Reductive metabolism and its role in the disposition of the hydroxamic angiotensin-converting enzyme inhibitor idrapril calcium in rat

Xenobiotica

Volumn 26, Issue 5, 1996, Pages 551-558

  Lippi, A ^a   Criscuoli, M ^a   Canali, S ^b   Subissi, A ^a  

^a Laboratori Guidotti SpA   (Italy)

^b Istituto di Ricerche Biomediche Antoine Marxer SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 SARCOSINAMIDE 1,2 CYCLOHEXANEDICARBOXYLAMIDE; 2 SARCOSINAMIDE 1,2 CYCLOHEXANEDICARBOXYLIC ACID; CARBON 14; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DRUG METABOLITE; IDRAPRIL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG EXCRETION; DRUG FECES LEVEL; DRUG GLUCURONIDATION; DRUG METABOLISM; DRUG URINE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; LIVER CYTOSOL; LIVER METABOLISM; LIVER MICROSOME; MALE; NONHUMAN; RAT; REDUCTION;

EID: 0029989021     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.3109/00498259609046731     Document Type: Article

References (13)

1. CRISCUOLI, M., LIPPI, A., MENGOZZI, G., SARDELLI, G., SUBISSI, A., and GIACHETTI, A., 1993, Pharmacokinetics and pharmacodynamics of idrapril in rats, dogs and humans. Drug Metabolism Disposition, 21, 835-840.
2. FISHBEIN, W. A., and STREETER, C. L., 1970, Physiological disposition of short chain aliphatic hydroxamates in the mouse. I. The one-through-four carbon hydroxamates: excretion and conversion to amides. Journal of Pharmacology and Experimental Therapeutics, 174, 239-248.
3. HIRAO, Y., KITAMURA, S., and TATSUMI, K., 1994, Epoxide reductase activity of mammalian liver cytosols and aldehyde oxidase. Carcinogenesis, 15, 739-743.
4. LIPPI, A., CRISCUOLI, M., SARDELLI, G., and SUBISSI, A., 1993, Inhibition of rabbit lung angiotensin converting enzyme by idrapril. Biochemical Pharmacology, 45, 1358-1362.
5. LIPPI, A., CRISCUOLI, M., SARDELLI, G., and SUBISSI, A., 1994, A high-performance liquid chromatography method with electrochemical detection for the determination of idrapril, a novel ACE inhibitor, in biological matrices. Journal of Chromatography, 660, 127-134.
6. 14C-acetamide in the rat. Drug Metabolism and Disposition, 12, 438-443.
7. SICA, D. A., 1992, Kinetics of ACE inhibitors in renal failure. Journal of Cardiovascular Pharmacology, 20, S13-20.
8. SUBISSI, A., CRISCUOLI, M., SARDELLI, G., GUELFI, M., and GIACHETTI, A., 1992, Pharmacology of idrapril: a new class of angiotensin converting enzyme inhibitors. Journal of Cardiovascular Pharmacology, 20, 139-146.
9. SUGIHARA, K., and TATSUMI, K., 1986, Participation of liver aldehyde oxidase in reductive metabolism of hydroxamic acids to amides. Archives of Biochemistry and Biophysics, 247, 289-293.
10. TATSUMI, K., KITAMURA, S., and NARAI, N., 1986, Reductive metabolism of aromatic nitro compounds including carcinogens by rabbit liver preparations. Cancer Research, 46, 1089-1093.
11. TURBANTI, L., CERBAI, G., DI BUGNO, C., GIORGI, R., GARZELLI, G., CRISCUOLI, M., RENZETTI, A. R., SUBISSI, A., BRAMANTI, G., and DEPRIEST, S. A., 1993, 1,2-Cyclomethylene-carboxylic monoamide hydroxamyc derivatives. A novel class of non-aminoacid angiotensin converting enzyme inhibitors. Journal of Medicinal Chemistry, 36, 699-707.
12. ZANCHI, A., NUSSBERGER, J., CRISCUOLI, M., CAPONE, P., and BRUNNER, H. R., 1994, ACE inhibition by hydroxamic zinc binding idrapril in humans. Journal of Cardiovascular Pharmacology, 24, 317-322.
13. WYLD, P. J., GRANT, J., LIPPI, A., CRISCUOLI, M., DEL RE, G., and SUBISSI, A., 1994, Pharmacokinetics and biochemical efficacy of idrapril calcium, a novel ACE inhibitor, after multiple oral administration in humans. British Journal of Clinical Pharmacology, 38, 421-425.