Primary cisplatin, methotrexate and vinblastine aiming at bladder preservation in invasive bladder cancer: Multivariate analysis on prognostic factors

Journal of Urology

Volumn 155, Issue 6, 1996, Pages 1897-1902

  Angulo, Javier C ^a   Sanchez Chapado, Manuel ^b   Lopez, Jose I ^b   Flores, Nicolas ^b  

^a HOSPITAL UNIVERSITARIO PRÍNCIPE DE ASTURIAS   (Spain)

^b NONE

Author keywords

bladder neoplasms; cisplatin; methotrexate; vinblastine

Indexed keywords

CISPLATIN; CREATININE; METHOTREXATE; VINBLASTINE;

ADULT; AGED; ARTICLE; BLADDER CANCER; CANCER COMBINATION CHEMOTHERAPY; CANCER STAGING; CLINICAL PROTOCOL; CLINICAL TRIAL; CONSERVATIVE TREATMENT; CYSTECTOMY; FEMALE; HUMAN; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; NAUSEA; NEPHROTOXICITY; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROGNOSIS; SURVIVAL RATE; THROMBOCYTOPENIA; TRANSITIONAL CELL CARCINOMA; TUMOR VOLUME; VOMITING;

EID: 0029989247     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(01)66041-5     Document Type: Article

References (23)

1. Lerner, S. P., Skinner, E. and Skinner, D. G.: Radical cystectomy in regionally advanced bladder cancer. Urol. Clin. N. Amer., 19: 713, 1992.
2. Soloway, M. S., Lopez, A. E., Patel, J. and Lu, Y.: Results of radical cystectomy for transitional cell carcinoma of the bladder and the effect of chemotherapy. Cancer, 73: 1926, 1994.
3. Herr, H. W.: A proposed simplified staging system of invasive bladder tumors. Urol. Int., 50: 17, 1993.
4. Lerner, S. P., Skinner, D. G., Lieskovsky, G., Boyd, S. D., Groshen, S. L., Ziogas, A., Skinner, E., Nichols, P. and Hopwood, B.: The rationale for en bloc pelvic lymph node dissection for bladder cancer patients with nodal metastases: long-term results. J. Urol., 149: 758, 1993.
5. Gospodarowicz, M. K. and Warde, P.: The role of radiation therapy in the management of transitional cell carcinoma of the bladder. Hematol. Oncol. Clin. N. Amer., 6: 147, 1992.
6. Stöckle, M., Meyenburg, W., Wellek, S., Voges, G. E., Rossman, M., Gertenbach, U., Thüroff, J. W., Huber, C. and Hohenfellner, R.: Adjuvant polychemotherapy of nonorgan-confined bladder cancer after radical cystectomy revisited: long-term results of a controlled prospective study and further clinical experience. J. Urol., 153: 47, 1995.
7. Splinter, T. A. W., Pavone-Macaluso, M., Jacqmin, D., Roberts, J. T., Carpentier, P., de Pauw, M. and Sylvester, R.: A European Organization for Research and Treatment of Cancer - Genitourinary Group phase 2 study of chemotherapy in stage T3-4N0-XM0 transitional cell cancer of the bladder: evaluation of clinical response. J. Urol., 148: 1793, 1992.
8. Maffezzini, M., Torelli, T., Villa, E., Corrada, P., Bolognesi, A., Leidi, G. L., Rigatti, P. and Campo, B.: Systemic preoperative chemotherapy with cisplatin, methotrexate and vinblastine for locally advanced bladder cancer: local tumor response and early followup results. J. Urol., 145: 741, 1991.
9. Martinez-Pineiro, J. A., Gonzalez Martin, M., Arocena, F., Flores, N., Ramos Roncero, C., Portillo, J. A., Escudero, A., Jimenez Cruz, F. and Isorna, J.: Neoadjuvant cisplatin chemotherapy before radical cystectomy in invasive transitional cell carcinoma of the bladder: a prospective randomized phase III study. J. Urol., part 2, 153: 964, 1995.
10. Scher, H. I., Herr, H. W., Sternberg, C. N., Fair, W. R., Bosl, G., Morse, M. J., Sogani, P. C., Watson, R. C., Dershaw, D. D., Reuter, V., Curley, T., Vaughan, E. D., Jr., Whitmore, W. F., Jr. and Yagoda, A.: Neo-adjuvant chemotherapy for invasive bladder cancer. Experience with the M-VAC regimen. Brit. J. Urol., 64: 250, 1989.
11. Kaufman, D. S., Shipley, W. U., Griffin, P. P., Heney, N. M., Althausen, A. F. and Efird, J. T.: Selective bladder preservation by combination treatment of invasive bladder cancer. New Engl. J. Med., 329: 1377, 1993.
12. Tester, W., Poerter, A., Asbell, S., Coughlin, C., Heaney, J., Krall, J., Martz, K., Venner, P. and Hammond, E.: Combined modality program with possible organ preservation for invasive bladder carcinoma: results of RTOG protocol 85-12. Int. J. Rad. Oncol. Biol. Phys., 25: 783, 1993.
13. Vikram, B., Malamud, S., Silverman, P., Hecht, H. and Grabstald, H.: A pilot study of chemotherapy alternating with twice-a-day accelerated radiation therapy as an alternative to cystectomy in muscle infiltrating (stages T2 and T3) cancer of the bladder: preliminary results. J. Urol., 151: 602, 1994.
14. Meyers, F. J., Palmer, J. M., Freiha, F. S., Harker, E. G., Shortliffe, L. D., Hannigan, J., McWhirter, K. and Torti, F. M.: The fate of the bladder in patients with metastatic bladder cancer treated with cisplatin, methotrexate and vinblastine: a Northern California Oncology Group study. J. Urol., 134: 1118, 1985.
15. Srougi, M. and Simon, S. D.: Primary methotrexate, vinblastine, doxorubicin and cisplatin chemotherapy and bladder preservation in locally invasive bladder cancer: a 5-year followup. J. Urol., 151: 593, 1994.
16. Simon, S. D. and Srougi, M.: Neoadjuvant M-VAC chemotherapy and partial cystectomy for treatment of locally invasive transitional cell carcinoma of the bladder. Prog. Clin. Biol. Res., 353: 169, 1990.
17. Hall, R. R., Roberts, J. T. and Marsh, M. M.: Radical TUR and chemotherapy aiming at bladder preservation. Prog. Clin. Biol. Res., 353: 163, 1990.
18. Solsona, E., Iborra, I., Ricós, J. V., Mourós, J. L. and Dumont, R.: Feasibility of transurethral resection of muscle-infiltrating carcinoma of the bladder: prospective study. J. Urol., 147: 1513, 1992.
19. Shipley, W. U., Prout, G. R., Kaufman, D. and Perrone, T. L.: Invasive bladder carcinoma. The importance of initial transurethral surgery and other significant prognostic factors for improved survival with full-dose irradiation. Cancer, suppl., 60: 514, 1987.
20. Scher, H. I. and Kantoff, P. W.: Chemotherapy for muscle-infiltrating bladder cancer. Hematol. Oncol. Clin. N. Amer., 6: 169, 1992.
21. Bahnson, R. R., Becich, M., Ernstoff, M. S., Sandlow, J., Cohen, M. B. and Williams, R. D.: Absence of immunohistochemical metallothionein staining in bladder tumor specimens predicts response to neoadjuvant cisplatin, methotrexate and vinblastine chemotherapy. J. Urol., part 2, 152: 2272, 1994.
22. Shipley, W. U., Rose, M. A., Perrone, T. L., Mannix, C. M., Heney, N. M. and Prout, G. R., Jr.: Full dose irradiation for patients with invasive bladder carcinoma: clinical and histological factors prognostic of improved survival. J. Urol., 134: 679, 1985.
23. Angulo, J. C., Lopez, J. I., Flores, N. and Toledo, J. D.: The value of tumour spread, grading and growth pattern as morphological predictive parameters in bladder carcinoma. A critical revision of the 1987 TNM classification. J. Cancer Res. Clin. Oncol., 119: 578, 1993.