Influence of subunit transcript and protein levels on formation of a mitochondrial multienzyme complex

Journal of Cellular Biochemistry

Volumn 61, Issue 1, 1996, Pages 118-126

  McConnell, Beth B ^a   McKean, Martha C ^a   Danner, Dean J ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

mitochondria; multienzyme complex formation; post translational events; protein levels; subunit transcript

Indexed keywords

CARBOXYLYASE; MULTIENZYME COMPLEX;

ARTICLE; BETA CHAIN; CELL METABOLISM; ENZYME ACTIVITY; LYMPHOBLASTOID CELL; PLASMID; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN SYNTHESIS; RNA TRANSCRIPTION; STEADY STATE;

3-METHYL-2-OXOBUTANOATE DEHYDROGENASE (LIPOAMIDE); BLOTTING, SOUTHERN; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL CULTURE TECHNIQUES; FLOW CYTOMETRY; HALF-LIFE; HUMANS; KETONE OXIDOREDUCTASES; LYMPHOMA, LYMPHOBLASTIC; MITOCHONDRIA; MULTIENZYME COMPLEXES; PLASMIDS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0029989228     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(19960401)61:1<118::AID-JCB13>3.0.CO;2-K     Document Type: Article

References (38)

1. Anderson ML, Spandidos DA, Coggins JR (1991): Electroporation of lymphoid cells: Factors effecting the efficiency of transfection. J Biochem Biophys Methods. 22:207-222.
2. Ausubel FM, Brent R, Kingston RE, Moore DD, Smith JA, Seidman JG, Struhl K (1989): Curr Prot Mol Biol New York: Greene Publishing Assoc. and Wiley-Interscience.
3. Chicc AG, Adibi SA, Liu, Jr. W.-Q, Morris SM, Paul HS (1994): Regulation of gene expression of branched-chain keto acid dehydrogenase complex in primary cultured hepatocytes by dexamethasone and a cAMP analog. J Biol Chem 269:19427-19434.
4. Chinsky JM, Bohlen LM, Costeas PA (1994): Noncoordinated responses of branched-chain alpha-ketoacid dehydrogenase subunit genes to dietary protein. FASEB J 8:114-120.
5. Cogswell AM, Stevens RJ, Hood DA (1993): Properties of skeletal muscle mitochondria isolated from subsarcolemmal and intermyofibrillar regions. Am J Physiol 264:C383-C389.
6. England BK, Greiber S, Mitch WE, Bowers BA, Herring WJ, McKean MC, Ebb RG, Price SR, Danner DJ (1995): Rat muscle branched-chain ketoacid dehydrogenase activity and mRNAs increase with extracellular acidemia. Am J Physiol 268:C1395-C1400.
7. Fujii H, Tokuyama K, Suzuki M, Popov KM, Zhao Y, Harris RA, Nakai N, Murakami T, Shimomura Y (1995): Regula-tion by physical training of enzyme activity and gene expression of branched-chain 2-oxo acid dehydrogenase complex in rat skeletal muscle. Biochim Biophys Acta 1243:277-281.
8. Goglia F, Lanni A, Iossa S, Barletta A (1988): Light mitochondria and cellular thermogenesis. Biochem Biophys Res Commun 151:1241-1249.
9. Gunning P, Ponte P, Okayama H, Engel J, Blau H, Kedes L (1983): Isolation and characterization of full-length cDNA clones for human α-, β-, and γ-actin mRNAs: Skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed. Mol Cell Biol 3:787-795.
10. Harris RA, Paxton R (1985): Regulation of branched chain alpha-ketoacid dehydrogenase complex by phosphorylation-dephosphorylation. Fed Proc 44:305-315.
11. Harrold S, Genovese C, Kobrin B, Morrison S, Milcarek C (1991): A comparison of apparent mRNA half-life using kinetic labeling techniques vs decay following administration of transcriptional inhibitors. Anal Biochem 198:19-29.
12. Heffelfinger SC, Sewell ET, Danner DJ (1983): Antibodies to bovine liver branched chain 2-oxoacid dehydrogenase cross-react with this enzyme complex from other tissues and species. Biochem J 213:339-344.
13. Herring WJ, Litwer S, Weber JL, Danner DJ (1991): Molecular genetic basis of maple syrup urine disease in a family with two defective alleles for branched chain acyltransferase and localization of the gene to human chromosome 1. Am J Hum Genet 48:342-350.
14. Hirt B (1967): Selective extraction of polyoma DNA from infected mouse cell cultures. J Mol Biol 26:365-369.
15. Hod Y (1992): A simplified ribonuclease protection assay. BioTechniques 13:852-853.
16. Honda K, Ono K, Mori T, Kochi H (1991): Both induction and activation of the branched-chain 2-oxo acid dehydrogenase complex in primary-cultured rat hepatocytes by clofibrate. J Biochem 109:822-827.
17. Hood DA, Balaban A, Conner MK, Craig EE, Nishio ML, Rezvani M, Takahashi M (1994): Mitochondrial biogenesis in straited muscle Can J Appl Physiol 19:12-48.
18. Kasperek GJ, Snider RD (1987): Effect of exercise intensity and starvation on activation of branched-chain keto acid dehydrogenase by exercise. Am J Physiol 252:E33-E37.
19. Keller LR, Schloss JA, Silflow CD, Rosenbaum JL (1984): Transcription of alpha- and beta-tubulin genes in vitro in isolated Chlmydomonas reinhardi nuclei. J Cell Biol 98: 1138-1143.
20. Lau KS, Chuang JL, Herring WJ, Danner DJ, Cox RP, Chuang DT (1992): The complete cDNA sequence for dihydrolipoyl transacylase (E2) of human branched chain alpha-keto acid dehydrogenase complex. Bioehim Biophys Acta 1132:319-321.
21. Lewin B (1994): Genes V. New York/Oxford: Oxford University Press/Cell Press.
22. Litwer S, Danner DJ (1988): Mitochondrial import and processing of an in vitro synthesized human pre-branched chain acyltransferase fragment. Am J Hum Genet 43:764-769.
23. Litwer S, Herring WJ, Danner DJ (1989): Reversion of maple syrup urine disease phenotype of impaired branched chain alpha-ketoacid dehydrogenase complex activity in fibroblasts from an affected child. J Biol Chem 264:14597-14600.
24. Lopez-Mediavilla C, Orfao A, Gonzalez M, Medina JM (1989): Identification by flow cytometry of two distinct rhodamine-123-stained mitochondrial populations in rat liver. FEBS Lett 254:115-120.
25. McCarthy JEG, Kollmus H (1995): Cytoplasmic mRNA-protein interactions in eukaryotic gene expression. TIBS 20:191-197.
26. McKean MC, Winkeler KA, Danner DJ (1992): Nucleotide sequence of the 5' end including the initiation codon of cDNA for the El alpha subunit of the human branched chain alpha-ketoacid dehydrogenase complex. Biochim Biophys Acta 1171:109-112.
27. Nobukuni Y, Mitsubuchi H, Endo F, Akaboshi I, Asaka J, Matsuda I (1990): Maple Syrup Urine Disease. Complete primary structure of the El beta subunit of human branched chain alpha-ketoacid dehydrogenase complex deduced from the nucleotide sequence and a gene analysis of patients with this disease. J Clin Invest 86:242-247.
28. Patston PA, Espinal J, Shaw JM, Randle PJ (1986): Rat tissue concentrations of branched chain 2-oxoacid dehydrogenase complex: Reevaluation by immunoassay and bioassay. Biochem J 235:429-434.
29. Paxton R, Kuntz M, Harris RA (1986): Phosphorylation sites and inactivation of branched-chain alpha-ketoacid dehydrogenase isolated from rat heart, bovine kidney, and rabbit liver, kidney, heart, brain, and skeletal muscle. Arch Biochem Biophys 244:187-201.
30. Reed LJ, Damuni Z, Merryfield ML (1985): Regulation of mammalian pyruvate and branched chain α-ketoacid dehydrogenase complexes by phosphorylation-dephosphorylation. Curr Top Cell Reg 27:41-49.
31. Reed LJ, Hackert ML (1990): Structure-function relationships in dihydrolipoamide acyltransferases. J Biol Chem 265:8971-8974.
32. Sitler TL, McKean MC, Peinemann F, Danner DJ (1995): Characterization of mitochondrial import for subunits of human branched chain α-ketoacid dehydrogenase complex. Arch Biochem Biophys (In press).
33. vanLoon APGM, Kreike J, DeRonde A, Van der Horst GTJ, Gasser SM, Grivell LA (1983): Biosynthesis of the ubiquinol-cytochrome c reductase complex in yeast. Discoordinate synthesis of the 11-kd subunit in response to increased gene copy number. EMBO J 2:1765-1770.
34. Wagenmakers AJM, Brookes JH, Coakley JH, Reilly T, Edwards RHT (1989): Exercise-induced activation of the branched-chain 2-oxo acid dehydrogenase in human muscle. Eur J Appl Physiol 59:159-167.
35. Wagenmakers AJM, Schepens JTG, Veldhuizen JAM, Veerkamp JH (1984): The activity state of the branched-chain 2-oxoacid dehydrogenase complex in rat tissues. Biochem J 220:273-281.
36. Wang X, Kiledjian M, Weiss IM, Liebhaber SA (1995): Detection and characterization of a 3′ untranslated region ribonucleoprotein complex associated with human α-globin mRNA stability. Mol Cell Biol 15:1769-1777.
37. Yeaman SJ (1986): The mammalian 2-oxoacid dehydrogenases: a complex family. Trends Biochem Sci 11:293-296.
38. Zhao Y, Popov KM, Shimomura Y, Kedishvili NY, Jaskiewicz J, Kuntz MJ, Kain J, Zhang B, Harris RA (1994): Effect of dietary protein on the liver content and subunit composition of the branched-chain alpha-ketoacid dehydrogenase complex. Arch Biochem Biophys 308:446-453.