Bacterial reduction of N-oxides of tobacco- specific nitrosamines (TSNA)

Human & Experimental Toxicology

Volumn 15, Issue 4, 1996, Pages 329-334

  Atawodi, S E ^a   Richter, E ^b  

^a NATIONAL VETERINARY RESEARCH INSTITUTE   (Nigeria)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

bacterial reduction; bladder cancer; N oxides; tobac co specific nitrosamine; urinary tract infection

Indexed keywords

NITROSAMINE;

ARTICLE; BLADDER CANCER; CULTURE MEDIUM; ENTEROBACTER CLOACAE; ESCHERICHIA COLI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KLEBSIELLA PNEUMONIAE; PH; PRIORITY JOURNAL; PROTEUS MIRABILIS; REDUCTION; SMOKING; TOBACCO; URINARY TRACT INFECTION;

ANIMALS; BACTERIA; CARCINOGENS; HUMANS; HYDROGEN-ION CONCENTRATION; NITROSAMINES; RATS; SMOKING; URINARY TRACT INFECTIONS;

BACTERIA (MICROORGANISMS); ENTEROBACTER CLOACAE; ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE; MIRABILIS; NICOTIANA TABACUM; PROTEUS MIRABILIS;

EID: 0029986353     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1177/096032719601500409     Document Type: Article

References (18)

1. Hoffmann D., Brunnemann KD, Prokopczyk B., Djordjevic MV Tobacco-specific N-nitrosamines and Areca-derived N-nitrosamines: chemistry, biochemistry, carcinogenicity, and relevance to humans. Journal of Toxicology and Environmental Health 1994; 41: 1-52.
2. Hecht SS Metabolic activation and detoxification of tobacco-specific nitrosamines - a model for cancer prevention strategies. Drug Metabolism Reviews 1994; 26: 373-390.
3. Morse MA et al. Characterization of a glucuronide metabolite of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its dose-dependent excretion in the urine of mice and rats. Carcinogenesis 1990; 11: 1819-1823.
4. Hecht SS et al. Metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the patas monkey: pharmacokinetics and characterization of glucuronide metabolites. Carcinogenesis 1993; 14: 229-236.
5. Richter E., Tricker AR Nicotine inhibits the metabolic activation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rats. Carcinogenesis 1994; 15: 1061-1064.
6. Schulze J., Richter E., Binder U., Zwickenpflug W. Biliary excretion of 4-(methylnitrosamino)-l-(3'pyridyl)-1-butanone in the rat. Carcinogenesis 1992; 13: 1961-1965.
7. Carmella SG, Akerkar S., Hecht SS Metabolites of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers’ urine. Cancer Research 1993; 53: 721-724.
8. Kutzer C., Richter E., Oehlmann C., Atawodi SE Effect of nicotine and cotinine on NNK metbolism in rats. In: Effects of Nicotine on Biological Systems II: Advances in Pharmacological Sciences. Clarke PBS, Quik M, Thurau K & Adlkofer F (eds.), Birkhäuser Verlag, Basel, Boston, Berlin, pp 385-390, 1995.
9. Hawksworth G., Hill MJ The in vivo formation of N-nitrosamines in the rat bladder and their subsequent absorption. British Journal of Cancer 1974; 29: 353-358.
10. Radomski JL et al. Nitrosamine formation in bladder infections and its role in the etiology of bladder cancer. Journal of Urology 1978; 120: 48-50.
11. Ohshima H. et al. N-Nitrosamine formation in urinary tract infections. In: The Relevance of N-nitroso Compounds to Human Cancer: Exposures and Mechanisms. Bartsch H, O'Neill IK & Schulte-Hermann R (eds.), International Agency for Research on Cancer, Lyon, France, IARC Scientific Publications 1987; 84: 384-390.
12. Calmels S., Ohshima H., Bartsch H. Nitrosamine formation by denitrifying and non-denitrifying bacteria: implication of nitrite reductase and nitrate reductase in nitrosation catalysis. Journal of General Microbiology 1988; 134: 221-226.
13. Leach SA, Thompson M., Hill M. Bacterially catalysed N-nitrosation reactions and their relative importance in the human stomach. Carcinogenesis 1987; 8: 1907-1912.
14. Jenner P., Gorrod JW, Beckett AH The absorption of nicotine-1′-N'-oxide and its reduction in the gastrointestinal tract in man. Xenobiotica 1973; 3: 341-349.
15. Dajani RM, Gorrod JW, Beckett AH Reduction in vivo of (—) -nicotine-1′-N-oxide by germ-free and conventional rats. Biochemical Pharmacology 1975; 24: 648-650.
16. Yi MJ, Sprouse CT, Bowman ER, McKennis H., Jr. The relationship between the metabolism of (S)-cotinine-N-oxide and (S)-cotinine. Drug Metabolism and Disposition 1977; 5: 355-362.
17. Sepkovic DW et al. Short-term studies on the in vivo metabolism of N-oxides of nicotine in rats. Journal of Toxicology and Environmental Health 1986; 18: 205-214.
18. Djordjevic M., Fan J., Ferguson S., Hoffmann D. Self-regulation of smoking intensity. Smoke yields of the low-nicotine, low-'tar’ cigarettes. Carcinogenesis 1995; 16: 2015-2021.