Heterocondensed quinazolones: Synthesis and protein-tyrosine kinase inhibitory activity of 3,4-dihydro-1h,6h-[1,4]oxazino-[3,4-b]quinazolin-6-one derivatives

Bioorganic and Medicinal Chemistry

Volumn 4, Issue 4, 1996, Pages 547-551

  Ôrfi, László ^a   Kökösi, József ^a   Szász, György ^a   Kövesdi, István ^b   Mák, Marianna ^c   Teplán, István ^d   Kéri, György ^d  

^a SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^b EGIS PHARMACEUTICALS LTD   (Hungary)

^c CHEMICAL RESEARCH CENTER   (Hungary)

^d SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

1 benzylidene 3; 1 phenylhydrazono 3; 4 dihydro 1h; 6h 1,4 oxazino 3,4 b quinazolin 6 ones; 6h 1,4 oxazino 3,4 b quinazolin 6 ones; Protein kinase inhibitory activity; SW 620 human colon carcinoma cells; Synthesis

Indexed keywords

1,4 OXAZINO[3,4 B]QUINAZOLINE DERIVATIVE; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; COLON CANCER; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE; ULTRAVIOLET SPECTROPHOTOMETRY;

ANTINEOPLASTIC AGENTS; CARCINOMA; COLONIC NEOPLASMS; MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN-TYROSINE KINASES; QUINAZOLINES; SPECTROPHOTOMETRY, ULTRAVIOLET; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0029989812     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/0968-0896(96)00040-5     Document Type: Article

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