Technetium-99m-sestamibi uptake by human benign and malignant breast tumor cells: Correlation with mdr gene expression

Journal of Nuclear Medicine

Volumn 37, Issue 2, 1996, Pages 286-289

  Cordobes, Muriel Duran ^b   Starzec, Anna ^b   Delmon Moingeon, Laurence ^b   Blanchot, Caroline ^b   Kouyoumdjian, Jean Claude ^b   Prévost, Grégoire ^b   Caglar, Meltem ^b   Moretti, Jean Luc ^a  

^a AVICENNE HOSPITAL   (France)

^b NONE

Author keywords

human breast tumor; multidrug resistance; P glycoprotein; technetium 99m sestamibi

Indexed keywords

GLYCOPROTEIN P; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; VERAPAMIL;

ARTICLE; BREAST TUMOR; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG UPTAKE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MULTIDRUG RESISTANCE; PRIORITY JOURNAL;

BLOTTING, WESTERN; BREAST NEOPLASMS; DRUG RESISTANCE, MULTIPLE; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; P-GLYCOPROTEIN; TECHNETIUM TC 99M SESTAMIBI; TEMPERATURE; TUMOR CELLS, CULTURED; VERAPAMIL;

EID: 0029987767     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Riordan JR, Deuchars K, Kartner N, Alon N, Trent J, Ling V. Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines Nature 1983;316. 817-819
2. Juliano RL, Ling V. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants Biochem Biophys Acta 1976,455:152-162.
3. Kartner N, Riordan JR, Ling V. Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines. Science 1983;221:1285-1288
4. Hamada H, Tsuruo T. Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies Proc Natl Acad Sci USA 1986,83.7785-7789
5. Van der Valk P, Van Kalken CK, Ketelaars H, et al. Distribution of multidrug resistance-associated P-glycoprotein in normal and neoplastic human tissues. Ann Oncol 1990;1:56-64.
6. Scagliotti GV, Michelotto F, Kalikatzaros G, et al Detection of multidrug resistance associated P-170 glycoprotein in previously untreated non small-cell lung cancer. Anticancer Res 1991;11 2207-2210.
7. Gros P, Tatbot F, Tang-Wai D, Bibi E, Kaback HR Lipophilic cations, a group of model substrates for the multidrug-resistance transporter Biochemistry 1992,31:1992-1998.
8. Piwnica-Worms D, Chiu ML, Budding M, Kronauge JF, Kramer RA, Croop JM. Functional imaging of multidrug-resistant P-glycoprotein with an organotechnetium complex. Cancer Res 1993,53 977-984
9. Rao VV, Chiu ML, Kronauge JF, Piwnica-Worms D Expression of recombinant human multidrug resistance P-glycoprotein in insect cells confers decreased accumulation of technetium-99m-sestamibi. J Nucl Med 1994;35.510-515.
10. Abrams MJ, Davison A, Jones AG, Costello C. Synthesis and characterization of Hexakis (alkyl isocyanide) and hexakis (aryl isocyanide) complexes of technetium(I). Inorg Chem 1983;22:2798-2800.
11. Wackers FJ, Berman DS, Maddahi J, et al Technetium-99m hexakis 2-methoxyisobutylisonitrile: human biodistribution, dosimetry, safety and preliminary comparison to thallium-201 for myocardial perfusion imaging J Nucl Med 1989;30 301-311.
12. Khalkhali I, Mena I, Jouanne E, Diggles L, Alle K, Klein S. Technetium-99m-sestamibi prone breast imaging in patients (PTS) with suspicion of breast cancer [Abstract] J Nucl Med 1993,34:140
13. Delmon-moingeon L, Piwnica-Worms D, Van den Abbele AD, Holman BL, Davison A, Jones AG Uptake of the cation hexakis (2-methoxyisobutylisonitrile)-technetium-99m by human carcinoma cells lines in vitro Cancer Res 1990;50. 2198-2202.
14. Maublant JC, Zhang Z, Rapp M, Michelot J, Veyre A In vitro uptake of technetium-99m-teboroxime in carcinoma cell lines and normal cells. comparison with technetium-99m-sestamibi and thallium-201 J Nucl Med 1993,34:1949-1952.
15. Piwnica-Worms D, Kronauge JF, Holman BL, Lister-James J, Davison A, Jones A, Hexakis (Carbomethoxyisopropylisonitrile) technetium(I), a new myocardial perfusion imaging agent: binding characteristics in cultured chick heart cells J Nucl Med 1988,29 55-61.
16. Piwnica-Worms D, Kronauge JF, Holman BL, Davison A, Jones AG Comparative myocardial uptake characteristics of hexakis (alkylisonitrile)technetium(I) complexes Effect of lipophilicity Invest Radiol 1989;24:25-29
17. Chiu ML, Kronauge JF, Piwnica-Worms D. Effect of mitochondrial and plasma membrane potentials on accumulation of hexakis (2-methoxyisobutylisonitrile) technetium(I) in cultured mouse fihroblasts J Nucl Med 1990,31:1646-1653
18. Piwnica-Worms D, Kronauge JF, Chiu ML Uptake and retention of hexakis (2-methoxyisobutyl isonitrile) technetium(I) in cultured chick myocardial cells, mitochondrial and plasma membrane potential dependence Circulation 1990,82:1826-1838
19. Chen LB. Mitochondrial membrane potential in living cells. Annu Rev Cell Biol 1988,4.155-181