Isolation and synthesis of novel farnesyl protein transferase inhibitors, valinoctins A and B, from Streptomyces strain MJ858-NF3

Journal of Natural Products

Volumn 59, Issue 3, 1996, Pages 232-236

  Sekizawa, Ryuichi ^a   Iinuma, Hironobu ^b   Muraoka, Yasuhiko ^b   Naganawa, Hiroshi ^b   Kinoshita, Naoko ^b   Nakamura, Hikaru ^b   Hamada, Masa ^b   Takeuchi, Tomio ^b   Umezawa, Kazuo ^a  

^a KEIO UNIVERSITY   (Japan)

^b INSTITUTE OF MICROBIAL CHEMISTRY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FARNESYL TRANS TRANSFERASE; GLIOTOXIN; LIMONENE; MANUMYCIN; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; VALINOCTIN A; VALINOCTIN B;

ARTICLE; CELL MEMBRANE PERMEABILITY; ENZYME INHIBITION; GENE ACTIVATION; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; ONCOGENE RAS; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; STREPTOMYCES; X RAY CRYSTALLOGRAPHY;

ANIMALS; BRAIN; CATTLE; CRYSTALLOGRAPHY, X-RAY; DIPEPTIDES; ENZYME INHIBITORS; FERMENTATION; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR CONFORMATION; PEPTIDYL TRANSFERASES; STREPTOMYCES;

STREPTOMYCES;

EID: 0029990072     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np960067t     Document Type: Article

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