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Volumn 4, Issue 3, 1996, Pages 159-166

Anticonvulsant activity of ester- and amide-type lipid conjugates of glycine and N-benzyloxycarbonylglycine

Author keywords

Anticonvulsant; Glycine; Glycine receptor; Lipid conjugates; N Benzyloxycarbonylglycine; NMDA receptor

Indexed keywords

AMIDE; DRUG CARRIER; ESTER DERIVATIVE; GLYCINE DERIVATIVE; GLYCINE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; STRYCHNINE;

EID: 0029989038     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/0928-0987(95)00044-5     Document Type: Article
Times cited : (14)

References (28)
  • 1
    • 0001828811 scopus 로고
    • The discovery of the neurotransmitter role of glycine
    • Ottersen, O.P. and Storm-Mathisen, J. (Eds.) Wiley, New York, NY
    • Aprison, M.H. (1990) The discovery of the neurotransmitter role of glycine. In Ottersen, O.P. and Storm-Mathisen, J. (Eds.) Glycine Neurotransmission. Wiley, New York, NY, pp. 1-23.
    • (1990) Glycine Neurotransmission , pp. 1-23
    • Aprison, M.H.1
  • 2
    • 33947295869 scopus 로고
    • An efficient synthesis of symmetrical 1,3-diglycerides
    • Bentley, P. H. and McCrae, N.J. (1970) An efficient synthesis of symmetrical 1,3-diglycerides. J. Org. Chem. 35, 2082-2083.
    • (1970) J. Org. Chem. , vol.35 , pp. 2082-2083
    • Bentley, P.H.1    McCrae, N.J.2
  • 3
    • 0027097784 scopus 로고
    • Structure and function of inhibitory glycine receptors
    • Betz, H. (1992) Structure and function of inhibitory glycine receptors. Q. Rev. Biophys. 25, 381-394.
    • (1992) Q. Rev. Biophys. , vol.25 , pp. 381-394
    • Betz, H.1
  • 6
    • 0024576617 scopus 로고
    • Systemically administered glycine protects against styrchnine convulsions but not the behavioural effects of high pressure in mice
    • Halsey, M.J., Little, H.J. and Wardley-Smith, B. (1989) Systemically administered glycine protects against styrchnine convulsions but not the behavioural effects of high pressure in mice. J. Physiol. 408, 431-441.
    • (1989) J. Physiol. , vol.408 , pp. 431-441
    • Halsey, M.J.1    Little, H.J.2    Wardley-Smith, B.3
  • 7
    • 37049149750 scopus 로고
    • An x-ray and thermal examination of the glycerides. Part XI. 1,2-Diglycerides and further observations on 1,3-diglycerides
    • Howe, J.R. and Malkin, T. (1951) An x-ray and thermal examination of the glycerides. Part XI. 1,2-Diglycerides and further observations on 1,3-diglycerides. J. Chem. Soc., 2663-2667.
    • (1951) J. Chem. Soc. , pp. 2663-2667
    • Howe, J.R.1    Malkin, T.2
  • 8
    • 0021991097 scopus 로고
    • γ-Aminobutyric acid esters. 2. Synthesis, brain uptake, and pharmacological properties of lipid esters of γ-aminobutyric acid
    • Jacob, J.N., Shashoua, V.E., Campbell, A. and Baldessarini (1985) γ-Aminobutyric acid esters. 2. Synthesis, brain uptake, and pharmacological properties of lipid esters of γ-aminobutyric acid. J. Med. Chem. 28, 106-110.
    • (1985) J. Med. Chem. , vol.28 , pp. 106-110
    • Jacob, J.N.1    Shashoua, V.E.2    Campbell, A.3    Baldessarini4
  • 9
    • 0023256637 scopus 로고
    • γ-Aminobutyric acid esters. 3. Synthesis, brain uptake, and pharmacological properties of C-18 glyceryl lipid esters of GABA with varying degree of unsaturation
    • Jacob, J.N., Hesse, J.W. and Shashoua, V.E. (1987) γ-aminobutyric acid esters. 3. Synthesis, brain uptake, and pharmacological properties of C-18 glyceryl lipid esters of GABA with varying degree of unsaturation. J. Med. Chem. 30, 1573-1576.
    • (1987) J. Med. Chem. , vol.30 , pp. 1573-1576
    • Jacob, J.N.1    Hesse, J.W.2    Shashoua, V.E.3
  • 10
    • 0025181707 scopus 로고
    • Synthesis, brain uptake, and pharmacological properties of a glyceryl lipid containing GABA and the GABA-T inhibitor γ-vinyl-GABA
    • Jacob, J.N., Hesse, J.W. and Shashoua, V.E. (1990) Synthesis, brain uptake, and pharmacological properties of a glyceryl lipid containing GABA and the GABA-T inhibitor γ-vinyl-GABA. J. Med. Chem. 33, 733-736.
    • (1990) J. Med. Chem. , vol.33 , pp. 733-736
    • Jacob, J.N.1    Hesse, J.W.2    Shashoua, V.E.3
  • 11
    • 0027469106 scopus 로고
    • The glycine site of the NMDA receptor. Five years on
    • Kemp, J.A. and Leeson, P.D. (1992) The glycine site of the NMDA receptor. Five years on. Trends Protein Sci. 14, 20-25.
    • (1992) Trends Protein Sci. , vol.14 , pp. 20-25
    • Kemp, J.A.1    Leeson, P.D.2
  • 13
    • 0028178432 scopus 로고
    • Anticonvulsant activities of N-benzyloxycarbonylglycine after parenteral administration
    • Lambert, D.M., Poupaert, J.H., Maloteaux, J.M. and Dumont, P. (1994) Anticonvulsant activities of N-benzyloxycarbonylglycine after parenteral administration. Neuroreport 5, 777-780.
    • (1994) Neuroreport , vol.5 , pp. 777-780
    • Lambert, D.M.1    Poupaert, J.H.2    Maloteaux, J.M.3    Dumont, P.4
  • 15
    • 0028942269 scopus 로고
    • Synthesis and pharmacological properties of 2-[S-acetylthiorphan]-1,3-diacylaminopropan-2-ol derivatives as chimeric lipid drug carriers containing an enkephalinase inhibitor
    • Lambert, D.M., Mergen, F., Berens, C., Poupaert, J.H. and Dumont, P. (1995b) Synthesis and pharmacological properties of 2-[S-acetylthiorphan]-1,3-diacylaminopropan-2-ol derivatives as chimeric lipid drug carriers containing an enkephalinase inhibitor. Pharm. Res. 12, 187-191.
    • (1995) Pharm. Res. , vol.12 , pp. 187-191
    • Lambert, D.M.1    Mergen, F.2    Berens, C.3    Poupaert, J.H.4    Dumont, P.5
  • 16
    • 0019421512 scopus 로고
    • Antagonism of glycine to seizures induced by L-kynurenine, quinolinic acid and strychnine in mice
    • Lapin, I.P. (1981) Antagonism of glycine to seizures induced by L-kynurenine, quinolinic acid and strychnine in mice. Eur. J. Pharmacol. 71, 495-498.
    • (1981) Eur. J. Pharmacol. , vol.71 , pp. 495-498
    • Lapin, I.P.1
  • 17
    • 84951384024 scopus 로고
    • A simplified method of evaluating dose-effect experiments
    • Litchfield, J.T. and Wilcoxon, F.J. (1949) A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther. 96, 99-113.
    • (1949) J. Pharmacol. Exp. Ther. , vol.96 , pp. 99-113
    • Litchfield, J.T.1    Wilcoxon, F.J.2
  • 18
    • 0022903197 scopus 로고
    • The glycine receptor: Pharmacological studies and mathematical modeling of the allosteric interaction between the glycine and strychnine binding sites
    • Marvizon, J.C.G., Vazquez, J., Calvo, M.G., Ruiz-Gomez, A., Valdivieso, F. and Benavides, J. (1986) The glycine receptor: pharmacological studies and mathematical modeling of the allosteric interaction between the glycine and strychnine binding sites. Mol. Pharmacol. 30, 590-597.
    • (1986) Mol. Pharmacol. , vol.30 , pp. 590-597
    • Marvizon, J.C.G.1    Vazquez, J.2    Calvo, M.G.3    Ruiz-Gomez, A.4    Valdivieso, F.5    Benavides, J.6
  • 19
    • 0025938728 scopus 로고
    • Antiepileptic activity of 1,3-dihexadecanoylamino-2-valproyl-propan-2-ol, a prodrug of valproic acid endowed with a tropism for the central nervous system
    • Mergen, F., Lambert, D.M., Goncalves-Saraiva, J.C., Poupaert, J.H. and Dumont, P. (1991a) Antiepileptic activity of 1,3-dihexadecanoylamino-2-valproyl-propan-2-ol, a prodrug of valproic acid endowed with a tropism for the central nervous system. J. Pharm. Pharmacol. 43, 815-816.
    • (1991) J. Pharm. Pharmacol. , vol.43 , pp. 815-816
    • Mergen, F.1    Lambert, D.M.2    Goncalves-Saraiva, J.C.3    Poupaert, J.H.4    Dumont, P.5
  • 20
    • 0025744858 scopus 로고
    • Synthesis of 1,3-diacylamino-2-propanols and corresponding 2 acyl derivatives as amide isosteres of natural lipids
    • Mergen, F., Lambert, D.M., Poupaert, J. H., Bidaine, A. and Dumont, P. (1991b) Synthesis of 1,3-diacylamino-2-propanols and corresponding 2 acyl derivatives as amide isosteres of natural lipids. Chem. Phys. Lipids 59, 267-272.
    • (1991) Chem. Phys. Lipids , vol.59 , pp. 267-272
    • Mergen, F.1    Lambert, D.M.2    Poupaert, J.H.3    Bidaine, A.4    Dumont, P.5
  • 21
    • 0025306531 scopus 로고
    • Potentiation by glycine of anticonvulsant drugs in maximal electroshock seizures in rats
    • Peterson, S.L., Trzeciakowski, J.P., Frye G.D. and Adams, H.R. (1990) Potentiation by glycine of anticonvulsant drugs in maximal electroshock seizures in rats. Neuropharmacology 29, 399-409.
    • (1990) Neuropharmacology , vol.29 , pp. 399-409
    • Peterson, S.L.1    Trzeciakowski, J.P.2    Frye, G.D.3    Adams, H.R.4
  • 22
    • 0026065407 scopus 로고
    • Glycine potentiation of anticonvulsant drugs in pentylenetetrazol seizures in rats
    • Peterson, S.L. (1991) Glycine potentiation of anticonvulsant drugs in pentylenetetrazol seizures in rats. Brain Res. Bull. 26, 43-47.
    • (1991) Brain Res. Bull. , vol.26 , pp. 43-47
    • Peterson, S.L.1
  • 23
    • 0021266710 scopus 로고
    • The amplification of the anticonvulsant effect of vinyl GABA (4-aminohexenoic acid) by esters of glycine
    • Sarhan, S., Kolb, M. and Seiler, N. (1984) The amplification of the anticonvulsant effect of vinyl GABA (4-aminohexenoic acid) by esters of glycine. Arzneim.-Forsch. 34, 687-690.
    • (1984) Arzneim.-Forsch. , vol.34 , pp. 687-690
    • Sarhan, S.1    Kolb, M.2    Seiler, N.3
  • 24
    • 0021280506 scopus 로고
    • Synergistic anticonvulsant effects of a GABA-T inhibitors and glycine
    • Seiler, N. and Sarhan S. (1984) Synergistic anticonvulsant effects of a GABA-T inhibitors and glycine. Naunyn-Schmiedeberg's Arch. Pharmacol. 15, 367-369.
    • (1984) Naunyn-Schmiedeberg's Arch. Pharmacol. , vol.15 , pp. 367-369
    • Seiler, N.1    Sarhan, S.2
  • 25
    • 84940141832 scopus 로고
    • Comparative assays of antiepileptic drugs in mice and rats
    • Swinyard, E. A., Brown, W. C. and Goodman, L. S. (1952) Comparative assays of antiepileptic drugs in mice and rats. J. Pharmacol. Exp. Ther. 106, 319-330.
    • (1952) J. Pharmacol. Exp. Ther. , vol.106 , pp. 319-330
    • Swinyard, E.A.1    Brown, W.C.2    Goodman, L.S.3
  • 26
    • 0020609431 scopus 로고
    • Anticonvulsant effects of some inhibitory neurotransmitter amino acids
    • Toth, E., Lajtha, A., Sarhan, S. and Seiler, N. (1983) Anticonvulsant effects of some inhibitory neurotransmitter amino acids. Neurochem. Res. 8, 291-302.
    • (1983) Neurochem. Res. , vol.8 , pp. 291-302
    • Toth, E.1    Lajtha, A.2    Sarhan, S.3    Seiler, N.4
  • 27
    • 0343191193 scopus 로고
    • Synthese et evaluation pharmacologique du lineolamide de glycine
    • Vamvakides, A. (1986) Synthese et evaluation pharmacologique du lineolamide de glycine. Ann. Pharm. Franc. 44, 144-155.
    • (1986) Ann. Pharm. Franc. , vol.44 , pp. 144-155
    • Vamvakides, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.