Immunoluminometric assay (ILMA) for intact human proinsulin and its conversion intermediates

Clinica Chimica Acta

Volumn 247, Issue 1-2, 1996, Pages 23-37

  Zilkens, Tobias M ^a,b   Eberle, Ansgar M ^a   Schmidt Gayk, Heinrich ^a  

^a Endocrine Laboratory   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

acridinium ester; diagnosis; immunoassay; insulinoma; luminescence

Indexed keywords

INSULIN; INSULIN DERIVATIVE; PROINSULIN;

ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; DIET RESTRICTION; DRUG DETERMINATION; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; IMMUNOASSAY; INSULINOMA; LUMINESCENCE; NORMAL HUMAN; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; TECHNIQUE;

CAVIA PORCELLUS; SUS SCROFA;

EID: 0029988867     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/0009-8981(95)06217-3     Document Type: Article

References (37)

1. Steiner DF, Oyer PE. The biogenesis of insulin and a possible precursor of insulin by a human islet cell adenoma. Proc Natl Acad Sci USA 1967;7:473-480.
2. de Haen C, Little SA, May JM, Williams RH. Characterization of proinsulin-insulin intermediates in human plasma. J Clin Invest 1978;62:727-737.
3. Ward WK, Paquettes TL, Frank BH, Porte D. A sensitive radioimmunoassay for human proinsulin with sequential use of antisera to C-peptide and insulin. Clin Chem 1986;32:728-733.
4. Robbins DC, Tager HS, Rubenstein AH. Biologic and clinical importance of proinsulin. [Review]. N Engl J Med 1984;310:1165-1175.
5. Davidson HW, Rhodes CJ, Hutton JC. Intracellular calcium and pH control proinsulin cleavage in the pancreatic β-cell via two distinct site-specific endopeptidases. Nature 1988;333:593-611.
6. Rhodes CJ, Alarcon C. What β-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism. Diabetes 1994;43:511-517.
7. Haffner SM, Mykkänen L, Stem MP, Valdez RA, Heisserman JA, Bowsher RR. Relationship of proinsulin and insulin to cardiovascular risk factors in nondiabetic subjects. Diabetes 1993;42:1297-1302.
8. Haffner SM, Mykkänen L, Valdez RA et al. Disproportionately increased proinsulin levels are associated with the insulin resistance syndrome. J Clin Endocrinol Metab 1994;79:1806-1810.
9. Gray IP, Siddle K, Docherty K, Frank BH, Hales CN. Proinsulin in human serum: problems in measurement and interpretation. Clin Endocrinol 1984;21:43-47.
10. Dornhorst A, Davies M, Anyaoku V et al. Abnormalities in fasting circulating proinsulin concentration in mild gestational diabetes. Clin Endocrinol 1991;34:211-213.
11. Revers RR, Henry R, Schmeiser L et al. The effects of biosynthetic human proinsulin on carbohydrate metabolism. Diabetes 1984;33:762-770.
12. Temple RC, Carrington CA, Luzio SD et al. Insulin deficiency in non-insulin-dependent diabetes. Lancet 1989;24:293-295.
13. Cohen RM, Given BD, Licino-Paixao J et al. Proinsulin radioimmunoassays in the evaluation of insulinomas and familial hyperproinsulinemia. Metabolism 1986;35:1137-1146.
14. Kitabchi AE. Proinsulin and C-peptide: a review. [Review]. Metabolism 1977;26:747-787.
15. Msever RN, Roberts JP, Gerber, JG, Mako ME, Rubenstein AH. Insulinoma with low circulating insulin levels: the diagnostic value of proinsulin measurements. Ann Intern Med 1975;82:347-350.
16. Sasakuma F, Shimizu T, Ishikawa O et al. [An improved method for determination of C-peptide levels in serum: pretreatment of test samples with anti-insulin antibody insolubilized with magnetic particles.] Rinsho-Byori 1994;42:183-188.
17. Kao PC, Taylor RL, Service-FJ. Proinsulin by immunochemiluminometric assay for the diagnosis of insulinoma. J Clin Endocrinol Metab 1994;78:1048-1051.
18. Service, FJ. Medical Progress: Hypoglycemic Disorders. [Review] N Engl J Med 1995;332:1144-1152.
19. Beer S, Parr J, Temple R, Hales CN. The effect of thyroid disease on proinsulin and C-peptide levels. Clin Endocrinol Oxf 1989;30:379-383.
20. Hampton SM, Beyzavi K, Teale D, Marks V. A direct assay for proinsulin in plasma and its applications in hypoglycemia. Clin Endocrinol 1988;29:9-16.
21. Melani F, Rubenstein AH, Oyer PE, Steiner DF. Identification of proinsulin and C-peptide in human serum by a specific immunoassay. Proc Natl Acad Sci USA 1970;67:148-155.
22. Kitabchi AE, Duckworth WC, Brush JS, Heinemann M. Direct measurement of proinsulin in human plasma by the use of an insulin-degrading enzyme. J Clin Invest 1971;50:1972-1979.
23. Deacon CF, Conlon JM. Measurement of circulating human proinsulin concentrations using a proinsulin-specific antiserum. Diabetes 1985;34:491-497.
24. Coben RM, Nakabayashi T, Blix PM et al. A radioimmunoassay for circulating human proinsulin. Diabetes 1985;34:84-91.
25. Hartling SG, Dinesen B, Kappelgaard AE, Faber OK, Binders C. ELISA for human proinsulin. Clin Chim Acta 1986;156:289-298.
26. Naylor BA, Matthews DR, Turner AC. A soluble-phase proinsulin radioimmunoassay and its use in diagnosis of hypoglycemia. Ann Clin Biochem 1987;24:352-362.
27. Rainbow SJ, Woodhead JS, Yue DK, Luzio SD, Hales CN. Measurement of human proinsulin by an indirect two-site immunoradiometric assay. Diabetologia 1979;17:229-234.
28. Sobey WJ, Beer SF, Carrington CA et al. Sensitive and specific two site immunoradiometric assays for human insulin, proinsulin, 65-66 split and 32-33 split proinsulins. Biochem J 1989;260:535-541.
29. Heding LG. Specific and direct radioimmunoassay for human proinsulin in serum. Diabetologia 1977;13:467-474.
30. Alpha B, Cox U, Crowther N, Clark PMS, Hales CN. Sensitive amplified immunoenzymometric assays (IEMA) for human insulin and intact insulin. Eur J Clin Chem Clin Biochem 1992;30:27-32.
31. Missler U, Engling U, Wood WG, Kerner W. A time-resolved immunofluorimetric assay for quantitative measurement of proinsulin in [Abstract]. Exp Clin Endocrinol 1993;101:178.
32. Dhahir FJ, Cook DB, Self CH. Amplified enzyme-linked immunoassay of human proinsulin in serum (detection limit: 0.1 pmol/l). Clin Chem 1992;38:227-232.
33. Chevenne D, Ruiz J, Lohmann L et al. Immunoradiometric assay of human intact proinsulin applied to patients with type 2 diabetes, impaired glucose tolerance and hyperandrogenism. Clin Chem 1994;40:754-757.
34. Fraik BH, Pettee JM, Zimmerman RE, Burck PJ. The production of human proinsulin and its transformation to human insulin and C-peptide. In: Rich DH, Gross E, eds. Peptides: synthesis - structure - function. Rockford, IL: Pierce Chemical Co, 1981;729-738.
35. Hage DS, Taylor B, Schryver P, Kao PC. Use of affinity chromatography in developing acridinium ester-labelled antibodies for an immunometric assay of parthyrin. Clin Chem 1991;37:117-118.
36. Weeks I, Sturgess M, Brown AC, Woodhead JS. Immunoassays using acridinium esters. Methods Enzymol 1986;133:366-387.
37. Cohen RM, Camus F. Update on insulinomas or the case of the missing (pro)insulinoma. Diabetes Care 1988;11:506-508.