The affinity of binding of digoxin to ovine anti-digoxin Fab (DIGIBINDTM) preparations

Biologicals

Volumn 24, Issue 1, 1996, Pages 19-24

  Allen, Geoffrey ^a,b  

^a WELLCOME RESEARCH LABORATORIES   (United Kingdom)

^b NONE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

OVIS;

DIGOXIN; DIGOXIN ANTIBODY F(AB) FRAGMENT;

ARTICLE; BINDING AFFINITY; DISSOCIATION CONSTANT; DRUG MANUFACTURE; EQUILIBRIUM DIALYSIS; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN POLYMORPHISM;

ANIMALS; ANTIBODY AFFINITY; DIGOXIN; IMMUNOGLOBULIN FAB FRAGMENTS; SHEEP; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 0029984692     PISSN: 10451056     EISSN: None     Source Type: Journal    
DOI: 10.1006/biol.1996.0002     Document Type: Article

References (22)

1. Hickey AR, Wenger TL, Carpenter VP et al. Digoxin immune Fab therapy in the management of digitalis intoxication: safety and efficacy results of an observational surveillance study. J Am Coll Cardiol 1991; 17: 590-598.
2. Smith TW. Digoxin in heart failure. New Engl J Med 1993; 329: 51-53.
3. Smith TW, Butler VP, Jr., Haber E et al. Treatment of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments. New Engl J Med 1982; 307: 1357-1362.
4. Hillenkamp F, Karas M. Mass spectrometry of peptides and proteins by matrix-assisted ultraviolet laser desorption/ionization. Methods Enzymol 1990; 193: 280-294.
5. Berzofsky JA, Epstein SL, Berkower IJ. Antigen-antibody interactions and monoclonal antibodies. In: Paul WE, ed. Fundamental immunology, 2nd Edn., New York: Raven Press, 1989; 315-352.
6. Schaumann W, Kaufmann B, Neubert P, Smolarz A. Kinetics of the Fab fragments of digoxin antibodies and of bound digoxin in patients with severe digoxin intoxication. Eur J Clin Pharmacol 1986; 30: 527-533.
7. Pauling L, Pressman D, Grossberg AL. The serological properties of simple substances. VII. A quantitative theory of the inhibition by haptens of the precipitation of heterogeneous antisera with antigens, and comparison with experimental results for polyhaptenic simple substances and for azoproteins. J Amer Chem Soc 1944; 66: 784-792.
8. Jeffrey PD, Strong RK, Sieker LC et al. 26-10 Fabdigoxin complex: affinity and specificity due to surface complementarity. Proc Natl Acad Sci USA 1993; 90: 10310-10314.
9. Smith TW, Butler VP, Jr., Haber E. Characterization of antibodies of high affinity and specificity for the digitalis glycoside digoxin. Biochemistry 1970; 9: 331-337.
10. Fujii Y, Ikeda Y, Yamazaki M. Highly specific antidigoxin antiserum from immunization with digoxin 3′-hemisuccinate-bovine serum albumin conjugate. Clin Chem 1994; 40: 172-173.
11. Curd J, Smith TW, Jaton J-C, Haber E. The isolation of digoxin-specific antibody and its use in reversing the effects of digoxin. Proc Natl Acad Sci USA 1971; 68: 2401-2406.
12. Smith TW, Skubitz KM. Kinetics of interactions between antibodies and haptens. Biochemistry 1975; 14: 1496-1502.
13. Hinds JA, Pincombe CF, Morris H, Duffy P. Competitive solid-phase enzyme immunoassay for measuring digoxin in serum. Clin Chem 1986; 32: 16-21.
14. Hunter MM, Margolies MN, Ju A, Haber E. High-affinity monoclonal antibodies to the cardiac glycoside, digoxin. J Immunol 1982; 129: 1165-1172.
15. Hudson NW, Mudgett-Hunter M, Panka DJ, Margolies MN Immunoglobulin chain recombination among antidigoxin antibodies by hybridoma-hybridoma fusion. J Immunol 1987; 139: 2715-2723.
16. Wong PC, Reilly TM, Karol RA, Timmermans PB. Functional antagonism by monoclonal antibody to digoxin in the guinea-pig atria. Eur J Pharmacol 1987; 136: 437-440.
17. Wahyono D, Piechaczyk M, Mourton C, Bastide J-M, Pau B. Novel anti-digoxin monoclonal antibodies with different binding specificities for digoxin metabolites and other glycosides. Hybridoma 1990; 9: 619-629.
18. Near RI, Bruccoleri R, Novotny J, Hudson NW, White A, Mudgett-Hunter M. The specificity properties that distinguish members of a set of homologous antidigoxin antibodies are controlled by H chain mutations. J Immunol 1991; 146: 627-633.
19. Ehrlich PH, Moustafa ZA, Justice JC et al. Human and primate monoclonal antibodies for in vivo therapy. Clin Chem 1988; 34: 1681-1688.
20. Danielsson L, Furebring C, Ohlin M et al. Human monoclonal antibodies with different fine specificity for digoxin derivatives: cloning of heavy and light chain variable region sequences. Immunology 1991; 74: 50-54.
21. Cambridge D, Morgan CR, Allen G. Digoxin and digoxin derivative induced arrhythmias: in vitro binding and in vivo abolition of arrhythmias by digoxin immune Fab (DIGIBIND). Cardiovasc Res 1992; 26: 906-911.
22. Balthazar J, Fung H-L. Utilization of antidrug antibody fragments for the optimization of intraperitoneal drug therapy: studies using digoxin as a model drug. J Pharmacol Exp Ther 1994; 268: 734-739.