Prognostic value of heart rate adjustment of exercise-induced ST segment depression in the Multiple Risk Factor Intervention Trial

Journal of the American College of Cardiology

Volumn 27, Issue 6, 1996, Pages 1437-1443

  Okin, Peter M ^a   Grandits, Greg ^b   Rautaharju, Pentti M ^c   Prineas, Ronald J ^d   Cohen, Jerome D ^e   Crow, Richard S ^b   Kligfield, Paul ^b  

^a WEILL CORNELL MEDICAL CENTER   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^e SAINT LOUIS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; ELECTROCARDIOGRAM; EXERCISE; HEART DEATH; HEART RATE; HUMAN; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; RISK FACTOR; ST SEGMENT DEPRESSION;

EID: 0029985452     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/0735-1097(96)00030-7     Document Type: Article

References (46)

1. Goldschlager N, Selzer A, Cohn K. Treadmill stress tests as indicators of the presence and severity of coronary artery disease. Ann Intern Med 1976;85: 277-86.
2. Weiner DA, Ryan TJ, McCabe CH, et al. Exercise stress testing correlations among history of angina, ST segment response and prevalence of coronary artery disease in the Coronary Artery Surgery Study (CASS). N Engl J Med 1979;301:230-5.
3. Sheffield LT. The exercise test in perspective. Circulation 1977;55:681-5.
4. Chaitman BR. The changing role of the exercise electrocardiogram as a diagnostic and prognostic test for chronic ischemic heart disease. J Am Coll Cardiol 1986;8:1195-1210.
5. Mark DB, Hlatky MA, Harrell FE, Lee KL, Califf RM, Pryor DB. Exercise treadmill score for predicting prognosis in coronary artery disease. Ann Intern Med 1987;106:793-800.
6. Mark DB, Shaw L, Harrell FE, et al. Prognostic value of a treadmill exercise score in outpatients with suspected coronary artery disease. N Engl J Med 1991;325:849-53.
7. Fleg JL, Gerstenblith G, Zonderman AB, et al. Prevalence and prognostic significance of exercise-induced silent myocardial ischemia detected by thallium scintigraphy and electrocardiography in asymptomatic volunteers. Circulation 1990;81:428-36.
8. Giagnoni E, Secchi MB, Wu SC, et al. Prognostic value of exercise EKG testing in asymptomatic normotensive subjects: a prospective matched study. N Engl J Med 1983;309:1085-9.
9. Gordon DJ, Ekelund LG, Karon JM, et al. Predictive value of the exercise tolerance test for mortality in North American men: the Lipid Research Clinics mortality follow-up study. Circulation 1986;74:252-61.
10. Rautaharju PM, Prineas RJ, Eifler WJ, et al. Prognostic value of exercise electrocardiogram in men at high risk of future coronary heart disease: Multiple Risk Factor Intervention Trial experience. J Am Coll Cardiol 1986;8:1-10.
11. Bruce RA, Hossack KF, DeRouen TA, Hofer V. Enhanced risk assessment for primary coronary heart disease events by maximal exercise testing: 10 years' experience of Seattle Heart Watch. J Am Coll Cardiol 1983;2:565-73.
12. Froelicher VF, Thomas MM, Pillow C, Lancaster MC. Epidemiologic study of asymptomatic men screened by maximal treadmill testing for latent coronary artery disease. Am J Cardiol 1974;34:770-6.
13. Okin PM, Anderson KM, Levy D, Kligfield P. Heart rate adjustment of exercise-induced ST segment depression: improved risk stratification in the Framingham Offspring Study. Circulation 1991;83:866-74.
14. Elamin MS, Mary DASG, Smith DR, Linden RJ. Prediction of severity of coronary artery disease using slope of submaximal ST segment/heart rate relationship. Cardiovasc Res 1980;14:681-91.
15. Berenyi I, Hajduczki S, Baszormenyi E. Quantitative evaluation of exercise-induced ST segment depression for estimation of degree of coronary artery disease. Eur Heart J 1984;5:289-94.
16. Detry JMR, Robert A, Luwaert RJ, et al. Diagnostic values of computerized exercise testing in men without previous myocardial infarction: a multivariate, compartmental and probabilistic approach. Eur Heart J 1985;6:227-38.
17. Finkelhor RS, Newhouse KE, Vrobel TR, Miron SD, Bahler RC. The ST segment/heart rate slope as a predictor of coronary artery disease: comparison with quantitative thallium imaging and conventional ST segment criteria. Am Heart J 1986;112:296-304.
18. Detrano R, Salcedo E, Passalaqua M, Friis R. Exercise electrocardiographic variables: a critical appraisal. J Am Coll Cardiol 1986;8:836-47.
19. Deckers JW, Rensing BJ, Tijssen JG, Vinke RVH, Azar AJ, Simoons ML. A comparison of methods of analysing exercise tests for diagnosis of coronary artery disease. Br Heart J 1989;62:438-44.
20. Watanabe M, Yokata M, Miyahara T, et al. Clinical significance of simple heart rate-adjusted ST segment depression in supine leg exercise in the diagnosis of coronary artery disease. Am Heart J 1990;120:1102-10.
21. Robert AR, Melin JA, Detry JMR. Logistic discriminant analysis improves diagnostic accuracy of exercise testing for coronary artery disease in women. Circulation 1991;83:1202-9.
22. Okin PM, Kligfield P, Ameisen O, Goldberg H, Borer JS. Identification of anatomically extensive coronary artery disease by the exercise electrocardiographic ST segment/heart rate slope. Am Heart J 1988;115:1002-13.
23. Okin PM, Kligfield P, Milner MR, Goldstein SA, Lindsay J Jr. Heart rate adjustment of ST segment depression for reduction of false positive electrocardiographic responses to exercise in asymptomatic men screened for coronary artery disease. Am J Cardiol 1988;62:1043-7.
24. Kligfield P, Ameisen O, Okin PM. Heart rate adjustment of ST segment depression for improved detection of coronary artery disease. Circulation 1989;79:245-55.
25. Okin PM, Ameisen O, Kligfield P. Recovery phase patterns of ST segment depression in the heart rate domain: identification of coronary artery disease by the rate recovery loop. Circulation 1989;80:533-41.
26. Okin PM, Kligfield P. Gender-specific criteria and performance of the exercise electrocardiogram. Circulation 1995;92:1209-16.
27. The Multiple Risk Factor Intervention Trial Group. Statistical design considerations in the NHLBI Multiple Risk Factor Intervention Trial (MRFIT). J Chronic Dis 1977;20:261-75.
28. Multiple Risk Factor Intervention Trial Group. Risk factor changes and mortality results. JAMA 1982;248:1456-77.
29. Multiple Risk Factor Intervention Trial Group. Baseline rest electrocardiographic abnormalities, antihypertensive treatment, and mortality in the Multiple Risk Factor Intervention Trial. Am J Cardiol 1985;55:1-15.
30. Multiple Risk Factor Intervention Trial Group. Exercise electrocardiogram and coronary heart disease mortality in the Multiple Risk Factor Intervention Trial. Am J Cardiol 1985;55:16-23.
31. Mason RE, Likar I. A new system of multiple lead exercise electrocardiography. Am Heart J 1966;71:196-205.
32. Blackburn H, Keys A, Simonson E, Rautaharju PM, Punsar S. The electrocardiogram in population studies: a classification system. Circulation 1960; 21:1160-75.
33. Okin PM, Chen J, Kligfield P. Effect of baseline ST segment elevation on test performance of standard and heart rate adjusted ST segment depression criteria. Am Heart J 1990;119:1280-6.
34. Morris JA, Gardner MJ. Calculating confidence intervals for relative risks (odds ratios) and standardised ratios and rates. BMJ 1988;296:1313-6.
35. Kaplan E, Meier P. Non-parametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-81.
36. Mantel N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 1966;50:163-70.
37. Cox DR. Regression models and life tables. J R Stat Soc 1972;34 Series 8:187-220.
38. Kalbfleisch JD, Prentice RL. The Statistical Analysis of Failure Time Data. New York: John Wiley, 1980:101-3, 199-201.
39. Machin D, Gardner MJ. Calculating confidence intervals for survival time analyses. BMJ 1988;296:1369-71.
40. Okin PM, Kligfield P. Heart rate adjustment of ST depression and perfor-mance of the exercise electrocardiogram: a critical evaluation. J Am Coll Cardiol 1995;25:1726-35.
41. Okin PM, Bergman G, Kligfield P. Heart rate adjustment of the time-voltage ST segment integral: identification of coronary disease and relationship to standard and heart rate adjusted ST segment depression criteria. J Am Coll Cardiol 1991;18:1487-92.
42. Okin PM, Grandits G, Rautaharju PM, et al. Heart rate adjustment of the exercise ST integral in the Multiple Risk Factor Intervention Trial [abstract]. Circulation 1994;90 Suppl 1:1-328.
43. Holland RP, Brooks H. Spatial and nonspatial influences on the TQ-ST segment deflection of ischemia. Theoretical and experimental analysis in the pig. J Clin Invest 1977;60:197-214.
44. Mirvis DM, Ramanathan KB, Wilson JL. Regional blood flow correlates of ST segment depression in tachycardia-induced myocardial ischemia. Circulation 1986;73:365-73.
45. Okin PM, Kligfield P. Solid angle theory and heart rate adjustment of ST segment depression for the identification and quantification of coronary artery disease. Am Heart J 1994;127:658-67.
46. Kitamura K, Jorgensen CR, Gobel FL, Taylor HL, Wang Y. Hemodynamic correlates of myocardial oxygen consumption during upright exercise. J Appl Physiol 1972;32:516-22.