Disposition of quinine in plasma after a single oral and intramuscular dose in healthy adult Africans

East African Medical Journal

Volumn 73, Issue 2, 1996, Pages 111-114

  Sowunmi, A ^a,b  

^a UNIVERSITY OF IBADAN   (Nigeria)

^b UNIVERSITY OF IBADAN   (Nigeria)

Author keywords

[No Author keywords available]

Indexed keywords

QUININE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; INTRAMUSCULAR DRUG ADMINISTRATION; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; RANDOMIZED CONTROLLED TRIAL;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AFRICA; ANTIMALARIALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG MONITORING; HUMANS; INJECTIONS, INTRAMUSCULAR; MALARIA, FALCIPARUM; MALE; QUININE; TISSUE DISTRIBUTION;

EID: 0029984246     PISSN: 0012835X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Salako, L.A., Sowummi, A. and Akinbami, F.O. The pharmacokinetics of quinine in African children suffering from kwashiorkor. Brit. J. Clin. Pharmacol. 1989; 28:197.
2. Sowunmi, A., Salako, L. A., Laoye, O.J. and Aderounmu, A.F. Combination of quinine, quinidine and cinchonine for the treatment of acute falciparum malaria: correlation with the susceptibility of Plasmodium falciparum to the cinchona alkaloids in-vitro. Trans. roy. Soc. trop. Med. Hyg. 1990; 84:626.
3. Sowunmi, A., Salako, L.A., Walker, O. and Ogundahunsi, O.A.T. Clinical efficacy of mefloquine in children suffering from chloroquine-resistant Plasmodium falciparum malaria in Nigeria. Trans. roy. Soc. trop. Med. Hyg. 1990; 84:761.
4. Salako, L. A., and Sowunmi, A. Disposition of quinine in plasma, red blood cells and saliva after and intravenous administration to healthy adult Africans. Europ. J. Clin. Pharmacol. 1992; 42:171.
5. Mansor, S.M., Taylor, T.E., McGrath, C.S., Edwards, G., Ward, S.A., Wirima, J.J. and Molyneux, M.E. The safety and kinetics of intramuscular quinine in Malawian children with moderately severe Plasmodium falciparum malaria. Trans. roy. Soc trop. med.Hyg. 1990; 84:482.
6. Waller, D., Krishna, S., Craddock, C., Brewster, D., Jammeh, A., Kwiatkowski, J., Karbwang, J., Molunto, P. and White, N.J. The pharmacokinetic properties of intramuscular quinine in Gambian children with severe falciparum malaria. Trans. roy. Soc. trop. Med. Hyg. 1990; 84:488.
7. Pasvol, G., Newton, C.R.J.C., Winstanley, P.A., Watkins W.M., Peshu, N.M., Were, J.B.O., Marsh, K. and Warrell, D.A. Quinine treatment of severe falciparum malaria in African children: a randomized comparison of three regimens. Amer. J. trop. Med. Hyg. 1991; 45:702.
8. Wanwimolruk, S., Chalcroft, S., Coville, P.F., and Campbell, A.J. Pharmacokinetics of quinine in young and elderly subjects. Trans. roy. Soc. trop. Med. Hyg. 1991; 85:714.
9. Babalola, C.P., Bolaji, O.O., Dixon, P.A.T and Ogunbona, P.A. Column liquid chromatographic analysis of quinine in human plasma, saliva and urine. J. Chromatogr. 1993; 616:151.
10. Strahan, J.H. Quinine by continous intravenous drip in the treatment of acute falciparum malaria. Trans. roy. Soc. trop. Med. Hyg. 1948; 41:669.