Massive apoptosis detected by in situ DNA nick end labeling in neuroblastoma

American Journal of Surgical Pathology

Volumn 20, Issue 6, 1996, Pages 649-655

  Ikeda, Hitoshi ^a   Hirato, Junko ^a,b   Akami, Masayuki ^a   Suzuki, Norio ^a   Takahashi, Atsushi ^a   Kuroiwa, Minoru ^a   Matsuyama, Shiro ^a  

^a Gumna Children S Medical Center   (Japan)

^b GUNMA UNIVERSITY   (Japan)

Author keywords

Apoptosis; bcl 2; Neuroblastoma

Indexed keywords

APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL DEATH; CHILD; DNA DEGRADATION; FEMALE; HUMAN; HUMAN TISSUE; INFANT; MALE; NEUROBLASTOMA; TUMOR REGRESSION;

ADRENAL GLAND NEOPLASMS; APOPTOSIS; CHILD; CHILD, PRESCHOOL; DNA NUCLEOTIDYLEXOTRANSFERASE; DNA, NEOPLASM; ELECTROPHORESIS, AGAR GEL; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IN SITU HYBRIDIZATION; INFANT; MALE; MEDIASTINAL NEOPLASMS; NEUROBLASTOMA; PLOIDIES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; REMISSION, SPONTANEOUS;

EID: 0029986459     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-199606000-00001     Document Type: Article

References (15)

1. Announcement of the Committee on Malignant Tumor of the Japanese Society of Pediatric Surgeons. J Jpn Soc Pediatr Surg 1980;16:856-69.
2. Chatten J, Shimada H, Sather HN, Wong KY, Siegel SE, Hammond GD. Prognostic value of histopathology in advanced neuroblastoma: a report from the Children's Cancer Study Group. Hum Pathol 1988;19:1187-98.
3. Dehner LP. Pathologic anatomy of classic neuroblastoma: including prognostic features and differential diagnosis. In: Pochedly C, ed. Neuroblastoma: tumor biology and therapy. Boca Raton, FL: CRC Press, 1990:111-43.
4. Fukasawa Y, Ishikura H, Takada A, et al. Massive apoptosis in infantile myofibromatosis: a putative mechanism of tumor regression. Am J Pathol 1994;144:480-5.
5. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992;119:493-501.
6. Gerschenson LE, Rotello RJ. Apoptosis: a different type of cell death. FASEB J 1992;6:2450-5.
7. Ikeda H, Matsuyama S, Suzuki N, Takahashi A, Kuroiwa M, Nagashima K. Favorable biological characteristics of mass screening-detected neuroblastoma. Proceedings of the Third International Symposium on Neuroblastoma Screening, 1994;125-8.
8. Ikeda H, Hirato J, Akami M, et al. Bcl-2 oncoprotein expression and apoptosis in neuroblastoma. J Pediatr Surg 1995;30:805-8.
9. Joshi VV, Cantor AB, Altshuler G, et al. Age-linked prognostic categorization based on a new histologie grading system of neuroblastomas. Cancer 1992;69:2197-211.
10. Joshi VV, Cantor AB, Brodeur GM, et al. Correlation between morphologic and other prognostic markers of neuroblastoma. Cancer 1993;71:3173-81.
11. Kerr JFR, Searle J. A suggested explanation tor the paradoxically slow growth rate of basal-cell carcinomas that contain numerous mitotic figures. J Pathol 1972;107:41-4.
12. Kerr JFR, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972;26:239-57.
13. Kerr JFR, Winterford CM, Harmon BV. Apoptosis: its significance in cancer and cancer therapy. Cancer 1994;73: 2013-26.
14. Raff MC. Social controls on cell survival and cell death. Nature 1992;356:397-400.
15. Shimada H, Chatten J, Newton WA, et al. Histopathologic prognostic factors in neuroblastic tumors: definition of subtypes of ganglioneuroblastoma and an age-linked classification of neuroblastomas. J Natl Cancer Inst 1984;73:405-16.