A history of immunosuppressive drugs in the treatment of inflammatory bowel disease: Origins at The Mount Sinai Hospital

Mount Sinai Journal of Medicine

Volumn 63, Issue 3-4, 1996, Pages 191-201

  Korelitz, Burton I ^a   Present, Daniel H ^a  

^a NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CORTICOSTEROID; CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; MERCAPTOPURINE;

CROHN DISEASE; ENTERITIS; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; ORAL DRUG ADMINISTRATION; REVIEW; ULCERATIVE COLITIS;

6-MERCAPTOPURINE; AZATHIOPRINE; CYCLOSPORINE; FEMALE; HISTORY, 20TH CENTURY; HOSPITALS, TEACHING; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATORY BOWEL DISEASES; NEW YORK CITY; PREGNANCY;

EID: 0029982576     PISSN: 00272507     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (63)

1. Crohn BB, Ginzburg L, Oppenheimer GB. Regional ileitis: A pathological and clinical entity. JAMA 1932; 99: 1323-1329.
2. Korelitz BI, Gribetz D, Danziger I. The prognosis of ulcerative colitis with onset in childhood. I. Presteroid era. Ann Intern Med 1962; 57:582-591.
3. Korelitz BI, Lindner AE. The influence of corticotrophin and adrenal steroids in the course of ulcerative colitis. Gastroenterology 1964; 46:671-679.
4. Spencer SA, Kirsner JB, Mlynaryk P, Reed PI, Palmer WL. Immediate and prolonged therapeutic effects of corticotrophin and adrenal steroids in ulcerative colitis: Observations in 340 cases of periods up to ten years. Gastroenterology 1962; 42:113-129.
5. Lennard-Jones JE, Misiewicz JT, Connell AM, et al. Prednisone as maintenance treatment for ulcerative colitis. Lancet 1965; 1:188-189.
6. Mackay IR, Burnet FM. Autoimmune disease: Pathogenesis, chemistry, and therapy. Springfield, IL: Charles C. Thomas, 1963: 237-239.
7. Skinner MD, Schwartz RS. Medical progress: Immunosuppressive therapy. N Engl J Med 1972; 287:221-227.
8. Broberger O. Immunologic studies in ulcerative colitis. Gastroenterology 1964; 47:229-240.
9. Elion GB, Hitchings GH. Azathioprine. In: Handbook of Experimental Pharmacology. New York: Springer Verlag. 1975:404-425.
10. Sparberg M, Kirsner JB. Long term corticosteroid therapy for regional enteritis. Am J Dig Dis 1966; 11:865-880.
11. Winkelman EJ, Brown GH. Nitrogen mustard in the treatment of chronic ulcerative colitis and regional enteritis. Clevel Clin Q 1965; 32:165-174.
12. Bean RHD. The treatment of chronic ulcerative colitis with 6-mercaptopurine. Med J Aust 1962; 2:592-593.
13. Bean RHD. Treatment of ulcerative colitis with antimetabolites. Br Med J 1966; 1:1081-1084.
14. Brooke BN, Hoffmann DC, Swarbrick ET. Azathioprine for Crohn's disease. Lancet 1969; 2:612-614.
15. Brooke BN, Javett SL, Davison OW. Further experience with azathioprine for Crohn's disease. Lancet 1970; 2:1050-1053.
16. Banks BM, Korelitz BI, Zetzel L. The course of nonspecific ulcerative colitis. Reviewing twenty years experience and late results. Gastroenterology 1957; 32:983-1012.
17. Korelitz BI, Gribetz D. The prognosis of ulcerative colitis with onset in childhood. II. The steroid era. Ann Inter Med 1962; 57:592-597.
18. Korelitz BI, Wisch N. Long term therapy of ulcerative colitis with 6-mercaptopurine: A personal series. Am J Dig Dis 1972; 17:111-118.
19. Bowen GE, Irons GV Jr., Rhodes JD, Kirsner JB. Early experience with azathioprine in ulcerative colitis. JAMA 1966; 195:166-170.
20. Korelitz BI, Glass JL, Wisch N. Long-term immunosuppressive therapy of ulcerative colitis. Continuation of a personal series. Am J Dig Dis 1973; 18:317-322.
21. Present DH, Korelitz BI, Wisch N, Glass JL, Sachar DB, Pasternack BS. Treatment of Crohn's disease with 6-mercaptopurine. A long-term, randomized, double blind study. N Engl J Med 1980; 302:981-987.
22. Summers RWL, Switz DM, Sessions JT Jr, et al. National Cooperate Crohn's Disease Study: Results of drug treatment. Gastroenterology 1979; 77:847-869.
23. Best WR, Becktel JM, Singleton JW, Kern F. Development of a Crohn's Disease Activity Index. Gastroenterology 1976; 70:433-444.
24. Goldstein F, Thornton JJ, Abramson J. Comments on National Cooperation Crohn's Disease Study (NCCDS). Gastroenterology 1980; 78:1647-1648.
25. Korelitz BI, Present DH. Shortcomings of the National Cooperative Crohn's Disease Study: In the exclusion of azathioprine without adequate trial. Gastroenterology 1981; 80:193-194.
26. Korelitz BI, Present DH. Favorable effect of 6 mercaptopurine in fistulas of Crohn's disease. Dig Dis Sci 1985; 30:58-64.
27. O'Donoghue DP, Dawson AM, Powell-Tuck J, et al. Double blind withdrawal trial of azathioprine as maintenance treatment of Crohn's disease. Lancet 1978; 2: 955-957.
28. Korelitz BI. Therapy of inflammatory bowel disease including use of immunosuppressive agents. Clin Gastroenterol 1980; 9:331-349.
29. Korelitz BI, Adler DJ, Mendelsohn RA, Sacknoff AL. Longterm experience with 6-mercaptopurine in the treatment of Crohn's disease. Am J Gastroenterol 1993; 88:1198-1205.
30. Rosenberg JL, Wall AJ, Levin B, et al. A controlled trial of azathioprine in the management of ulcerative colitis. Dig Dis 1975; 20:721-726.
31. George J, Pou R, Bodian C, et al. 6-Mercaptopurine (6-MP) is effective in chronic ulcerative colitis but how long do you use it? Gastroenterology 1994; 106:A686.
32. Lobo AJ, Foster PN, Burke DA, et al. The role of azathioprine in the management of ulcerative colitis. Dis Colon Rectum 1990; 33:374-377.
33. Adler DJ, Korelitz BI. The therapeutic efficacy of 6 mercaptopurine in refractory ulcerative colitis. Am J Gastroenterol 1990; 85:717-722.
34. Hawthorne AB, Logan RFA, Hawkey CJ, et al. Randomized controlled trial of azathioprine withdrawal in ulcerative colitis. Br Med J 1992; 305:20-22.
35. Gemlo BT, Wong WD, Rotherberger DA, Goldberg SM. Heal pouch anal anastomosis. Arch Surg 1992; 127: 784-786.
36. Salemans JMJI, Nagengat FM, Lubbers BSC, Kuijper's JH. Post-operative and long-term results of ileal pouch anal anastomosis for ulcerative colitis and familial polyposis coli. Dig Dis Sci 1992; 37:1882-1889.
37. Setti-Carraro P, Ritchie K, Wilkinson KH, et al. The first 10 years experience of restorative proctocolectomy for ulcerative colitis. Gut 1994; 35:1070-1075.
38. Present DH, Meltzer SJ, Krumholz M, et al. 6-mercaptopurine in the management of inflammatory bowel disease: Short-term and long-term toxicity. Ann Intern Med 1989; 3:641-649.
39. Haber CJ, Meltzer SJ, Present DH, et al. Natural course of pancreatitis caused by 6-mercaptopurine in the treatment of inflammatory bowel disease. Gastroenterology 1986; 91:982-986.
40. Burke DA, Dixon MF, Axon ATR. Ulcerative colitis. Prolonged remission following azathioprine-induced pancreatitis. J Clin Gastroenterol 1989; 11:327-330.
41. Connell WR, Kamm MA, Lennard-Jones JE, et al. Twenty-seven years experience in 739 patients of bone marrow toxicity from azathioprine in inflammatory bowel disease. Gastroenterology 1992; 102:A609.
42. Korelitz BI, Present DH, Rubin PH, et al. Desensitization to sulfasalazine after hypersensitivity reactions in patients with inflammatory bowel disease. J Clin Gastroenterol 1984; 6:27-31.
43. Greenstein AJ, Gennuso R, Sachar DB, et al. Extraintestinal cancers in inflammatory bowel disease. Cancer 1985; 56:2914-2921.
44. Lemann M, Bonhomme P, Bitoun A, et al. Traitement de la maladie de Crohn par l'azathioprine ou la 6-mercaptopurine. Étude retrospective chez 126 maladies. Gastroenterol Clin Biol 1990; 14:548-554.
45. Connell WR, Kinlen LJ, Ritchie JK, et al. Cancer risks from azathioprine in inflammatory bowel disease. Gastroenterology 1994; 106:A667.
46. Schenk SA, Penn I. De-novo brain tumors in renal transplant recipients. Lancet 1971; 1:983-986.
47. Penn I, Hammond W, Brettschneider L, et al. Malignant lymphoma in the transplantation patient. Transplant Proc 1969; 1:106-112.
48. Glick SN, Teplick SK, Goodman LR, et al. The development of lymphoma in patient with Crohn's disease. Radiology 1984; 153:337-339.
49. Greenstein AJ, Mullin GE, Strauchen JA, et al. Lymphoma in inflammatory bowel disease. Cancer 1992; 69:1119-1123.
50. Alstead EM, Ritchie JK, Lennard-Jones JE, et al. Safety of azathioprine in pregnancy in inflammatory bowel disease. Gastroenterology 1990; 90:443-446.
51. Brynskov J, Freund L, Rasmussen SM, et al. A placebo controlled, double-blind randomized trial of cyclosporine, therapy in active Crohn's disease. N Engl J Med 1985; 321:845-850.
52. Jewell DP, Lennard-Jones JE and the Cyclosporine Study Group of Great Britain and Ireland. Oral cyclosporine for chronic active Crohn's disease: A multicenter controlled trial. Eur J Gastroenterol Hepatol 1994; 6:499-505
53. Feagan BG, McDonald JWD, Rochon J, et al. Low dose cyclosporine for the treatment of Crohn's disease. N Engl J Med 1994; 330:1846-1851.
54. Stange EF, Modigliani R, Pena AS, et al. European trial of cyelosporine in chronic active Crohn's disease: A 12-month study. Gastroenterology 1995; 109:774-782.
55. Present DH, Lichtiger S. Efficacy of cyclosporine in treatment of fistula of crohn's disease. Dig Dis Sci 1994; 39:374-380.
56. Hanauer SB, Smith MB. Rapid closure of Crohn's disease fistulas with continuous intravenous cyclosporine. Am J Gastroenterol 1993; 88:646-649.
57. Lichtiger S, Present DH. Preliminary report: Cyclosporine in treatment of severe active ulcerative colitis. Lancet 1990; 1:16-19.
58. Lichtiger S, Present DH, Kornbluth A, et al. Cyclosporine in severe ulcerative colitis refractory to steroid therapy. N Engl J Med 1994; 330:1841-1845.
59. Kornbluth A, Lichtiger S, Present DH, Hanauer S. Long-term results of oral cyclosporine in patients with severe ulcerative colitis: A double blind, randomized multi-center trial (Abstract). Gastroenterology 1994; 106: A714.
60. Colonna T, Korelitz BI. The role of leukopenia in the 6-mercaptopurine induced remission of refractory Crohn's Disease. Am J Gastroenterol 1994; 89:362-366.
61. Present DH. Cyclosporine and other immunosuppressive agents: Current and future role in the treatment of inflammatory bowel disease. Am J Gastroenterol 1993; 88:627-630.
62. Korelitz BI. My thoughts on using cyclosporine in the treatment of inflammatory bowel disease (Editorial). Am J Gastroenterol 1995; 90:2095-2086.
63. Korelitz BI, Present DH. Methotrexate for Crohn's Disease. N Engl J Med 1995; 333:600-601.