A direct approach to the synthesis of famciclovir and penciclovir

Nucleosides and Nucleotides

Volumn 15, Issue 5, 1996, Pages 981-994

  Choudary, Bernadette M ^a   Geen, Graham R ^a   Kincey, Peter M ^a   Parratt, Martin J ^a   Dales, J Robert M ^a   Johnson, Graham P ^a   O'Donnell, Steven ^a   Tudor, David W ^a   Woods, Neil ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; FAMCICLOVIR; PENCICLOVIR;

ANTIVIRAL ACTIVITY; ARTICLE; COLUMN CHROMATOGRAPHY; DRUG ISOLATION; DRUG SYNTHESIS; ESTERIFICATION; HERPES VIRUS; NUCLEAR MAGNETIC RESONANCE;

EID: 0029985688     PISSN: 07328311     EISSN: None     Source Type: Journal    
DOI: 10.1080/07328319608002029     Document Type: Article

References (19)

1. Harnden, M.R. Drugs of the Future, 1989, 14, 347-358; and references cited therein.
2. a) Pandit, U.K.; Grose, W.F.A.; Eggelte, T.A. Synth. Commun., 1972, 2, 345-351.
3. b) Tippie, M.A.; Martin, J.C.; Smee, D.F.; Matthews, T.R.; Verheyden, J.P.H. Nucleosides, Nucleotides, 1984, 3, 525-535.
4. c) Harnden, M.R.; Jarvest, R.L. Tetrahedron Lett., 1985, 26, 4265-4268.
5. d) Harnden, M.R.; Jarvest, R.L.; Bacon, T.H.; Boyd, M.R. J. Med. Chem., 1987, 30, 1636-1642.
6. e) Hannah, J.; Tolman, R.L.; Karkas, J.D.; Liou, R.; Perry, H.C.; Field, A.K. J. Het. Chem., 1989, 26, 1261-1271.
7. f) Choudary, B.M.; Geen, G.R.; Grinter, T.J.; MacBeath, F.S.; Parratt, M.J. Nucleosides, Nudeotides, 1994, 13, 979-996.
8. a) Harnden, M.R.; Jarvest, R.L.; Boyd, M.R.; Sutton, D.; Vere Hodge, R.A. J. Med. Chem., 1989, 32, 1738-1743.
9. b) Geen, G.R.; Grinter, T.J.; Kincey, P.M.; Jarvest, R.L. Tetrahedron, 1990, 46, 6903-6914.
10. c) Geen, G.R.; Kincey, P.M.; Choudary, B.M. Tetrahedron Lett., 1992, 33, 4609-4612.
11. a) Beecham Group PLC. Eur. Pat., 203 685 A2, (1986).
12. b) SmithKline Beecham PLC. Wo. Pat., 92 13 859, (1992).
13. c) Sumika Fine Chemicals Co. Eur. Pat., 543 095, (1993).
14. Padgett, H.C.; Csendes, I.G.; Rapoport, H. J. Org. Chem., 1979, 44, 3492-3496.
15. Danishefsky, S.; Singh, R.K. J. Am. Chem. Soc., 1975, 97, 3239-3241.
16. Soai, K.; Oyamada, H.; Ookawa, A. Synth. Commun., 1982, 12, 463-467.
17. Newkome, G.R.; Baker, G.R. Org. Prep. Proc. Intl., 1986, 18, 117-144.
18. Harnden, M.R.; Jarvest, R.L.; Slawin, A.M.Z.; Williams, D.J. Nucleosides, Nucleotides, 1990, 9, 499-513.
19. SmithKline Beecham PLC. Int. Pat. Appl., WO/28402, (1995).