Effect of terfenadine and KW-4679, a novel antiallergic compound, on action potential of guinea pig ventricular myocytes

Japanese Journal of Pharmacology

Volumn 70, Issue 2, 1996, Pages 199-202

  Kato, Yoshimitsu ^a   Mori, Tatsuya ^a   Ohmori, Kenji ^a   Ichimura, Michio ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Action potential; Antiallergic drug; Ventricular myocyte

Indexed keywords

OLOPATADINE; TERFENADINE;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SAFETY; GUINEA PIG; HEART MUSCLE CELL; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE WALL; NONHUMAN; TORSADE DES POINTES;

EID: 0029987126     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.70.199     Document Type: Article

References (15)

1. Davies AJ, Harindra V, McEwan A and Ghose RR: Cardiotoxic effect with convulsions in terfenadine overdose. Br Med J 298, 325 (1989)
2. Monahan BP, Ferguson CL, Killeavy ES, Lloyd BK, Troy J and Cantilena LR: Torsades de pointes occuring in association with terfenadine use. JAMA 264, 2788-2790 (1990)
3. Hoppu K, Tikanoja T, Tapanainen P, Remes M, Saarenpaa-Heikilla O and Kouvalainen K: Accidental astemizole overdose in young children. Lancet 338, 538-539 (1991)
4. Leor J, Harman M, Rabinowitz B and Mozes B: Giant U waves and associated ventricular tachycardia complicating astemizole overdose. Am J Med 91, 94-97 (1991)
5. 1 receptor antagonists astemizole and terfenadine compared with chlorpheniramine and pyrilamine. Circ Res 76, 110-119 (1995)
6. Ohshima E, Otaki S, Sato H, Kumazawa T, Obase H, Ishii A, Ishii H, Ohmori K and Hirayama N: Synthesis and antiallergic activity of 11-(aminoalkylidene)-6,11-dihydrobibenz[b,e]oxepin derivatives. J Med Chem 35, 2074-2084 (1992)
7. Akagi M, Mio M, Miyoshi K and Tasaka K: Antiallergic effects of terfenadine on immediate type hypersensitivity reaction. Immunopharmacol Immunotoxicol 9, 257-279 (1987)
8. Takahashi S, Kato Y, Adachi M, Agata N, Tanaka H and Shigenobu K: Effects of cyclopiazonic acid on rat myocardium: inhibition of calcium uptake into sarcoplasmic reticulum. J Pharmacol Exp Ther 272, 1095-1100 (1995)
9. Pinney SP, Koller BS, Franz MR and Woosley RL: Terfenadine increases the QT interval in isolated guinea pig heart. J Cardiovasc Pharmacol 25, 30-34 (1995)
10. Rampe D, Wible B, Brown AR and Dage RC: Effects of terfenadine and its metabolites on a delayed rectifier K channel cloned from human heart. Mol Pharmacol 44, 1240-1245 (1993)
11. Woosley RL, Chen Y, Frieman JP and Gillis RA: Mechanism of the cardiotoxic actions of terfenadine. JAMA 269, 1532-1536 (1993)
12. Crumb WJ, Wible B, Arnold DJ, Payne JP and Brown AM: Blockade of multiple human cardiac potassium currents by the antihistamine terfenadine: possible mechanism for terfenadine-associated cardiotoxicity. Mol Pharmacol 47, 181-190 (1995)
13. Lang D, Wang C and Wenger T: Terfenadine alters action potentials in isolated canine Purkinje fibers more than acrivastine. J Cardiovasc Pharmacol 22, 432-442 (1993)
14. Tanaka H, Masumiya H, Kato Y and Shigenobu K: Inhibitory effects of terfenadine on the rising phase of action potentials and sinus rates in isolated guinea pig myocardium. Gen Pharmacol (in press)
15. 1 antagonist, and some related compounds. J Pharm Pharmacol 45, 63-66 (1993)