TCR triggering of anergic CD4 T cells in murine AIDS induces apoptosis rather than cytokine synthesis and proliferation

Journal of Immunology

Volumn 157, Issue 2, 1996, Pages 625-635

  Muralidhar, Girija ^a   Koch, Susanne ^a   Broome, H Elizabeth ^b   Swain, Susan L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CD4 ANTIGEN; CYTOKINE; INTERLEUKIN 2; OKT 3; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN BCL 2; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL CYCLE; CELL DEATH; CLONAL ANERGY; CONTROLLED STUDY; ETIOLOGY; LYMPHADENOPATHY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RODENT DISEASE; SIGNAL TRANSDUCTION; SPLENOMEGALY; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; APOPTOSIS; BASE SEQUENCE; BROMODEOXYURIDINE; CD4-POSITIVE T-LYMPHOCYTES; CELL CYCLE; CLONAL ANERGY; CYTOKINES; GENES, BCL-2; INTERLEUKIN-2; LEUKEMIA VIRUS, MURINE; LEUKEMIA, EXPERIMENTAL; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MURINE ACQUIRED IMMUNODEFICIENCY SYNDROME; RECEPTORS, ANTIGEN, T-CELL; RETROVIRIDAE INFECTIONS; SIGNAL TRANSDUCTION; TUMOR VIRUS INFECTIONS;

EID: 0029982871     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Jolicoeur, P. 1991. Murine acquired immunodeficiency syndrome (MAIDS): an animal model to study the AIDS pathogenesis. FASEB J. 5:2398.
2. Morse, H. C., III, S. K. Chattopadhyay, M. Makino, T. N. Fredrickson, A. W. Hugin, and J. W. Hartley. 1992. Retrovirus-induced immunodeficiency in the mouse: MAIDS as a model for AIDS. AIDS 6:607.
3. Muralidhar, G., S. Koch, M. Haas, and S. L. Swain. 1992. CD4 T cells in MAIDS: polyclonal progression to anergy. J. Exp. Med. 175:1589.
4. Koch, S., G. Muralidhar, and S. L. Swain. 1994. Both naive and memory CD4 T cell subsets become anergic during MAIDS and each subset can sustain disease. J. Immunol. 152:5548.
5. Gougeon, M. L., and L. Montagnier. 1993. Apoptosis in AIDS. Science 260: 1269.
6. Banda, N. K., J. Bernier, D. K. Kurahara, R. Kurrle, N. Haigwood, S. R. P, and T. H. Finkel. 1992. Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis. J. Exp. Med. 176:1099.
7. Gougeon, M. L., A. G. Laurent-Crawford, A. G. Hovanessian, and L. Montagnier. 1993. Direct and indirect mechanisms mediating apoplosis during HIV infection: contribution to in vivo CD4 T cell depletion. Semin. Immunol. 5:187.
8. + T cells during murine AIDS. Cell. Immunol. 151:392.
9. Howie, S. E. M., D. J. Harrison, and A. H. Wyllie. 1994. Lymphocyte apoptosis: mechanisms and implications in disease. Immunol. Rev. 142:141.
10. Zhang, X., L. Giangreco, H. E. Broome, C. M Dargan, and S. L. Swain. 1995. Control of CD4 effector fate: TGFβ1 and IL-2 synergize to prevent apoptosis and promote effector expansion. J. Exp. Med. 182:699.
11. + T cells in mice tolerant to Staphylococcus aureus enterotoxin B. Nature 349:245.
12. Mueller, D. L., M. K. Jenkins, and R. H. Schwartz. 1989. Clonal expansion versus functional clonal inactivation: a costimulatory pathway determines the outcome of T cell receptor occupancy. Annu. Rev. Immunol. 7:445.
13. Gill, B. M., H. Nishikata, G. Chan, T. L. Delovitch, and A. Ochi. 1994. Fas antigen and sphingomyelin-ceramide turnover-mediated signaling: role in life and death of T lymphocytes. Immunol. Rev. 142:114.
14. Brunner, T., R. J. Mogil, D. LaFace, N. J. Yoo, A. Mahboubi, F. Echeverri, S. J. Martin, W. R. Force, D. H. Lynch, C. F. Ware, and D. R. Green. 1995. Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature 373:441.
15. Dhein, J., H. Walczak, C. Baumler, K. M. Debatin, and P. H. Krammer. 1995. Autocrine T-cell suicide mediated by APO-1/(Fas-CD95). Nature 373:438.
16. Ju, S. T., D. J. Panka, H. Cui, R. Ettinger, M. El-Khatib, D. H. Sherr, B. Z. Stanger, and A. Marshak-Rothstein. 1995. Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature 373:444.
17. Williams, G. T., and C. A. Smith. 1993. Molecular regulation of apoptosis: genetic controls on cell death. Cell 74:777.
18. Hawkins, C. J., and D. L. Vaux. 1994. Analysis of the role of bcl-2 in apoptosis. Immunol. Rev. 142:128.
19. Akbar, A. N., N. Borthwick, M. Salmon, W. Gombert, M. Bofill, N. Shamsadeen, D. Pilling, S. Pett, J. E. Grundy, and G. Janossay. 1993. The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infection: the role of apoptosis in memory. J. Exp. Med. 178:427.
20. Haas, M., and T. Reshef. 1980. Non-malignant lymphomas induced in C57BL/6 mice by cloned dual tropic viruses isolated from hematopoietic stromal cell lines. Eur. J. Cancer. 16:909.
21. Karasuyama, H., and F. Melchers. 1988. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2,3,4 and 5 using cDNA expression vectors. Eur. J. Immunol. 18:97.
22. Tough, D. F., and J. Sprent. 1994. Turnover of naive- and memory-phenotype T cells. J. Exp. Med. 179:1127.
23. Muralidhar, G., H. Sepulveda, A. Feeney, R. Riblet, and R. W. Dutton. 1992. V gene specific regulation of immunoglobulin gene expression. I. Igh V gene usage in the response to the ese epitope on 'Hi' SRBC. J. Immunol. 149:3574.
24. Nicoletti, I., G. Migliorati, M. C. Paliacci, F. Grignanci, and F. Riccardi. 1991. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods 139:271.
25. Darzynkiewicz, Z., S. Bruno, G. Del Bino, W. Gorczyca, M. Hotz, P. Lassota, and F. Traganos. 1991. Features of apoptotic cells measured by flow cytometry. Cytometry 13:795.
26. Broome, H. E., C. M. Dargan, E. F. Bessent, S. Krajewski, and J. C. Reed. 1995. Apoptosis and Bcl-2 expression in cultured murine splenic T cells. Immunology 84:375.
27. Gorczyca, W., K. Bigman, A. Mittelman, T. Ahmed, J. Gong, M. R. Mellamed, and Z. Darzynkiewicz. 1993. Induction of DNA strand breaks associated with apoptosis during treatment of leukemias. Leukemia 7:659.
28. Wetzel, G. D., S. L. Swain, R. W. Dutton, and J. R. Kettman. 1984. Evidence for two distinct activation states available to B lymphocytes. J. Immunol. 133:2327.
29. Zhu, L., and C. Anasetti. 1995. Cell cycle control of apoptosis in human leukemia T cells. J. Immunol. 154:192.
30. Boehme, S. A., and M. J. Lenardo. 1993. Propriocidal apoptosis of mature T lymphocytes occurs at S phase of the cell cycle. Eur. J. Immunol. 23:1552.
31. Shan, B., and W. H. Lee. 1994. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol. Cell. Biol. 14:8166.
32. Herman, A., J. W. Kappler, P. Marrack, and A. Pullen. 1991. Superantigens: mechanisms of T-cell stimulation and role in immune responses. Annu. Rev. Immunol. 9:745.
33. + T cells in Staphylococcus enterotoxin B-primed mice. J. Exp. Med. 172:7065.
34. Hugin, A. W., M. S. Vacchio, and H. C. Morse III. 1991. A virus encoded "superantigen" in a retrovirus-induced immunodeficiency syndrome of mice. Science 252:424.
35. Giese, N. A., T. Giese, and H. C. Morse III. 1994. Murine AIDS is an antigen-driven disease: requirement for major histocompatibility complex class II expression and CD4 T cells. J. Virol. 68:5819.
36. + T cells from human immunodeficiency virus-infected asymptomatic individuals. J. Exp. Med. 175:331.
37. Gougeon, M. L., S. Garcia, J. Heeney, R. Tschopp, H. Lecoeur, D. Guetard, V. Rame, C. Dauguet, and L. Montagnier. 1993. Programmed cell death in AIDS-related HIV and SIV infections. AIDS Res. Hum. Retroviruses. 9:553.
38. Clerici, M., D. R. Lucey, J. A. Berzofsky, L. A. Pinto, T. A. Wynn, S. P. Blatt, M. J. Dolan, C. W. Hendrix, S. F. Wolf, and G. M. Shearer. 1993. Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro. Science 262:1721.
39. Mizuochi, T., J. Mizuguchi, T. Uchida, K. Ohnishi, M. Nakanishi, Y. Asano, T. Kakiuch, Y. Fukushima, K. Okuyama, H. C. Morse III, and K. Komuro. 1990. A selective signaling defect in helper T cells induced by antigen-presenting cells from mice with murine acquired immunodeficiency syndrome. J. Immunol. 144: 313.
40. Selvey, L. A., H. C. Morse III, C. H. June, and R. J. Hodes. 1994. Analysis of antigen receptor signaling in B cells from mice with a retrovirus-induced acquired immunodeficiency syndrome. J. Immunol. 154:171.
41. Suzuki, G., M. Nomura, A. Uzawa, M. Akashi, and Y. Nakata. 1995. Impaired CD28-mediated costimulation in anergic T cells. Int. Immunol. 7:37.
42. Razvi, E. S., and R. M. Welch. 1993. Programmed cell death of T lymphocytes during acute viral infection: a mechanism for virus induced immunodeficiency. J. Virol. 67:5754.
43. Hiromatsu, K., Y. Aoki, M. Makino, Y. Matsumoto, T. Mizuochi, Y. Gotoh, K. Nomoto, J. Ogasawara, S. Nagata, and Y. Yoshikai. 1994. Increased Fas antigen expression in murine retrovirus-induced immunodeficiency syndrome, MAIDS. Eur. J. Immunol. 24:2446.
44. Kanagawa, O., B. A. Vaupel, S. J. Korsmeyer, and J. H Russel. 1995. Apoptotic death of lymphocytes in murine acquired immunodeficiency syndrome: involvement of Fas-Fas ligand interaction. Eur. J. Immunol 25:2421.
45. O'Rourke, A. M., M. F. Mescher, and S. R. Webb. 1990. Activation of polyphosphoinositide hydrolysis in T cells by H-2 alloantigen but not Mls determinants. Science 249:171.
46. Gaugler, B., C. Langlet, J. M. Martin, A. M. Schmitt-Verhulst, and A. Guimezanes. 1991. Evidence for quantitative and qualitative difference in functional activation of Mls-reactive T cell clones and hybridomas by antigen or TCR/CD3 antibodies. Eur. J. Immunol. 21:2581.
47. Weber, G., S. Abromson-Leeman, and H. Cantor. 1995. A signaling pathway coupled to T cell receptor ligation by MMTV superantigen leading to transient activation and programmed cell death. Cell 2:363.