
Kant, J.A.9
|