Glial differentiation predicts poor clinical outcome in primitive neuroectodermal brain tumors

Annals of Neurology

Volumn 39, Issue 4, 1996, Pages 481-489

  Janss, Anna J ^a   Yachnis, Anthony T ^a   Silber, Jeffrey H ^a   Trojanowski, John Q ^b   Lee, Virginia M Y ^b   Sutton, Leslie N ^a   Perilongo, Giorgio ^a   Rorke, Lucy B ^a   Phillips, Peter C ^a  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; NEUROFILAMENT PROTEIN; RETINA S ANTIGEN;

ADOLESCENT; ADULT; ARTICLE; BRAIN TUMOR; CANCER RECURRENCE; CANCER SURVIVAL; CHILD; CONTROLLED STUDY; FEMALE; GLIA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFANT; MAJOR CLINICAL STUDY; MALE; NERVE CELL DIFFERENTIATION; NEUROECTODERM TUMOR; PRIORITY JOURNAL; PROGNOSIS;

ADOLESCENT; ADULT; ANTIGENS; ARRESTIN; BRAIN NEOPLASMS; CELL DIFFERENTIATION; CHILD; CHILD, PRESCHOOL; EYE PROTEINS; FEMALE; FORECASTING; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; INFANT; MALE; NEUROECTODERMAL TUMORS, PRIMITIVE; NEUROFILAMENT PROTEINS; NEUROGLIA; RECURRENCE; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 0029986667     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.410390410     Document Type: Article

References (59)

1. Allen JC, Epstein F. Medulloblastoma and other primary malignant neuroectodermal tumors of the CNS. J Neurosurg 1982;57:446-451
2. Rorke LB. The cerebellar medulloblastoma and its relationship to primitive neuroectodermal tumors. J Neuropathol Exp Neurol 1983;42:1-15
3. Cohen BH, Zeltzer PM, Boyett JM, et al. Prognostic factors and treatment results for supratentorial primitive neuroectodermal tumors in children using radiation and chemotherapy: a children's cancer group randomized trial. J Clin Oncol 1995;13:1687-1696
4. Tomita T, McLone DG, Yasue M. Cerebral primitive neuroectodermal tumors in childhood. J Neurooncol 1988;6:233-243
5. Kleihues P, Burger PC, Scheithauer BW. Histological typing of tumours of the central nervous system. 2nd ed. Berlin: Springer-Verlag, 1993
6. Kovnar EH, Kellie SJ, Horowitz MW, et al. Preirradiation cisplatin and eroposide in the treatment of high-risk medulloblastoma and other malignant embryonal tumors of the central nervous system: a phase II study. J Clin Oncol 1990;8:330-336
7. Baram TZ, Eys JV, Dowell RE, et al. Survival and neurologic outcome of infants with medulloblastoma treated with surgery and MOPP chemotherapy: a preliminary report. Cancer 1987;60:173-177
8. Brand WN, Schneider PA, Tokars PP. Long term results of a pilot study of low dose cranial-spinal irradiation for cerebellar medulloblastoma. Int J Radiat Oncol Biol Phys 1987;13:1641-1645
9. Packer RJ, Siegel KR, Sutton LN, et al. Efficacy of adjuvant chemotherapy for patients with poor-risk medulloblastoma: a preliminary report. Ann Neurol 1988;24:503-508
10. Packer RJ, Sutton LN, Elterman R, et al. Outcome for children with medulloblastoma treated with radiation and cisplatin, CCNU, and vincristine chemotherapy. J Neurosurg 1994;18:690-698
11. Jankovic M, Brouwersa P, Veldhuizen MGV, et al. Association of 1800 cGy cranial irradiation with intellectual function in children with acute lymphoblastic leukemia. Lancet 1994;344:224-227
12. Olshan JS, Gubernick J, Packer RJ, et al. The effects of adjuvant chemotherapy on growth in children with medulloblastoma. Cancer 1992;70:2013-2017
13. Radcliffe J, Packer RJ, Atkins TE, et al. Three and four-year cognitive outcome in children with noncortical brain tumors treated with whole-brain radiotherapy. Ann Neurol 1992;32:551-554
14. Cohen ME, Duffner PK. Long-term consequences of CNS treatment for childhood cancer, Part I: pathologic consequences and potential for oncogenesis. Pediatr Neurol 1991;7:157-163
15. Duffner PK, Cohen ME. Long-term consequences of CNS treatment for childhood cancer, Part II: clinical consequences. Pediatr Neurol 1991;7:237-242
16. Silber JH, Radcliffe J, Peckham V, et al. Whole-brain irradiation and decline in intelligence: the influence of dose and age on IQ score. J Clin Oncol 1992;10:1390-1396
17. Goldwein JW, Radcliffe J, Packer RJ, et al. Results of a Pilot study of low-dose craniospinal radiation therapy plus chemotherapy for children younger than 5 years with primitive neuroectodermal tumors. Cancer 1993;71:2647-2652
18. Kopelson G, Linggood RM, Kleinman GM. Medulloblastoma: identification of prognostic subgroups and implications for multimodal management. Cancer 1983;51:312-319
19. Evans AE, Jenkin RDT, Sposto R, et al. The treatment of medulloblastoma: results of a prospective randomized trial of radiation therapy with and without CCNU, vincristine and prednisone. J Neurosurg 1990;72:572-582
20. Brodeur GM, Pritchard J, Berthold F, et al Revisions of the international criteria for neuroblastoma diagnosis, staging and response to treatment. J Clin Oncol 1993;11:1466-1477
21. Silber JH, Evans AE, Friedman M. Models to predict outcome from childhood neuroblastoma: the role of serum ferritin and tumor histology. Cancer Res 1991;51:1426-1433
22. Gajjar A, Heideman R, Douglas E, et al. Relation of tumor-cell ploidy to survival in children with medulloblastoma. J Clin Oncol 1993;11:2211-2217
23. Tait DM, Eeles RA, Carter R, et al. Ploidy and proliferative index in medulloblastoma: useful prognostic factors? Eur J Cancer 1993;29A:1383-1387
24. Tomita T, Yasue M, Engelhard HH, et al. Flow cytometric DNA analysis of medulloblastoma: prognostic implication of aneuploidy. Cancer 1988;61:744-749
25. Zerbini C, Gelber R, Weinberg D, et al. Prognostic factors in medulloblastoma, including DNA ploidy. J Clin Oncol 1993;11:616-622
26. Bigner SH, Friedman HS, Vogelstein B, et al Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts. Cancer Res 1990;50:2347-2350
27. Caputy AJ, McCullough DC, Manz HJ, et al. A review of the factors influencing the prognosis of medulloblastoma: the importance of cell differentiation. J Neurosurg 1987;66:80-87
28. Cogan P, Daneshvar L, Metzger A, et al. Involvement of multiple chromosome 17p loci in medulloblastoma tumorigenesis. Am J Hum Genet 1992;50:584-589
29. Cruz-Sanchez, FF, Rossi ML, Hughes JT, et al. Medulloblastoma: an immunohistological study of 50 cases. Acta Neuropathol 1989;79:205-210
30. Czerwionka M, Korf HW, Hoffmann O, et al. Differentiation in medulloblastomas: correlation between the immunocytochemical demonstration of photoreceptor markers (S-antigen, rod-opsin) and the survival in 66 patients. Acta Neuropathol 1989;78:629-636
31. Goldberg-Stern H, Gadoth N, Stern S, et al. The prognostic significance of glial fibrillary acidic protein staining in medulloblastoma. Cancer 1991;68:568-573
32. Yachnis AT, Rorke LB, Trojanowski JQ. Cerebellar dysplasias in humans: development and possible relationship to glial and primitive neuroectodermal tumors of the cerebellar vermis. J Neuropathol Exp Neurol 1994;53:61-71
33. Yachnis AT, Trojanowski JQ: Studies of childhood brain tumors using immunohistochemistry and microwave technology: methodological considerations. J Neurosci Methods 1994;55:191-200
34. Shi R-S, Key ME, Kalra KL. Antigen retrieval in formalin-fixed paraffin embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J Histochem Cytochem 1991:39:741-748
35. Chang CH, Housepian EM Jr, Herbert C. An operative staging system and a megavoltage radiotherapeutic technique for cerebellar medulloblastomas. Radiology 1969;93:1351-1359
36. Lee VM-Y, Carden MJ, Trojanowski JQ. Novel monoclonal antibodies provide evidence for the in-situ existence of a non-phosphorylated form of the largest neurofilament subunit. J Neurosci 1986;6:850-858
37. Lee VM-Y, Carden MJ, Schlaepfer WW, Trojanowski JQ. Monoclonal antibodies distinguish several differentially phosphorylated states of the two largest rat neurofilament subunits (NF-H and NF-M) and demonstrate their existence in the normal nervous system of adult rats. J Neurosci 1987;7:3474-3488
38. Lee VM-Y, Otvos MJ, Carden MJ, et al. Identification of the major phosphorylation site in mammalian neurofilaments. Proc Natl Acad Sci USA 1988;85:7384-7388
39. Trojanowski JQ, Kelsten ML, Lee VM-Y. Phosphate-dependent and independent neurofilament protein epitopes are expressed throughout the cell cycle in human medulloblastoma (D283 MED) cells. Am J Pathol 1989;135:747-758
40. Schmidt ML, Carden MJ, Lee VM-Y, Trojanowski JQ. Phosphate dependent and independent neurofilament epitopes in the axonal swellings of patients with motor neuron disease and controls. Lab Invest 1987;56:282-294
41. Debus E, Webber K, Osborn M. Monoclonal antibodies specific for glial fibrillary acidic (GFP) protein for each of the neurofilament triplet polypeptides. Differentiation 1983;25:193-203
42. Cox DR, Oaks D. Analysis of survival data. London: Chapman and Hall, 1984:50
43. Bailey P, Cushing H. Medulloblastoma cerebelli: a common type of midcerebellar glioma of childhood. Arch Neurol Psychiatry 1925;14:192-224
44. Packer RJ, Sutton LN, Rorke LB, et al. Prognostic importance of cellular differentiation in medulloblastoma in children. J Neurosurg 1984;61:296-301
45. Tomlinson FH, Scheithauer BW, Jenkins RB. Medulloblastoma: II. A pathobiologic overview. J Child Neurol 1992;7:240-252
46. Jennings MT, Jennings VDL, Asadourian LLH, et al. Five novel cell surface antigens of CNS neoplasms. J Neurol Sci 1989;89:63-78
47. Cruz-Sanchez FF, Rossi ML, Hughes JT, Moss TH. Differentiation in embryonal neuroepithelial tumors of the central nervous system. Cancer 1991;67:965-976
48. Rorke LB. Just what is a medulloblastoma? Concepts Pediatr Neurosurg 1985;6:6-15
49. Yachnis AT, Rorke LB, Lee VM-Y, Trojanowski JQ, Expression of neuronal and glial polypeptides during histogenesis of the human cerebellar cortex including observations on the dentate nucleus. J Comp Neurol 1993;334:356-369
50. Szymas J, Biczysko W, Gabryel P, Morkowski S. Medulloblastoma: histological evaluation and prognosis: a clinical immunohistochemical and electron microscopic study. Childs Nerv Syst 1987;3:74-80
51. Coffin CM, Braun JT, Wick MR, Dehner LP. A clinicopathologic and immunohistochemical analysis of 53 cases of medulloblastoma with emphasis of synaptophysin expression. Mod Pathol 1990;3:164-170
52. Molenaar WM, Trojanowski JQ. Biological markers of glial and primitive tumors. In: Salcman M, ed. Neurobiology of brain tumors: concepts in neurosurgery. 1st ed. Baltimore: Williams and Wilkins, 1991:185-210
53. Gomi H, Yokoyama T, Fujimoto K, et al. Mice devoid of glial fibrillary acidic protein develop normally and are susceptible to scrapie prions. Neuron 1995;14:29-41
54. Eng LF, Yu ACH, Lee YL. Astrocytic response to injury. Prog Brain Res 1992;94:353-365
55. Molenaar WM, Leij Lde, Trojanowski JQ. Neuroectodermal tumors of the peripheral and the central nervous system share neuroendocrine N-CAM-related antigens with small cell lung carcinomas. Acta Neuropathol 1991;83:46-54
56. Maraziotis J, Perentes E, Karamitopoulou E, et al. Neuron-associated class III beta-tubulin isotype, retinal S-antigen, synaptophysin and glial fibrillary acidic protein in human medulloblastomas: a clinicopathological analysis of 36 cases. Acta Neuropathol 1992;84:355-363
57. Sime PJ, Gordon A, Hooper ML, Bell JE. Differentiation in medulloblastomas and other primitive neuroectodermal tumours. Br J Neurosurg 1989;3.89-100
58. Gajjar A, Mulhern RK, Heidman RL, et al. Medulloblastoma in very young children: outcome of definitive craniospinal irradiation following incomplete response to chemotherapy. J Clin Oncol 1994;12:1212-1216
59. Tait DM, Thornton-Jones H, Bloom HJG, et al. Adjuvant chemotherapy for medulloblastoma: the first multi-centre control trial of the international society of paediatric oncology. Eur J Cancer 1990;26:464-469