메뉴 건너뛰기




Volumn 10, Issue 3, 1996, Pages 275-279

The parathyroid calcium receptor: A novel therapeutic target for treating hyperparathyroidism

Author keywords

Calcimimetic hyperparathyroidism; Calcitonin; Calcium; Calcium receptor; End stage renal disease; Parathyroid hormone

Indexed keywords

CALCITONIN; CALCIUM ION; CELL SURFACE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; METABOTROPIC RECEPTOR; N [3 (2 CHLOROPHENYL)PROPYL] 1 (3 METHOXYPHENYL)ETHYLAMINE; PARATHYROID HORMONE; RECEPTOR; UNCLASSIFIED DRUG;

EID: 0029982638     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00866757     Document Type: Conference Paper
Times cited : (36)

References (30)
  • 1
    • 0026467550 scopus 로고
    • Primary hyperparathyroidism: Recent advances in pathogenesis, diagnosis, and management
    • Heath H III (1991) Primary hyperparathyroidism: recent advances in pathogenesis, diagnosis, and management. Adv Intern Med 37: 275-293
    • (1991) Adv Intern Med , vol.37 , pp. 275-293
    • Heath III, H.1
  • 2
    • 0002915009 scopus 로고
    • Hyperparathyroidism in renal failure. Clinical features, diagnosis, and management
    • Bilezikian JP, Levine MA, Marcus R, (eds) Raven, New York
    • Coburn JW, Salusky IB (1994) Hyperparathyroidism in renal failure. Clinical features, diagnosis, and management. In: Bilezikian JP, Levine MA, Marcus R, (eds) The parathyroids. Raven, New York, pp 519-529
    • (1994) The Parathyroids , pp. 519-529
    • Coburn, J.W.1    Salusky, I.B.2
  • 4
    • 0022558902 scopus 로고
    • 2+ and the regulation of secretion in parathyroid cells
    • 2+ and the regulation of secretion in parathyroid cells. FEBS Lett 203: 15-19
    • (1986) FEBS Lett , vol.203 , pp. 15-19
    • Nemeth, E.F.1    Scarpa, A.2
  • 6
    • 0028924833 scopus 로고
    • Cloning and functional expression of a rat kidney extracellular calcium/polyvalent cation-sensing receptor
    • Riccardi D, Park J, Lee W-S, Gamba G, Brown EM, Hebert SC (1995) Cloning and functional expression of a rat kidney extracellular calcium/polyvalent cation-sensing receptor. Proc Natl Acad Sci USA 92: 131-135
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 131-135
    • Riccardi, D.1    Park, J.2    Lee, W.-S.3    Gamba, G.4    Brown, E.M.5    Hebert, S.C.6
  • 7
    • 0024552847 scopus 로고
    • Divalent cations suppress 3′,5′-adenosine monophosphate accumulation by stimulating a pertussis toxin-sensitive guanine nucleotide-binding protein in cultured bovine parathyroid cells
    • Chen CJ, Barnett JV, Congo DA, Brown EM (1989) Divalent cations suppress 3′,5′-adenosine monophosphate accumulation by stimulating a pertussis toxin-sensitive guanine nucleotide-binding protein in cultured bovine parathyroid cells. Endocrinology 124: 233-239
    • (1989) Endocrinology , vol.124 , pp. 233-239
    • Chen, C.J.1    Barnett, J.V.2    Congo, D.A.3    Brown, E.M.4
  • 9
    • 0023654485 scopus 로고
    • 2+ in bovine parathyroid cells evoked by extracellular divalent cations. Evidence for a cell surface calcium receptor
    • 2+ in bovine parathyroid cells evoked by extracellular divalent cations. Evidence for a cell surface calcium receptor. J Biol Chem 262: 5188-5196
    • (1987) J Biol Chem , vol.262 , pp. 5188-5196
    • Nemeth, E.F.1    Scarpa, A.2
  • 10
    • 0025922923 scopus 로고
    • 2+ and other ions as extracellular (first) messengers
    • 2+ and other ions as extracellular (first) messengers. Physiol Rev 71: 371-411
    • (1991) Physiol Rev , vol.71 , pp. 371-411
    • Brown, E.M.1
  • 11
    • 21844524135 scopus 로고
    • 2+ receptor-dependent regulation of cellular functions
    • 2+ receptor-dependent regulation of cellular functions. News in Physiol Sci 10: 1-5
    • (1995) News in Physiol Sci , vol.10 , pp. 1-5
    • Nemeth, E.F.1
  • 13
    • 0027522832 scopus 로고
    • Calcium infusion suggests a "set-point" abnormality of parathyroid gland function in familial benign hypercalcemia and more complex disturbances in primary hyperparathyroidism
    • Khosla S, Ebeling PR, Firek AF, Burritt MM, Kao PC, Heath H III (1993) Calcium infusion suggests a "set-point" abnormality of parathyroid gland function in familial benign hypercalcemia and more complex disturbances in primary hyperparathyroidism. J Clin Endocrinol Metab 76: 715-720
    • (1993) J Clin Endocrinol Metab , vol.76 , pp. 715-720
    • Khosla, S.1    Ebeling, P.R.2    Firek, A.F.3    Burritt, M.M.4    Kao, P.C.5    Heath III, H.6
  • 14
    • 0001427257 scopus 로고
    • Calcimimetics: Structurally and mechanistically novel compounds that inhibit hormone secretion from parathyroid cells
    • Steffey ME, Fox J, Van Wagenen BC, DelMar EG, Balandrin MF, Nemeth EF (1993) Calcimimetics: structurally and mechanistically novel compounds that inhibit hormone secretion from parathyroid cells. J Bone Miner Res 8: S175
    • (1993) J Bone Miner Res , vol.8
    • Steffey, M.E.1    Fox, J.2    Van Wagenen, B.C.3    DelMar, E.G.4    Balandrin, M.F.5    Nemeth, E.F.6
  • 16
    • 0025787210 scopus 로고
    • Neomycin mimics the effects of high extracellular calcium concentrations on parathyroid function in dispersed bovine parathyroid cells
    • Brown EM, Katz C, Butters R, Kifor O (1991) Neomycin mimics the effects of high extracellular calcium concentrations on parathyroid function in dispersed bovine parathyroid cells. Endocrinology 128: 3047-3054
    • (1991) Endocrinology , vol.128 , pp. 3047-3054
    • Brown, E.M.1    Katz, C.2    Butters, R.3    Kifor, O.4
  • 17
    • 0001566242 scopus 로고
    • A first generation calcimimetic compound (NPS R-568) that acts on the parathyroid cell calcium receptor: A novel therapeutic approach for hyperparathyroidism
    • Fox J, Hadfield S, Petty BA, Nemeth EF (1993) A first generation calcimimetic compound (NPS R-568) that acts on the parathyroid cell calcium receptor: a novel therapeutic approach for hyperparathyroidism. J Bone Miner Res 8: S181
    • (1993) J Bone Miner Res , vol.8
    • Fox, J.1    Hadfield, S.2    Petty, B.A.3    Nemeth, E.F.4
  • 19
    • 0013579956 scopus 로고
    • NPS R-568 acts on calcium receptors to inhibit parathyroid hormone and stimulate calcitonm secretion: A novel therapeutic approach for hyperparathyroidism
    • Fox J, Hadfield S, Petty BA, Conklin RL, Nemeth EF (1993) NPS R-568 acts on calcium receptors to inhibit parathyroid hormone and stimulate calcitonm secretion: a novel therapeutic approach for hyperparathyroidism. J Am Soc Nephrol 4: 719
    • (1993) J Am Soc Nephrol , vol.4 , pp. 719
    • Fox, J.1    Hadfield, S.2    Petty, B.A.3    Conklin, R.L.4    Nemeth, E.F.5
  • 20
    • 0025279014 scopus 로고
    • Regulation of cytosolic calcium by extracellular divalent cations in C-cells and parathyroid cells
    • Nemeth EF (1990) Regulation of cytosolic calcium by extracellular divalent cations in C-cells and parathyroid cells. Cell Calcium 11:323-327
    • (1990) Cell Calcium , vol.11 , pp. 323-327
    • Nemeth, E.F.1
  • 21
    • 0037652211 scopus 로고
    • Prevention of hypocalcemia prolongs the plasma parathyroid hormone and calcitonin responses to the calcimimetic compound NFS R-568 in rats
    • Fox J, Conklin RL, Hadfield S, Petty BA, Nemeth EF (1994) Prevention of hypocalcemia prolongs the plasma parathyroid hormone and calcitonin responses to the calcimimetic compound NFS R-568 in rats. J Bone Miner Res 9: S409
    • (1994) J Bone Miner Res , vol.9
    • Fox, J.1    Conklin, R.L.2    Hadfield, S.3    Petty, B.A.4    Nemeth, E.F.5
  • 22
    • 0002857008 scopus 로고
    • Inhibition of human parathyroid hormone secretion in vivo by NPS R-568, a calcimimetic drug that targets the parathyroid cell-surface calcium receptor
    • Heath H III, Sanguinetti EL, Oglesby S, Marriott TB (1995) Inhibition of human parathyroid hormone secretion in vivo by NPS R-568, a calcimimetic drug that targets the parathyroid cell-surface calcium receptor. Bone 16: 85S
    • (1995) Bone , vol.16
    • Heath III, H.1    Sanguinetti, E.L.2    Oglesby, S.3    Marriott, T.B.4
  • 23
    • 0028211726 scopus 로고
    • Pathogenesis of secondary hyperparathyroidism
    • Slatopolsky E, Delmez JA (1994) Pathogenesis of secondary hyperparathyroidism. Am J Kidney Dis 23: 229-236
    • (1994) Am J Kidney Dis , vol.23 , pp. 229-236
    • Slatopolsky, E.1    Delmez, J.A.2
  • 25
    • 0013579956 scopus 로고
    • NPS R-568 inhibits parathyroid hormone secretion and stimulates calcitonin secretion in hyperparathyroid rats with chronic renal failure
    • Fox J, Hadfield S, Petty BA, Conklin RL, Nemeth EF (1993) NPS R-568 inhibits parathyroid hormone secretion and stimulates calcitonin secretion in hyperparathyroid rats with chronic renal failure. J Am Soc Nephrol 4: 719
    • (1993) J Am Soc Nephrol , vol.4 , pp. 719
    • Fox, J.1    Hadfield, S.2    Petty, B.A.3    Conklin, R.L.4    Nemeth, E.F.5
  • 27
    • 0007804695 scopus 로고
    • The calcimimetic NPS R-568 prevents the development of secondary hyperparathyroidism and elevated bone formation in rats with mild chronic renal insufficiency
    • Fox J, Miller MA, Conklin RL, Lowe SH, Petty BA, Nemeth EF (1995) The calcimimetic NPS R-568 prevents the development of secondary hyperparathyroidism and elevated bone formation in rats with mild chronic renal insufficiency. J Bone Miner Res 10: S191
    • (1995) J Bone Miner Res , vol.10
    • Fox, J.1    Miller, M.A.2    Conklin, R.L.3    Lowe, S.H.4    Petty, B.A.5    Nemeth, E.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.