Pituitary enlargement due to primary hypothyroidism: Growth hormone response to GHRH, GHRP-6 and GHRH plus GHRP-6

Journal of Pediatric Endocrinology and Metabolism

Volumn 9, Issue 5, 1996, Pages 549-553

  Damjanović, Svetozar ^a,c   Popović, Vera ^a   Petakov, Milan ^a   Djurović, Marina ^a   Dieguez, Carlos ^b   Casanueva, Felipe F ^b  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^c CLINICAL CENTER OF SERBIA   (Serbia)

Author keywords

GHRH; GHRP 6; Growth hormone; Pituitary thyrotrope and lactotrope hyperplasia; Primary hypothyroidism

Indexed keywords

GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; LEVOTHYROXINE; SERMORELIN;

ADOLESCENT; ARTICLE; CASE REPORT; FEMALE; GROWTH HORMONE RELEASE; HUMAN; HYPERPLASIA; HYPOPHYSIS DISEASE; HYPOTHYROIDISM; INTRAVENOUS DRUG ADMINISTRATION; PSEUDOTUMOR;

EID: 0029988256     PISSN: 0334018X     EISSN: None     Source Type: Journal    
DOI: 10.1515/JPEM.1996.9.5.549     Document Type: Article

References (19)

1. Momany FA, Bowers CY, Reynolds GA, Chang D, Hong A, Newlander K. Design, synthesis and biological activity of peptides which release growth hormone in vitro. Endocrinology 1981; 108: 31-39.
2. Goth Ml, Lyonis CE, Canny BJ, Thorner MO. Pituitary adenylate cyclase activating polypeptide, GH-releasing peptide, and GH-releasing hormone stimulate GH release through distinct pituitary receptors. Endocrinology 1992; 130: 939-944.
3. Bowers CY, Alister DK, Frentz JM. The growth hormone-releasing activity of a synthetic hexapeptide in normal men and short statured children after oral administration. J Clin Endocrinol Metab 1992; 74: 292-298.
4. Bowers CY, Reynolds GA, Durham D, Barrera CM, Pezzoli SS, Thorner MO Growth hormone (GH)-releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormone. J Clin Endocrinol Metab 1990; 70: 975-982.
5. Bowers CY, Sartor AO, Reynolds GA, Badger TM. On the actions of the growth hormone-releasing hexapeptide, GHRP. Endocrinology 1991; 128: 2027-2035.
6. Popovic V, Damjanovic S, Micic D, Djurovic M, Dieguez C, Casanueva FF. Blocked growth hormone-releasing peptide (GHRP-6)-induced GH secretion and absence of the synergic action of GHRP-6 plus GH-releasing hormone in patients with hypothalamo-pituitary disconnection: Evidence that GHRP-6 main action is exerted at the hypothalamic level. J Clin Endocrinol Metab 1995; 80: 942-947.
7. Van Wyk JJ, Grumbach M. Syndrome of precocious menstruation and galactorrhea in juvenile hypothyroidism. An example of hormonal overlap in pituitary feedback. J Pediatr 1960; 57: 416-435.
8. Nishi Y, Hamamoto K, Kajiyama M, Fujita A, Kawamura I, Kagawa Y, Kajima T, Yamanaka M, Uozumi T. Pituitary enlargement, hypertrichosis and blunted growth hormone secretion in primary hypothyroidism. Acta Paediatr Scand 1989; 78: 136-140.
9. Zelissen PM, Croughs RJ, Koppeschaar HP, de Bruin TW, Hendriks MJ, van't Verlaat JW. Primary hypothyroidism mimicking pituitary adenoma. Neth J Med 1989; 35: 95-99.
10. Cannavo S, Li Calzi L, Trimarchi F. Pituitary enlargement in post-surgical hypothyroidism misdiagnosed as thyrotroph neoplasia. Report of a case. Minerva Endocrinol 1989; 14: 193-196.
11. Koyama T, Shinoda S, Tani S, Kamikubo T, Nakamura O, Okuda M. A case of pseudo-TSH, PRL-producing pituitary adenoma with secondary hypothyroidism. No To Shinkei 1991; 43: 187-191.
12. Nyborg JK, Nguyen AP, Spindler SR. Relationship between thyroid and glycocorticoid hormone receptor occupancy, growth hormone gene transcription and mRNA accumulation. J Biol Chem 1984; 259: 12377-12381.
13. Williams T, Maxon H, Thorner MO, Frohman LA. Blunted growth hormone (GH) response to GH-releasing hormone in hypothyroidism resolves in the euthyroid state. J Clin Endocrinol Metab 1985; 61: 454-456.
14. Valcavi R, Jordan V, Dieguez C, John R, Manicardi E, Portiolo I, Rodriguez-Arnao MD, Gomez-Pan A, Hall R, Scanlon M. Growth hormone responses to GRF 1-29 in patients with primary hypothyroidism before and during replacement therapy with thyroxine. Clin Endocrinol 1986; 24: 693-698.
15. Dieguez C, Ford SM, Peters JR, Hall R, Scanlon MF. The effects of the thyroid hormone deprivation in vivo and in vitro on growth hormone (GH) responses to human pancreatic GH-releasing factor (GRF 1-40) by dispersed rat anterior pituitary cells. Endocrinology 1985; 116: 1066-1070.
16. Valcalvi R, Valente F, Dieguez C, Zini M, Procopto M, Partioli I, Chigo E. Evidence against depletion of growth hormone (GH)-releasable pool in human primary hypothyroidism studies with GH-releasing hormone, pyridostigmine and arginine. J Clin Endocrinol Metab 1993; 77: 616-620
17. Codd EE, Shy AYL, Walker RF. Binding of a growth hormone releasing hexapeptide to specific hypothalamic and pituitary binding sites. Neuropharmacology 1989; 28: 1139-1144.
18. Smals AEM, Pieters GFFM, Smals AGH, Benraad TJ, Laarhoven JV, Kloppenborg PWC. Sex difference in human growth hormone (GH) response to intravenous human pancreatic GH-releasing hormone administration in young adults. J Clin Endocrinol Metab 1986; 62: 336-341.
19. Penalva A, Pombo M, Carballo A, Barriere J, Casanueva FF, Dieguez C. Influence of sex, age and adrenergic pathways on the growth hormone response to GHRP-6. Clin Endocrinol 1993; 38: 87-91.