Prognostic implications of HLA genotyping in the early assessment of patients with rheumatoid arthritis

Journal of Rheumatology

Volumn 23, Issue SUPPL. 44, 1996, Pages 5-9

  Nepom, Gerald T ^a   Gersuk, Vivian ^a   Nepom, Barbara S ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b VMRC   (United States)

Author keywords

Disease susceptibility; Genetic prediction; Rheumtoid arthritis

Indexed keywords

CLINICAL TRIAL; CONFERENCE PAPER; DISEASE PREDISPOSITION; GENOTYPE; HLA TYPING; HUMAN; PRIORITY JOURNAL; PROGNOSIS; RHEUMATOID ARTHRITIS; GENE; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; REVIEW;

DNA; HLA ANTIGEN; HLA DR4 ANTIGEN;

ARTHRITIS, RHEUMATOID; DNA; GENES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HLA ANTIGENS; HLA-DR4 ANTIGEN; HUMANS; PROGNOSIS;

EID: 0029983084     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (36)

1. Nepom GT, Nepom BS: Prediction of susceptibility to rheumatoid arthritis by human leukocyte antigen genotyping. In: Nepom GT, ed. Rheumatic Disease Clinics of North America. Philadelphia: WB Saunders, 1992:785-92.
2. Nepom GT, Hansen JA, Nepom BS: The molecular basis for HLA class II associations with rheumatoid arthritis. J Clin Immunol 1987;7:1-1.
3. Wordsworth B, Lanchbury JSS, Sakkas LI, Welsh KI, Panayi GS, Bell JI: HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region. Proc Natl Acad Sci USA 1989;86:10049-53.
4. Ollier W, Thomson W: Population genetics of rheumatic diseases. In: Nepom GT, ed. Rheumatic Disease Clinics of North America. Philadelphia: WB Saunders, 1992:741-59.
5. Winchester R: Genetic determination of susceptibility and severity in rheumatoid arthritis. Ann Intern Med 1992;117:869-71
6. Gregersen PK, Silver J, Winchester RJ: The shared epitope hypothesis: An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987;30:1205-13.
7. Nepom GT HLA-DR4 and Rheumatoid Arthritis In: Wolfe F, Pincus T, eds Prognosis and Treatment of Rheumatic Diseases. New York: Marcel Dekker, 1994:115-29.
8. Hiraiwa A, Yamanaka K, Kwok WW, et al: Structural requirements for recognition of the HLA-Dw14 class II epitope: A key HLA determinant associated with rheumatoid arthritis. Proc Natl Acad Sci USA 1990;87:8051-5.
9. Krieger JI, Karr RW, Grey HM, et al: Single amino acid changes in DR and antigen define residues critical for peptide-MHC binding and T cell recognition. J Immunol 1991;146:2331-40.
10. Drover S, Karr RW, Kovats S, Nepom GT, Marshall WH: Amino acids in the groove influence an antibody-defined disease associated HLA-DR epitope. Human Immunol 1993;(suppl 1)37:67.
11. Stastny P: Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. New Engl J Med 1978;298:869-71.
12. Nepom GT, Seyfried CE, Holbeck SL, Wilske KR, Nepom BS: Identification of HLA-Dw14 genes in DR4+ rheumatoid arthritis. Lancet 1986;2:1002-5.
13. Nepom GT, Byers P, Seyfried C, et al: HLA genes associated with rheumatoid arthritis. Arthritis Rheum 1989;32:15-21.
14. Ronningen KA, Spurkland A, Egeland T, et al: Rheumatoid arthritis may be primarily associated with HLA-DR4 molecules sharing a particular sequence at residues 67-74. Tissue Antigens 1990;36:235-40.
15. Gao X, Olsen NJ, Pincus T, Stastny P: HLA-DR alleles with naturally occurring amino acid substitutions and risk for development of rheumatoid arthritis. Arthritis Rheum 1990;33:939-46.
16. Ohta N, Nishimura YK, Tanimoto K, et al: Association between HLA and Japanese patients with rheumatoid arthritis. Human Immunol 1982;5:123-32.
17. Olsen NJ, Callahan LF, Brooks RH, et al Associations of HLA-DR4 with rheumatoid factor and radiographic severity in rheumatoid arthritis Am J Med 1988;84:257-64.
18. Young A, Jaraquemada D, Awad J, et al: Association of HLA-DR4/Dw4 and DR2/Dw2 with radiologic changes in a prospective study of patients with rheumatoid arthritis. Arthritis Rheum 1984;27:20-5.
19. van Zeben D, Hazes JMW, Zwinderman AH, et al: Association of HLA-DR4 with a more progressive disease course in patients with rheumatoid arthritis Arthritis Rheum 1991;34:822-30.
20. McMahon MJ, Hillarby MC, Clarkson RWE, Hollis S, Grennan DM: Major histocompatibility complex variants and articular disease severity in rheumatoid arthritis. Br J Rheumatol 1993;32:899-902.
21. Vehe R, Nepom GT, Wilske K, et al: Erosive rheumatoid factor negative and positive rheumatoid arthritis are immunogenetically similar. J Rheumatol 1994;21:194-6.
22. Nepom BS, Nepom GT, Mickelson E, Schaller JG, Antonelli P, Hansen JA: Specific HLA-DR4-associated histocompatibility molecules characterize patients with seropositive juvenile rheumatoid arthritis. J Clin Invest 1984;74:287-91.
23. Weyand CM, Hicok KC, Conn DL, Goronzy JJ: The influence of HLA-DRB1 genes on disease severity in rheumatoid arthritis. Ann Intern Med 1992;117:801-6.
24. Toda Y, Minamikawa Y, Akagi S, et al: Rheumatoid-susceptible alleles to HLA-DRB1 are genetically recessive to non-susceptible alleles in the progression of bone destruction in the wrists and fingers of patients with RA. Ann Rheum Dis 1994;53:587-92.
25. Weyand CM, Goronzy JJ: Disease mechanisms in rheumatoid arthritis Gene dosage effect of HLA-DR haplotypes. J Lab Clin Med 1994;124:335-8.
26. Salmon M, Wordsworth P, Emery P, Tunn E, Bacon PA, Bell JI: The association of HLA DR B alleles with self-limiting and persistent forms of early symmetrical polyarthritis. Br J Rheumatol 1993;32:628-30.
27. Wordsworth P, Pile KD, Buckley D, et al. HLA heterozygosity contributes to susceptibility to rheumatoid arthritis. Am J Hum Genet 1992;51:585-91.
28. Willkens RF, Nepom GT, Marks CR, Nettles JW, Nepom BS: The association of HLA-Dw16 with rheumatoid arthritis in Yakima Indians: Further evidence for the "shared epitope" hypothesis. Arthritis Rheum 1991;34:43-7.
29. Thomson W, Pepper L, Payton A, et al: Absence of an association between HLA-DRB 1*04 and rheumatoid arthritis in newly diagnosed cases from the community. Annals Rheum Dis 1993;52:539-41.
30. Bulpitt K, Nepom GT, Sharp J, et al: X-ray erosions and DR4 susceptibility alleles in early active rheumatoid arthritis (abstr). Arthritis Rheum 1995;(suppl)38:S331.
31. Furst DE: Predictors of worsening clinical variables and outcomes in rheumatoid arthritis. In: Trentham DE, ed. Rheumatic Disease Clinics of North America. Philadelphia: WB Saunders, 1994:309-19.
32. Emery P: Assessment of rheumatoid arthritis - a clinician's viewpoint. J Rheumatol 1994;(suppl 42)21:20-4.
33. Gough A, Faint J, Salmon M, et al: Genetic typing of patients with inflammatory arthritis at presentation can be used to predict outcome Arthritis Rheum 1994;37:1166-70.
34. Emery P, Salmon M, Bradley H, et al: Genetically determined factors as predictors of radiological change in patient with early symmetrical arthritis. BMJ 1992;305:1387-9.
35. Nepom GT: Class II antigens and disease susceptibility. Ann Rev Med 1995;46:17-25.
36. Gersuk V, Nepom B, Nepom GT, Kochik S, Vermeulen N, Harris P: Rapid automated determination of HLA class II DR4 subtypes associated with susceptibility to rheumatoid arthritis (abstr). Arthritis Rheum 1994;(suppl)37:S330.