D-tagatose is a bulk sweetener with zero energy determined in rats

Journal of Nutrition

Volumn 126, Issue 6, 1996, Pages 1601-1609

  Livesey, G ^a   Brown, J C ^a  

^a INSTITUTE OF FOOD RESEARCH   (United Kingdom)

Author keywords

body composition; D tagatose; net energy value; rats; supplement induced energy loss

Indexed keywords

SUCROSE; SWEETENING AGENT; TAGATOSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE ANALYSIS; CONTROLLED STUDY; DIABETOGENESIS; DIET SUPPLEMENTATION; ENERGY BALANCE; ENERGY METABOLISM; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; TREATMENT INDICATION; WEIGHT REDUCTION;

EID: 0029989031     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/126.6.1601     Document Type: Article

References (25)

1. Biospherics (1995) Status of D-Tagatose as a Bulk Sweetener: Rationale, Safety and Efficacy: Manufacturing Process. Biospherics, Beltsville, MD.
2. Brown, J. C. (1993) Energy: measurement of food. In: Encyclopedia of Food Science, Food Technology and Nutrition (MacRae, R., Robinson, R.K., Sadler, M.J., eds.), pp. 1590-1595. Academic Press, London, UK.
3. Brown, J. C. & Livesey, G. (1993) A study designed to determine the calorific values of sugar substitutes using a new model of energy expenditure in the rat (for Biospherics). Institute of Food Research, Norwich, UK.
4. Brown, J. C. & Livesey, G. (1994) Energy balance and expenditure while consuming guar gum at various fat intakes and ambient temperatures. Am. J. Clin. Nutr. 60: 955-964.
5. Brown, D., Livesey, G., Dauncey, M. J. (1991) Influence of mild cold on the components of 24 h thermogenesis in rats. J. Physiol 441: 137-154.
6. Bunn, H. F. & Higgins, P. L. (1994) Reactions of monosaccharides with proteins: possible evolutionary significances. Science 213: 222-224.
7. Davies, I. R., Brown, J. C. & Livesey, G. (1991) Energy values and energy balance in rats fed on supplements of guar gum or cellulose. Br. J. Nutr. 65: 415-433.
8. Dulloo, A. G. & Girardier, L. (1990) Adaptive changes in energy expenditure during refeeding follow low-caloric intake: evidence for a specific metabolic component favouring fat storage. Am. J. Clin. Nutr. 52: 415-420.
9. Levin, G. V., Zehner, L. R., Saunders, J. P. & Beadle, J. R. (1995) Sugar substitutes, their energy values, bulk characteristics and potential health benefits. Am. J. Clin. Nutr. 62 (suppl. 1): 1161S-1168S.
10. Life Sciences Research Office (1994) The Evaluation of the Energy of Certain Sugar Alcohols Used as Food Ingredients. Prepared for the Calorie Control Council. Life Sciences Research Office, Federation of American Societies of Experimental Biology, Bethesda, MD.
11. Livesey, G. (1990) Energy values of unavailable carbohydrates and diets: an inquiry and analysis. Am. J. Clin. Nutr. 51: 617-637.
12. Livesey, G. (1990) On the energy value of sugar alcohols with the example of isomalt. In: Caloric Evaluation of Carbohydrates (Norimasa Hosoya, ed.), pp. 141-164. Int. Symp. Caloric Evaluation, Jan. 11-12, 1990, Kyoto, Japan. Pub. The Japan Association of Dietetic and Enriched Foods.
13. Livesey, G. (1992) The energy values of dietary fibre and sugar alcohols for man. Nutr. Res. Rev. 5: 61-84.
14. Livesey, G. (1993) Comments on the methods used to determine the energy values of carbohydrates: dietary fibre, sugar alcohols and other bulking agents. Int. J. Food Sci. Nutr. 44: 221-241.
15. Livesey, G. & Brown, J. (1995) Whole-body metabolism is not restricted to D-sugars as energy metabolism of L-sugars fits a computational model in rats. J. Nutr. 125: 3020-3029.
16. McPhearson, J. D., Shilton, B. H. & Walton, D. J. (1988) Role of fructose in glycosylation and cross-linking of proteins. Biochemistry 27: 1901-1907.
17. Mead, R. &. Curnow, R. N. (1983) Statistical Methods in Agriculture and Experimental Biology. Chapman & Hall, London, UK.
18. Puller, J. D. & Webster, A. J. F. (1977) The energy cost of fat and protein deposition in the rat. Br. J. Nutr. 27: 355-363.
19. Ryan, B. F., Joiner, B. L. & Ryan, T. A. (1985) Minitab Handbook. Duxbury Press, Boston, MA.
20. Syrovy, L. (1994) Glycation of myofibrillar proteins and ATPase activity after incubation with eleven sugars. Physiol. Res. 43: 61-64.
21. Szepesi, B. (1996) Carbohydrates. In: Present Knowledge in Nutrition (Ziegler, E. E., ed.), 7th ed. ILSI. (in press).
22. Szepesi, B. & Michaelis, O. E. IV (1986) Disaccharide effect - comparison of metabolic effects of the intake of disaccharide and of their monosaccharide equivalents. In: Metabolic Effects of Dietary Carbohydrates (Macdonald, I. & Viana, A., eds), pp. 192-219. Karger, S. Basel, Switzerland.
23. Wise, A. (1982) Interaction of diet and toxicity - the future role of purified diets in toxicological research. Arch. Toxicol. 50:287-299.
24. Zehner, L. R., Levin, G. V., Saunders, J. P. & Beadle, J. R. (1994) D-Tagatose as anti-hyperglyceamic agent. US Patent 5,356,879 (Oct. 18).
25. Zehner, L. R., Levine, G. V., Saunders, J. P. & Beadle, J. R. (1995) D-Tagatose as anti-glyceamic agent. US Patent 5,447,917 (Sept. 5).