Autoimmunity to RNA polymerase II is focused at the carboxyl terminal domain of the large subunit

Arthritis and Rheumatism

Volumn 39, Issue 11, 1996, Pages 1886-1891

  Hirakata, Michito ^a,b   Kanungo, Jyotshna ^b   Suwa, Akira ^a,b   Takeda, Yoshihiko ^b   Craft, Joe ^c   Hardin, John A ^b  

^a KEIO UNIVERSITY   (Japan)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; RNA POLYMERASE II;

ADULT; ANTIBODY SPECIFICITY; ARTICLE; AUTOIMMUNITY; CARBOXY TERMINAL SEQUENCE; CLINICAL ARTICLE; CONTROLLED STUDY; ETIOLOGY; FEMALE; HUMAN; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MALE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; SCLERODERMA;

ADULT; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNITY; EPITOPES; FEMALE; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; PROTEIN STRUCTURE, TERTIARY; RNA POLYMERASE II;

EID: 0029987375     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.1780391115     Document Type: Article

References (36)

1. Stetler DA, Rose KM, Wenger ME, Berlin CM, Jacob ST: Antibodies to distinct polypeptides of RNA polymerase I in sera from patients with rheumatic autoimmune disease. Proc Natl Acad Sci USA 79:7499-7503, 1982
2. Reimer G, Rose KM, Scheer U, Tan EM: Autoantibody to RNA polymerase I in scleroderma sera. J Clin Invest 79:65-72, 1987
3. Stetler DA, Reichlin M, Berlin CM, Jacob ST: Autoantibodies against RNA polymerase I in scleroderma and Sjögren's syndrome sera. Biochem Biophys Res Commun 144:1296-1302, 1987
4. Okano Y, Steen VD, Medsger TA Jr: Autoantibody reactive with RNA polymerase III in systemic sclerosis. Ann Intern Med 119:1005-1013,1993
5. Hirakata M, Okano Y, Pati U, Suwa A, Medsger TA Jr, Hardin JA, Craft J: Identification of autoantibodies to RNA polymerase II. Occurrence in systemic sclerosis and association with autoantibodies to RNA polymerase I and III. J Clin Invest 91:2665-2672, 1993
6. Satoh M, Ajmani AK, Ogasawara T, Langdon JJ, Hirakata M, Wang J, Reeves WH: Autoantibodies to RNA polymerase II are common in systemic lupus erythematosus and overlap syndrome: specific recognition of the phosphorylated (IIo) form by a subset of human sera. J Clin Invest 94:1981-1989, 1994
7. Sentenac A: Eukaryotic RNA polymerases. Crit Rev Biochem Mol Biol 8:31-90, 1985
8. Young RA: RNA polymerase II. Annu Rev Biochem 60:689-715, 1991
9. Woychik NA, Liao S, Kolodziej PA, Young RA: Subunits shared by eukaryotic nuclear RNA polymerases. Genes Dev 4:313-323, 1990
10. Corden JL, Cadena DL, Ahearn JM, Dahmus ME: A unique structure at the carboxyl terminus of the largest subunit of eukaryotic RNA polymerase II. Proc Natl Acad Sci U S A 82:7934-7938, 1985
11. Schwartz LB, Roeder RG: Purification and subunit structure of deoxyribonucleic acid-dependent ribonucleic acid polymerase II from the mouse plasmacytoma, MOPC 315. J Biol Chem 250: 3221-3228, 1975
12. Allison LA, Moyle M, Shales M, Ingles CJ: Extensive homology among the large subunits of eukaryotic and prokaryotic RNA polymerases. Cell 42:599-610, 1985
13. Wintzerith M, Acker J, Vicaire S, Vigneron M, Kedinger C: Complete sequence of the human RNA polymerase II large subunit. Nucleic Acids Res 20:910, 1992
14. Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee: Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum 23:581-590, 1980
15. Thompson NE, Steinberg TH, Aronson DB, Burgess RR: Inhibition of in vivo and in vitro transcription by monoclonal antibodies prepared against wheat germ RNA polymerase II that react with the heptapeptide repeat of eukaryotic RNA polymerase II. J Biol Chem 264:11511-11520, 1989
16. Thompson NE, Aronson DB, Burgess RR: Purification of eukaryotic RNA polymerase II by immunoaffinity chromatography. J Biol Chem 265:7069-7077, 1990
17. Lerner EA, Lerner MR, Janeway CA Jr, Steitz JA: Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease. Proc Natl Acad Sci U S A 78:2737-2741, 1981
18. Craft J, Mimori T, Olsen TL, Hardin JA: The U2 small ribonucleoprotein particle as an autoantigen. J Clin Invest 81:1716-1724, 1988
19. Hirakata M, Mimori T, Akizuki M, Craft J, Hardin JA, Homma M: Autoantibodies to small nuclear and cytoplasmic ribonucleoproteins in Japanese patients with inflammatory muscle disease. Arthritis Rheum 35:449-456, 1992
20. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685, 1970
21. Ahearn JM Jr, Bartolomei MS, West ML, Cisek LJ, Corden JL: Cloning and sequence analysis of the mouse genomic locus encoding the largest subunit of RNA polymerase II. J Biol Chem 262:10695-10705, 1987
22. Sanger F, Nicklen S, Coulson AR: DNA sequencing with chain terminating inhibitors. Proc Natl Acad Sci U S A 74:5463-5467, 1977
23. Smith DB, Johnson KS: Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67:31-40, 1988
24. Towbin H, Staehelin T, Gordon J: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A 76:4350-4354, 1979
25. Barany G. Merrifield RB: The Peptides: Analysis, Synthesis, Biology. Edited by E Gross, J Meienhofer. New York, Academic Press, 1979
26. Gregory M, Tjian R: The tell-tail trigger. Nature 358:620-621, 1992
27. Christmann JL, Dahmus ME: Monoclonal antibody specific for calf thymus RNA polymerase IIo and IIA. J Biol Chem 256:11798-11803, 1987
28. Rokeach L, Jannatipour M, Hoch SO: Heterologous expression and epitope mapping of a human small nuclear ribonucleoproteinassociated SmB'/B autoantigen. J Immunol 144:1015-1022, 1990
29. Hirakata M, Craft J, Hardin JA: Autoantigenic epitopes of the B and D polypeptides of the U1 snRNP: analysis of domain recognized by the Y12 monoclonal anti-Sm antibody and by patient sera. J Immunol 150:3592-3601, 1993
30. Brendel V, Dohlman J, Blaisdell BE, Karlin S: Very long charge runs in systemic lupus erythematosus-associated autoantigens. Proc Natl Acad Sci U S A 88:1536-1540, 1991
31. Sillekens PTG, Habets WJ, Beijer RP, van Venrooij WJ: cDNA cloning of the human U1 snRNP associated A protein: extensive homology between U1 and U2 snRNP-specific proteins. EMBO J 6:3841-3845, 1987
32. Habets WJ, Sillekens PTG, Hoet MH, McAllister G, Lerner MR, van Venrooij WJ: Small nuclear RNA-associated proteins are immunologically related as revealed by mapping of autoimmune reactive B cell epitopes. Proc Natl Acad Sci U S A 86:4674-4678, 1989
33. Rokeach LA, Haselby JA, Hoch SO: Molecular cloning of a cDNA encoding the human Sm-D autoantigen. Proc Natl Acad Sci U S A 85:4832-4836, 1988
34. Williams DG, Sharpe NG, Wallace G, Latchman DS: A repeated proline-rich sequence in SmB/B' and N is a dominant epitope recognized by human and murine autoantibodies. J Autoimmun 3:715-725, 1990
35. Zang H, Wang JC, Liu LF: Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes. Proc Natl Acad Sci U S A 85:1060-1064, 1988
36. Suwa A, Hirakata M, Takeda Y, Mimori T, Hardin JA: The Ku (p70/p80) protein assembles into an autoimmunogenic complex with the 350 kDa catalytic polypeptide of DNA-dependent protein kinase (DNA-PK) (abstract). Clin Res 41:187A, 1993