Specific recognition of a tetrahedral phosphonamidate transition state analogue group by a recombinant antibody Fab fragment

Amino Acids

Volumn 10, Issue 2, 1996, Pages 167-172

  Hua, T D ^a,b   Lamaty, F ^a   Souriau, C ^b   Rolland Fulcrand, V ^a   Lazaro, R ^a   Viallefont, P ^a   Lefranc, M P ^b   Weill, M ^b  

^a CNRS   (France)

^b CNRS and University Montpellier II   (France)

Author keywords

Amino acids; Combinatorial library; Phosphonamidate; Transition state

Indexed keywords

HAPTEN; IMMUNOGLOBULIN F(AB) FRAGMENT; PHOSPHORUS;

ANTIGEN RECOGNITION; ARTICLE; BINDING COMPETITION; PEPTIDE SYNTHESIS; PRIORITY JOURNAL;

EID: 0029984693     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00806589     Document Type: Article

References (11)

1. Dawson PE, Muir TW, Clark-Lewis I, Kent SBH (1994) Synthesis of proteins by native chemical ligation. Science 266: 776-779
2. Gaertner HF, Rose K, Cotton R, Timms D, Camble R, Offord RE (1992) Construction of proteins analogues by site-specific condensation of unprotected fragments. Bioconjugate Chem 3: 262-268
3. Griffiths AD, William SC, Hartley O, Tomlinson IM, Waterhouse P, Croby WL, Kotermann RE, Jones PT, Low NM, Allison TJ, et al (1994) Isolation of high affinity human antibodies directly from large synthetic repertoire. EMBO J 13: 3245-3260
4. Hariharan M, Chaberek S, Martell AE (1973) Synthesis of phosphonopeptide derivatives. Syn Commun 3: 375-379
5. Hirschmann R, Smith AB, Taylor CM, Benkovic PA, Taylor SD, Yager KM, Sprengeler PA, Benkovic SJ (1994) Peptide synthesis catalyzed by an antibody containing a binding site for variable amino acids. Science 265: 234-237
6. Jacobsen JR, Schultz PG (1994) Antibody catalysis of peptide bond formation. Proc Natl Acad Sci 91: 5888-5892
7. Jakubke H-D (1995) Peptide ligases-tools for peptide synthesis. Angew Chem Int Ed Engl 34: 175-177
8. Liu C-F, Tam JP (1994) Chemical ligation approach to form a peptide bond between unprotected peptide segments. Concept and model study. J Am Chem Soc 116: 4149-4153
9. Pollack SJ, Jacobs WJ, Schultz PG (1986) Selective chemical catalysis by an antibody. Science 234: 1570-1573
10. Stewart JD, Benkovic SJ (1995) Transition-state stabilization as a measure of the efficiency of antibody catalysis. Nature 375: 388-391
11. Tramontano A, Janda KD, Lerner RA (1986) Catalytic antibodies. Science 234: 1566-1570