On the possible origin of "giant or slow-rising" miniature end-plate potentials at the neuromuscular junction

Pflugers Archiv European Journal of Physiology

Volumn 431, Issue 3, 1996, Pages 325-334

  Sellin, L C ^a   Molgo J ^b   Tornquist K ^c   Hansson, B ^d   Thesleff, S ^d  

^a UNIVERSITY OF OULU   (Finland)

^b CNRS   (France)

^c UNIVERSITY OF HELSINKI   (Finland)

^d LUND UNIVERSITY   (Sweden)

Author keywords

Constitutive secretion; Giant miniature end plate potentials; Miniature end plate potentials; Neurotransmitter release; Protein kinase C

Indexed keywords

ACETYLCHOLINE; BOTULINUM TOXIN; EMETINE; PROTEIN KINASE C;

ACETYLCHOLINE RELEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPOLARIZATION; ENDPLATE POTENTIAL; MALE; MEMBRANE STEADY POTENTIAL; MINIATURE ENDPLATE POTENTIAL; MOUSE; NERVE ENDING; NEUROMUSCULAR SYNAPSE; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL;

ACRIDINE ORANGE; ANIMALS; BOTULINUM TOXINS; DIAPHRAGM; EMETINE; EVOKED POTENTIALS; MALE; MEMBRANE POTENTIALS; MICE; MOTOR ENDPLATE; NEUROMUSCULAR JUNCTION; PROTEIN KINASE C; RECEPTORS, CHOLINERGIC;

EID: 0029990197     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02207269     Document Type: Article

References (41)

1. Alkadhi KA (1987) Effects of emetine and dehydroemetine at the frog neuromuscular junction. Eur J Pharmacol 138:257-264
2. Alkadhi KA (1989) Giant miniature end-plate potentials at the untreated and emetine-treated frog neuromuscular junction. J Physiol (Lond) 412:475-491
3. Bauerfeind R, Régnier-Vigoureux A, Flatmark T, Huttner WB (1993) Selective storage of acetylcholine, but not catecholamines, in neuroendocrine synaptic-like microvesicles of early endosomal origin. Neuron 11:105-121
4. Bauerfeind R, Hutlner WB, Aimers W, Augustine GJ (1994) Quantal neurotransmitter release from early endosomes? Trends Cell Biol 4:155-156
5. Bittner MA, Holz RW (1993) Protein kinase C and clostridial neurotoxins affect discrete and related steps in the secretory pathway. Cell Mol Neurobiol 13:649-664
6. Blasi J, Chapman ER, Link E, Binz T, Yamasaki S, DeCamilli P. Südhof TC, Niemann H, Jahn R (1993) Botulinum neurotoxin-A selectively cleaves the synaptic protein SNAP-25. Nature 365:160-163
7. Burgess TL, Kelly RB (1987) Constitutive and regulated secretion of proteins. Annu Rev Cell Biol 3:243-249
8. Cherkivakil R, Ginsburg S, Meiri H. (1995) The difference in shape of spontaneous and uniquantal evoked synaptic potentials in frog muscle. J Physiol (Lond) 482:641-650
9. Colméus C, Gomez S, Molgó J, Thesleff S (1982) Discrepancies between spontaneous and evoked synaptic potentials at normal, regenerating and botulinum toxin poisoned mammalian neuromuscular junctions. Proc R Soc Lond Biol 215:63-74
10. Considine RV, Handler CM, Simpson LL, Sherwin JR (1991) Tetanus toxin inhibits neurotensin-induced mobilization of cytosolic protein kinase C in NG-108 cells. Toxicon 29:1351-1357
11. Dan Y, Poo M-M (1992) Quantal transmitter secretion from myocytes loaded with acetylcholine. Nature 359:733-736
12. Dekker LV, De Graan PNE, Gispen WH (1991) Transmitter release: target of regulation by protein kinase C? Prog Brain Res 89:209-233
13. Duchen LW, Strich SJ (1968) The effects of botulinum toxin on the pattern of innervation of skeletal muscle in the mouse. Q J Exp Physiol 53:84-89
14. Girod R, Popov S, Alder J, Zheng JQ, Lohof A, Poo M-M (1995) Spontaneous quantal transmitter secretion from myocytes and fibroblasts: comparison with neural secretion. J Neurosci 15:2826-2838
15. Gundersen K (1990) Spontaneous activity at long-term silenced synapses in rat muscle. J Physiol (Lond) 430:399-418
16. Hannum YA, Bell RM (1988) Aminoacridines, potent inhibitors of protein kinase C. J Biol Chem 263:5124-5131
17. Hartwig JH, Thelen M, Rosen A, Janmey PA, Nairn AC, Aderem A (1992) MARCKS is an actin filament cross-linking protein regulated by protein kinase C and calcium-calmodulin. Nature 356:618-622
18. Hartzell HC, Kufller SW, Yoshikami D (1975) Post-synaptic potentialion: interaction between quanta of acetylcholine at the skeletal neuromuscular synapse. J Physiol (Lond) 251:427-463
19. Haylett T, Thilo L (1991) Endosome-lysosome fusion at low temperature. J Biol Chem 266:8322-8327
20. Jahn R, Südhof TC (1994) Synaptic vesicles and exocytosis. Annu Rev Neurosci 17:219-246
21. Johnson RG (1987) Cellular and molecular biology of hormone- and neurotransmitter-containing secretory vesicles. Ann NY Acad Sci 493:1-58
22. Katz B, Thesleff S (1957) On the factors which determine the amplitude of the "miniature end-plate potential". J Physiol (Lond) 137:267-278
23. Kelly RB (1993 a) Storage and release of neurotransmitter. Neuron [suppl] 10:43-53
24. Kelly RB (1993 b) Secretion. A question of endosomes. Nature 364:537-540
25. Kim, YI, Lömo T, Lupa MT, Theslelf S (1984) Miniature endplate potentials in rat skeletal muscle poisoned with botulinum toxin. J Physiol (Lond) 356:587-599
26. Kriebel ME, Llados F, Matteson DR (1982) Histograms of the unitary evoked potential of the mouse diaphragm show multiple peaks. J Physiol (Lond) 322:211-222
27. Liley AW (1957) Spontaneous release of transmitter substance in multiquantal units. J Physiol (Lond) 136:595-605
28. Lupa MT, Tabti N, Thesleff S, Vyskocil F, Yu S-P (1986) The nature and origin of calcium-insensitive miniature end-plate potentials at rodent neuromuscular junctions. J Physiol (Lond) 381:607-618
29. McMahon HT, Foran P, Dolly JO, Verhage M, Weigart VM, Nicholls DG (1992) Tetanus and botulinum toxins type A and B inhibit glutamate, gamma-amino butyric acid, asparlate and met-enkephalin release from synaptosomes. J Biol Chem 267:21238-21242
30. Presek P, Jessen S, Dreyer F, Jarvie PE, Findik D, Dunkley PR (1992) Tetanus toxin inhibits depolarization-stimulated protein phosphorylation in rat cortical synaptosomes: effect on synapsin I phosphorylation and translocation. J Neurochem 59:1336-1343
31. Régnier-Vigouroux A, Tooze SA, Huttner WB (1991) Newly synthesized synaptophysin is transported to synaptic-like microvesicles via constitutive secretory vesicles and the plasma membrane. EMBO J 10:3589-3601
32. Robinson FM (1992) The role of protein kinase C and its neuronal substrates dephosphin, B-50, and MARCKS in neurotransmitter release. Mol Neurobiol 5:87-130
33. Robinson PJ, Liu J-P, Powell KA, Fykse EM, Südhof TC (1994) Phosphorylation of dynamin I and synaptic-vesicle recycling. Trends Neurosci 17:348 353
34. Sala C, Andreose JS, Fumagalli G, Lömo T (1995) Calcitonin gene-related peptide: possible role in formation and maintenance of neuromuscular junctions. J Neurosci 15:520-528
35. Söllner T, Bennett MK, Whiteheart SW, Scheller RH, Rothman JF (1993) A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic docking, activation and fusion. Cell 75:409-418
36. Tabti N, Lupa MT, Yu S-P, Thesleff S (1986) Pharmacological characterization of the calcium-insensitive intermittent acetylcholine release at the rat neuromuscular junction. Acta Physiol Scand 128:429-436
37. Thesleff S, Molgo J (1983) A new type of transmitter release at the neuromuscular junction. Neuroseience 9:1-8
38. Thesleff S, Molgó J, Lundh H (1983) Botulinum toxin and 4-aminoquinoline induce a new type of spontaneous quantal transmitter release at the rat neuromuscular junction. Brain Res 264:89-99
39. Thesleff S, Sellin LC, Tågerud S (1990) Tetrahydroaminoacridine (tacrine) stimulates neurosecretion at mammalian motor endplates. B J Pharmacol 100:487-490
40. Van der Kloot W (1988) Estimating the timing of quantal releases during end-plate currents at the frog neuromuscular junction. J Physiol (Lond) 402:595-603
41. Von Grafenstein H, Borges R, Knight DE (1992) The effect of botulinum toxin type D on the triggered and constitutive exocytosis/endocytosis cycles in cultures of bovine adrenal medullary cells. FFBS Lett 298:118-122