Low concentrations of actinomycin D potentially cause therapeutic differentiation in human rhabdomyosarcoma cell line RD

Pathology Research and Practice

Volumn 192, Issue 2, 1996, Pages 188-194

  Melguizo, C ^a   Prados, J ^a   Marchal, J A ^b   Aranega A E ^b   Alvarez, L ^b   Aranega A ^b  

^a UNIVERSITY OF ALMERÍA   (Spain)

^b UNIVERSITY OF GRANADA   (Spain)

Author keywords

Actinomycin D; Cell differentiation; Differentiation therapy; Rhabdomyosarcoma

Indexed keywords

ANTINEOPLASTIC AGENT; DACTINOMYCIN;

ARTICLE; CANCER CHEMOTHERAPY; CELL DEATH; CELL DIFFERENTIATION; CELL LINE; CELL MATURATION; CELL PROLIFERATION; CELL ULTRASTRUCTURE; DRUG RESPONSE; HUMAN; HUMAN CELL; MORBIDITY; RHABDOMYOSARCOMA;

EID: 0029982984     PISSN: 03440338     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0344-0338(96)80219-6     Document Type: Article

References (30)

1. Aguanno S, Bouche M, Adamo S, Molinaro M (1990) 12-O-Tetradecanoylphorbol-13-acetate-induced differentation of a human rhabdomyosarcoma cell line. Cancer Res 50: 3377-3382
2. d'Amore ESG, Tollot M, Stracca-Pansa V, Menegon A, Mell S, Carli M, Ninfo V (1994) Therapy associated differentiation in rhabdomyosarcomas. Modern Pathol 7: 69-75
3. Barbet JP, Kurzenne JY, Butler-Browne GS, Mouly V, Laurent M, Gubler JP (1989) Rhabdomyosarcomas discovered in newborn infants. Study of markers of muscle differentiation. Ann Pathol 9: 363-368
4. Beksac M, Akan H, Koc H, Ilhan O, Erturk S, Guneyli A, Ikizunal Y, Sardas OS (1992) P-glycoprotein expression in refractory hematological neoplasms and circumvention of resistance with verapamil or cyclosporine A containing protocols. Med Oncol Tumor Pharmacother 9: 101-105
5. Brouwer M, Smets LA, Jongsma APM (1983) Isolation and characterization of subclones of L1210 murine leukaemia with different sensitivities to various cytotoxic agents. Cancer Res 43: 2884-2890
6. Clements GB (1975) Selection of biochemically variant, in some cases mutant, mammalian cells in culture. Adv Cancer Res 21: 273-277
7. Enzinger FM, Weiss SW (1983) Malignant tumors of uncertain histogenesis. In: Soft Tissue Tumors 780-787. St. Louis, Mosby
8. Freshney RI (1985) Induction of differentiation in neoplastic cells. Anticancer Res 5: 111-130
9. Garvin AJ, Stanley WS, Bennett D, Sullivan JL, Sens DA (1986) The in vitro growth, heterotransplantation, and differentiation of a human rhabdomyosarcoma cell line. Am J Pathol 125: 208-217
10. Gerharz CD, Gabbert HE, Engers R, Ramp H, Biesalski HK, Luley C (1989) Heterogeneous response to differentiation induction in different clonal subpoplations of a rat rhabdomyosarcoma cell line (BA-HAN-1). Cancer Res 49: 7132-7140
11. Hassan HT, Rees JK (1989) Low concentrations of cytosine arabinoside, 6-thioguanine, actinomycin D and aclacinomycin A stimulates the differentiation of normal human marrow myeloid progenitor cells. Med Oncol Tumor Pharmacother 6: 213-217
12. Hassan HT, Rees JK (1990) Triple combination of retinoic acid plus actinomycin D plus dimethylformamide induces differentiation of human acute myeloid leukaemic blast in primary cultures. Cancer Chemother Pharmacol 26: 26-30
13. Honma Y, Honma C, Bloch A (1986) Mechanism of interaction between antineoplastic agents and natural differentiation factors in the induction of human leukemic cell maturation. Cancer Res 46: 6311-6315
14. Ishiguro K, Schwartz EL, Sartorelli AC (1984) Characterization of the metabolic forms of 6-thioguanine responsible for cytotoxicity and induction of differentiation of HL-60 acute promyelocytic leukemia cells. J Cell Physiol 121: 383-389
15. Kaye SB (1993) P-glycoprotein and drug resistance -time for reappraisal? Br J Cancer 67: 641-643
16. Kodet R (1989) Rhabdomyosarcoma in childhood. An immunohistological analysis with myoglobin, desmin and vimentin. Path Res Pract 13S: 207-213
17. Levine EA, Holzmayer TA, Roninson IB, Das Gupta TK (1993) MDR 1 expression in metastatic malignant melanoma. J Surg Res 54: 621-624
18. Lollini PL, De Giovanni C, Del Re B, Landuzzi L, Nicoletti G, Prodi G (1989) Myogenic differentiation of human rhabdomyosarcoma cells induced in vitro by antineoplastic drugs. Cancer Res 49: 3631-3636
19. Melguizo C, Prados J, Fernández JE, Vélez C, Alvarez L, Aránega A (1994) Actinomycin D causes multidrug resistance and differentiation in a human cell line of rhabdomyosarcoma. Cell Mol Biol 40: 137-145
20. Melguizo C, Prados J, Aneiros J, Fernández JE, Vélez C, Aránega A (1995) Differentiation of a human rhabdomyosarcoma cell line after antineoplastic drug treatment. J. Pathol 175: 23-29
21. Molenaar WM, Oosterhuis MD, Kamps WA (1984) Cytologie differentiation in childhood rhabdomyosarcomas following polychemotherapy. Human Pathol 15: 973-979
22. Prados J, Melguizo C, Fernández JE, Aránega AE, Alvarez L, Aránega A (1993) Actin, tropomyosin and alpha-actinin as markers of differentiation in human rhabdomyosarcoma cell lines induced with dimethyl sulfoxide. Cell Mol Biol 39: 525-536
23. Rangdaeng S, Troung LD (1992) Comparative immunohistochemical staining for desmin and muscle-specific actin. Am J Clin Pathol 96: 32-38
24. Reiss M, Gamba-Vitalo C, Sartorelli AC (1986) Induction of tumor cell differentiation as a therapeutic approach: Preclinical models for hematopoietic and solid neoplasms. Cancer Treat Rep 70: 201-218
25. Sachs L (1987) Cell differentiation and bypassing of genetic defects in the suppression of malignancy. Cancer Res 47: 1981-1986
26. Sartorelli A (1985) Malignant cell differentiation as a potential therapeutic approach. Br J Cancer 52: 293-302
27. Skipper HE, Schabel FM, Lloyd HH (1978) Experimental therapeutics and kinetics. Selection and overgrouth of specifically and permanently drug-resistant tumour cells. Semin Hematol 15: 207-211
28. Tabata M, Ohnoshi T, Ueoka H, Kiura K, Kimura I (1993) MDR 1 gen expression and treatment outcome in small cell lung cancer: MDR 1 gene expression as an independent prognostic factor. Acta Med Okayama 47: 243-248
29. Vergier B, Cany L, Bonnet F, Robert J, De Mascarel A, Coindre JM (1993) Expression of MDR 1/P-glycoproetin in human sarcomas. Br J Cancer 68: 1221-1226
30. Vaxman S (1990) Meeting report: differentiation therapy. Cancer Res 50: 3453-3464