SIN3-dependent transcriptional repression by interaction with the Mad1 DNA-binding protein

Molecular and Cellular Biology

Volumn 16, Issue 8, 1996, Pages 4215-4221

  Kasten, Margaret M ^a   Ayer, Donald E ^a,b   Stillman, David J ^a  

^a UNIVERSITY OF UTAH   (United States)

^b USA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; HELIX LOOP HELIX PROTEIN; LEUCINE ZIPPER PROTEIN; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; INHIBITION KINETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN INTERACTION; REPRESSOR GENE; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; TRANSCRIPTION REGULATION;

EID: 0029982704     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.8.4215     Document Type: Article

References (50)

1. Amati, B., M. W. Brooks, N. Levy, T. D. Littlewood, G. I. Evans, and H. Land. 1993. Oncogenic activity of the c-Myc protein requires dimerization with Max. Cell 72:233-245.
2. Amati, B., S. Dalton, M. W. Brooks, T. D. Littlewood, G. I. Evan, and H. Land. 1992. Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max. Nature (London) 359:423-426.
3. Ayer, D. E., and R. N. Eisenman. 1993. A switch from Myc:Max to Mad:Max heterocomplexes accompanies monocyte/macrophage differentiation. Genes Dev. 7:2110-2119.
4. Ayer, D. E., L. Kretzner, and R. N. Eisenman. 1993. Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity. Cell 72:211-222.
5. Ayer, D. E., C. D. Laherty, Q. A. Lawrence, A. Armstrong, and R. N. Eisenman. Mad proteins contain a dominant transcription repression domain. Submitted for publication.
6. Ayer, D. E., Q. A. Lawrence, and R. N. Eisenman. 1995. Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. Cell 80:767-776.
7. Blackwood, E. M., B. Lüscher, and R. N. Eisenman. 1992. Myc and Max associate in vivo. Genes Dev. 6:71-80.
8. Bowdish, K. S., and A. P. Mitchell. 1993. Bipartite structure of an early meiotic upstream activation sequence from Saccharomyces cerevisiae. Mol. Cell. Biol. 13:2172-2181.
9. Breeden, L., and K. Nasmyth. 1987. Cell cycle control of the yeast HO gene: cis- and trans-acting regulators. Cell 48:389-397.
10. Chen, J. D., and R. M. Evans. 1995. A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature (London) 377:454-457.
11. Chien, C., P. L. Bartel, R. Sternglanz, and S. Fields. 1991. The two-hybrid system: a method to identity and clone genes for proteins that interact with a protein of interest. Proc. Natl. Acad. Sci. USA 88:9578-9582.
12. Chin, L., N. Schreiber-Agus, I. Pellicer, K. Chen, H.-W. Lee, M. Dudast, C. Cordon-Cardo, and R. A. DePinho. 1995. Contrasting roles for Myc and Mad proteins in cellular growth and differentiation. Proc. Natl. Acad. Sci. USA 92:8488-8492.
13. Dawson, S. R., D. L. Turner, H. Weintraub, and S. M. Parkhurst. 1995. Specificity for the hairy/enhancer of split basic helix-loop-helix (bHLH) proteins maps outside the bHLH domain and suggests two separable modes of transcriptional repression. Mol. Cell. Biol. 15:6923-6931.
14. Fields, S., and O. Song. 1989. A novel genetic system to detect protein-protein interactions. Nature (London) 340:245-246.
15. Hanes, S. D., and R. Brent. 1989. DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9. Cell 57:1275-1283.
16. Hörlein, A. J., A. M. Näär, T. Heinzel, J. Torchia, B. Gloss, R. Kurokawa, A. Ryan, Y. Kamei, M. Söderström, C. K. Glass, and M. G. Rosenfeld. 1995. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature (London) 377:397-404.
17. Hudak, K., J. Lopes, and S. Henry. 1994. A pleiotropic phospholipid biosynthetic regulatory mutation in Saccharomyces cerevisiae is allelic to sin3 (sdi1, ume4, rpd1). Genetics 136:475-483.
18. Hudak, K., J. Lopes, and S. Henry. Personal communication.
19. Hurlin, P. J., C. Queva, P. J. Koskinen, E. Steingrimsson, D. E. Ayer, N. G. Copeland, N. A. Jenkins, and R. N. Eisenman. 1995. Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. EMBO J. 14:5646-5659.
20. Jiang, Y. W., P. R. Dohrmann, and D. J. Stillman. 1995. Genetic and physical interactions between yeast RGR1 and SIN4 in chromatin organization and transcriptional regulation. Genetics 140:47-54.
21. Jiang, Y. W., and D. J. Stillman. 1995. Regulation of HIS4 expression by the Saccharomyces cerevisiae SIN4 transcriptional regulator. Genetics 140:103-114.
22. Jones, N. 1990. Transcriptional regulation by dimerization: two sides to an incestuous relationship. Cell 61:9-11.
23. Kasten, M. M., and D. J. Stillman. Unpublished data.
24. Keleher, C. A., M. J. Redd, J. Schultz, M. Carlson, and A. D. Johnson. 1992. Ssn6/Tup1 is a general repressor of transcription in yeast. Cell 68:709-719.
25. Komachi, K., M. J. Redd, and A. D. Johnson. 1994. The WD repeats of Tup1 interact with the homeo domain protein alpha 2. Genes Dev. 8:2857-2867.
26. Kretzner, L., E. M. Blackwood, and R. N. Eisenman. 1992. Myc and Max proteins possess distinct transcriptional activities. Nature (London) 359:426-429.
27. Lamb, J. R., S. Tugendreich, and P. Hieter. 1995. Tetratrico peptide repeat interactions: to TPR or not to TPR? Trends Biochem. Sci. 20:257-259.
28. Mukherjee, B., S. D. Morgenbesser, and R. A. DePinho. 1992. Myc family oncoproteins function through a common pathway to transform normal cells in culture: cross-interference by Max and trans-acting dominant mutants. Genes Dev. 6:1480-1492.
29. Mylin, L. M., J. P. Bhat, and J. E. Hopper. 1989. Regulated phosphorylation and dephosphorylation of GAL4, a transcriptional activator. Genes Dev. 3:1157-1165.
30. Nasmyth, K., D. Stillman, and D. Kipling. 1987. Both positive and negative regulators of HO transcription are required for mother-cell-specific mating-type switching in yeast. Cell 48:579-587.
31. Park, H. O., J. Chant, and I. Herskowitz. 1993. BUD2 encodes a GTPase-activating protein for Bud1/Rsr1 necessary for proper bud-site selection in yeast. Nature (London) 365:269-274.
32. Paroush, Z., R. L. Finley, Jr., T. Kidd, S. M. Wainwright, P. W. Ingham, R. Brent, and D. Ish-Horowitz. 1994. Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins. Cell 79:805-815.
33. Schreiber-Agus, N., L. Chin, K. Chen, R. Torres, G. Rao, P. Guida, A. I. Skoultchi, and R. A. DePinho. 1995. An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3. Cell 80:777-786.
34. Sherman, F. 1991. Getting started with yeast. Methods Enzymol. 194:1-21.
35. Sikorski, R. S., and P. Hieter. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122:19-27.
36. Song, D., J. W. Dolan, Y. L. Yuan, and S. Fields. 1991. Pheromone-dependent phosphorylation of the yeast STE12 protein correlates with transcriptional activation. Genes Dev. 5:741-750.
37. Sternberg, P. W., M. J. Stern, I. Clark, and I. Herskowitz. 1987. Activation of the yeast HO gene by release from multiple negative controls. Cell 48: 567-577.
38. Strich, R., M. R. Slater, and R. E. Esposito. 1989. Identification of negative regulatory genes that govern the expression of early meiotic genes in yeast. Proc. Natl. Acad. Sci. USA 86:10018-10022.
39. Treitel, M. A., and M. Carlson. 1995. Repression by SSN6-TUP1 is directed by MIG1, a repressor/activator protein. Proc. Natl. Acad. Sci. USA 92:3132-3136.
40. Tzamarias, D., and K. Struhl. 1994. Functional dissection of the yeast Cyc8-Tup1 transcriptional co-repressor complex. Nature (London) 369:758-761.
41. Tzamarias, D., and K. Struhl. 1995. Distinct TPR motifs of Cyc8 are involved in recruiting the Cyc8-Tup1 corepressor complex to differentially regulated promoters. Genes Dev. 9:821-831.
42. Vidal, M., R. Strich, R. E. Esposito, and R. F. Gaber. 1991. RPD1 (SIN3/ UME4) is required for maximal activation and repression of diverse yeast genes. Mol. Cell. Biol. 11:6306-6316.
43. Vojtek, A. B., S. M. Hollenberg, and J. A. Cooper. 1993. Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74:205-214.
44. Wang, H., I. Clark, P. R. Nicholson, I. Herskowitz, and D. J. Stillman. 1990. The Saccharomyces cerevisiae SIN3 gene, a negative regulator of HO, contains four paired amphipathic helix motifs. Mol. Cell. Biol. 10:5927-5936.
45. Wang, H., L. Reynolds-Hager, and D. J. Stillman, 1994. Genetic interactions between SIN3 and the Saccharomyces cerevisiae MCM1, STE12, and SWI1 transcriptional activators. Mol. Gen. Genet. 245:675-685.
46. Wang, H., and D. J. Slillman. 1990. In vitro regulation of a SIN3-dependent DNA-binding activity by stimulatory and inhibitory factors. Proc. Natl. Acad. Sci. USA 87:9761-9765.
47. Wang, H., and D. J. Stillman. 1993. Transcriptional repression in Saccharomyces cerevisiae by a SIN3-LexA fusion protein. Mol. Cell. Biol. 13:1805-1814.
48. Williams, F. E., U. Varanasi, and R. T. Trumbly. 1991. The CYC8 and TUP1 proteins involved in glucose repression in Saccharomyces cerevisiae are associated in a protein complex. Mol. Cell. Biol. 11:3307-3316.
49. Yoshimoto, H., M. Ohmae, and I. Yamashita, 1992. The Saccharomyces cerevisiae GAM2/SIN3 protein plays a role in both activation and repression of transcription. Mol. Gen. Genet. 233:327-330.
50. Zervos, A. S., J. Gyuris, and R, Brent 1993. Mxi1, a protein that specifically interacts with Max to hind Myc-Max recognition sites. Cell 72:223-232.