The genes encoding the Eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3

Genomics

Volumn 33, Issue 2, 1996, Pages 277-282

  Cerretti, Douglas Pat ^a   Lyman, Stewart D ^a   Kozlosky, Carl J ^a   Copeland, Neal G ^b   Gilbert, Debra J ^b   Jenkins, Nancy A ^b   Valentine, Virginia ^c   Kirstein, Mark N ^c   Shapiro, David N ^c   Morris, Stephan W ^c  

^a AMGEN INC   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CERVUS ELAPHUS; RODENTIA;

MEMBRANE PROTEIN; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CHROMOSOMAL LOCALIZATION; CHROMOSOME 1; CHROMOSOME 3; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; HYBRID CELL; LIGAND BINDING; METAPHASE CHROMOSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SOUTHERN BLOTTING;

ANIMALS; CELL LINE; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 1; EPHRIN-A1; EPHRIN-A3; EPHRIN-A4; FEMALE; GLYCOSYLPHOSPHATIDYLINOSITOLS; HUMANS; HYBRID CELLS; IN SITU HYBRIDIZATION, FLUORESCENCE; LIGANDS; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MULTIGENE FAMILY; PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES;

EID: 0029990095     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.1996.0192     Document Type: Article

References (36)

1. Bartley, T. D., Hunt, R. W., Welcher, A. A., Boyle, W. J., Parker, V. P., Lindberg, R. A., Lu, H. S., Colombero, A. M., Elliott, R. L., Guthrie, B. A., Holst, P. L., Skrine, J. D., Toso, R. J., Zhang, M., Fernandez, E., Trail, G., Varnum, B., Yarden, Y., Hunter, T., and Fox, G. M. (1994). B61 is a ligand for the ECK receptor protein-tyrosine kinase. Nature 368: 558-560.
2. Beckmann, M. P., Cerretti, D. P., Baum, P., Vanden Bos, T., James, L., Farrah, T., Kozlosky, C., Hollingsworth, T., Shilling, H., Maraskovsky, E., Fletcher, F. A., Lhotak, V., Pawson, T., and Lyman, S. D. (1994). Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors. EMBO J. 13: 3757-3762.
3. Bennett, B. D., Zeigler, F. C., Gu, Q., Fendly, B., Goddard, A. D., Gillett, N., and Matthews, W. (1995). Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase Htk. Proc. Natl. Acad. Sci. USA 92: 1866-1870.
4. Böhme, B., Holtrich, U., Wolf, G., Luzius, H., Grzeschik, K.-H., Strebhardt, K., and Rübsamen-Waigmann, H. (1993). PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2. Oncogene 8: 2857-2862.
5. Cerretti, D. P., Hollingsworth, L. T., Kozlosky, C. J., Valentine, M. B., Shapiro, D. N., Morris, S. W., and Nelson, N. (1994). Molecular characterization of the gene for human interleukin-1 beta converting enzyme (IL1BC). Genomics 20: 468-473.
6. Cerretti, D. P., VandenBos, T., Nelson, N., Kozlosky, C. J., Reddy, P., Maraskovsky, E., Park, L. S., Lyman, S. D., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., and Fletcher, R. A. (1995). Isolation of LERK-5: A ligand of the eph-related kinases. Mol. Immunol. 32: 1197-1205.
7. Cheng, H.-J., and Flanagan, J. G. (1994). Identification and cloning of ELF-1, a developmentally expressed ligand for the mek4 and sek receptor tyrosine kinases. Cell 79: 157-168.
8. Copeland, N. G., and Jenkins, N. A. (1991). Development and applications of a molecular genetic linkage map of the mouse genome. Trends Genet. 7: 113-118.
9. Davis, S., Gale, N. W., Aldrich, T. H., Maisonpierre, P. C., Lhotak, V., Pawson, T., Goldfarb, M., and Yancopoulos, G. D. (1994). Ligands for eph-related receptor tyrosine kinases that require membrane attachment or clustering for activity. Science 266: 816-819.
10. Douglass, E. C., Rowe, S. T., Valentine, M., Parham, D., Meyer, W. H., and Thompson, E. I. (1990). A second nonrandom translocation, der(16)t(1; 16)(q21; q13), in Ewing sarcoma and peripheral neuroectodermal tumor. Cytogenet. Cell Genet. 53: 87-90.
11. Eipers, P. G., Lahti, J. M., and Kidd, V. J. (1992). Structure and expression of the human p58clk-1 protein kinase chromosomal gene. Genomics 13: 613-621.
12. Fletcher, F. A., Renshaw, B., Hollingsworth, T., Baum, P., Lyman, S. D., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., and Davison, B. L. (1994). Genomic organization and chromosomal localization of mouse Eplg2, a gene encoding a binding protein for the receptor tyrosine kinase elk. Genomics 24: 127-132.
13. Gilardi-Hebenstreit, P., Nieto, M. A., Frain, M., Mattéi, M.-G., Chestier, A., Wilkinson, D. G., and Charnay, P. (1992). An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain. Oncogene 7: 2499-2506.
14. Green, E. L. (1981). Linkage, recombination, and mapping. In "Genetics and Probability in Animal Breeding Experiments," pp. 77-113, Oxford Univ. Press, New York.
15. Henkemeyer, M., Marengere, L. E. M., McGlade, J., Olivier, J. P., Conlon, R. A., Holmyard, D. P., Letwin, K., and Pawson, T. (1994). Immunolocalization of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis. Oncogene 9: 1001-1014.
16. Hirai, H., Maru, Y., Hagiwara, K., Nishida, J., and Takaku, F. (1987). A novel putative tyrosine kinase receptor encoded by the eph gene. Science 238: 1717-1720.
17. Jenkins, N. A., Copeland, N. G., Taylor, B. A., and Lee, B. K. (1982). Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus. J. Virol. 43: 26-36.
18. Kozlosky, C. J., Maraskovsky, E., McGrew, J. T., VandenBos, T., Teepe, M., Lyman, S. D., Srinivasan, S., Fletcher, F. A., Gayle, R. B., Cerretti, D. P., and Beckmann, M. P. (1995). Ligands for the receptor tyrosine kinases hek and elk: Isolation of cDNAs encoding a family of proteins. Oncogene 10: 299-306.
19. Lhoták, V., Greer, P., Letwin, K., and Pawson, T. (1991). Characterization of elk, a brain-specific receptor tyrosine kinase. Mol. Cell. Biol. 11: 2496-2502.
20. Lindberg, R. A., and Hunter, T. (1990). cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases. Mol. Cell. Biol. 10: 6316-6324.
21. Maisonpierre, P. C., Berrezueta, N. X., and Yancopoulos, G. D. (1993). Ehk-1 and Ehk-2: Two novel members of the Eph receptor-like tyrosine kinase family with distinctive structures and neuronal expression. Oncogene 8: 3277-3288.
22. McKusick, V. A. (1992). "Mendelian Inheritance in Man," Johns Hopkins Univ. Press, Baltimore.
23. Mitelman, F. (1991). "Catalog of Chromosome Aberration in Cancer," Wiley-Liss, New York.
24. Morris, S. W., Nelson, N., Valentine, M. B., Shapiro, D. N., Look, A. T., Kozlosky, C. J., Beckmann, M. P., and Cerretti, D. P. (1992). Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35. Genomics 14: 685-691.
25. Morris, S. W., Valentine, M. B., Shapiro, D. N., Sublett, J. E., Deaven, L. L., Foust, J. T., Roberts, W. M., Cerretti, D. P., and Look, A. T. (1991). Reassignment of the human CSF1 gene to chromosome 1p13-p21. Blood 78: 2013-2020.
26. Nieto, M. A., Gilardi-Hebenstreit, P., Charnay, P., and Wilkinson, D. G. (1992). A receptor protein tyrosine kinase implicated in the segmental patterning of the hindbrain and mesoderm. Development 116: 1137-1150.
27. Pasquale, E. B. (1991). Identification of chicken embryo kinase 5, a developmentally regulated receptor-type tyrosine kinase of the Eph family. Cell Regul. 2: 523-534.
28. Sajjadi, F. G., Pasquale, E. B., and Subramani, S. (1991). Identification of a new eph-related receptor tyrosine kinase gene from mouse and chicken that is developmentally regulated and encodes at least two forms of the receptor. New Biol. 3: 769-778.
29. Scales, J. B., S., W. R., Renaud, C. S., J., S. L., and Sargent, T. D. (1995). Novel members of the eph receptor tyrosine kinase subfamily expressed during Xenopus development. Oncogene 11: 1745-1752.
30. Shao, H., Lou, L., Pandey, A., Pasquale, E. B., and Dixit, V. M. (1994). cDNA cloning and characterization of a ligand for the Cek5 receptor protein-tyrosine kinase. J. Biol. Chem. 269: 26606-26609.
31. Shao, H., Pandey, A., O'Shea, K. S., Seldin, M., and Dixit, V. M. (1995). Characterization of B61, the ligand for the Eck receptor protein-tyrosine kinase. J. Biol. Chem. 270: 5636-5641.
32. Tessarollo, L., Tsoulfas, P., Martin, Z. D., Gilbert, D. J., Jenkins, N. A., Copeland, N. G., and Parada, L. F. (1993). trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues. Development 118: 463-475.
33. van der Geer, P., Hunter, T., and Lindberg, R. A. (1994). Receptor protein-tyrosine kinases and their signal transduction pathways. Annu. Rev. Cell Biol. 10: 251-337.
34. Wicks, I. P., Wilkinson, D., Salvaris, E., and Boyd, A. W. (1992). Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines. Proc. Natl. Acad. Sci. USA 89: 1611-1615.
35. Xu, Q., Holder, N., Patient, R., and Wilson, S. W. (1994). Spatially regulated expression of three receptor tyrosine kinase genes during gastrulation in the zebrafish. Development 120: 287-299.
36. Zhou, R., Copeland, T. D., Kromer, L. F., and Schulz, N. T. (1994). Isolation and characterization of Bsk, a growth factor receptor-like tyrosine kinase associated with the limbic system. J. Neurosci. Res. 37: 129-143.