메뉴 건너뛰기




Volumn 17, Issue 3, 1996, Pages 197-207

Discontinuous oral absorption pharmacokinetic model and bioavailability of 1-(2-fluoro-5-methyl-β-L-arabinofuranosyl)uracil (L-FMAU) in rats

Author keywords

Bioavailability; Discontinuous oral absorption; L FMAU; Pharmacokinetics

Indexed keywords

1 (2 FLUORO 5 METHYL BETA L ARABINOFURANOSYL)URACIL; ANTIVIRUS AGENT; UNCLASSIFIED DRUG;

EID: 0029990509     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-081X(199604)17:3<197::AID-BDD948>3.0.CO;2-1     Document Type: Article
Times cited : (23)

References (17)
  • 2
    • 0028820292 scopus 로고
    • Pharmacokineties of 1-(2-deoxy-2-fluoro-5-methyl-β-L-arabinofuranosyl)-5-methyluracil (L.-FMAU) in rats
    • J. D. Wright, T. Ma, C. K. Chu and F. D. Boudinot, Pharmacokineties of 1-(2-deoxy-2-fluoro-5-methyl-β-L-arabinofuranosyl)-5-methyluracil (L.-FMAU) in rats. Pharm. Res., 12, 1350-1353 (1995).
    • (1995) Pharm. Res. , vol.12 , pp. 1350-1353
    • Wright, J.D.1    Ma, T.2    Chu, C.K.3    Boudinot, F.D.4
  • 3
    • 0020641162 scopus 로고
    • Ranitidine bioavailability and kinetics in normal male subjects
    • D. C. Garg, D. J. Weidler and F. N. Eshelman, Ranitidine bioavailability and kinetics in normal male subjects. Clin. Pharmacol. Ther., 33, 445-452 (1983).
    • (1983) Clin. Pharmacol. Ther. , vol.33 , pp. 445-452
    • Garg, D.C.1    Weidler, D.J.2    Eshelman, F.N.3
  • 4
    • 0026706597 scopus 로고
    • Influence of gastrointestinal site of drug delivery on the absorption characteristics of ranitidine
    • M. F. Williams, G. E. Dukes, W. Heizer, Y.-H. Han, D. J. Hermann, T. Lampkin and L. J. Hak, Influence of gastrointestinal site of drug delivery on the absorption characteristics of ranitidine. Pharm. Res., 9, 1190-1194 (1992).
    • (1992) Pharm. Res. , vol.9 , pp. 1190-1194
    • Williams, M.F.1    Dukes, G.E.2    Heizer, W.3    Han, Y.-H.4    Hermann, D.J.5    Lampkin, T.6    Hak, L.J.7
  • 6
    • 0023425558 scopus 로고
    • The influence of variable gastric emptying and intestinal transit rates on the plasma level curve of cimetidine
    • R. L. Oberle and G. L. Amidon, The influence of variable gastric emptying and intestinal transit rates on the plasma level curve of cimetidine. J. Pharmacokinet. Biopharm., 15, 529-545 (1987).
    • (1987) J. Pharmacokinet. Biopharm. , vol.15 , pp. 529-545
    • Oberle, R.L.1    Amidon, G.L.2
  • 7
    • 0022640190 scopus 로고
    • The absorption of piretanide from the gastro-intestinal tract is site-dependent
    • D. Brockmeier, H.-G. Grigoleit and H. Leonhardt, The absorption of piretanide from the gastro-intestinal tract is site-dependent. Eur. J. Clin. Pharmacol., 30, 79-82 (1986).
    • (1986) Eur. J. Clin. Pharmacol. , vol.30 , pp. 79-82
    • Brockmeier, D.1    Grigoleit, H.-G.2    Leonhardt, H.3
  • 8
    • 0021236365 scopus 로고
    • Pharmacokineties of furosemide in man after intravenous and oral administration. Application of moment analysis
    • M.M. Hammarlund, L. K. Paalzow and B. Odlind, Pharmacokineties of furosemide in man after intravenous and oral administration. Application of moment analysis. Eur. J. Clin. Pharmacol., 26, 197-207 (1984).
    • (1984) Eur. J. Clin. Pharmacol. , vol.26 , pp. 197-207
    • Hammarlund, M.M.1    Paalzow, L.K.2    Odlind, B.3
  • 9
    • 0026501545 scopus 로고
    • Use of a pharmacokinetic model incorporating discontinuous gastrointestinal absorption to examine the occurrence of double peaks in oral concentration-time profiles
    • A. B. Suttle, G. M. Pollack and K. L. R. Brouwer, Use of a pharmacokinetic model incorporating discontinuous gastrointestinal absorption to examine the occurrence of double peaks in oral concentration-time profiles. Pharm. Res., 9, 350-356 (1992).
    • (1992) Pharm. Res. , vol.9 , pp. 350-356
    • Suttle, A.B.1    Pollack, G.M.2    Brouwer, K.L.R.3
  • 10
    • 0022341203 scopus 로고
    • Fluorocarbohydrates in synthesis. An efficient synthesis of 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil (β-FIAU) and 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-thymine (β-FMAU)
    • C. H. Tann, P. R. Brodfuehrer, S. P. Brundidge, C. Sapino, Jr. and H. G. Howell, Fluorocarbohydrates in synthesis. An efficient synthesis of 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil (β-FIAU) and 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-thymine (β-FMAU). J. Org. Chem., 50, 3644-3647 (1985).
    • (1985) J. Org. Chem. , vol.50 , pp. 3644-3647
    • Tann, C.H.1    Brodfuehrer, P.R.2    Brundidge, S.P.3    Sapino Jr., C.4    Howell, H.G.5
  • 11
    • 0028214975 scopus 로고
    • Enhanced brain delivery of an anti-HIV nucleoside 2-F-ara-ddI by xanthine oxidase mediated biotransformation
    • K. Shanmaganathan, T. Koudriakova, S. Nampalli, J. M. Gallo and C. K. Chu, Enhanced brain delivery of an anti-HIV nucleoside 2-F-ara-ddI by xanthine oxidase mediated biotransformation. J. Med. Chem., 37, 821-827 (1994).
    • (1994) J. Med. Chem. , vol.37 , pp. 821-827
    • Shanmaganathan, K.1    Koudriakova, T.2    Nampalli, S.3    Gallo, J.M.4    Chu, C.K.5
  • 12
    • 0020965053 scopus 로고
    • LAGRAN program for area and moments in pharmacokinetic analysis
    • M. L. Rocci and W. J. Jusko, LAGRAN program for area and moments in pharmacokinetic analysis. Comput. Prog. Biomed., 16, 203-216 (1983).
    • (1983) Comput. Prog. Biomed. , vol.16 , pp. 203-216
    • Rocci, M.L.1    Jusko, W.J.2
  • 13
    • 0017884783 scopus 로고
    • A comparison of numerical integrating algorithms by trapezoidal, Lagrange and spline approximation
    • K. C. Yeh and K. C. Kwan, A comparison of numerical integrating algorithms by trapezoidal, Lagrange and spline approximation. J. Pharmacokinet. Biopharm., 6, 79-98 (1978).
    • (1978) J. Pharmacokinet. Biopharm. , vol.6 , pp. 79-98
    • Yeh, K.C.1    Kwan, K.C.2
  • 15
    • 0025322413 scopus 로고
    • Tissue distribution and metabolic disposition of zidovudine in rats
    • P. D. Miranda, T. C. Burnette and S. S. Good, Tissue distribution and metabolic disposition of zidovudine in rats. Drug Metab. Disposit., 18, 315-320 (1990).
    • (1990) Drug Metab. Disposit. , vol.18 , pp. 315-320
    • Miranda, P.D.1    Burnette, T.C.2    Good, S.S.3
  • 16
    • 0026780779 scopus 로고
    • Preclinical pharmacology and pharmacokinetics of the anti-hepatitis virus agent 2-fluoro-5-ethyl-1-β-D-arabinofuranosyluracil in mice and rats
    • X.-B. Kong, P. Vidai, W. P. Tong, J. Chiang, C. A. Gloff and T.-C. Chou, Preclinical pharmacology and pharmacokinetics of the anti-hepatitis virus agent 2-fluoro-5-ethyl-1-β-D-arabinofuranosyluracil in mice and rats. Antimicrob. Agents Chemother., 36, 1472-1477 (1992).
    • (1992) Antimicrob. Agents Chemother. , vol.36 , pp. 1472-1477
    • Kong, X.-B.1    Vidai, P.2    Tong, W.P.3    Chiang, J.4    Gloff, C.A.5    Chou, T.-C.6
  • 17
    • 0020963903 scopus 로고
    • Physiologically based pharmacokinetic modeling: Principles and applications
    • L. E. Gerlowski and R. K. Jain, Physiologically based pharmacokinetic modeling: principles and applications. J. Pharm. Sci., 72, 1103-1126 (1983).
    • (1983) J. Pharm. Sci. , vol.72 , pp. 1103-1126
    • Gerlowski, L.E.1    Jain, R.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.