Chemical modification of normal tissue damage induced by photodynamic therapy

British Journal of Cancer

Volumn 74, Issue SUPPL. XXVII, 1996, Pages

  Sigdestad, C P ^a   Fingar, V H ^b   Wieman, T J ^b   Lindberg, R D ^a  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE   (United States)

Author keywords

Photofrin; Radiation protective agent; WR 2721; WR 3689

Indexed keywords

AMIFOSTINE; FLUORESCEIN; PHOSPHOROTHIOIC ACID S [2 (3 METHYLAMINOPROPYLAMINO)ETHYL] ESTER; PHOTOFRIN; PORPHYRIN; RADIOPROTECTIVE AGENT; DRUG DERIVATIVE; S 2 (3 METHYLAMINOPROPYLAMINO)ETHYLPHOSPHOROTHIOIC ACID; S-2-(3-METHYLAMINOPROPYLAMINO)ETHYLPHOSPHOROTHIOIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; CHEMICAL MODIFICATION; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DYE LASER; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PHOTOSENSITIVITY DISORDER; PRIORITY JOURNAL; SKIN INJURY; TISSUE INJURY; ANIMAL; ARTICLE; C3H MOUSE; DRUG HYPERSENSITIVITY; PHOTOCHEMOTHERAPY; SKIN;

AMIFOSTINE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG HYPERSENSITIVITY; HEMATOPORPHYRIN PHOTORADIATION; MALE; MICE; MICE, INBRED C3H; RADIATION-PROTECTIVE AGENTS; SKIN;

EID: 0029990642     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (17)

1. BEDWELL J, CHATLANI PT, MACROBERT AJ, ROBERTS JE, BARR H, DILLON J AND BOWN SG. (1991). Enhanced tumor selectivity of photodynamic therapy in the rat colon using a radioprotective agent. Photochem. Photobiol., 53, 753-756.
2. BELLNIER DA AND DOUGHERTY TJ. (1989). Protection of murine foot tissue and transplantable tumor against Photofrin II mediated photodynamic sensitizalion with WR-2721. J. Photochem. Photobiol B., 4, 219-225.
3. BUGELSKI PJ, PORTER CW AND DOUGHERTY TJ. (1981). Autoradiographic distribution of hematoporphyrin in normal and tumor tissue of the mouse. Cancer Res., 41, 4606.
4. DILLON J, KENNEDY JC, POTTIER RH AND ROBERTS JE. (1988). In vitro and in vivo protection against phototoxic side effects of photodynamic therapy by radioprotective agents WR-2721 and WR-77913. Photochem. Photobiol., 48, 235-238.
5. FINGAR VH and HENDERSON BW. (1987). Drug and light dose dependence of photodynamic therapy: A study of tumor and normal tissue response. Photochem. Photobiol., 46(5), 837-841.
6. GRDINA DJ AND SIGDESTAD CP. (1992). Chemical protection and cell-cycle effect on radiation-induced mutagenesis. Cell Prolif., 25, 23-29.
7. GRDINA DJ, NAGY B, HILL CK, WELLS RL AND PERAINO C. (1985). The radioprotector WR-1065 reduces radiation-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in V79 cells. Carcinogenesis, 6, 929-931.
8. HARIHARAN PV, COURTNEY J AND ELECZKO S. (1980). Production of hydroxyl radicals in cell systems exposed to haematoporphyrin and red light. Int. J. Radiatio. Biol., 37, 691-694.
9. HENDERSON BW AND DOUGHERTY TJ. (1992). How does Photodynamic therapy work? Photochem. Photobiol., 55, 145-157.
10. HENDERSON BW AND MILLER AC. (1986). Effects of scavengers of reactive oxygen and radical species on cell survival following photodynamic treatment in vitro: Comparison to ionizing radiation. Radiat. Res., 108, 196-205.
11. HENDERSON BW, WALDOW SM, MANG TS, POTTER WR, MALONE PB AND DOUGHERTY TJ. (1985). Tumor destruction and kinetics of tumor cell death in two experimental mouse tumors following photodynamic therapy. Cancer Res., 45, 572-576.
12. MILAS L, HUNTER N, REID BO AND THAMES HD. (1982). Protective effects of S-2-(3-Aminopropylamino)ethyl phosphorothioic acid against radiation damage of normal tissues and a fibrosarcoma in mice. Cancer Res., 42, 1888-1897.
13. NAGY B AND GRDINA DJ. (1986). Protective effects of 2-[(aminopropyl)amino] ethanethiol against bleomycin and nitrogen mustard-induced mutagenicity in V79 cells. Int. J. Radiat. Oncol. Biol. Phys., 12, 1475-1478.
14. NAGY B, DALE PJ AND GRDINA DJ. (1986). Protection against cis-diamine dichloroplatinum cytotoxicity and mutagenicity in V79 cells by 2-[(aminopropyl) amino] ethanethiol. Cancer Res. 46, 1132-1135.
15. SCHWARTZ JL, GIOVANAZZI SM, KARRISON T, JONES CA AND GRDINA DJ. (1988). 2-[(Aminopropyl)amino] ethanethiol-mediated reduction in Co-60 gamma ray and fission spectrum neutron-induced chromosome damage in V79 cells. Radiat. Res. 113, 145-154.
16. SIGDESTAD CP, CONNOR AM AND SIMS CS. (1992) Modification of neutron-induced hematopoietic effects by chemical radioprotectors. Int. J. Radiat. Onc. Biol. Phys.. 22, 807-811.
17. WEISHAUPT KR, GOMER CJ AND DOUGHERTY TJ. (1976). Identification of singlet oxygen as the cytotoxic agent in photoactivation of a murine tumor. Cancer Res., 36, 2326-2329.