Remifentanil reduces auditory and somatosensory evoked responses during isoflurane anaesthesia in a dose-dependent manner

British Journal of Anaesthesia

Volumn 76, Issue 6, 1996, Pages 795-801

  Crabb, I ^b   Thornton, C ^b   Konieczko, K M ^b   Chan, A ^b   Aquilina, R ^b   Frazer, N ^a   Dore C J ^b   Newton, D E F ^b  

^a GLAXOSMITHKLINE   (United States)

^b NONE

Author keywords

Anaesthetics volatile, isoflurane; Analgesics opioids, remifentanil; Brain, evoked potentials; Monitoring, evoked potentials

Indexed keywords

INHALATION ANESTHETIC AGENT; ISOFLURANE; NARCOTIC ANALGESIC AGENT; REMIFENTANIL; TEMAZEPAM;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; ENDOTRACHEAL INTUBATION; EVOKED AUDITORY RESPONSE; EVOKED SOMATOSENSORY RESPONSE; HEART RATE; HUMAN; INHALATION ANESTHESIA; INHALATIONAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MEDIAN NERVE; PREMEDICATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN INCISION; SYSTOLIC BLOOD PRESSURE;

EID: 0029990543     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/76.6.795     Document Type: Article

References (21)

1. Murphy MR, Hug CC. The enflurane sparing effect of morphine, butorphenol and nalbuphine. Anesthesiology 1982; 57: 489-492.
2. Murphy MR, Hug CC. The anesthetic potency of fentanyl in terms of its reduction of enflurane MAC. Anesthesiology 1982; 57: 485-488.
3. Rosow C. Remifentanil: A unique opioid analgesic. Anesthesiology 1993; 79: 875-876.
4. Glass PSA, Hardman D, Kamiyama Y, Quill TJ, Marton G, Grosse CM, Hermann D. Preliminary pharmacokinetics and pharmacodynamics of an ultrashort acting opioid: Remifentanil (GI87084B). Anesthesia and Analgesia 1993; 77: 1031-1040.
5. Egan TD, Lemmens HJM, Fiset P, Hermann DJ, Muir KT, Stanski DR, Schafer SL. The pharmacokinetics of the new short-acting opioid remifentanil (GI87084) in healthy volunteers. Anesthesiology 1993; 79: 881-892.
6. Monk TG, Batenhorst RL, Folger WH, Kirkham AJT, Lemon DJ, Martin KJ, Venker DC. A comparison of remifentanil and alfentanil during nitrous-narcotic anesthesia. Anesthesia and Analgesia 1994; 78: S293.
7. Thornton C, Creagh-Barry P, Jordan C, Luff NP, Doré CJ, Henley M, Newton DBF. Somatosensory and auditory evoked responses recorded simultaneously: differential effects of nitrous oxide and isoflurane. British Journal of Anaesthesia 1992; 68: 508-514.
8. Thornton C, Creagh-Barry P, Jordan C, Newton DEF. Anaesthetic depth and auditory evoked potentials. Acta Anaesthesiologica Scandinavica 1993; 37(Suppl. 100): 105-108.
9. Abbruzzesse M, Favale E, Leandri M, Ratto S. New subcortical components of the cerebral somatosensory evoked potential in man. Acta Neurologica Scandinavica 1978; 58: 325-332.
10. Chiappa KH. Short latency somatosensory evoked responses: interpretation. In: Chiappa KH, ed. Evoked Potentials in Clinical Medicine. New York: Raven Press, 1985; 251-324.
11. Freye E, Buhl RW. Somatosensory evoked potentials for the evaluation of analgesic properties of nalbuphine in man. Anesthesia and Analgesia 1986; 65: S51.
12. Freye E, Buhl R, Ciaramelli F. Opioids with different affinity for subreceptors induce different effects on early and late sensory evoked potentials (SEP) in man. National Institute of Drug Research Monograph Service 1986; 75: 551-554.
13. Selinger K, Lanzo C, Sekut A. Determination of remifentanil in human and dog blood by HPLC with UV detection. Journal of Pharmaceutical and Biomedical Analysis 1994; 12: 243-248.
14. Kallar SK, Hurt TW, Wetchler BV, Shaw DL, Jamerson B. A single blind comparative study of the safety and efficacy of remifentanil and alfentanil for outpatient anesthesia. Anesthesiology 1994; 61: A32.
15. Westmorland CL, Hoke JF, Sebel PS, Hug CC, Muir KT. Pharmacokinetics of remifentanil (GI87084B) and its major metabolite (GI90291) in patients undergoing elective inpatient surgery. Anesthesiology 1993; 79: 893-903.
16. Schwender D, Keller I, Klasing S, Madler C. Middle-latency auditory evoked potentials during high-dose opioid analgesia. Anaesthesist 1990; 39: 299-305.
17. Schwender D, Rimkus T, Haessler R. Effects of increasing doses of alfentanil, fentanyl, and morphine on mid latency auditory evoked potentials. British Journal of Anaesthesia 1993; 71: 622-628.
18. Schwender D, Weninger E, Daunderer M, Klasing S, Poppel E, Peter K. Anesthesia with increasing doses of sufentanil and midlatency auditory evoked potentials in humans. Anesthesia and Analgesia 1995; 80: 499-505.
19. Thornton C, Konieczko K, Jones JG, Jordan G, Doré CJ, Heneghan CPH. Effect of surgical stimulation on the auditory evoked response. British Journal of Anaesthesia 1988; 60: 372-378.
20. Schwender D, Golling W, Klasing S. Effects of surgical stimulation on midlatency auditory evoked potentials during general anaesthesia with propofol/fentanyl, isoflurane/ fentanyl and flunitrazepam/fentanyl. Anaesthesia 1994; 49: 572-578.
21. Sebel PS, Withington PS, Rutherfoord CF, Markham K. The effect of tracheal intubation and surgical stimulation on median nerve somatosensory evoked potentials during anaesthesia. Anaesthesia 1988; 43: 857.