Synthesis and trypanocedal activity of the bis-carba analogue of pentamedine

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 9, 1996, Pages 1035-1036

  Zhang, Xini ^a   Berger, Bradley J ^a   Ulrich, Peter ^a  

^a PICOWER INST FOR MEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRYPANOSOMA; TRYPANOSOMA BRUCEI;

1,7 BIS(4 AMIDINOPHENYL)HEPTANE; ANTIPROTOZOAL AGENT; PENTAMIDINE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; DRUG SYNTHESIS; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER METABOLISM; MOUSE; NONHUMAN; RAT; TRYPANOSOMA BRUCEI; TRYPANOSOMIASIS;

EID: 0029984914     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00168-0     Document Type: Article

References (6)

1. Berger, B. J.; Naiman, N. A.; Hall, J. E.; Peggins, J.; Brewer, T. G.; Tidwell, R. R. Antimicrob. Agents Chemother. 1992, 36, 1825.
2. Berger, B. J.; Hall, J. E.; Tidwell, R. R.; unpublished results
3. Kantor, S. W.; Sung, T.-C.; Atkins, E. D. T. Macromolecules 1992, 25, 2789.
4. 3OD; 270 MHz) δ (ppm): 1.45 (6H, m), 1.75 (4H, m), 2.80 (4H, t) 7.45 (4H, d), 7.72 (4H, d).
5. 3OD) δ (ppm): 28.8, 29.0, 30.9, 35.5, 125.3, 127.7, 129.2, 150.0, 166.8.
6. Das, B. P.; Zalkow, V. B.; Forrester, M. L.; Molock, F. F.; Boykin, D. W. J. Pharm. Sci. 1982, 71, 465.