The activation of murine macrophages and natural killer cells by the partially thiolated double stranded RNA poly(I)·mercapto poly(C)

Research Communications in Molecular Pathology and Pharmacology

Volumn 91, Issue 2, 1996, Pages 131-147

  Cavanaugh Jr , Paul F ^a,b   Ho, Yau Kwan ^a   Bardos, Thomas J ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL RESPONSE MODIFIER; DOUBLE STRANDED RNA; POLYINOSINIC POLYCYTIDYLIC ACID;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LABELING; DOSE TIME EFFECT RELATION; DRUG POTENCY; DRUG STRUCTURE; IMMUNOSTIMULATION; INTRAPERITONEAL DRUG ADMINISTRATION; MACROPHAGE ACTIVATION; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL;

ANIMALS; BIOLOGICAL RESPONSE MODIFIERS; CHEMISTRY, PHYSICAL; HEAT; KILLER CELLS, NATURAL; MACROPHAGE ACTIVATION; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED STRAINS; POLY I-C; RNA, DOUBLE-STRANDED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029983043     PISSN: 00345164     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Alexander, P. and Evans, R (1971), Endotoxin and double stranded RNA render macrophages cytotoxic. Nature New Biol. 232. 76-78.
2. Armstrong, J.A., McMahon, D , Huang, X..L., Pazin, G.J., Gupta, P., Rinaldo, C.R., Jr., Schoenfeld, D.A., Gaccione, P., Tripoli, C.A., and Bensasi, S , et. al. (1992). A phase I study of ampligen in human immunodeficiency virus-infected subjects. 166: 717-722.
3. Aurelian, L , Rinehart, CL, Wachsman, M., Kulka, M., and Ts'o, P.O.P. (1987). Augmentation of natural immune defense mechanisms and therapeutic potential of a mismatched double-stranded polynucleotide in cutaneous herpes simplex type 2 infection. J. Gen. Virol. 68: 2831-2838.
4. Bardos, T J., Novak, L., Chakrabarti, P., and Ho, Y-K. (1978). Partially thiolated polycytidylic acid. In: Nucleic Acid Chemistry, Edited By Townsend, L.B. and Tipson, R. S. Wiley, N. Y. USA. Pt 2, p. 881
5. Bardos, T.J., Schinazi, R F , Ling, K H., and Heider, A.R (1992). Structure-activity relationships and mode of action of 5-mercapto-substituted oligo- and polynucleotides as antitemplates inhibiting replication of human immunodeficiency virus type 1. Antimicrob. Agents Chemother. 36: 108-114.
6. Carter, W.A., Pitha, P.M , Marshall, L.W., Tazawa, I., Tazawa, S , and Ts'O, P.O.P. (1972). Structural requirements of the rIn-rCn complex for induction of human interferon. J. Mol. Biol. 70 567-587
7. Carter, W A., Ventura, D., Shapiro, D.E., Strayer, D.R., Gillespie, D H., and Hubbell, H.R. (1991) Mismatched double-stranded RNA, AMPLIGEN (poly(I):poly(C12U)), demonstrates antiviral and immunostimulatory activities in HIV disease. Int. J. Immunopharmacol. 13: 69-76
8. Cavanaugh, P F. Jr., Ho, Y-K., Hughes, R G Jr., and Bardos, T.J (1982). Selectivity of antitemplates as inhibitors of deoxyribonucleic acid polymerases. Biochem. Pharmacol. 31: 4055-4060.
9. Chandra, P. and Bardos, T.J. (1972). Inhibition of DNA-polymerases from RNA tumor viruses by novel template analogues: Partially thiolated polycytidylic acid. Res. Comm. Chem. Pathol. Pharmacol. 4:615-622.
10. Djeu, J.Y , Heinbaugh, J.A., Holden, H.T., and Herberman, R.B. (1979a). Augmentation of mouse natural killer cell activity by interferon and interferon inducers. J. Immunol. 122: 175-181.
11. Djeu, J.Y., Heinbaugh, J.A , Holden, H.T., and Herberman, R B. (1979b). Role of macrophages in the augmentation of mouse natural killer cell activity by poly I:C and interferon. J. Immunol. 122: 182-188
12. Geng, B-Q , Ho, Y-K., Hughes, R.G. Jr., and Bardos, T.J. (1991). Inhibition of human cancer cell lines in vitro with mono- and polynucleotides containing 5-mercaptocytosine bases. Acta Pharmacologica Sinica 12: 115-120.
13. Gillespie, D.H , Hubbell, H.R., Carter, W A., Midgette, P., Elsasser, W., Mullaney, R., and Strayer, D.R. (1994) Synergistic inhibition of AZT-resistant HIV by AZT combined with poly(I):poly(C12U), without synergistic toxicity to bone marrow progenitor cell elements. In Vivo 8: 375-382.
14. Heider, A R. and Bardos, T.J. (1995) Oligonucleotides and polynucleotides as potential cancer chemotherapeutic agents. In: Cancer Chemotherapeutic Agents, Edited By Foye, W O Amer. Chem. Soc , Washington, D.C. USA. pp. 529-576.
15. Herberman, R.B , Nunn, M.E., and Lavrin, D.H. (1975a). Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogenic tumors, I. Distribution of reactivity and specificity. Int. J. Cancer 16, 216-229.
16. Herberman, R.B , Nunn, M E., Holden, H.T , and Lavrin, D.H (1975b). Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. II. Characterization of effector cells. Int. J. Cancer 16: 230-239.
17. Herberman, R.B. and Pinsky, C.M. (1985). Polyribonucleotides for cancer therapy: summary and recommendations for further research. J. Biol. Resp. Mod. 4: 680-684
18. Ho, Y-K., Fiel, R J., Aradi, J., and Bardos, T.J. (1979). Structural characterization of partially thiolated poly(cytidylic acid). Biochemistry 18: 5630-5635.
19. Hochman, P S , Cudkowicz, G., and Dausset, J. (1978) Decline of natural killer cell activity in sublethally irradiated mice. J Natl. Cancer Inst. 61: 265-268.
20. Kung, M-P., Ho, Y-K., and Bardos, T.J. (1976). Action of partially thiolated polynucleotides on the DNA polymerase alpha from regenerating rat liver. Cancer Res 36: 4537-4542.
21. Kung, M-P , Ho, Y-K, and Bardos, TJ. (1982). 5-mercaptopolyuridylic acid (MPU), a potent inhibitor of reverse transcriptase from avian myeloblastosis virus. Res. Commun. Chem Pathol. Pharmacol. 36. 215-228.
22. Kung, M-P , Ho, Y-K., Lalka, D , and Bardos, T J (1984) Plasma clearance and tissue distribution of partially thiolated polycytidylic acid and its degradation products in rodents. Cancer Res. 44: 4602-4606.
23. Le, H. V. (1977) Ph.D. Thesis. State University of New York at Buffalo.
24. Levy, H.B. (1985). Historical overview of the use of polynucleotides in cancer. J. Biol. Resp Mod. 4: 475-480
25. Mikulski, A.J , Bardos, T.J., Chakrabarti, P., Kaiman, T.I , and Zsindely, A., (1973). Inhibition of DNA-dependent RNA polymerase with partially thiolated polynucleotides. Biochim. Biophys. Acta 319. 294-303
26. Mitchell, W.M., Montefiori, D.C , Robinson, W.E. Jr. (1987). Mismatched double-stranded RNA (ampligen) reduces concentration of zidovudine (azidothymidine) required for in vitro inhibition of human immunodeficiency virus. Lancet 1(8538): 890-892.
27. Montefiori, D.C., Robinson, W.E., Jr., and Mitchell, W M. (1988) Mismatched dsRNA (ampligen) induces protection against genomic variants of the human immunodeficiency virus type 1 (HIV-1) in a multiplicity of target cells. Antiviral Res. 9: 47-55.
28. Montefiori, D.C., Robinson, W.E. Jr., and Mitchell, W.M., (1989). In vitro evaluation of mismatched double-stranded RNA (ampligen) for combination therapy in the treatment of acquired immunodeficiency syndrome. AIDS Res. Hum. Retroviruses 5: 193-203.
29. Montefiori, D.C , Pellegrino, M.G., Robinson, W.E. Jr., Engle, K., Field, M., Mitchell, W.M., and Gillespie, D.H. (1989). Inhibition of HIV-1 proviral DNA synthesis and RNA accumulation by mismatched dsRNA Biochem Biophys. Res. Comm 158: 943-950.
30. O'Malley, J.A., Ho, Y-K., Chakrabarti, P., DiBerardino, L, Chandra, P., Orinda, D.A.O., Byrd, D.M., Bardos, T.J., and Carter, W.A (1975). Antiviral activity of partially thiolated polynucleotides. Molec Pharmacol 11: 61-69.
31. O'Malley, J.A., Leong, S.S., Horoszewicz, J S., Carter, W.A., Alderfer, J.L., and Ts'o, P.O.P. (1979). Polyinosinic acid-polycytidylic acid and its mismatched analogues: differential effects on human cell function. Molec. Pharmacol 15. 165-173.
32. Paffenholz, V., Le, H. V., and Bardos, T.J. (1977). Uptake of partially thiolated DNA by ascites tumor cells Cancer Res. 36: 1445-1452.
33. Pinto, A.J , Morahan, P.S., and Brinton, M A. (1988). Comparative study of various immunomodulators for macrophage and natural killer cell activation and antiviral efficacy against exotic RNA viruses Int. J. Immunol. 10: 197-209
34. Schultz, R.M., Papametheakis, J.D., Luetzeler, J., and Chirigos, M.A. (1977). Association of macrophage activation with antitumor activity by synthetic and biological agents. Cancer Res 37: 3338-3343.