The role of GM1-ganglioside in the injured spinal cord of rats: An immunohistochemical study using GM1-antisera

Journal of Neurotrauma

Volumn 13, Issue 3, 1996, Pages 163-170

  Imanaka, Toru ^a   Hukuda, Sinsuke ^a   Maeda, Toshihiro ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

demyelination; GM1 ganglioside; immunohistochemistry; motor function; spinal cord injury

Indexed keywords

GANGLIOSIDE GM1;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEMYELINATION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOTOR PERFORMANCE; NONHUMAN; RAT; SPINAL CORD INJURY; TISSUE DISTRIBUTION;

EID: 0029981314     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.1996.13.163     Document Type: Article

References (39)

1. AGNATI, L.F., FUXE, K., CALZA, L., et al. (1983). Gangliosides increase the survival of lesioned nigral dopamine neurons and favour the recovery of dopaminergic synaptic function in striatum of rats by collateral sprouting. Acta Physiol. Scand. 119, 347-363.
2. ANDO, S. (1983). Gangliosides in the nervous system. Neurochem. Int. 5, 507-537.
3. BLACK, J.A., FRIEDMAN, B., WAXMAN, S.G., ELMER, L.W., and ANGELIDES, K.J. (1989). Immuno-ultrastructural localization of sodium channels at nodes of Ranvier and perinodal astrocytes in rat optic nerve. Proc. R. Soc. Lond. B 238, 38-57.
4. BLIGHT, A.R. (1983). Axonal physiology of chronic spinal cord injury in the cat: Intracellular recording in vitro. Neuroscience 10, 1471-1486.
5. BLIGHT, A.R., and YOUNG, W. (1989). Central axons in injured cat spinal cord recover electrophysiological function following remyelination by Schwann cells. J. Neurol. Sci. 91, 15-34.
6. BOSE, B., OSTERHOLM, J.L., and KALIA, M. (1986). Ganglioside-induced regeneration and reestablishment of axonal continuity in spinal cord-transected rats. Neurosci. Lett. 63, 165-169.
7. +)-ATPase activity in cats following intravenous methylprednisolone. Brain Res. 219, 464-469.
8. CONSTANTINI, S., and YOUNG, W. (1994). The effects of methylprednisolone and the ganglioside GM1 on acute spinal cord injury in rats. J. Neurosurg. 80, 97-111.
9. CUELLO, A.C., STEPHENS, P.H., TAGARI, P.C., SOFRONIEW, M.V., and PEARSON, P.C.A. (1986). Retrograde changes in the nucleus basalis of the rat, caused by cortical damage, are prevented by exogenous ganglioside GM1. Brain Res. 376, 373-377.
10. FAVARON, M., MANEV, H., ALHO, H., et al. (1988). Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex. Proc. Natl. Acad. Sci. U.S.A. 85, 7351-7355.
11. FIHSHMAN, P.S., and KELLY, J.P. (1984). The fate of severed corticospinal axons. Neurology 34, 1161-1167.
12. GEISLER, F.H., DORSEY, F.C., and COLEMAN, W.P. (1991). Recovery of motor function after spinal-cord injury: A randomized, placebo-controlled trial with GM-1 ganglioside. N. Engl. J. Med. 324, 1829-1838.
13. GEISLER, F.H., DORSEY, F.C., and COLEMAN, W.P. (1992). GM-1 ganglioside in human spinal cord injury. J. Neurotrauma 9, S407-S416.
14. GORIO, A., MARLNI, P., and ZANONI, R. (1983). Muscle reinnervation-III. Motomeuron sprouting capacity, enhancement by exogenous gangliosides. Neuroscience 8, 417-429.
15. HALL, E.D., and BRAUGHLER, J.M. (1981). Acute effects of intravenous glucocorticoid pretreatment on the in vitro peroxidation of cat spinal cord tissue. Exp. Neurol. 73, 321-324.
16. 2+-dependent protein kinase by GM1 ganglioside in nerve growth factor-treated PC12 cells. Proc. Natl. Acad. Sci. U.S.A. 88, 5616-5620.
17. JANIGRO, D., DI GREGORIO, F., VYSKOCIL, F., and GORIO, A. (1984). Gangliosides' dual mode of action: A working hypothesis. J. Neurosci. Res. 12, 499-509.
18. KARPIAK, S.E. (1984). Exogenous gangliosides enhance recovery from CNS injury, in: Ganglioside Structure, Function, and Biomedical Potential. W. Ledeen, R.K. Yu, M.M. Rapport, and K. Suzuki (eds), Plenum Press: New York, pps. 489-497.
19. KIMURA, H., MCGREER, P.L., PENG, J.H., and MCGEER, E.G. (1981). The central cholinergic system studied by cholin acetyltransferase immunohistochemistry in the cat. J. Comp. neurol. 200, 151-201.
20. LANG, W. (1981). Pharmacokinetic studies with 3H-labeled exogenous gangliosides injected intramuscularly in rats, in: Gangliosides in Neurological and Neuromuscular Function, Development and Repair. M.M. Rapport and A. Gorio (eds), Raven Press: New York, pps. 241-251.
21. LEDEEN, R.W. (1978). Ganglioside structure and distribution: Are they located at the nerve ending? J. Supramol. Struct. 8, 1-17.
22. LEDEEN, R.W., STRIVANEK, J.A., NUNEZ, J., SCLAFANI, J.R., NORTON, W.T., and FAROOQ, M. (1981). Implications of the distribution and transport of gangliosides in the nervous system, in: Gangliosides in Neurological and Neuromuscular Function, Development and Repair. M.M. Rapport and A. Gorio (eds), Raven Press: New York, pps. 211-223.
23. LEON, A., FACCI, L., BENVEGNU, D., and TOFFANO, G. (1982). Morphological and biochemical effects of gangliosides in neuroblastoma cells. Dev. Neurosci. 5, 108.
24. RIVLIN, A.S., and TATOR, C.H. (1977). Objective clinical assessment of motor function after experimental spinal cord injury in the rat. J. Neurosurg. 47, 577-581.
25. ROISEN, F.J., BARTFELD, H., NAGELE, R., and YORKE, G. (1981). Ganglioside stimulation of axonal sprouting in vitro. Science 214, 577-578.
26. SARUHASHI, Y., HUKUDA, S., and MAEDA, T. (1990). Acute aggregation of serotonin-immunoreactive platelets in the injured spinal cord of rat and change of serotonin content in the neural fibers. J. Neurotrauma 7, 237-246.
27. SARUHASHI, Y., HUKUDA, S., and MAEDA, T. (1991). Evidence for a neural source of acute accumulation of serotonin in platelets in the injured spinal cord of rats. An experimental study using 5,6-dihydroxytryptamine treatment. J. Neurotrauma 8, 121-128.
28. SKAPER, S.D., and LEON, A. (1992). Monosialogangliosides, neuroprotection, and neuronal repair processes. J. Neurotrauma 9, S507-S516.
29. SKAPER, S.D., LEON, A., and TOFFANO, G. (1989). Ganglioside function in the development and repair of the nervous system: From basic science to clinical application. Mol. Neurobiol. 3, 173.
30. SKAPER, S.D., LEON, A., and FACCI, L. (1991a). Ganglioside GM1 prevents death induced by excessive excitatory neurotransmission in cultured hippocampal pyramidal neurons. Neurosci. Lett. 126, 98-101.
31. SKAPER, S.D., MAZZARI, S., VANTINI, G., FACCI, L., TOFFANO, G., and LEON, A. (1991b). Monosialoganglioside GM1 and modulation of neuronal plasticity in CNS repair processes, in: Plasticity and Regeneration of the Nervous System. P.S. Timiras, et al. (eds), Plenum Press: New York, pps. 257-266.
32. SOFRONIEW, M.V., PEARSON, R.C.A., CUELLO, A.C., TAGARI, P.C., and STEPHENS, P.H. (1986). Parenterally administered GM1 ganglioside prevents retrograde degeneration of cholinergic cells of the rat basal forebrain. Brain Res. 398, 393-396.
33. STEPHENS, P.H., TAGARI, P.C., GAROFALO, L., MAYSINGER, D., PIOTTE, M., and CUELLO, A.C. (1987). Neural plasticity of basal forebrain cholinergic neurons: Effects of gangliosides. Neurosci. Lett. 80, 80-84.
34. TARLOV, I.M., and KLINGER, H. (1957). Spinal cord compression studies. II. Time limits for recovery after acute compression in dogs. Arch. Neurol. Psychiat. 71, 271-290.
35. TOFFANO, G., BENVEGNU, D., BONETTI, A.C., et al. (1980). Interactions of GM1 ganglioside with crude rat brain neuronal membranes. J. Neurochem. 35, 861-866.
36. TRACEY, D.J. (1985). Ascending and descending pathways in the spinal cord, in: The Rat Nervous System, Vol. 2. G. Paxinos (ed), Academic Press: Australia, pps. 311-324.
37. WAXMAN, S.G. (1992). Demyelination in spinal cord injury and multiple sclerosis: what can we do to enhance functional recovery? J. Neurotrauma 9, S105-S117.
38. WIEGANDT, H. (1971). Glycosphingolipids. Adv. Lipid Res. 9, 249-289.
39. YOUNG, W. (1992). Role of calcium in central nervous system injuries. J. Neurotrauma 9, S9-S25.