Lymphoproliferative responses to Borrelia burgdorferi in the diagnosis of Lyme arthritis in children and adolescents

European Journal of Pediatrics

Volumn 155, Issue 4, 1996, Pages 297-302

  Huppertz, H I ^a   Mosbauer S ^a   Busch, D H ^a   Karch, H ^b  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Borrelia burgdorferi; Lyme arthritis; Lyme borreliosis; Lymphocyte proliferation assay

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL ANTIGEN; CEFTRIAXONE; CLARITHROMYCIN; NONSTEROID ANTIINFLAMMATORY AGENT; ROXITHROMYCIN;

ADOLESCENT; ARTICLE; BORRELIA BURGDORFERI; CHILD; CONTROLLED STUDY; DIAGNOSTIC TEST; DIAGNOSTIC VALUE; FEMALE; HUMAN; LYME DISEASE; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

EID: 0029983075     PISSN: 03406199     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02002716     Document Type: Article

References (20)

1. Cassidy JT, Levinson JE, Bass JC, Baum J, Brewer EJ, Fink CW, Hanson V, Jacobs JC, Masi AT, Schaller JG, Fries JF, McShane D, Young D (1986) A study of classification criteria for a diagnosis of juvenile rheumatoid arthritis. Arthritis Rheum 29 : 274-281
2. Dattwyler RJ, Volkman DJ, Luft BJ, Halperin JJ, Thomas J, Golightly MG (1988) Seronegative Lyme disease: dissociation of the specific T- and B-lymphocyte responses to Borrelia burgdorferi. N Engl J Med 319 : 1441-1446
3. Dougados M, Linden S van der, Juhlin R, Huitfelt B, Amor B, Calin A, Cats A, Dijkmans B, Olivieri I, Pasero G, Veys E, Zeidler H (1991) The European spondyloarthropathy study group preliminary criteria for the classification of spondyloarthropathy. Arthritis Rheum 34 : 1218-1227
4. Dressler F, Yoshinari NH, Steere AC (1991) The T-cell proliferative assay in the diagnosis of Lyme disease. Ann Intern Med 115 : 533-539
5. Fink CW (1988) Reactive arthritis. Pediatr Infect Dis J 7 : 58-65
6. Häupl T, Hahn G, Rittig M, Krause A, Schoerner C, Schönherr U, Kalden JR, Burmester GR (1993) Persistence of Borrelia burgdorferi in ligamentous tissue from a patient with chronic Lyme borreliosis. Arthritis Rheum 36 : 1621-1626
7. Huppertz HI, Karch H (1991) Die Lyme-Arthritis im Kindesalter: Monarthritis des Kniegelenkes, klinisch nicht unterscheidbar von Monarthritiden unbekannter Ursache. Monatsschr Kinderheilkd 139 : 759-764
8. Huppertz HI, Schmidt H, Karch H (1993) Detection of Borrelia burgdorferi by nested polymerase chain reaction in cerebrospinal fluid and urine of children with neuroborreliosis. Eur J Pediatr 152 : 414-417
9. Huppertz HI, Horneff G, Neudorf U, Karch H (1994) Acute childhood neuroborreliosis with a selective immune response to a low molecular weight protein expressed by Borrelia garinii. Eur J Pediatr 153 : 898-902
10. Huppertz HI, Karch H, Suschke HJ, Döring E, Ganser G, Thon A, Bentas W, Pediatric Rheumatology Collaborative Group (1995) Lyme arthritis in European children and adolescents. Arthritis Rheum 38 : 361-368
11. Karch H, Huppertz HI, Böhme M, Schmidt H, Wiebecke D, Schwarzkopf A (1994) Demonstration of Borrelia burgdorferi DNA in urine samples from healthy humans whose sera contain B. burgdorferi-specific antibodies. J Clin Microbiol 32 : 2312-2314
12. Krause A, Brade V, Schoerner C, Solbach W, Kalden JR, Burmester GR (1991) T cell proliferation induced by Borrelia burgdorferi in patients with Lyme borreliosis. Arthritis Rheum 34 : 393-402
13. Kunnamo I, Kallio P, Pekonen P (1986) Incidence of arthritis in urban Finnish children. Arthritis Rheum 1986; 29 : 1232
14. Magnarelli LA, Anderson JF, Johnson RC (1987) Cross reactivity in serological tests for Lyme disease and other spirochetal infections. J Infect Dis 156 : 183-188
15. Melin-Aldana H, Giannini EH, Taylor J, Lovell DJ, Levinson JE, Passo MH, Ginsberg J, Burke MJ, Glass DN (1992) Human leukocyte antigen DRB1*1104 in the chronic iridocyclitis of pauciarticular juvenile rheumatoid arthritis. J Pediatr 121 : 56-60
16. Peltz G (1991) A role for CD4 T-cell subsets producing a selective pattern of lymphokines in the pathogenesis of human chronic inflammatory and allergic diseases. Immunol Rev 123 : 23-35
17. Roessner K, Fikrig E, Russel JQ, Cooper SM, Flavell RA, Budd RC (1994) Prominent T lymphocyte response to Borrelia burgdorferi from peripheral blood of unexposed donors. Eur J Immunol 24 : 320-324
18. Steere AC (1989) Lyme disease. N Engl J Med 321 : 586-596
19. Yssel H, Shanafelt MC, Soderberg C, Schneider PV, Anzola J, Peltz G (1991) Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis. J Exp Med 174 : 593-601
20. Zoschke DC, Skemp AA, Defosse DL (1991) Lymphoproliferative responses to Borrelia burgdorferi in Lyme disease. Ann Intern Med 114 : 285-289